{"paper_id":"16777a85-e9ea-4613-b3e6-07aeb4255014","body_text":"Abstract\nObjective\nTo determine the effectiveness of different concentrations of lauromacrogol injections for the treatment of endometriosis in an experimental animal model and to provide an experimental basis for a pre-clinical application of the drug.\nMethods\nAfter autologous transplantation of endometrial tissue, 40 endometrial cysts were successfully established and randomly divided into three groups: a 1 % lauromacrogol injection group, a 0.5 % lauromacrogol injection group, and cysts without intervention (control group). We measured the changes in the volumes of the cysts in each group. We then compared the volumes of the endometrial implants before and after treatment and between the different groups and examined the histological findings.\nResults\nA significant difference in the spherical volume was found between the 1 % lauromacrogol injection group (P < 0.05). No significant difference was observed between the volume of the endometrial implants in the 0.5 % lauromacrogol injection group (P > 0.05). Regarding the histopathological observations, in the 1 % lauromacrogol injection group, the epithelia of the cystic implants had atrophied, and the glands had atrophied and were reduced in number. The surrounding stromal tissue had become loose and edematous.\nConclusions\nA 1 % lauromacrogol injection produced significant regression of the endometrial foci compared with a 0.5 % lauromacrogol injection or no treatment in a rat model of endometriosis.\nSimilar content being viewed by others\nReferences\nFortin M, Lépine M, Pagé M et al (2003) An improved mouse model for endometriosis allows noninvasive assessment of lesion implantation and development. Fertil Steril 80(Suppl 2):832–838\nCayci T, Akgul EO, Kurt YG et al (2011) The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. 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J Exp Clin Cancer Res 29:4\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nFunding\nThis study was funded by the Shan Xi Tian Yu Pharmaceutical Co, LTD in China.\nConflict of interest\nWe declare that we have no conflict of interest.\nEthical standards\nAll experimental animals were handled in accordance with institutional and national guidelines for the care and use of laboratory animals.\nAdditional information\nThis study was completed as part of a master’s thesis at the Chinese PLA General Hospital.\nRights and permissions\nAbout this article\nCite this article\nLiu, W., Wang, L. & Guo, CX. The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study. Arch Gynecol Obstet 294, 555–559 (2016). https://doi.org/10.1007/s00404-016-4095-9\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-016-4095-9","source_license":"CC0","license_restricted":false}