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Mohod\" }, { \"@type\": \"Person\", \"name\": \"Vidya Lohe\" }, { \"@type\": \"Person\", \"name\": \"Shraddha Patel\" } ], \"publisher\": { \"@type\": \"Organization\", \"name\": \"F1000Research\", \"logo\": { \"@type\": \"ImageObject\", \"url\": \"https://f1000research.com/img/AMP/F1000Research_image.png\", \"height\": 480, \"width\": 60 } }, \"image\": { \"@type\": \"ImageObject\", \"url\": \"https://f1000research.com/img/AMP/F1000Research_image.png\", \"height\": 1200, \"width\": 150 }, \"description\": \" Background Sushruta (600 B.C.) described a condition called &ldquo;Vidari&rdquo; linked with progressive narrowing of mouth, depigmentation of the oral mucosa, and pain on taking food, oral submucous fibrosis (OSMF). With an overall Indian prevalence rate of between 0.2&ndash;0.5%, OSMF is primarily found in India and Southeast Asia, according to global estimations. Patients with OSMF need regular follow-ups and to maintain this follow-up it is not always possible for the patient to visit a dental clinic. Hence developing a smartphone-based application for the follow-up of OSMF will be of great value to the patients. The study aims to evaluate the effectiveness of a smartphone application on OSMF self-examination in the follow-up of patients. Methods There will be three phases of the research. The first phase will be the development of a smartphone-based application for the follow-up of patients with OSMF. The second phase will be distribution and training the patients regarding the usage of the application and the third phase will be evaluating the effectiveness of the smartphone application in maintaining the follow-up of the patients. Expected results The follow-up of patients with OSMF is expected to be better and feasible using a smartphone application as compared to regular Outpatient Department-based follow-up. Conclusions Designing a mobile application for the ease of users presents difficulties since it must take user-friendliness and accessibility into account, which influences how well the application is received by users. In addition to follow-up, the smartphone-based application promotes the awareness towards Self-examination and knowledge in OSMF patients. Thus, it will act as an educational tool providing information, to enhance OSMF screening practice. CTRI registration CTRI/2023/06/054514 (registration pending). \" } { \"@context\": \"http://schema.org\", \"@type\": \"BreadcrumbList\", \"itemListElement\": [ { \"@type\": \"ListItem\", \"position\": \"1\", \"item\": { \"@id\": \"https://f1000research.com/\", \"name\": \"Home\" } }, { \"@type\": \"ListItem\", \"position\": \"2\", \"item\": { \"@id\": \"https://f1000research.com/browse/articles\", \"name\": \"Browse\" } }, { \"@type\": \"ListItem\", \"position\": \"3\", \"item\": { \"@id\": \"https://f1000research.com/articles/13-165/v2\", \"name\": \"Comparative evaluation of efficacy of a smartphone application for...\" } } ] } Home Browse Comparative evaluation of efficacy of a smartphone application for... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Dadgal KV, Panchbhai A, Mohod SC et al. Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.12688/f1000research.133893.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Study Protocol Revised Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] Komal Vilas Dadgal https://orcid.org/0000-0001-6462-411X 1 , Aarati Panchbhai 1 , Swapnil C. Mohod 1 , Vidya Lohe 1 , Shraddha Patel https://orcid.org/0000-0002-1925-0590 1 Komal Vilas Dadgal https://orcid.org/0000-0001-6462-411X 1 , Aarati Panchbhai 1 , [...] Swapnil C. Mohod 1 , Vidya Lohe 1 , Shraddha Patel https://orcid.org/0000-0002-1925-0590 1 PUBLISHED 14 May 2025 Author details Author details 1 Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, Maharashtra, 442001, India Komal Vilas Dadgal Roles: Funding Acquisition, Investigation, Writing – Original Draft Preparation, Writing – Review & Editing Aarati Panchbhai Roles: Conceptualization, Data Curation, Methodology, Resources, Software, Validation, Visualization Swapnil C. Mohod Roles: Conceptualization, Resources, Software, Supervision, Validation, Visualization Vidya Lohe Roles: Data Curation, Formal Analysis Shraddha Patel Roles: Methodology, Project Administration OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Datta Meghe Institute of Higher Education and Research collection. Abstract Background Sushruta (600 B.C.) described a condition called “Vidari” linked with progressive narrowing of mouth, depigmentation of the oral mucosa, and pain on taking food, oral submucous fibrosis (OSMF). With an overall Indian prevalence rate of between 0.2–0.5%, OSMF is primarily found in India and Southeast Asia, according to global estimations. Patients with OSMF need regular follow-ups and to maintain this follow-up it is not always possible for the patient to visit a dental clinic. Hence developing a smartphone-based application for the follow-up of OSMF will be of great value to the patients. The study aims to evaluate the effectiveness of a smartphone application on OSMF self-examination in the follow-up of patients. Methods There will be three phases of the research. The first phase will be the development of a smartphone-based application for the follow-up of patients with OSMF. The second phase will be distribution and training the patients regarding the usage of the application and the third phase will be evaluating the effectiveness of the smartphone application in maintaining the follow-up of the patients. Expected results The follow-up of patients with OSMF is expected to be better and feasible using a smartphone application as compared to regular Outpatient Department-based follow-up. Conclusions Designing a mobile application for the ease of users presents difficulties since it must take user-friendliness and accessibility into account, which influences how well the application is received by users. In addition to follow-up, the smartphone-based application promotes the awareness towards Self-examination and knowledge in OSMF patients. Thus, it will act as an educational tool providing information, to enhance OSMF screening practice. CTRI registration CTRI/2023/06/054514 (registration pending). READ ALL READ LESS Keywords oral submucous fibrosis, self-examination, follow-up, smartphone applications, public awareness Corresponding Author(s) Komal Vilas Dadgal ( [email protected] ) Swapnil C. Mohod ( [email protected] ) Close Corresponding authors: Komal Vilas Dadgal, Swapnil C. Mohod Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Dadgal KV et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Dadgal KV, Panchbhai A, Mohod SC et al. Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.12688/f1000research.133893.2 ) First published: 08 Mar 2024, 13 :165 ( https://doi.org/10.12688/f1000research.133893.1 ) Latest published: 14 May 2025, 13 :165 ( https://doi.org/10.12688/f1000research.133893.2 ) Revised Amendments from Version 1 The revised version of the article has explained the phases of the study along with the timeline and medical intervention, while follow-ups are added to the methodology of the article. In addition, the article has clarified the patient outcome, generalizability, and effectiveness of smartphone applications in augmenting patient compliance, follow-up, and awareness towards self-examination in OSMF screening. Thus, a defined timeline of all the phases has been added to the manuscript. The modifications in the smartphone application will be done according to feedback on the patient's understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment findings will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD, and the submitted data of these patients through a smartphone app and observations on physical examination will be compared. A new author was added to the paper for their contributions. The revised version of the article has explained the phases of the study along with the timeline and medical intervention, while follow-ups are added to the methodology of the article. In addition, the article has clarified the patient outcome, generalizability, and effectiveness of smartphone applications in augmenting patient compliance, follow-up, and awareness towards self-examination in OSMF screening. Thus, a defined timeline of all the phases has been added to the manuscript. The modifications in the smartphone application will be done according to feedback on the patient's understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment findings will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD, and the submitted data of these patients through a smartphone app and observations on physical examination will be compared. A new author was added to the paper for their contributions. See the authors' detailed response to the review by Prasad Nalabothu See the authors' detailed response to the review by Supriya Kheur See the authors' detailed response to the review by Harshkant Gharote READ REVIEWER RESPONSES Introduction Background The World Health Organization (WHO) described this condition as “a slowly progressing disease in which fibrous bands form in the oral mucosa, ultimately leading to the severe restriction of movement of the mouth including tongue” in 1978. 1 In 2019, More and Rao described it as “a debilitating, progressive, irreversible collagen metabolic disorder induced by chronic chewing of areca nut and its commercial preparations; affecting the oral mucosa and occasionally the pharynx and esophagus; leading to mucosal stiffness and functional morbidity, and has a potential risk of malignant transformation”. 2 , 3 Prevalence According to estimates, 7–30% of oral submucous fibrosis (OSMF) cases will develop into oral squamous cell carcinoma (OSCC). 4 Due to the high malignant transformation rate of this illness (1.5–15%), death rates are high. OSMF incidence varies by area and ethnicity and is strongly correlated with culture, habits, and diet. 5 Patients with OSMF are most predominant in South and South-East Asia. The high percentage of Indian immigrants in South Africa also contributes to the high prevalence of patients with OSMF there. 6 Different South-East Asian nations have different oral submucous fibrosis (OSMF) prevalence rates. According to statistics, the prevalence is 0.9–4.7% in China, 0.6–6.42% in India, 0.15–14.6% in Vietnam, and 0.086–17.6% in Taiwan. According to statistics from WHO, more than five million individuals are living with OSMF worldwide. 7 Patients with OMSF can range from 8 to 80 years old, and the mean age varies between studies. OSMF is closely linked with the use of betel nut/areca nut, which is classified as grade I hazard by WHO. The use of betelnut is very common in the Indian population being part of cultural events. The betelnut and its products are easily accessible. 8 Various preparations of betel nut including smokeless tobacco, e.g. , kharra, gutkha, and processed packed supari, are very common in this region, giving rise to the number of patients with OSMF. The oral mucosa of patients with the condition has a leathery feel and perceptible vertical fibrous bands, which finally restricts mouth opening and makes the tongue hard. Early signs of the condition include a burning feeling when eating spicy food, losing normal pigmentation, and blanching of the mucosa. Ulcers, dry mouth, burning in the mouth, and restricted mouth opening are some of the clinical symptoms of OSMF. 9 As the condition worsens, it could cause distress to the throat and esophagus, causing fibrosis of the upper digestive tract, while mouth-opening limitation is triggered by fibrosis of oral mucosa in the late phases of OSMF. Oral mucosa blanching is a significant clinical characteristic in the initial phases. 7 Life quality is directly impacted by the characteristic manifestations and signs of OSMF patients who exhibit a constrained mouth opening. 5 It should be noted that many patients with OSMF exhibit symptoms of anxiety, sadness, stress, and poor social interaction, and the incidence of these symptoms is proportionally linked to the severity of ailment’s. 2 A mobile application containing material that is specifically designed for end users, such as the general public, may increase the intervention’s acceptability and effectiveness. The creation of mobile applications that incorporate theory may emphasize and support behavior modification for health promotion in patients with OSMF. 10 Public health promotion will be practiced by the built mobile application. Therefore, enhancing the mobile application’s visual appeal, usability, acceptance, and effectiveness is necessary. 11 Objectives Phase 1 : Development of an evidence based self-assessment smartphone application (2 months): a. To develop evidence based relevant content for the development of a user-friendly self-assessment smartphone application for patients with OSMF. Phase 2 : Distribution of the smartphone application (2 months): a. To train and counsel patients regarding the utilization of the smartphone application. b. To modify the application as per the requirement and suggestions of the user. Phase 3 : To assess the outcome of the smart phone-based application on patient follow-up (6 months): a. To assess the efficacy of smartphone self-assessment application in maintaining the follow-up of the patients. Methods Ethical considerations Ethical approval has been received from Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha IEC reference number DMIHER (DU)/2023/568. Consent from the intervention group will be taken using electronic consent forms. For the routine outpatient department (OPD)-based follow-up, written consent form will be taken manually. This clinical trial study protocol adhered to the SPIRIT checklist. 16 Study setting This prospective study will be conducted at Sharad Pawar Dental College, Sawangi (Meghe), Wardha in the Dept. of Oral Medicine and Radiology. After getting ethical approval from “The Institutional Ethics Committee (IEC)” of Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, for this study, the patients who will be clinically diagnosed with OSMF will be recruited in the study. The participants will be selected as per the inclusions and exclusions given in the criteria. All the recruited participants will be divided into two groups: control group (OPD-based follow-up) and the intervention group (smartphone-based follow-up). The control group will be monitored by the conventional follow-up method of assessment in patients with OSMF, and the intervention group will be monitored using the smartphone application for the follow-up of the patients. Depending on the findings of the two comparative groups, the efficacy of the smartphone application will be assessed in maintaining the follow-up of the patients with OSMF. Eligibility criteria The investigator will perform the intervention with the following inclusion and exclusion criteria. Inclusion criteria 1. Patients habitual to betelnut chewing (more than six months duration). 2. Patients clinically diagnosed with OSMF. 3. Patients having an acceptable literacy level ( e.g. , are able to read and write Hindi, Marathi, and English). 4. Patients having access to smartphones. 5. Patients who agreed to provide electronic informed consent for the study. Exclusion criteria 1. Patients who refuse to consent to participate in the study will not be included. 2. Patients having malignant lesions are also excluded from the study. 3. Patients who are unable to read the application’s teaching materials on their smartphones. 4. Patients who are unable to use the smartphone application efficiently. 