{"paper_id":"1d6add72-1ea3-4359-b9f6-00621cdc748d","body_text":"Abstract\nObjective. Improving the accuracy of the diagnosis of endometrial consistency and predicting endometriopathy.\nSubjects and methods. 96 patients with a history of reproductive failure were examined. An analysis was made of menstrual blood \nwith the measurement of glutathione peroxidase-1, interleukin-6 and E-selectin by the ELISA method of the “sandwich” type \nwith monoclonal antibodies. In order to determine the normative parameters, the material of 30 healthy women was examined. \nTo evaluate the results, the logistic regression method was applied. A mathematical model was developed that made it possible to \ndetermine the probability of endometriopathy at the threshold value of the integrative index P≥0.29.\nResults. Patients with diagnostically significant P levels have signs of chronic inflammation, dyshormonal mucosa, and dystrophic \nchanges in the endometrium. The average probability of the disease is Pc. For the patients it was 0.59, for the healthy - 0.22. The \ndiagnostic sensitivity of the test is 93.3%, specificity is 92.86%.\nConclusion. The calculation of the prognostic probability of endometriopathy based on the measurement of the concentration of \nbiologically active substances in menstrual secretions is appropriate for the primary non-invasive diagnosis (screening) of the non-\ntumor pathology of the endometrium. The diagnostic technique is patented.\nBiography\nMotovilova, Tatyana M is an Associate Professor of the Department of Obstetrics and Gynecology, V olga Regional Research Medical University, Ministry of Health \nof the Russian Federation, Nizhny Novgorod, Russia, and Doctor of the highest qualification category.\nPublication \n1. Yu.I. Insolvent endometrium in IVF programs: pathogenesis, diagnosis and rehabilitation. In the book: Reproductive technologies today and tomorrow. \nMaterials of the XXV Anniversary International Conference of the Russian Association of Human Reproduction. September 9-12, 2015, Sochi. 2015: 47-9.(in \nRussian)]. Зуев В.М., Калинина Е.А., Александров М.Т., Пиманчева Ю.И. Несостоятельный эндометрий в программах ЭКО: патогенез, диагностика \nи реабилитация. В кн.: Репродуктивные технологии сегодня и завтра. Материалы XXV Юбилейной международной конференции Российской \nАссоциации Репродукции Человека. 9-12 сентября 2015 г., г. Сочи. 2015: 47-9. [Zuev V .M., Kalinina E.A., Aleksandrov M.T., Pimancheva\n2. N.A., Aidagulova S.V ., Nepomnyaschik G.I. Endometrial atrophy as a manifestation of the syndrome of regenerative-plastic insufficiency with habitual \nmiscarriage. Bulletin of Peoples’ Friendship University of Russia. Series: Medicine. 2012; 5: 223-30. (in Russian)]. Г.И. Атрофия эндометрия как проявление \nсиндрома регенераторно-пластической недостаточности при привычном невынашивании беременности. Вестник Российского университета дружбы \nнародов. Серия: Медицина. 2012; 5: 223-30. [Marinkin I.O., Kuleshov V .M., Ilizarova Маринкин И.О., Кулешов В.М., Илизарова Н.А., Айдагулова С.В., \nНепомнящих\n3. Волкова Е.Ю., Силантьева Е.С., Корнеева И.Е. Роль физиотерапии в коррекции нарушений маточной гемодинамики у женщин с нарушением \nрепродуктивной функции и «тонким» эндометрием. В кн.: Здоровье девочки, девушки, женщины. Материалы Всероссийской научно-практической \nконференции. Томск, 4-5 декабря 2012. Томск: НИИАГиП СО Р АМН; 2012: 8-10. [V olkova E.Yu., Silantieva E.S., Korneeva I.E. The role of physiotherapy \nin the correction of uterine hemodynamic disorders in women with impaired reproductive function and «thin» endometrium. In the book: Health girls, girls, \nwomen. Materials of the All-Russian scientific-practical conference. Tomsk, December 4-5, 2012. Tomsk: NIIAGiP SB RAMS; 2012: 8-10. (in Russian)].\n4. Кузнецова И.В., Землина Н.С., Рашидов Т.Н., Коваленко М.А. Проблема тонкого эндометрия и возможные пути ее решения. Эффективная \nфармакотерапия. 2015; 5: 42-9. [Kuznetsova I.V ., Zemlina N.S., Rashidov T.N., Kovalenko M.A. The problem of thin endometrium and possible solutions. \nEffective pharmacotherapy. 2015; 5: 42-9. (in Russian)].\nIntegrative assessment of menstrual blood biomarkers as \nan opportunity to predict endometriopathy\nMotovilova Tatyana\nPrivolzhsky Medical Research University, Russian Federation\nGynecology and Reproductive Endocrinology\nISSN: 2591-7994 V olume 4  | Issue 4 | 11\nAuthor Citation: Motovilova Tatyana, Integrative assessment of menstrual blood biomarkers as an opportunity to predict endometriopathy, \nGynecology 2020, European Gynecology and Obstetrics Congress, Paris, 17-18 February, 2020, pp. 11\nEuropean Gynecology and Obstetrics Congress, \nFebruary 17-18, 2020 | Paris, Frace\nGynecology and Reproductive Endocrinology allied\nacademies","source_license":"CC0","license_restricted":false}