{"paper_id":"194b4822-8d52-42b8-8df6-43290bde7455","body_text":"- Library Home /\n- Search Collections /\n- Open Collections /\n- Browse Collections /\n- UBC Faculty Research and Publications /\n- Nerve bundles and deep dyspareunia in endometriosis\nOpen Collections\nUBC Faculty Research and Publications\nNerve bundles and deep dyspareunia in endometriosis Williams, Christina; Hoang, Lien N.; Yosef, Ali; Fahad, Alotaibi; Allaire, Catherine; Brotto, Lori A.; Fraser, Ian S.; Bedaiwy, Mohamed Ali, 1968-; Ng, Tony Ling Tin; Lee, Anna F.; Yong, Paul J.\nAbstract\nThe etiology of deep dyspareunia in endometriosis is unclear. Our objective was to determine\nwhether nerve bundle density in the cul-de-sac/uterosacrals (Zone II) is associated with deep\ndyspareunia in women with endometriosis. We conducted a blinded retrospective\nimmunohistochemistry study (n=58) at a tertiary referral center (2011-2013). Patients were\nstringently phenotyped into a Study Group and two Control Groups. The Study Group (tender\nendometriosis, n=29) consisted of patients with deep dyspareunia, a tender Zone II on\nexamination, and an endometriosis lesion in Zone II excised at surgery. Control Group 1 (nontender\nendometriosis, n=17) consisted of patients without deep dyspareunia, a non-tender Zone II\non examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 2\n(tender non-endometriosis, n=12) consisted of patients with deep dyspareunia, a tender Zone II\non examination, and a non-endometriosis lesion (e.g. normal histology) in Zone II excised at\nsurgery. PGP9.5 immunohistochemistry was performed to identify nerve bundles (nerve fibers\nsurrounded by perineurium) in the excised Zone II lesion. PGP9.5 nerve bundle density\n(bundles/HPF) was then scored by a pathologist blinded to the Group. We found a significant\ndifference in PGP9.5 nerve bundle density between the three Groups (ANOVA, F[2,55]=6.39,\np=0.003). Mean PGP9.5 nerve bundle density was significantly higher in the Study Group\n(1.16+/-0.56 bundles/HPF [+/-SD]), compared to Control Group 1 (0.65+/-0.36, Tukey test,\np=0.005) and Control Group 2 (0.72+/-0.56, Tukey test, p=0.044). This study provides evidence\nthat neurogenesis in the cul-de-sac/uterosacrals may be an etiological factor for deep dyspareunia\nin endometriosis.\nItem Metadata\n| Title |\nNerve bundles and deep dyspareunia in endometriosis\n|\n| Creator | |\n| Date Issued |\n2015\n|\n| Description |\nThe etiology of deep dyspareunia in endometriosis is unclear. Our objective was to determine\nwhether nerve bundle density in the cul-de-sac/uterosacrals (Zone II) is associated with deep\ndyspareunia in women with endometriosis. We conducted a blinded retrospective\nimmunohistochemistry study (n=58) at a tertiary referral center (2011-2013). Patients were\nstringently phenotyped into a Study Group and two Control Groups. The Study Group (tender\nendometriosis, n=29) consisted of patients with deep dyspareunia, a tender Zone II on\nexamination, and an endometriosis lesion in Zone II excised at surgery. Control Group 1 (nontender\nendometriosis, n=17) consisted of patients without deep dyspareunia, a non-tender Zone II\non examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 2\n(tender non-endometriosis, n=12) consisted of patients with deep dyspareunia, a tender Zone II\non examination, and a non-endometriosis lesion (e.g. normal histology) in Zone II excised at\nsurgery. PGP9.5 immunohistochemistry was performed to identify nerve bundles (nerve fibers\nsurrounded by perineurium) in the excised Zone II lesion. PGP9.5 nerve bundle density\n(bundles/HPF) was then scored by a pathologist blinded to the Group. We found a significant\ndifference in PGP9.5 nerve bundle density between the three Groups (ANOVA, F[2,55]=6.39,\np=0.003). Mean PGP9.5 nerve bundle density was significantly higher in the Study Group\n(1.16+/-0.56 bundles/HPF [+/-SD]), compared to Control Group 1 (0.65+/-0.36, Tukey test,\np=0.005) and Control Group 2 (0.72+/-0.56, Tukey test, p=0.044). This study provides evidence\nthat neurogenesis in the cul-de-sac/uterosacrals may be an etiological factor for deep dyspareunia\nin endometriosis.\n|\n| Subject | |\n| Genre | |\n| Type | |\n| Language |\neng\n|\n| Date Available |\n2017-02-01\n|\n| Provider |\nVancouver : University of British Columbia Library\n|\n| Rights |\nAttribution-NonCommercial-NoDerivatives 4.0 International\n|\n| DOI |\n10.14288/1.0303148\n|\n| URI | |\n| Affiliation | |\n| Citation |\nWilliams, C., Hoang, L., Yosef, A., Alotaibi, F., Allaire, C., Brotto, L., . . . Yong, P. J. (2015). Nerve bundles and deep dyspareunia in endometriosis. Reproductive Sciences,\n|\n| Publisher DOI |\n10.1177/1933719115623644\n|\n| Peer Review Status |\nReviewed\n|\n| Scholarly Level |\nFaculty\n|\n| Copyright Holder |\nSAGE\n|\n| Rights URI | |\n| Aggregated Source Repository |\nDSpace\n|\nItem Media\nItem Citations and Data\nRights\nAttribution-NonCommercial-NoDerivatives 4.0 International","source_license":"CC0","license_restricted":false}