{"paper_id":"1b948412-8e2e-4712-a487-aa725d3f2e63","body_text":"Zhu et al. Case report - Acupuncture treatment for endometrial hyperplasia\nCASE REPORT                                              UDC 618.14-018.74-007.61-085.814.1                 \nCase report - Acupuncture treatment for endometrial hyperplasia\nJihe Zhu1, Blagica Arsovska1, Kristina Kozovska1, 2 Julijana Velkovska1,\n1 Centar of Traditional Chinese Medicine \"Tong Da Tang\", Republic of N. Macedonia;\n2 Medicine Faculty, University \"St. Cyril and Methodius\",Skopje, Republic of N.\nMacedonia;\nDOI : https://www.doi.org/10.59710/oaijoaru2312019z\nAbstract\nThe endometrium is the lining of the uterus, the pear-shaped organ that houses a fetus.\nEndometrial  thickness  varies  during  the  menstrual  process.  Abnormalities  of  the\nendometrium,  also  called  the  endometrial  lining,  can  result  in  concerns  such  as\nendometriosis, hyperplasia, and cancer. According to Chinese Medicine too thin of an\nendometrial lining can mean that yin or blood are compromised. Yin is stored in the\nKidneys and because of the densest of matter, it creates bones, marrow, and blood. Yin\nand  Blood  are  responsible  for  building  and  nurturing  the  lining  of  the  uterus  and\nsupporting pregnancy. In this article is presented a case of 41 years old woman with\ninfertility and a problem with endometrium thickness (endometrial hyperplasia). S he has\ndone 5 in  vitro procedures but they were unsuccessful . She came to our acupuncture\nclinic because she want ed to do an embryo transfer with frozen eggs, which have\nalready been frozen for half a year. She made 15 acupuncture treatments twice weekly.\nАt her last gynecological examination on the 11th day of menstruation, the thickness of\nthe endometrium was 10 mm. Acupuncture has a distinctive capacity to improve uterine\nblood circulation making it a first-line treatment for a thin endometrium.\nKeywords: traditional  chinese  medicine,  acupuncture,  endometrium,  infertility,\ntreatment\nIntroduction\nThe endometrium is the lining of the uterus, the pear-shaped organ that houses a fetus.\nEndometrium plays an important role in women's reproductive health and is connected\nwith  the  menstrual  cycle,  also  in  response  to  the  body's  reproductive  hormones,\nestrogen, and progesterone. The endometrial lining, sometimes is abnormally thin or\nthick, which may impact the ability of becoming pregnant and therefore lead to irregular\nbleeding. The endometrial lining has the main function during women’s reproductive\nyears. This inner lining of the uterus begins to thicken to prepare for an embryo to\nimplant, when pregnancy occurs, the lining helps to keep the pregnancy. If pregnancy\nOAIJOARU  Open Access International Journal of Academic Research UNIVERSES                              Online ISSN 2955-\n2133, Print ISSN 2955-2177                                                    2023 July,1(2): 19-22         19                                                    \n\n Zhu et al. Case report - Acupuncture treatment for endometrial hyperplasia\ndoes  not  occur,  the  lining  sheds,  and  the  process  starts  again  for  the  following\nmenstrual cycle.\nThe thickness of the endometrium is usually measured by  ultrasound, or if not suitable,\nbecause of the position of a woman’s uterus or other health conditions, then the doctors\nuse MRI.\nFactors that contribute to a greater  thickness of the  endometrium include: obesity,\nhormone  therapy,  chronic  high  blood  pressure,  diabetes,  scar  tissue,  endometrial\npolyps, and endometrial hyperplasia. The medical term for very thin endometrium is\nendometrial hyperplasia. This is often related to excessive levels of estrogen and not\nenough progesterone.\nTreatments for excessive endometrial thickness include progestinand treatment for thin\nendometrium includes: estrogen, human chorionic gonadotrophin, and medications and\nsupplements used to improve blood flow. [1,2]\nOvulation rates, female hormones, and appropriate thickness of the endometrial lining\nare part of the standards of Traditional Chinese Medicine (TCM) on fertility factors,\nwhich are essential biomarkers for the analysis of TCM on fertility-related diseases.\nTCM  plays  a  role  in  curing  and  protecting  fertility-related  diseases,  and  it  is  well\ndocumented.  Acupuncture  positively  regulates  numerous  molecules  related  to\nendometrial receptivity through different pathways and targets. Acupuncture promotes\nendometrial  microcirculation  and  increases  the  clinical  pregnancy  rate  of  patients\nundergoing in vitro fertilization and embryo transfer. Acupuncture, as a complementary\nalternative  medicine,  functions  mainly  by  the  basic  theories  of  TCM  and  selects\ncorrelated acupoints for treatment according to the differentiation of the collaterals and\nmeridians. Relevant reports have proved that acupuncture can improve endometrial\nthickness and uterine artery blood flow. The researches have found that acupuncture\ncan increase the blood supply of the endometrium, and improve the receptivity of the\nendometrium, regulate the endocrine system and the microenvironment of the ovary.[3]\n[4] [5]\nCase report\nThe  treated  patient  is  a  41  years  old  woman  with  infertility  and  a  problem  with\nendometrium thickness (endometrial hyperplasia). She has done 5 invitro procedures\nbut they were unsuccessful. She came to our acupuncture clinic because she wants to\ndo an embryo transfer with frozen eggs, which have already been frozen for half a year.