{"paper_id":"16ceff7f-103b-414b-b572-a1df2f67c25a","body_text":"Figures and Supplementary Materials for \"Integrated Bulk and Single-Cell Transcriptomics Identify a Five-Gene Immune–Endothelial–Matrix Signature in Endometriosis\"\nAuthors/Creators\nDescription\nThis record provides the complete set of publication-quality main figures and supplementary materials accompanying the manuscript above. The study integrates two GEO microarray cohorts (GSE23339, GSE25628) with WGCNA, differential expression, and PPI topology; combines LASSO + Random Forest + ANN to derive a compact five-gene panel (BGN, CXCL12, SERPINF1, TIMP2, SELE); profiles the immune landscape via CIBERSORT; anchors signals to cell states using an independent single-cell atlas (GSE247695); runs gene-stratified GSEA; explores GWAS–eQTL colocalization (FinnGen/GTEx v8); and performs DSigDB-guided docking and 100-ns MD for early translational prioritization. The results support an immune–endothelial–matrix axis as a tractable core of endometriosis biology and diagnostics.\nContents\n-\nFigures: All main figures (numbering matches the manuscript).\n-\nSupplementary:\n-\nTables S1–S16 (CSV/XLSX): DEG lists; WGCNA modules/overlaps; enrichment outputs (GO/KEGG/DO); PPI hubs; ML feature sets; ROC/AUC metrics; immune-infiltration results; single-cell summaries; GSEA outputs; TF–miRNA–lncRNA network tables; colocalization statistics; DSigDB results; docking/MD summaries.\n-\nFigures S1–S9: Extended analyses/quality controls.\n-\nReadme: File inventory and variable descriptions.\n-\nNote: This deposit aggregates derived figures and supplementary tables supporting the manuscript’s findings; primary datasets remain hosted by third-party repositories listed below.\nPrimary public data sources\n-\nNCBI GEO: GSE23339, GSE25628 (bulk microarrays) and GSE247695 (single-cell RNA-seq) — https://www.ncbi.nlm.nih.gov/geo/\n-\nFinnGen: Endometriosis GWAS summary statistics, phenocode N14,Endometriosis — https://www.finngen.fi/\n-\nGTEx v8: Cross-tissue cis-eQTLs — https://www.gtexportal.org/\n-\nRCSB PDB: Protein structures — https://www.rcsb.org/\n-\nPubChem: Compound records — https://pubchem.ncbi.nlm.nih.gov/\n-\nDSigDB: Drug–gene signature database — https://dsigdb.genesigdb.org/\nFiles\nFigure 1.tif\nFiles\n(584.7 MB)\n| Name | Size | Download all |\n|---|---|---|\n|\nmd5:c499b6b2664a39c62b87f1b9d0b10de1\n|\n33.2 MB | Preview Download |\n|\nmd5:afe288244f57c860c860a8cbcdb2a012\n|\n6.4 MB | Preview Download |\n|\nmd5:b419bf9d29d0c03e0ba6533114ffd2c6\n|\n8.8 MB | Preview Download |\n|\nmd5:220a39628b802b5009c400b61035b0b1\n|\n19.6 MB | Preview Download |\n|\nmd5:13df78cfd5be382e9497115cc99a63e2\n|\n5.9 MB | Preview Download |\n|\nmd5:687cbec8d0e43b438361a23163bcf29e\n|\n25.2 MB | Preview Download |\n|\nmd5:0e4fea19c4b73b17610932107790e37a\n|\n1.1 MB | Preview Download |\n|\nmd5:e17aaf5ae2010168c70ff241bb858078\n|\n8.4 MB | Preview 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