5. Patients who presented with congenital or developmental abnormalities of jaw. 6. Patients with post-surgical defect of jaw. Intervention The participants of the intervention group will be given access to smartphone application for the follow-up of the OSMF. Whereas the control group will not be given access to the application. The participants in the control group will be referred to the OPD for the follow-up of OSMF. The intervention will be accustomed for six months. The initial two months will be the training period for the participants for the usage and various features of the smartphone application. The smartphone application will also be surveyed for any modifications in the smartphone application. The smartphone application will contain monthly and weekly follow-ups for the users and information regarding the disease and ill-effects of the use of betelnut and its products. After downloading the application, the user will have to fill the demographic details for the sign-in of the application. After the sign-in, the user will have access to follow-up section and the information available on the smartphone application. The user can follow the steps and answer the questions of the follow-up for the monthly and weekly follow-up. To improve the adherence of the participants in the intervention group, the smartphone application will have a feature of notification reminder to adhere to the follow-up of OSMF on weekly and monthly basis. All the participants of the control and intervention group will be provided with the medicinal treatment over a period of 6 months. As all the participants are recruited from the OPD-setup, the participants will be examined and will be provided with medicinal treatment depending on their grades or severity of OSMF. Also, all the participants of the intervention group will be in contact with the investigator through telephonic communication. As the main objective of the smartphone application is maintaining long-term follow-ups and patients compliance, more emphasis is given on regular follow-ups. Outcomes The outcomes of the study will be measured in terms of augmented patient compliance and regular follow-up of the patients who have OSMF or have the habit of betel-nut chewing. In addition, the smartphone application will be of help in increasing awareness and promoting self assessment in OSMF patients. The participants can adhere to the follow-up more efficiently using the smartphone application for the follow-up and inspect for the improvement of the signs of OSMF on their own. It may not be always feasible for the patients to travel and report the OPD-setup for every-follow-up. Many patients residein the remote regions which are very far from the OPD-setups. Moreover, the patients must maintain long term follow-ups for OSMF, as it has high rate of malignant transformation. Development of such smartphone applications would be very beneficial in maintaining patient compliance and long-term follow-ups of patients. Participant timeline After introducing the participants of the intervention group to the smartphone application, they will perform the weekly and monthly follow-ups for a period of 6 months. Sample size N 0 = [ ( Z α + Z β ) 2 ( σ 1 2 / r + σ 0 2 ) ( d − δ ) 2 ] • Significance level Type I error rate, α = 0.05 • Power (1-beta) = 0.8 • Z alpha value = at 90% 1.645 • Z beta value = at 80% 0.842 • Expected population standard deviation, SD = 1.5 • δ (>0), Margin = 1.1 G power software analysis α err prob = 0.05 Power (1-β err prob) = 0.95 Df = 80 Total sample size = 110 Recruitment All the patients visiting the out-patient department (OPD) will be thoroughly inspected for the habit of betelnut chewing and clinically diagnosed with OSMF will be recruited. The participants of the intervention group will be introduced to the developed smartphone application for the follow-up. They will be explained about the efficacy of the use of the application for the follow-up of the habit and OSMF which will also help them to cease the habit. Whereas, the participants of the control group will report to the OPD for every follow-up visit. Allocation Sequence generation for both the groups will be done using simple randomization. Allocation concealment mechanism The mechanism of implementing the allocation sequence is by sequential numbering. Implementation The investigator will generate the allocation sequence, enroll the participants, and will assign the participants to intervention and the control group. Blinding The participants belonging to both, intervention and control groups will be blinded. Phases Phase 1: Development of the self-assessment smartphone application The evidence-based informational materials on OSMF, cancer prevention, and self-examination will be taken from reliable sources such as articles published in indexed journals i.e. scopus, pubmed and web of sciences. 12 Following which, the contents will be modified, and animated educational videos will be created. Then, with the assistance of professionals in the creation of electronic content, the materials will be created with modifying rules and converting lessons to electronic formats, images, animations, also audio and video clips will be included. 11 The resources will then be created using Android Studio, a software development environment for the Android platform, in the form of installable applications for mobile devices. The application will be multilingual. The OSMF application will consist of two components: the OSMF self-assessment and the OSMF educational resources. 11 The OSMF self-assessment section will consist of weekly and monthly follow-up questions. For a better understanding of the questionnaire, various animated photos and techniques to verify the symptoms will be mentioned with the follow-up questions. Three content experts will assess the content validity of the questionnaire. The participants’ smart electronic devices will have the application downloaded, and it can be utilized online. Patients will also be trained by the researcher for the handling of the application. It should be noted that an internet connection will be necessary for the application’s installation. The piloting of the validated self-examination questionnaire will be done by giving to 10 OSMF patients as a trial prior to the study to check the feasibility and understanding of the questionnaire. Phase 2: Distribution of the application The main objective of this phase is to train and counsel patients regarding the utilization of the smartphone application and to modify the application as per the requirements and suggestions of the participants. The goals and methods of the study will be explained to each participant. The participants will be made made aware that they need internet access to use the developed smartphone application for OSMF. After installation of the application on their Android phone, which will be made available on Google Play Store, electronically generated informed. Consent popped up. Only after accepting the consent, the participants will have access to the smartphone application. Concerns over the privacy of personal information will be reassured. The participants will fill their basic demographic details for the sign-in of the app, which will create a unique username and password for all the participants. The participants will also have an option to change their username and password according to their will whenever required. The participants will be trained and made acquainted on how to use the application for the follow-up of the habit and OSMF and its features. After introducing the participants of the intervention group to the smartphone application, they will perform weekly and monthly follow-ups for 6 months. After a month of using the smartphone application regularly, the verbal feedback will be obtained from each participant in case they need any changes or issues with the app or its understandability. Participants will be requested to get in touch with the