{"paper_id":"1d0adcf4-32fa-4e6a-8788-d91aa5473686","body_text":"Chronic endometritis in groupe of a women of fertile age with infertility and uterine surgery\nDOI:\nhttps://doi.org/10.15574/HW.2025.3(178).2833Keywords:\nchronic endometritis, assisted reproductive technologies, gynecological surgical interventions, decidualization pathology, placentation disordersAbstract\nChronic endometritis (CE) is known to have a negative impact on decidualization, and therefore is the cause of implantation failure, miscarriage and placentation disorders with the formation of both placental insufficiency and pathological placental invasion.\nAim - to determine the frequency of CE in women of childbearing age without a history of cesarean section (CS), with infertility requiring the use of assisted reproductive technologies (IVF) or uterine surgery, who are planning pregnancy in the short term.\nMaterials and methods. The study included 309 women of childbearing age, who were divided into 2 groups: the first - 152 women with IVF and without a history of CS; the second - 157 women of childbearing age without a history of CS, who underwent elective uterine surgery. The control group was 54 women without ART and uterine surgery in history, who applied for a scheduled examination. The presence of HE was established when 5 or more plasma cells were found in the endometrial stroma, determining the specific marker of plasma cells - CD138 by immunohistochemical method. Endometrial tissue samples were taken by Pipelle biopsy using a device (Pipelle de Cornier, CCD).\nResults. According to the results of the study, HE was detected in 79 (52.0%) women of the first, 73 (46.5%) of the second and in 2 (3.7%) of the control group.\nConclusions. The results of the study showed that in the groups of women with IVF and gynecological surgical interventions on the uterus, a high frequency of HE was observed (52% and 46.5%, respectively), which suggests that HE may be one of the factors contributing to the development of placental disorders. However, further studies are necessary to confirm this hypothesis.\nThe study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the local ethics committee of the participating institution. Informed consent of the patients was obtained for the study.\nThe authors declare that there is no conflict of interest.\nReferences\nAvagliano L, Massa V, Bulfamante GP. (2016). Histology of Human Placenta: 1-16.\nBayer-Garner IB, Nickell JA, Korourian S. (2004). Routine syndecan-1 immunohistochemistry aids in the diagnosis of chronic endometritis. 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Am J Reprod Immunol. 82: e13177. https://doi.org/10.1111/aji.13177; PMid:31373128\nDownloads\nPublished\nIssue\nSection\nLicense\nCopyright (c) 2025 Ukrainian Journal Health of Woman\nThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.\nThe policy of the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC).\nAuthors transfer the copyright to the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. 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