{"paper_id":"1c8e6323-6fc8-48ce-b785-6136c61f0ab3","body_text":"Abstract\nNatural killer cells are found in large numbers in the endometrium and decidua, and data suggest that NK cell functions and interactions with fetal-derived trophoblasts can have a profound impact on pregnancy. Altered NK cell numbers and activity have been associated with a variety of clinical conditions such as endometriosis, recurrent pregnancy loss, and preeclampsia. Uterine NK cells have a unique phenotype compared to blood NK cells and this is likely due to the specific tissue environment in which they reside. Specific chemokines produced by human endometrium and trophoblasts have been identified that may be responsible for recruitment of NK cells. Uterine NK cells can produce cytokines and may be an important part of vascular remodelling during placenta! development. This chapter summarizes current knowledge of NK cells in the uterus and their role in pregnancy and reproductive disorders.\nPreview\nUnable to display preview. Download preview PDF.\nSimilar content being viewed by others\nReferences\nTrundley A, Moffett A. Human uterine leukocytes and pregnancy. Tissue Antigens 2004;63(1):1–12.\nMoffett-King A. Natural killer cells and pregnancy. Nat Rev Immunol 2002;2(9):656–663.\nBiron CA, Nguyen KB, Pien GC et al. Natural killer cells in antiviral defense: Function and regulation by innate cytokines. Annu Rev Immunol 1999; 17:189–220.\nFerlazzo G, Morandi B, D’Agostino A et al. The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells. Eur J Immunol 2003; 33(2):306–313.\nBellone G, Valiante NM, Viale O et al. Regulation of hematopoiesis in vitro by alloreactive natural killer cell clones. J Exp Med 1993;177(4):1117–1125.\nRebmann V, Regel J, Stolke D et al. Secretion of sHLA-G molecules in malignancies. Semin Cancer Biol 2003; 13(5):371–377.\nMa D, Gu MJ, Liu BQ. A preliminary study on natural killer activity in patients with gynecologic malignancies. J Tongji Med Univ 1990; 10(3):159–163.\nYang JH, Chen MJ, Chen HF et al. Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis. Hum Reprod 2004; 19(9):1974–1978.\nMaeda N, Izumiya C, Yamamoto Y et al. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis. Fertil Steril 2002; 77(2):297–302.\nThum MY, Bhaskaran S, Abdalla HI et al. An increase in the absolute count of CD56dimCD16+CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod 2004; 19(10):2395–2400.\nDosiou C, Giudice LC. Natural killer cells in pregnancy and recurrent pregnancy loss: Endocrine and immunologic perspectives. Endocr Rev 2004; 26(1):44–62.\nHiby SE, Walker JJ, O’Shaughnessy KM et al. Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 2004; 200(8):957–965.\nSakai M, Ogawa K, Shiozaki A et al. Serum granulysin is a marker for Thl type immunity in preeclampsia. Clin Exp Immunol 2004; 136(1):114–119.\nJacobs R, Hintzen G, Kemper A et al. CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells. Eur J Immunol 2001; 31(10):3121–3127.\nCooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol 2001; 22(11):633–640.\nJonges LE, Albertsson P, van Vlierberghe RL et al. The phenotypic heterogeneity of human natural killer cells: Presence of at least 48 different subsets in the peripheral blood. Scand J Immunol 2001; 53(2):103–110.\nFehniger TA, Cooper MA, Nuovo GJ et al. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: A potential new link between adaptive and innate immunity. Blood 2003; 101(8):3052–3057.\nFerlazzo G, Pack M, Thomas D et al. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci USA 2004; 101(47):16606–16611.\nMoretta A, Bottino C, Vitale M et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 2001; 19:197–223.\nBulmer JN, Morrison L, Longfellow M et al. Granulated lymphocytes in human endometrium: Histochemical and immunohistochemical studies. Hum Reprod 1991; 6(6):791–798.\nKing A, Hiby SE, Verma S et al. Uterine NK cells and trophoblast HLA class I molecules. Am J Reprod Immunol 1997; 37(6):459–462.\nEriksson M, Meadows SK, Wira CR et al. Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta. J Leukoc Biol 2004; 76(3):667–675.\nHo HN, Chao KH, Chen CK et al. Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy. Hum Immunol 1996; 49(2):130–136.\nVerma S, King A, Loke YW. Expression of killer cell inhibitory receptors on human uterine natural killer cells. Eur J Immunol 1997; 27(4):979–983.\nKoopman LA, Kopcow HD, Rybalov B et al. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 2003; 198(8):1201–1212.\nHenderson TA, Saunders PT, Moffett-King A et al. Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab 2003; 88(1):440–449.\nKing A. Uterine leukocytes and decidualization. Hum Reprod Update 2000;6(1):28–36.\nEidukaite A, Siaurys A, Tamosiunas V. Differential expression of KIR/NKAT2 and CD94 molecules on decidual and peripheral blood CD56bright and CD56dim natural killer cell subsets. Fertil Steril 2004; 81(Suppl 1):863–868.\nSentman CL, Meadows SK, Wira CR et al. Recruitment of uterine NK cells: Induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone. J Immunol 2004;173(11):6760–6766.\nHanna J, Wald O, Goldman-Wohl D et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16-human natural killer cells. Blood 2003; 102(5):1569–1577.\nCampbell JJ, Qin S, Unutmaz D et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol 2001;166(11):6477–6482.\nSlukvin II, Chernyshov VP, Merkulova AA et al. Differential expression of adhesion and homing molecules by human decidual and peripheral blood lymphocytes in early pregnancy. Cell Immunol 1994; 158(1):29–45.\nCalatayud S, Vivier E, Bernaud J et al. Expression of a NK cell-restricted epitope on decidual large granular lymphocytes. Int Immunol 1996; 8(10):1637–1642.\nTabibzadeh S. Proliferative activity of lymphoid cells in human endometrium throughout the menstrual cycle. J Clin Endocrinol Metab 1990; 70(2):437–443.\nWira CR, Fahey JV, White HD et al. The mucosal immune system in the human female reproductive tract: Influence of stage of the menstrual cycle and menopause on mucosal immunity in the uterus. In: Glasser S, Aplin J, Giudice L, Tabibzadeh S, eds. Endometrium. UK: Harwood Academic Publishers, 2002:371–404.\nGivan AL, White HD, Stern JE et al. Flow cytometric analysis of leukocytes in the human female reproductive tract: Comparison of fallopian tube, uterus, cervix, and vagina. Am J Reprod Immunol 1997; 38(5):350–359.\nHunt JS. Immunologically relevant cells in the uterus. Biol Reprod 1994;50(3):461–466.\nKing A, Wellings V, Gardner L et al. Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol 1989; 24(3):195–205.\nKing A, Balendran N, Wooding P et al. CD3-leukocytes present in the human uterus during early placentation: Phenotypic and morphologic characterization of the CD56++ population. Dev Immunol 1991; 1(3):169–190.\nKammerer U, Marzusch K, Krober S et al. A subset of CD 56+ large granular lymphocytes in first-trimester human decidua are proliferating cells. Fertil Steril 1999;71(1):74–79.\nGuimond MJ, Wang B, Croy BA. Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice. J Exp Med 1998; 187(2):217–223.\nWhite HD, Crassi KM, Givan AL et al. CD3+ CD8+ CTL activity within the human female reproductive tract: Influence of stage of the menstrual cycle and menopause. J Immunol 1997; 158(6):3017–3027.\nYeaman GR, Guyre PM, Fanger MW et al. Unique CD8+ T cell-rich lymphoid aggregates in human uterine endometrium. J Leukoc Biol 1997; 61(4):427–435.\nInngjerdingen M, Damaj B, Maghazachi AA. Expression and regulation of chemokine receptors in human natural killer cells. Blood 2001; 97(2):367–375.\nKitaya K, Nakayama T, Okubo T et al. Expression of macrophage inflammatory protein-1 beta in human endometrium: Its role in endometrial recruitment of natural killer cells. J Clin Endocrinol Metab 2003; 88(4):1809–1814.\nKitaya K, Nakayama T, Daikoku N et al. Spatial and temporal expression of ligands for CXCR3 and CXCR4 in human endometrium. J Clin Endocrinol Metab 2004; 89(5):2470–2476.\nDrake PM, Gunn MD, Charo IF et al. Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein-1 alpha. J Exp Med 2001;193(10):1199–1212.