researcher in case any issues or concerns about using the application. The data of the participants using the self-examination smartphone application for OSMF follow-up who belong to the intervention group will be stored in the application, which can be accessed by the investigator through an account created in the same smartphone application. The developed smartphone application will have provision that no other person except the investigator will be able to login into that account which receives patient-related data. Phase 3: To assess the outcome of the smartphone-based application on patient follow-up The data generated from application will be used to assess: i) Patient compliance; ii) modifications in symptoms; and iii) analysis of patient feedback will be done. The participants of the control group, who will not be given access to the smartphone application, will be referred to the OPD for the follow-up of OSMF. A proforma will be designed that includes personal details of the participants along with the clinical oral examination for 6-month follow-up. All the collected data of the patients from either the control or intervention will be converted into a tabulated form, and statistical analysis of the data will be performed. For the maintenance of the data quality, once the data will be collected from the control and intervention group participants, it will be cross-checked by all the investigators. To confirm the authenticity and reliability of the data from the smartphone app, for 15 participants of the intervention group the submitted data of the patients will be cross-checked by examining the patients in the OPD on physical mode. The comparative analysis will be done statistically. Data collection The data will be collected from the patients for follow-up of OSMF visiting OPD for the control group. The data of the participants using the self-assessment smartphone application for OSMF follow-up who belongs to the intervention group will be stored in the application which can be accessed by the investigator. The data collected includes demographic details such as age, address, and contact details. Data will also be collected from the questionnaire of the self-assessment application for OSMF follow-up over a period of six months. Retention The participants will get regular reminder notifications on their smartphone application which they will be using for the follow-up of OSMF, which will improve participant retention. This will also ensure complete follow-up of the participants of the intervention group. Data management For the maintenance of the data quality, once the data is collected from the participants of the control and intervention group it will be cross-checked by all the investigators. Statistical analysis Statistical analysis will be done by using descriptive and inferential statistics using Chisquare test, and Student’s paired and unpaired t-test. Interobserver reliability score will be done by Cronbach alpha test and kappa test. Software used in the analysis is SPSS 27.0 version and Graph Pad Prism 7.0 version and p<0.05 is considered as a level of significance. Study status Not yet started. Discussion The follow-up of the OSMF patients is expected to be better using a smartphone application as compared to the regular OPD-based follow-up. Numerous studies on these applications have been carried out, and more than 40,000 mobile health applications are already accessible on several platforms. However, there isn’t enough research to prove that these mobile apps integrate theory and were created using a qualitative design process. However, as mobile health technologies advance, there is growing concerned about how mobile application performance is constrained by their usability, accuracy, and data privacy. 11 , 13 Rêgo et al. , 2022, undertook a study with the goal of creating and validating a tool for identifying oral cancer risk factors. To evaluate the probability of developing oral cancer, an application was created that included predictors of the disease. 14 For 40 experts in oral diagnostics to evaluate the algorithm and test its usability and accessibility, simulated clinical scenarios were created. The oral cancer screening was efficient, had good sensitivity and usability, and may even help find early oral lesions. 14 Chang et al. , 2019 conducted a study to show the methodical development course and content of the oral self-care application. Behavioral diagnosis, intervention design, and oral self-care assessment are the three phases of the systematic development process for oral self-care assessment. 15 Through skilled assessment of the beta and final versions of the application and serviceability testing of the final version by patients with periodontal disease, the produced oral self-care app was evaluated and found to have good usability. This study described a meticulous design procedure for creating a customized, evidence-based mobile application for oral self-care, which makes it a personalized application for enhancing oral health in individuals with periodontal disease. 15 Interpretation The OSMF self-examination awareness approach using Smartphone application involves inspecting and palpating one’s oral mucosa or oral cavity periodically in order to become familiar with it and spot anomalies. The goal of OSMF examination awareness facilitation and intervention is to raise public knowledge. Educational activities significantly contribute to the advancement of information, convictions, and OSMF screening practice. 13 Generalizability The adverse habits such as consumption of betelnut chewing and tobacco chewing are prevalent in Indian population, consequently prevention and development of oral potentially malignant disorders such as OSMF is of concern. The population that consumes betel nut and tobacco products is the main focus of the study. The consumption of betel nut and tobacco products is done by a vast number of the Indian population. It is not always feasible for the patients to visit a dental setup for maintaining the follow-up. The study will be helpful in the follow-up of OSMF patients more promptly as well as in awareness towards self-examination. Dissemination The study will be published in PubMed, Scopus, and Web of Sciences journal. Data availability Underlying data No data are associated with this article. Reporting guidelines Zenodo: SPIRIT checklist for ‘Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up’. https://doi.org/10.5281/zenodo.7965059 . 16 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Acknowledgements I would like to acknowledge the financial support of ICMR PG thesis programme (reference number: MD22DEC-0115). I would like to thank my institute and my colleagues. References 1. Gupta S, Jawanda MK: Oral submucous fibrosis: An overview of a challenging entity. Indian J. Dermatol. Venereol. Leprol. 2021 Oct 23; 87 (6): 768–777. PubMed Abstract | Publisher Full Text 2. Sheshaprasad R, Pai A, Yaji A: Habit History in Oral Submucous Fibrosis: Have We Over Emphasized? Asian Pac. J. Cancer Prev. 2019; 20 (2): 451–455. Publisher Full Text 3. Sharma SR, Chavan S, Karjodkar FR, et al. : Correlation of Clinical Features in Oral Submucous Fibrosis: A 9-Year Retrospective Study. Ethiop. J. Health Sci. 2022 Jan 1; 32 (1). 4. Niaz K, Maqbool F, Khan F, et al. : Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer. Epidemiology and health. 5. Shah G, Chaturvedi P, Vaishampayan S: Arecanut as an emerging etiology of oral cancers in India. Indian J. Med. Paediatr. Oncol. 