{"paper_id":"1307dc4c-c87b-4f18-a453-e46743b4203f","body_text":"Abstract\nEndometriosis commonly presents with symptoms that mimic chronic gastrointestinal disorders. The authors used the autotransplantion model of endometriosis in rats to investigate the possible underlying mechanisms. After the rats were killed, the presence of endometriotic vesicles, colonic inflammation, and white blood cell (WBC) numbers in the peritoneal fluid was determined. Sections of colon and of jejunum were collected for measurement of myeloperoxidase (MPO) activity and bacterial counts, and isometric recording in response to acetylcholine was measured in segments of longitudinal and circular smooth muscle. Experimental animals had significantly more colonic damage, MPO activity, and WBC numbers than controls did. There was no significant difference in the total bacterial load; however, experimental animals demonstrated an increased tension in the longitudinal muscle, which correlated with WBC numbers and colonic damage. In summary, this study presents evidence for a significant effect of peritoneal endometriosis on colonic function and integrity, which may help explain the gastrointestinal symptoms associated with this disease.\nSimilar content being viewed by others\nReferences\nZwas FR, Lyon DT Endometriosis: an important condition in clinical gastroenterology. Dig Dis Sci. 1991;36:353–364.\nPrystowsky JB, Stryker SJ, Ujiki GT, Poticha SM Gastrointestinal endometriosis. Incidence and indications for resection. Arch Surg. 1988;123:855–858.\nShah M., Tager D., Feller E. Intestinal endometriosis masquerading as a common digestive disorder. Arch Intern Med. 1995;155:977–980.\nSkoog SM, Foxx-Orenstein AE, Levy MJ, Session DR Intestinal endometriosis: the great masquerader. 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Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NCRR or NIH. The authors wish to acknowledge the technical assistance of Olga I. Santiago and Lynnette A. Ruiz. We would also like to acknowledge statistical support for this article provided by the Epidemiology and Biostatistics Core Program of the Ponce School of Medicine, federally funded by NIH/NCRR/Research Centers in Minority Institutions (grant 2G12-RR03050).\nRights and permissions\nAbout this article\nCite this article\nAppleyard, C.B., Cruz, M.L., Rivera, E. et al. Experimental Endometriosis in the Rat Is Correlated With Colonic Motor Function Alterations but Not With Bacterial Load. Reprod. Sci. 14, 815–824 (2007). https://doi.org/10.1177/1933719107309722\nPublished:\nIssue date:\nDOI: https://doi.org/10.1177/1933719107309722","source_license":"CC0","license_restricted":false}