{"paper_id":"20963e33-1d15-48fe-802c-b8a6f6001c49","body_text":"Abstract\nPurpose An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3). Patients and Methods Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test. Results Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] <.001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het\n| Original language | English |\n|---|---|\n| Pages (from-to) | 2888-2898 |\n| Number of pages | 11 |\n| Journal | Journal of Clinical Oncology |\n| Volume | 34 |\n| Issue number | 24 |\n| DOIs | |\n| Publication status | Published - 20 Aug 2016 |\nFingerprint\nDive into the research topics of 'Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium'. Together they form a unique fingerprint.Cite this\n- APA\n- Author\n- BIBTEX\n- Harvard\n- Standard\n- RIS\n- Vancouver","source_license":"CC0","license_restricted":false}