2012 Apr; 33 (02): 71–79. Publisher Full Text 6. Ali FM, Aher V, Prasant MC, et al. : Oral submucous fibrosis: Comparing clinical grading with duration and frequency of habit among areca nut and its products chewers. J. Cancer Res. Ther. 2013 Jul 1; 9 (3): 471–476. PubMed Abstract | Publisher Full Text 7. Shivakumar GC, Sahana S, Saha S: Prevalence and site distribution of oral mucosal lesions in patients attending outpatient clinics of Oxford Dental College, Bangalore. J. Indian Assoc. Public Health Dent. 2010 Jan 1; 8 (15): 69. Publisher Full Text 8. Muthukrishnan A, Warnakulasuriya S: Oral health consequences of smokeless tobacco use. Indian J. Med. Res. 2018 Jul; 148 (1): 35–40. PubMed Abstract | Publisher Full Text 9. Arakeri G, Thomas D, Aljabab AS, et al. : TFM classification and staging of oral submucous fibrosis: A new proposal. J. Oral Pathol. Med. 2018 Apr; 47 (4): 403–409. PubMed Abstract | Publisher Full Text 10. Cheng AS, Liu X, Ng PH, et al. : Protocol: Breast cancer application protocol: a randomised controlled trial to evaluate a self-management app for breast cancer survivors. BMJ Open. 2020; 10 (7): e034655. PubMed Abstract | Publisher Full Text | Free Full Text 11. Shrivastava SR, Shrivastava PS, Ramasamy J: Self breast examination: A tool for early diagnosis of breast cancer. Am. J. Public Health Res. 2013 Jun 22; 1 (6): 135–139. Publisher Full Text 12. Heo J, Chun M, Lee KY, et al. : Effects of a smartphone application on breast self-examination: a feasibility study. Healthc. Inform. Res. 2013 Dec 31; 19 (4): 250–260. Publisher Full Text 13. Nasution A, Yusuf A, Keng SL, et al. : Development of Mobile App for Breast Examination Awareness Using Health Belief Model: A Qualitative Study. Asian Pac. J. Cancer Prev. 2021 Oct; 22 (10): 3151–3163. PubMed Abstract | Publisher Full Text | Free Full Text 14. Rêgo TJ, Lemos JV, Matos AP, et al. : Development and professional validation of an App to support Oral Cancer Screening. Braz. Dent. J. 2022 Dec 5; 33 : 44–55. PubMed Abstract | Publisher Full Text | Free Full Text 15. Chang WJ, Lo SY, Kuo CL, et al. : Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease. PLoS One. 2019 Nov 21; 14 (11): e0225453. PubMed Abstract | Publisher Full Text | Free Full Text 16. Dadgal K, Mohod S: Comparative evaluation of the efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Out Patient Department based (OPD) follow-up. [Dataset]. Zenodo. 2023. Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 08 Mar 2024 ADD YOUR COMMENT Comment Author details Author details 1 Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, Maharashtra, 442001, India Komal Vilas Dadgal Roles: Funding Acquisition, Investigation, Writing – Original Draft Preparation, Writing – Review & Editing Aarati Panchbhai Roles: Conceptualization, Data Curation, Methodology, Resources, Software, Validation, Visualization Swapnil C. Mohod Roles: Conceptualization, Resources, Software, Supervision, Validation, Visualization Vidya Lohe Roles: Data Curation, Formal Analysis Shraddha Patel Roles: Methodology, Project Administration Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 14 May 2025, 13:165 https://doi.org/10.12688/f1000research.133893.2 version 1 Published: 08 Mar 2024, 13:165 https://doi.org/10.12688/f1000research.133893.1 Copyright © 2025 Dadgal KV et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Dadgal KV, Panchbhai A, Mohod SC et al. Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.12688/f1000research.133893.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 14 May 2025 Revised Views 0 Cite How to cite this report: Kheur S. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r385351 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-385351 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 13 Jun 2025 Supriya Kheur , Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.180552.r385351 The concept of the study is very sound that the patients will be monitored using the smartphone. It can improve patient compliance, enable remote monitoring, and support early intervention, ultimately reducing the disease burden and preventing malignant transformation. ... Continue reading READ ALL The concept of the study is very sound that the patients will be monitored using the smartphone. It can improve patient compliance, enable remote monitoring, and support early intervention, ultimately reducing the disease burden and preventing malignant transformation. While India has seen rapid growth in mobile technology, recent surveys suggest: The use of Smartphone still uneven in our population —higher in urban areas, lower in rural. Elderly patients may have very limited digital literacy and those from lower socioeconomic strata may not own smartphones The other important point is that the monitoring features includes only timely follow-up and educational features. There should have been a wider range of symptoms that can be monitored using the app. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Partly Competing Interests: No competing interests were disclosed. Reviewer Expertise: Oral potentially malignant disorders, Oral cancer, Stem cells, Biomaterial research I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Kheur S. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r385351 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-385351 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 20 Oct 2025 KOMAL DADGAL , Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India 20 Oct 2025 Author Response Thank you, mam for your suggestions that could be inculcated into the study Competing Interests: No competing interests were disclosed. Thank you, mam for your suggestions that could be inculcated into the study Thank you, mam for your suggestions that could be inculcated into the study Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 20 Oct 2025 KOMAL DADGAL , Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India 20 Oct 2025 Author Response Thank you, mam for your suggestions that could be inculcated into the study Competing Interests: No competing interests were disclosed. Thank you, mam for your suggestions that could be inculcated into the study Thank you, mam for your suggestions that could be inculcated into the study Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Gharote H. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r384873 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-384873 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 May 2025 Harshkant Gharote , Batterjee Medical College, Jeddah, Saudi Arabia Approved VIEWS 0 https://doi.org/10.5256/f1000research.180552.r384873 The manuscript has been revised by the authors as per the comments and suggestions. References 1. Campos LFXA, Cavalcante JP, Machado DP, Marçal E, et al.: Development and Evaluation of a Mobile Oral Health Application for Preschoolers. Telemed J E Health . 2019; ... Continue reading READ ALL The manuscript has been revised by the authors as per the comments and suggestions. References 1. Campos LFXA, Cavalcante JP, Machado DP, Marçal E, et al.: Development and Evaluation of a Mobile Oral Health Application for Preschoolers. Telemed J E Health . 2019; 25 (6): 492-498 PubMed Abstract | Publisher Full Text Competing Interests: No competing interests were disclosed. Reviewer Expertise: As an Oral Physician I understand the epidemiology, clinical presentation and molecular pathogenesis of the disease studied in the present article. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Gharote H. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r384873 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-384873 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 20 Oct 2025 KOMAL DADGAL , Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India 20 Oct 2025 Author Response Thank you sir for approving this version Competing Interests: No competing interests were disclosed. Thank you sir for approving this version Thank you sir for approving this version Competing Interests: No competing interests were disclosed. