{"paper_id":"21c804fb-df1f-4808-be30-a94a41401d8e","body_text":"Abstract\nA Saudi Arabian infant with severe factor X deficiency who had had two intracranial haemorrhages is described. Attempts to raise his factor X level and improve his prothrombin time (PT) and partial thromboplastin time (PTT) by using vitamin K, oestradiol and danazol have failed. New therapeutic trials are necessary for patients with severe forms of this rare disorder.\nSimilar content being viewed by others\nAbbreviations\n- PT:\n-\nprothrombin time\n- PTT:\n-\npartial thromboplastin time\n- FFP:\n-\nfresh frozen plasma\nReferences\nGralnick HR, Rick ME (1983) Danazol increases factor VIII and factor IX in classic hemophilia and Christmas disease. N Engl J Med 308:1393–1395\nLechler E, Webster WP, Roberts HR, Penick GD (1965) The inheritance of Stuart disease: investigation of a family with factor X deficiency. Am J Med Sci 249:291–294\nMori K, Sakai H, Nakano N (1981) Congenital factor X deficiency in Japan. Tokoho J Exp Med 133:1–19\nO'leary DS, Ruymann FB, Conrad ME (1971) Therapeutic approaches to factor X deficiency with emphasis on the use of a new clotting-factor concentrate (Konyne). J Lab Clin Med 77:23–32\nPechet L, Alexander B (1961) Increased clotting factors in pregnancy. N Engl J Med 265:1093–1096\nSarup BM, Perkash A, Aikat BK (1972) Congenital Stuart-Prower factor (factor X) deficiency. J Indian Med Assoc 59:110–114\nTelfer TP, Denson KW, Wright DR (1956) A new coagulation defect. Br J Haematol 2:308–316\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nSumer, T., Ahmad, M., Sumer, N.K. et al. Severe congenital factor X deficiency with intracranial haemorrhage. Eur J Pediatr 145, 119–120 (1986). https://doi.org/10.1007/BF00441870\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF00441870","source_license":"CC0","license_restricted":false}