{"paper_id":"1365b2c1-565b-4707-94a9-e543af018d02","body_text":"Abstract\nBackground\nEndometriosis is a common, estrogen-dependent, gynecological disease, which is defined as the presence of endometrial tissue outside the uterine cavity. Current data have associated endometriosis with specific malignancies, including ovarian and breast cancer.\nPurpose\nThe purpose of our study is to summarize and present published literature providing evidence regarding the possible relationship between endometriosis and breast cancer.\nMethods\nPubmed and Scopus databases were searched systematically for studies that sought to identify a potential association of endometriosis and breast cancer. 15 relevant articles were retrieved and included in the present review.\nResults\nA small number of observational studies have shown a correlation of endometriosis and breast cancer. Other studies found that the risk of breast cancer increases with age. The scenario of an early interruption of the inflammatory process, derived from endometriosis, by oophorectomy and a possible consequent decrease in the risk of breast cancer has also been proposed. The hypothesis that both conditions could be related through common mutations on BRAC1 and BRAC2 genes has also been investigated.\nConclusion\nThe available published evidence is inconclusive. Further studies are needed to evaluate the association of endometriosis and breast cancer and the possible pathogenetic pathways that relate the two disorders.\nSimilar content being viewed by others\nReferences\nPanidis DK, Matalliotakis IM (1998) Subfertility associated with minimal to mild endometriosis. Main mechanisms. J Reprod Med 43:1034–1042\nOzkan S, Murk W, Arici A (2008) Endometriosis and infertility, epidemiology and evidence-based treatments. 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Clin Endocrinol (Oxf) 61:190–194\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nWe declare that we have no conflict of interest.\nRights and permissions\nAbout this article\nCite this article\nAnifantaki, F., Boutas, I., Kalampokas, T. et al. Association of endometriosis and breast cancer: mini review of the literature. Arch Gynecol Obstet 293, 5–10 (2016). https://doi.org/10.1007/s00404-015-3809-8\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-015-3809-8","source_license":"public-domain-us","license_restricted":false}