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 20 Oct 2025 KOMAL DADGAL , Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India 20 Oct 2025 Author Response Thank you sir for approving this version Competing Interests: No competing interests were disclosed. Thank you sir for approving this version Thank you sir for approving this version Competing Interests: No competing interests were disclosed. Close Report a concern COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 08 Mar 2024 Views 0 Cite How to cite this report: Nalabothu P. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r359598 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-359598 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 22 Jan 2025 Prasad Nalabothu , University of Basel, Basel, Switzerland Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.146908.r359598 The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. This information is critical to assessing the effectiveness of the smartphone application ... Continue reading READ ALL The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. The sample size calculation is overly complicated and difficult to verify. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. I recommend not indexing of the study protocol due to significant gaps in methodology, ethical considerations and feasibility. Is the rationale for, and objectives of, the study clearly described? No Is the study design appropriate for the research question? No Are sufficient details of the methods provided to allow replication by others? No Are the datasets clearly presented in a useable and accessible format? No Competing Interests: No competing interests were disclosed. Reviewer Expertise: smart phone technologies. digital dentistry applications I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Nalabothu P. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r359598 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-359598 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 14 May 2025 KOMAL DADGAL , DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India 14 May 2025 Author Response The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, ... Continue reading The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, all the participants of Control (OPD-based follow-up) and intervention group (smartphone application-based follow-up) will be provided with medicinal treatment or clinical intervention. For both groups, patients will be recruited from outpatient department, the treatment protocol will be explained and medications will be prescribed at first visit. In control group, as the patients report to the OPD for every follow-up, the participants are examined and medicinal treatment is provided to them depending on their grades or severity of OSMF. For intervention group, the follow-up information of the participants is recorded via smartphone application as well as participants will be in contact with the researcher through telephonic network. The medicinal intervention to the participants of intervention group will be done through telephonic communication. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. - All the data of the participants in intervention group will reach the investigator through an account created in the same smartphone application for which only the investigator has access. No other person is able to login into the account in smartphone app of patient related data other than the investigator. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. -As OSMF is a chronic disease which needs regular and long-term follow-up and patient compliance due to its high malignant transformation rate, development of such smartphone application can be beneficial in maintaining the follow-up in the patients who are unable to report to OPD for follow-up. The sample size calculation is overly complicated and difficult to verify. The sample size formula has been edited and simplified in consultation with statistician. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. - Defined timeline of all the phases have been added to manuscript. The modifications in the smartphone application will be done according feedback on the patients understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment finding will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD and the submitted data of these patients through smartphone app and observations on physical examination will be compared. The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, all the participants of Control (OPD-based follow-up) and intervention group (smartphone application-based follow-up) will be provided with medicinal treatment or clinical intervention. For both groups, patients will be recruited from outpatient department, the treatment protocol will be explained and medications will be prescribed at first visit. In control group, as the patients report to the OPD for every follow-up, the participants are examined and medicinal treatment is provided to them depending on their grades or severity of OSMF. For intervention group, the follow-up information of the participants is recorded via smartphone application as well as participants will be in contact with the researcher through telephonic network. The medicinal intervention to the participants of intervention group will be done through telephonic communication. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. - All the data of the participants in intervention group will reach the investigator through an account created in the same smartphone application for which only the investigator has access. No other person is able to login into the account in smartphone app of patient related data other than the investigator. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. -As OSMF is a chronic disease which needs regular and long-term follow-up and patient compliance due to its high malignant transformation rate, development of such smartphone application can be beneficial in maintaining the follow-up in the patients who are unable to report to OPD for follow-up. The sample size calculation is overly complicated and difficult to verify. The sample size formula has been edited and simplified in consultation with statistician. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. - Defined timeline of all the phases have been added to manuscript. The modifications in the smartphone application will be done according feedback on the patients understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment finding will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD and the submitted data of these patients through smartphone app and observations on physical examination will be compared. Competing Interests: no Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 14 May 2025 KOMAL DADGAL , DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India 14 May 2025 Author Response The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, ... Continue reading The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, all the participants of Control (OPD-based follow-up) and intervention group (smartphone application-based follow-up) will be provided with medicinal treatment or clinical intervention. For both groups, patients will be recruited from outpatient department, the treatment protocol will be explained and medications will be prescribed at first visit. In control group, as the patients report to the OPD for every follow-up, the participants are examined and medicinal treatment is provided to them depending on their grades or severity of OSMF. For intervention group, the follow-up information of the participants is recorded via smartphone application as well as participants will be in contact with the researcher through telephonic network. The medicinal intervention to the participants of intervention group will be done through telephonic communication. