{"paper_id":"16539903-dcb6-482c-8968-d9ad0652c55c","body_text":"Abstract\nEndometriosis has been associated with aberrant methylation in the eutopic endometrium. Using a genome-wide methylation array, we identified differentially methylated genes in the endometrium from women with or without endometriosis. One hundred and twenty genes were significantly altered by >1.5-fold. In all, 59 genes were significantly hypermethylated and 61 genes were significantly hypomethylated. Changes in gene expression associated with the altered methylation status were validated using quantitative real-time polymerase chain reaction. A limited number of candidate genes are selectively methylated in the endometrium of women with endometriosis. Several genes not previously associated with endometriosis are aberrantly methylated and expressed. 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Expert Opin Pharmacother. 2009;9(2):243–255.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nNaqvi, H., Ilagan, Y., Krikun, G. et al. Altered Genome-Wide Methylation in Endometriosis. Reprod. Sci. 21, 1237–1243 (2014). https://doi.org/10.1177/1933719114532841\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719114532841","source_license":"CC0","license_restricted":false}