{"paper_id":"15511279-e1ea-4321-95be-62ef18923f96","body_text":"Zusammenfassung\nZwischen der Inzidenz der Endometriose und gesichertem Wissen über ihre Pathogenese besteht eine erstaunliche Diskrepanz. Viele Eigenschaften von Endometrioseherden sind noch ungeklärt oder erscheinen gar widersprüchlich. Experimentelle Daten zur Existenz von Stammzellpopulationen ín den Läsionen, vergleichbar mit dem Vorkommen von Stammzellen im eutopen Endometrium, bieten neue Interpretationsmöglichkeiten von Befunden zur Pathogenese. Darüber hinaus eröffnen sie gedankliche Perspektiven für zukünftige Therapieansätze. In Bezug auf den Ursprung der Stammzellen existiert die Annahme primär residenzieller Stammzellen neben Theorien zu einer möglichen Herkunft aus dem Knochenmark. Eng damit verbunden ist die Frage nach dem Umfang der Differenzierungspotenz dieser Stammzellen. Schließlich richtet sich der Blick auch auf die limitierte Fähigkeit somatischer Stammzellen zur Selbsterneuerung – eine Eigenschaft, die mit der „Erschöpfung“ der zyklischen Regenerationsfähigkeit von Endometrioseherden in Zusammenhang stehen und durchaus therapeutische Implikationen haben könnte.\nAbstract\nThere is a surprising discrepancy between the incidence of endometriosis and facts about the pathogenesis of this highly frequent disease. Many features displayed by the lesions are not clear or are even contradictory. Experimental data on the occurrence of stem cell populations in the lesions and on the existence of stem cells in the eutopic endometrium offer new opportunities to explain the pathogenesis of the disease. Moreover, they can suggest new strategies for its therapy. As to the origin of these stem cells, two main possibilities are discussed. They may be either residential cells or derive from pluripotent bone marrow stem cells driven by hematogenic spread. Closely related to this question is the potential of the stem cells to differentiate. Finally, the limited ability of somatic stem cells for self renewal is an interesting focus of research into endometriosis which may explain limited abilities of the lesions themselves to regenerate cyclically.\nSimilar content being viewed by others\nLiteratur\nSteck T, Felberbaum R, Küpker W et al (2004) Endometriose. Springer, Wien New York. ISBN 3-211-00746-6\nGargett CE, Masuda H (2010) Adult stem cells in the endometrium. Mol Hum Reprod 16:818–834\nKao AP, Wang KH, Chang CC et al (2011) Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model. Fertil Steril 95:1308–1315\nFigueira PG, Abrão MS, Krikun G, Taylor HS (2011) Stem cells in endometrium and their role in the pathogenesis of endometriosis. 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Kaohsiung J Med Sci 28:63–71\nInteressenkonflikt\nDer korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nMarkowski, D., Küpker, W. & Bullerdiek, J. Endometriose. Gynäkologische Endokrinologie 10, 250–254 (2012). https://doi.org/10.1007/s10304-012-0483-9\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s10304-012-0483-9","source_license":"CC0","license_restricted":false}