\nShe made 15 acupuncture treatments twice weekly. When she had a gynecological\nexamination on the 4th day of menstruation, the thickness of the endometrium was 7\nmm,  and on her last gynecological examination on the 11th day of menstruation, the\nthickness of the endometrium was 10 mm, which is a good result.\nThe acupuncture treatments were made in an acupuncture clinic for acupuncture and\nTCM in Skopje, North Macedonia by a doctor specialist in acupuncture. Acupuncture\nOAIJOARU  Open Access International Journal of Academic Research UNIVERSES                              Online ISSN 2955-\n2133, Print ISSN 2955-2177                                                    2023 July,1(2): 19-22         20                                                    \n\n Zhu et al. Case report - Acupuncture treatment for endometrial hyperplasia\ntreatments were with a duration of 30 to 45 minutes. Treatments were done indoors, on\na room temperature, with normal (dry) acupuncture with fine sterile disposable needles\nsized  0.25x25mm.  Acupuncture  points  used  in  the  treatments  are:  DU21,  BL6,\nLI4,RN10, RN5, ST25, ST29, ST 30, RN 2, ST36, SP6, LV3,DU3, BL26\nTraditional  Chine  Medicine  (TCM)  is  a  medicine  with  a  very  great  history.  The\ntheoretical basis of TCM is different from that of Western medicine. TCM is around\n2.500 years old medicineand is anatural form of healing. This medicine is about the way\nof thinking about health and the body and includes a wide range of health interventions.\nAncient TCM is based on the concept that the body is a smaller version of the universe\nand of the harmony between yin and yang, which through the meridians flows the vital\npower called Qi in the body and maintains health. In TCM all phenomena can be\nrepresented by the five elements (wood, fire, earth, water, and metal). For diagnosis in\ntheir  assessments,  TCM  practitioners  use  5  basic  methods:  inspection  (looking),\nauscultation (listening), olfaction (smelling),palpation (touching), and inquiry (asking).\nTCM encompasses a small group of 6 methods designed to help patients achieve and\nmaintain health like acupuncture, moxibustion, tui na massage, cupping, TCM nutrition,\nand Chinese herbs. Acupuncture is the most often practiced component. Acupuncture is\nthe practice of inserting needles into the surface of the skin, and muscles of the body at\nparticular acupuncture points. There are 2,000 acupuncture points on the human body,\nwhich are connected by 12 main meridians. [6] [7] [8]\nConclusion\nAcupuncture as a part of Traditional  Chinese Medicine  is  very effective in treating\nendometrial hyperplasia in women. Treatment with acupuncture brings balance and\nharmony to the body and restores health to the mind and body.\nSource of funding\nThis  research  received  no  specific  grant  from  any  funding  agency  in  the  public,\ncommercial, or not-for profit sectors.\nConflict of interest\nThe author have declared that no competing interests exist.\nAcknowledgement\nNone.\nStatement of Informed Consent\nWritten  informed  consent  was  obtained  from  the  patient  for  their  anonymized\ninformation to be published in this article.\nOAIJOARU  Open Access International Journal of Academic Research UNIVERSES                              Online ISSN 2955-\n2133, Print ISSN 2955-2177                                                    2023 July,1(2): 19-22         21                                                    \n\n Zhu et al. Case report - Acupuncture treatment for endometrial hyperplasia\nReferences \n1. Rebecca Valdez, MS, RDN, Medically reviewed by Anita Sadaty, MD, All About\nthe Endometrial Lining, February 23, 2022 (www.verywellhealth.com)\n2. Danielle Dresden, Medically reviewed by Valinda Riggins Nwadike, MD, MPH,\nWhat  to  know  about  endometrial  thickness,November  19,\n2019(www.medicalnewstoday.com) \n3. Bo  Lv,  Yuan-de  Peng,  Wen-hui  Fu,  Wen-jing  Li,  Li-jun  Chen,  Zhi  Wang,  \"A\nTraditional Chinese Medicine for the Treatment of Endometrial Hyperplasia via\nRegulating  the  HPO  Axis  in  Rats\",  Evidence-Based  Complementary  and\nAlternative  Medicine,  vol.  2022,  Article  ID  5200608,  13  pages,  2022.\nhttps://doi.org/10.1155/2022/5200608 \n4. Jin Xi et al; \"Electroacupuncture Improves Pregnancy Outcomes in Rats with Thin\nEndometrium  by  Promoting  the  Expression  of  Pinopode-Related  Molecules\",\nBioMed Research International, vol. 2021, Article ID 6658321, 12 pages, 2021.\nhttps://doi.org/10.1155/2021/6658321\n5. Xiaoyan ZHENG et al; Endometrium receptivity and the dose-related effects of\nAcupuncture therapies in infertile women: a protocol for systematic review and\nmeta-analysis, https://doi.org/10.1101/2021.04.02.21254309\n6. Tian, G, Zhao, C, Zhang, X, et al. Evidence-based traditional Chinese medicine\nresearch: Two decades of development, its impact, and breakthrough. J Evid\nBased Med. 2021; 14: 65– 74. https://doi.org/10.1111/jebm.12420\n7. Ryding,  Sara. (2019,  April  29).  The  Efficacy  of Traditional  Chinese  Medicine.\nNews-Medical.(https://www.news-medical.net)\n8. Cosio D, Lin E. Traditional Chinese Medicine & Acupuncture. Pract Pain Manag.\n2015;15(7).\nOAIJOARU  Open Access International Journal of Academic Research UNIVERSES                              Online ISSN 2955-\n2133, Print ISSN 2955-2177                                                    2023 July,1(2): 19-22         22","source_license":"CC0","license_restricted":false}