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. - All the data of the participants in intervention group will reach the investigator through an account created in the same smartphone application for which only the investigator has access. No other person is able to login into the account in smartphone app of patient related data other than the investigator. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. -As OSMF is a chronic disease which needs regular and long-term follow-up and patient compliance due to its high malignant transformation rate, development of such smartphone application can be beneficial in maintaining the follow-up in the patients who are unable to report to OPD for follow-up. The sample size calculation is overly complicated and difficult to verify. The sample size formula has been edited and simplified in consultation with statistician. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. - Defined timeline of all the phases have been added to manuscript. The modifications in the smartphone application will be done according feedback on the patients understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment finding will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD and the submitted data of these patients through smartphone app and observations on physical examination will be compared. The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, all the participants of Control (OPD-based follow-up) and intervention group (smartphone application-based follow-up) will be provided with medicinal treatment or clinical intervention. For both groups, patients will be recruited from outpatient department, the treatment protocol will be explained and medications will be prescribed at first visit. In control group, as the patients report to the OPD for every follow-up, the participants are examined and medicinal treatment is provided to them depending on their grades or severity of OSMF. For intervention group, the follow-up information of the participants is recorded via smartphone application as well as participants will be in contact with the researcher through telephonic network. The medicinal intervention to the participants of intervention group will be done through telephonic communication. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. - All the data of the participants in intervention group will reach the investigator through an account created in the same smartphone application for which only the investigator has access. No other person is able to login into the account in smartphone app of patient related data other than the investigator. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. -As OSMF is a chronic disease which needs regular and long-term follow-up and patient compliance due to its high malignant transformation rate, development of such smartphone application can be beneficial in maintaining the follow-up in the patients who are unable to report to OPD for follow-up. The sample size calculation is overly complicated and difficult to verify. The sample size formula has been edited and simplified in consultation with statistician. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. - Defined timeline of all the phases have been added to manuscript. The modifications in the smartphone application will be done according feedback on the patients understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment finding will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD and the submitted data of these patients through smartphone app and observations on physical examination will be compared. Competing Interests: no Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Gharote H. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r255951 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-255951 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 30 May 2024 Harshkant Gharote , Batterjee Medical College, Jeddah, Saudi Arabia Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.146908.r255951 The article is well written and elaborates materials and method. Authors need to explain about follow up wherein only counselling and discontinuation of the habit will be included or any medical management will be employed? As chances ... Continue reading READ ALL The article is well written and elaborates materials and method. Authors need to explain about follow up wherein only counselling and discontinuation of the habit will be included or any medical management will be employed? As chances of loss of follow up in conventional method will increase if no medical intervention is done. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: As an Oral Physician I understand the epidemiology, clinical presentation and molecular pathogenesis of the disease studied in the present article. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Gharote H. Reviewer Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r255951 ) The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-255951 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 25 Jun 2024 KOMAL DADGAL , DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India 25 Jun 2024 Author Response During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. Competing Interests: The authors have no competing interests to declare. During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. Competing Interests: The authors have no competing interests to declare. Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 25 Jun 2024 KOMAL DADGAL , DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India 25 Jun 2024 Author Response During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. Competing Interests: The authors have no competing interests to declare. During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. Competing Interests: The authors have no competing interests to declare. Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 08 Mar 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 14 May 25 read read Version 1 08 Mar 24 read read Harshkant Gharote , Batterjee Medical College, Jeddah, Saudi Arabia Prasad Nalabothu , University of Basel, Basel, Switzerland Supriya Kheur , Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, India Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Kheur S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 13 Jun 2025 | for Version 2 Supriya Kheur , Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India 0 Views copyright © 2025 Kheur S. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The concept of the study is very sound that the patients will be monitored using the smartphone. It can improve patient compliance, enable remote monitoring, and support early intervention, ultimately reducing the disease burden and preventing malignant transformation. While India has seen rapid growth in mobile technology, recent surveys suggest: The use of Smartphone still uneven in our population —higher in urban areas, lower in rural. Elderly patients may have very limited digital literacy and those from lower socioeconomic strata may not own smartphones The other important point is that the monitoring features includes only timely follow-up and educational features. There should have been a wider range of symptoms that can be monitored using the app. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Partly Are sufficient details of the methods provided to allow replication by others? Partly Are the datasets clearly presented in a useable and accessible format? Partly Competing Interests No competing interests were disclosed. Reviewer Expertise Oral potentially malignant disorders, Oral cancer, Stem cells, Biomaterial research I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 20 Oct 2025 KOMAL DADGAL, Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India Thank you, mam for your suggestions that could be inculcated into the study View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Kheur S. Peer Review Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r385351) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-385351 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Gharote H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 29 May 2025 | for Version 2 Harshkant Gharote , Batterjee Medical College, Jeddah, Saudi Arabia 0 Views copyright © 2025 Gharote H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript has been revised by the authors as per the comments and suggestions. References 1. Campos LFXA, Cavalcante JP, Machado DP, Marçal E, et al.: Development and Evaluation of a Mobile Oral Health Application for Preschoolers. Telemed J E Health . 