{"paper_id":"16f89ada-d07d-4215-821a-33a608e70320","body_text":"Abstract\nPurpose\nThe risks of gynecologic cancer have not been well established in women with endometriosis. The objective of the present study was to investigate the influence of endometriosis on the risk for three gynecologic cancer (ovarian cancer, endometrial cancer and cervical cancer).\nMethods\nWe gathered updated evidence about the risk relationship between endometriosis and gynecologic cancers by conducting a comprehensive search of several medical literature electronic databases, including PubMed, Embase and the Cochrane Library. The design and quality of all studies were evaluated using the Newcastle–Ottawa Scale (NOS), and a random-effects model was used to calculate pooled risk ratio (RR).\nResults\nOf the 8538 articles our search produced, we selected 25 qualified studies, including 16 cohort studies and 9 case–control studies. Patients with endometriosis had both an increased risk of ovarian cancer [RR 1.964; 95% CI (1.685, 2.290)]. The risk of endometrial cancer (EC) is not necessarily higher in patients with endometriosis [RR 1.176, 95% CI (0.878, 1.575)]. Endometriosis was not associated with an increased risk for cervical cancer (CC) [RR 0.670, 95% CI (0.537, 0.838)].\nConclusions\nPatients with endometriosis need to be closely observed and rechecked regularly to prevent malignant changes.\nSimilar content being viewed by others\nReferences\nGarry Md Frcog R (2001) Endometriosis an invasive disease. Gynecol Endosc 10:79–82\nVlahos NF, Economopoulos KP, Fotiou S (2010) Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer. Best Pract Res Clin Obstet Gynaecol 24(1):39–50. https://doi.org/10.1016/j.bpobgyn.2009.08.004\nRe S (1987) Classification of human ovarian tumors.pdf. 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Cun Liu: the use of software, statistical analysis. Lu Wang: the use of software, statistical analysis. Wenge Zhao: validate the results, write the original article. Tingting Zhang: write, review, and edit the original article. Yan Yao: write the original article. Xue Wang: literature search. Changgang Sun: select topic, review original article.\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare to have no conflict of interest.\nEthical approval\nThis article does not contain any studies with human participants or animals performed by any of the authors.\nElectronic supplementary material\nBelow is the link to the electronic supplementary material.\nRights and permissions\nAbout this article\nCite this article\nli, J., Liu, R., Tang, S. et al. Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. Arch Gynecol Obstet 299, 35–46 (2019). https://doi.org/10.1007/s00404-018-4968-1\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-018-4968-1","source_license":"public-domain-us","license_restricted":false}