\nAkiyama M, Okabe H, Takakura K et al. Expression of macrophage inflammatory protein-1alpha (MIP-1 alpha) in human endometrium throughout the menstrual cycle. Br J Obstet Gynaecol 1999; 106(7):725–730.\nRed-Horse K, Drake PM, Gunn MD et al. Chemokine ligand and receptor expression in the pregnant uterus: Reciprocal patterns in complementary cell subsets suggest functional roles. Am J Pathol 2001;159(6):2199–2213.\nChantakru S, Kuziel WA, Maeda N et al. A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha. J Reprod Immunol 2001; 49(1):33–47.\nRot A, Von Andrian UH. Chemokines in innate and adaptive host defense: Basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22:891–928.\nButcher EC, Williams M, Youngman K et al. Lymphocyte trafficking and regional immunity. Adv Immunol 1999; 72:209–253.\nBurrows TD, King A, Loke YW. Expression of adhesion molecules by human decidual large granular lymphocytes. Cell Immunol 1993; 147(1):81–94.\nKruse A, Martens N, Fernekorn U et al. Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy. Biol Reprod 2002;66(2):333–345.\nFrey M, Packianathan NB, Fehniger TA et al. Differential expression and function of L-selectin on CD56bright and CD56dim natural killer cell subsets. J Immunol 1998; 161(1):400–408.\nChantakru S, Wang WC, van den Heuvel M et al. Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones. J Immunol 2003; 171(8):4011–4019.\nvan den Heuvel M, Bashar S, Junkins ME et al. Functional adhesion of CD56 cells to decidual endothelium predicts pregnancy success in in vitro fertilization. Montreal, Canada: Paper presented at: 12th International Congress of Immunology and 4th Annual Conference of FOCIS, 2004.\nMarzusch K, Ruck P, Geiselhart A et al. Distribution of cell adhesion molecules on CD56++, CD3-, CD 16-large granular lymphocytes and endothelial cells in first-trimester human decidua. Hum Reprod 1993;8(8):1203–1208.\nKruse A, Merchant MJ, Hallmann R et al. Evidence of specialized leukocyte-vascular homing interactions at the maternal/fetal interface. Eur J Immunol 1999; 29(4):1116–1126.\nWegmann TG, Lin H, Guilbert L et al. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14(7):353–356.\nJokhi PP, King A, Sharkey AM et al. Screening for cytokine messenger ribonucleic acids in purified human decidual lymphocyte populations by the reverse-transcriptase polymerase chain reaction. J Immunol 1994; 153(10):4427–4435.\nJokhi PP, King A, Loke YW. Cytokine production and cytokine receptor expression by cells of the human first trimester placental-uterine interface. Cytokine 1997; 9(2):126–137.\nRieger L, Kammerer U, Hofmann J et al. Choriocarcinoma cells modulate the cytokine production of decidual large granular lymphocytes in coculture. Am J Reprod Immunol 2001; 46(2):137–143.\nLidstrom C, Matthiesen L, Berg G et al. Cytokine secretion patterns of NK cells and macrophages in early human pregnancy decidua and blood: Implications for suppressor macrophages in decidua. Am J Reprod Immunol 2003; 50(6):444–452.\nLi XF, Charnock-Jones DS, Zhang E et al. Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells. J Clin Endocrinol Metab 2001; 86(4):1823–1834.\nStewart CL, Kaspar P, Brunet LJ et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992; 359(6390):76–79.\nKelly RW, King AE, Critchley HO. Cytokine control in human endometrium. Reproduction 2001\nChaouat G, Zourbas S, Ostojic S et al. A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Thl/Th2 dichotomy. J Reprod Immunol 2002; 53(1–2):241–256.\nKitaya K, Yasuda J, Yagi I et al. IL-15 expression at human endometrium and decidua. Biol Reprod 2000; 63(3):683–687.\nGolander A, Barrett JR, Tyrey L et al. Differential synthesis of human placental lactogen and human chorionic gonadotropin in vitro. Endocrinology 1978; 102(2):597–605.\nMaslar LA, Riddick DH. Prolactin production by human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 1979; 135(6):751–754.\nGubbay O, Critchley HO, Bowen JM et al. Prolactin induces ERK phosphorylation in epithelial and CD56(+) natural killer cells of the human endometrium. J Clin Endocrinol Metab 2002;87(5):2329–2335.