{"paper_id":"1710ea8a-84f3-4940-a546-0c854199512f","body_text":"Abstract\nObjective\nTo assess the efficacy, safety and acceptability of cyclic medroxyprogesterone acetate (MPA) compared to continuous MPA for treatment of endometrial hyperplasia (EH) without atypia.\nMaterials and methods\nA prospective observational study conducted on premenopausal women with EH without atypia (n = 80) who were randomly assigned into two groups; 40 patients received cyclic 15 mg MPA and 40 patients received continuous 15 mg MPA. Follow-up endometrial sampling was done after 6 months. Primary outcome measure was regression of hyperplasia. Secondary outcome measures include side effects and patient acceptability.\nResults\nThere was no significant difference between the two groups regarding regression of endometrial hyperplasia (90 % in the cyclic MPA group in comparison to 82.5 % in the continuous MPA group with p value >0.05). There was a significant higher women suffering from nausea, acne and menstrual changes in the continuous MPA group (p value <0.05). Cyclic MPA regimen was more acceptable to the patients in comparison to continuous MPA intake.\nConclusions\nCyclic MPA regimen seems a safer and more acceptable therapy in comparison to continuous MPA regimen in patients with endometrial hyperplasia without atypia. Larger studies are warranted to confirm these results.\nSimilar content being viewed by others\nChange history\n08 September 2025\nAn Editorial Expression of Concern to this paper has been published: https://doi.org/10.1007/s00404-025-08155-8\nReferences\nEpplein M, Reed SD, Voigt LF, Newton KM, Holt VL, Weiss NS (2009) Endometrial hyperplasia risk in relation to recent use of oral contraceptives and hormone therapy. Ann Epidemiol 19:1–7\nClark TJ, Neelakantan D, Gupta JK (2006) The management of endometrial hyperplasia: an evaluation of current practice. 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Arch Gynecol Obstet 291(6):1347–1354\nAcknowledgments\nThe authors would like to acknowledge the contribution of the residents and nursing staff of the Gynecology ward and members of Pathology department of Menoufia university Hospital. The author would like to thank all the participants for taking out time to share in this study. I also wish to thank Dr. Mohamed Rezk for his logistic support.\nConflict of interest\nThe author reports no declarations of interest.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nEmarh, M. Cyclic versus continuous medroxyprogesterone acetate for treatment of endometrial hyperplasia without atypia: a 2-year observational study. Arch Gynecol Obstet 292, 1339–1343 (2015). https://doi.org/10.1007/s00404-015-3749-3\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-015-3749-3","source_license":"CC0","license_restricted":false}