2019; 25 (6): 492-498 PubMed Abstract | Publisher Full Text Competing Interests No competing interests were disclosed. Reviewer Expertise As an Oral Physician I understand the epidemiology, clinical presentation and molecular pathogenesis of the disease studied in the present article. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (1) Author Response 20 Oct 2025 KOMAL DADGAL, Dapertmant of Oral Medicine and Radiology, Datta Meghe Institute of Higher Education, Nagpur, 442001, India Thank you sir for approving this version View more View less Competing Interests No competing interests were disclosed. reply Respond Report a concern Gharote H. Peer Review Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.180552.r384873) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-165/v2#referee-response-384873 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Nalabothu P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 22 Jan 2025 | for Version 1 Prasad Nalabothu , University of Basel, Basel, Switzerland 0 Views copyright © 2025 Nalabothu P. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. The sample size calculation is overly complicated and difficult to verify. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. I recommend not indexing of the study protocol due to significant gaps in methodology, ethical considerations and feasibility. Is the rationale for, and objectives of, the study clearly described? No Is the study design appropriate for the research question? No Are sufficient details of the methods provided to allow replication by others? No Are the datasets clearly presented in a useable and accessible format? No Competing Interests No competing interests were disclosed. Reviewer Expertise smart phone technologies. digital dentistry applications I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (1) Author Response 14 May 2025 KOMAL DADGAL, DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India The protocol raises several important concerns. One important issue is the lack of clarity about whether medical management or clinical interventions will be part of the follow-up process. - Yes, all the participants of Control (OPD-based follow-up) and intervention group (smartphone application-based follow-up) will be provided with medicinal treatment or clinical intervention. For both groups, patients will be recruited from outpatient department, the treatment protocol will be explained and medications will be prescribed at first visit. In control group, as the patients report to the OPD for every follow-up, the participants are examined and medicinal treatment is provided to them depending on their grades or severity of OSMF. For intervention group, the follow-up information of the participants is recorded via smartphone application as well as participants will be in contact with the researcher through telephonic network. The medicinal intervention to the participants of intervention group will be done through telephonic communication. This information is critical to assessing the effectiveness of the smartphone application for patients with OSMF. In addition, the protocol doesn't provide adequate information on how participants' privacy will be protected, particularly with regard to the protection of their personal health data. This is a critical issue in mobile health research. - All the data of the participants in intervention group will reach the investigator through an account created in the same smartphone application for which only the investigator has access. No other person is able to login into the account in smartphone app of patient related data other than the investigator. The study also lacks a clear definition of how the application will affect patient outcomes, leaving questions about its practical relevance unanswered. -As OSMF is a chronic disease which needs regular and long-term follow-up and patient compliance due to its high malignant transformation rate, development of such smartphone application can be beneficial in maintaining the follow-up in the patients who are unable to report to OPD for follow-up. The sample size calculation is overly complicated and difficult to verify. The sample size formula has been edited and simplified in consultation with statistician. The study also does not include a well-defined timeline or feasibility analysis for the phases of the study, in particular how the application will be modified based on user feedback. Without clear results, it is impossible to assess the effectiveness of the intervention being tested. - Defined timeline of all the phases have been added to manuscript. The modifications in the smartphone application will be done according feedback on the patients understandability and usability regarding the self-assessment of any parameter of OSMF. To assess the effectiveness of the intervention being tested, the authenticity and reliability of the self-assessment finding will be cross-checked in 15 participants of the intervention group. These 15 patients will be called in OPD and the submitted data of these patients through smartphone app and observations on physical examination will be compared. View more View less Competing Interests no reply Respond Report a concern Nalabothu P. Peer Review Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r359598) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-359598 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2024 Gharote H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 30 May 2024 | for Version 1 Harshkant Gharote , Batterjee Medical College, Jeddah, Saudi Arabia 0 Views copyright © 2024 Gharote H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The article is well written and elaborates materials and method. Authors need to explain about follow up wherein only counselling and discontinuation of the habit will be included or any medical management will be employed? As chances of loss of follow up in conventional method will increase if no medical intervention is done. Is the rationale for, and objectives of, the study clearly described? Yes Is the study design appropriate for the research question? Yes Are sufficient details of the methods provided to allow replication by others? Yes Are the datasets clearly presented in a useable and accessible format? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise As an Oral Physician I understand the epidemiology, clinical presentation and molecular pathogenesis of the disease studied in the present article. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 25 Jun 2024 KOMAL DADGAL, DEPARTMENT OF ORAL MEDICINE AND RADIOLOGY, DATTA MEGHE INSTITUTE OF HIGHER EDUCATION AND RESEARCH, WARDHA, 442001, India During the follow-up of the participants with OSMF, counseling, discontinuation of habit as well as medical intervention will be provided. View more View less Competing Interests The authors have no competing interests to declare. reply Respond Report a concern Gharote H. Peer Review Report For: Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] . F1000Research 2025, 13 :165 ( https://doi.org/10.5256/f1000research.146908.r255951) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-165/v1#referee-response-255951 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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