\nChambers WH, Amoscato AA, Smith MS et al. Prolactin receptor expression by rat NK cells. Nat Immun 1995; 14(3):145–156.\nWaldmann TA, Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 1999; 17:19–49.\nRosmaraki EE, Douagi I, Roth C et al. Identification of committed NK cell progenitors in adult murine bone marrow. Eur J Immunol 2001;31(6):1900–1909.\nYe W, Zheng LM, Young JD et al. The involvement of interleukin (IL)-15 in regulating the differentiation of granulated metrial gland cells in mouse pregnant uterus. J Exp Med 1996; 184(6):2405–2410.\nOkada H, Nakajima T, Sanezumi M et al. Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro. J Clin Endocrinol Metab 2000; 85(12):4765–4770.\nBarber EM, Pollard JW. The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. J Immunol 2003; 171(1):37–46.\nOkada S, Okada H, Sanezumi M et al. Expression of interleukin-15 in human endometrium and decidua. Mol Hum Reprod 2000; 6(1):75–80.\nDunn CL, Critchley HO, Kelly RW. IL-15 regulation in human endometrial stromal cells. J Clin Endocrinol Metab 2002; 87(4):1898–1901.\nChegini N, Ma C, Roberts M et al. Differential expression of interleukins (IL) IL-13 and IL-15 throughout the menstrual cycle in endometrium of normal fertile women and women with recurrent spontaneous abortion. J Reprod Immunol 2002; 56(1–2):93–110.\nPeel S. Granulated metrial gland cells. Adv Anat Embryol Cell Biol 1989; 115:1–112.\nAllavena P, Giardina G, Bianchi G et al. IL-15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endothelium. J Leukoc Biol 1997; 61(6):72–735.\nCastriconi R, Cantoni C, Delia Chiesa M et al. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci USA 2003; 100(7):4120–4125.\nHayashi H, Inoue Y, Tsutsui H et al. TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6. Biochem Biophys Res Commun 2003; 300(4):980–985.\nSeo N, Tokura Y, Takigawa M et al. Depletion of IL-10-and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells. J Immunol 1999; 163(1):242–249.\nNaganuma H, Sasaki A, Satoh E et al. Transforming growth factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells. Neurol Med Chir (Tokyo) 1996; 36(11):789–795.\nBellone G, Aste-Amezaga M, Trinchieri G et al. Regulation of NK cell functions by TGF-beta 1. J Immunol 1995; 155(3):1066–1073.\nKehrl JH, Wakefield LM, Roberts AB et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986;163(5):1037–1050.\nRuegemer JJ, Ho SN, Augustine JA et al. Regulatory effects of transforming growth factor-beta on IL-2-and IL-4-dependent T cell-cycle progression. J Immunol 1990;144(5):1767–1776.\nWira CR, Roche MA, Rossoll RM. Antigen presentation by vaginal cells: Role of TGFbeta as a mediator of estradiol inhibition of antigen presentation. Endocrinology 2002; 143(8):2872–2879.\nNelson BJ, Ralph P, Green SJ et al. Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1. J Immunol 1991; 146(6):1849–1857.\nKhalil N. Post translational activation of latent transforming growth factor beta (L-TGF-beta): Clinical implications. Histol Histopathol 2001; I6(2):541–551.\nClark DA, Vince G, Flanders KC et al. CD56+ lymphoid cells in human first trimester pregnancy decidua as a source of novel transforming growth factor-beta 2-related immunosuppressive factors. Hum Reprod 1994; 9(12):2270–2277.\nOgasawara MS, Aoki K, Aoyama T et al. Elevation of transforming growth factor-betal is associated with recurrent miscarriage. J Clin Immunol 2000; 20(6):453–457.\nAin R, Trinh ML, Soares MJ. Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface. Dev Dyn 2004; 231(4):700–708.\nBuhner JN, Lash GE. Human uterine natural killer cells: A reappraisal. Mol Immunol 2005; 42(4):511–521.\nKing A, Loke YW. Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2-stimulated decidual NK cells. Cell Immunol 1990; 129(2):435–448.\nVerma S, Hiby SE, Loke YW et al. Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15. Biol Reprod 2000; 62(4):959–968.\nErlebacher A, Lukens AK, Glimcher LH. Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc Natl Acad Sci USA 2002; 99(26):16940–16945.\nRajagopalan S, Fu J, Long EO. Cutting edge: Induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells, J Immunol 2001; 167(4):1877–1881.\nvan der Meer A, Lukassen HG, van Lierop MJ et al. Membrane-bound HLA-G activates proliferation and interferon-gamma production by uterine natural killer cells. Mol Hum Reprod 2004; 10(3):189–195.\nGreenwood JD, Minhas K, di Santo JP et al. Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Placenta 2000; 21(7):693–702.\nAshkar AA, Black GP, Wei Q et al. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 2003; 171(6):2937–2944.\nHunt JS, Miller L, Vassmer D et al. Expression of the inducible nitric oxide synthase gene in mouse uterine leukocytes and potential relationships with uterine function during pregnancy. Biol Reprod 1997; 57(4):827–836.\nAoki K, Kajiura S, Matsumoto Y et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345(8961):1340–1342.\nCoulam CB, Goodman C, Roussev RG et al. Systemic CD56+ cells can predict pregnancy outcome. Am J Reprod Immunol 1995; 33(1):40–46.\nKwak JY, Beaman KD, Gilman-Sachs A et al. Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 1995; 34(2):93–99.\nEmmer PM, Nelen WL, Steegers EA et al. Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion. Hum Reprod 2000; 15(5):1163–1169.\nNtrivalas El, Kwak-Kim JY, Gilman-Sachs A et al. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001;16(5):855–861.\nRaghupathy R. Th1-type immunity is incompatible with successful pregnancy. Immunol Today 1997;18(10):478–482.\nRaghupathy R. Pregnancy: Success and failure within the Thl/Th2/Th3 paradigm. Semin Immunol 2001;13(4):219–227.\nPiccinni MP, Beloni L, Livi C et al. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 1998;4(9):1020–1024.\nLachapelle MH, Miron P, Hemmings R et al. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1996;156(10):4027–4034.\nFukui A, Fujii S, Yamaguchi E et al. Natural killer cell subpopulations and cytotoxicity for infertile patients undergoing in vitro fertilization. Am J Reprod Immunol 1999;41(6):413–422.\nYamada H, Polgar K, Hill JA. Cell-mediated immunity to trophoblast antigens in women with recurrent spontaneous abortion. Am J Obstet Gynecol 1994; 170(5 Pt 1):1339–1344.\nHo HN, Chao KH, Chen HF et al. Peritoneal natural killer cytotoxicity and CD25+ CD3+ lymphocyte subpopulation are decreased in women with stage III–IV endometriosis. Hum Reprod 1995; 10(10):2671–2675.\nWu MY, Yang JH, Chao KH et al. Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with endometriosis. Fertil Steril 2000; 74(6):1187–1191.\nWagner LK. Diagnosis and management of preeclampsia. Am Fam Physician 2004;70(12):2317–2324.\nParham P. NK cells and trophoblasts: Partners in pregnancy. J Exp Med 2004;200(8):951–955.\nDarmochwal-Kolarz D, Rolinski J, Leszczynska-Goarzelak B et al. The expressions of intracellular cytokines in the lymphocytes of preeclamptic patients. Am J Reprod Immunol 2002;48(6):381–386.\nBujold E, Chaiworapongsa T, Romero R et al. Neonates born to preeclamptic mothers have a higher percentage of natural killer cells (CD3-/CD56+16+) in umbilical cord blood than those without preeclampsia. J Matern Fetal Neonatal Med 2003; 14(5):305–312.\nAuthor information\nAuthors and Affiliations\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 2006 Eurekah.com and Springer Science + Business Media\nAbout this chapter\nCite this chapter\nEriksson, M., Basu, S., Sentman, C.L. (2006). NK Cells and Pregnancy. In: Mor, G. (eds) Immunology of Pregnancy. Medical Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/0-387-34944-8_8\nDownload citation\nDOI: https://doi.org/10.1007/0-387-34944-8_8\nPublisher Name: Springer, New York, NY\nPrint ISBN: 978-0-387-30612-4\nOnline ISBN: 978-0-387-34944-2\neBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)\nKeywords\n- Natural Killer Cell\n- Recurrent Pregnancy Loss\n- Recurrent Spontaneous Abortion\n- Human Endometrium\n- Spiral Artery\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}