{"paper_id":"1f0c5d81-b788-4b21-99a9-926c14375bf4","body_text":"Documenti full-text disponibili:\nAbstract\nPurpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis.\nMethods: a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively.\nResults: No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate.\nConclusions: A combination of serum and molecular markers could allow a better diagnosis of endometriosis.\nAbstract\nPurpose: to quantify the mRNA levels of MMP-3, MMP-9, VEGF and Survivin in peripheral blood and the serum levels of CA-125, Ca19-9 in women with and without endometriosis and to investigate the performance of these markers to differentiate between deep and ovarian endometriosis.\nMethods: a case controls study enrolled a series of 60 patients. Twenty controls have been matched with 20 cases of ovarian and 20 cases of deep endometriosis. Univariable and multivariable performance of serum CA125 and CA19-9, mRNA for Survivin, MMP9, MMP3 and VEGF genes have been evaluated by means of ROC curves and logistic regression respectively.\nResults: No difference in markers concentration were detected between ovarian and deep endometriosis. In comparison with controls serum CA19 and CA125 yielded the better sensitivity followed by mRNA for Survivin gene (81.5%, 51.9% and 7.5% at 10% false positive rate respectively). Multivariable estimated odds of endometriosis yielded a sensitivity of 87% at the same false positive rate.\nConclusions: A combination of serum and molecular markers could allow a better diagnosis of endometriosis.\nTipologia del documento\nTesi di dottorato\nAutore\nElmakky, Amira\nSupervisore\nCo-supervisore\nDottorato di ricerca\nScuola di dottorato\nScienze biologiche, biomediche e biotecnologiche\nCiclo\n23\nCoordinatore\nSettore disciplinare\nSettore concorsuale\nParole chiave\nEndometriosis VEGF MMPs Survivin\nURN:NBN\nData di discussione\n14 Aprile 2011\nURI\nAltri metadati\nTipologia del documento\nTesi di dottorato\nAutore\nElmakky, Amira\nSupervisore\nCo-supervisore\nDottorato di ricerca\nScuola di dottorato\nScienze biologiche, biomediche e biotecnologiche\nCiclo\n23\nCoordinatore\nSettore disciplinare\nSettore concorsuale\nParole chiave\nEndometriosis VEGF MMPs Survivin\nURN:NBN\nData di discussione\n14 Aprile 2011\nURI\nGestione del documento:","source_license":"CC0","license_restricted":false}