{"paper_id":"12c49109-de03-48ae-821e-9b57e00be6b2","body_text":"Abstract\nPurpose\nThe current study investigated the potential therapeutic efficiency of atosiban, an oxytocin receptor antagonist, in an experimental endometriosis model.\nMethods\nEndometriosis was surgically induced in 35 female rats during estrus. Four weeks after this procedure, relaparotomy was performed. The viability and dimensions of the endometriosis foci were recorded. Rats were then randomly divided into three groups. In the first group (n = 8), a daily dose of 0.2 ml 0.9 % NaCl was injected intraperitoneally (i.p.) (control cases). In the second and third groups (n = 8 and n = 8), 0.5 mg/kg/day i.p. atosiban and 1 mg/day i.p. diltiazem were given, respectively. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriosis foci were recorded. The endometrial implants were processed for histological and immunohistochemical studies. The volumes of endometriotic implants were measured, and immunohistochemical analyses were performed, and compared between the groups.\nResults\nAfter the treatment with atosiban, volumes of endometriotic implants decreased significantly. Proliferating cell nuclear antigen expression levels were significantly reduced in the atosiban and diltiazem groups compared with the control group.\nConclusions\nIn a rat endometriosis model, atosiban, an agent used for the first time for the medical treatment of endometriosis, has shown significant therapeutic efficiency.\nSimilar content being viewed by others\nReferences\nVignali M, Infantino M, Matrone R, Chiodo I, Somigliana E, Busacca M et al (2002) Endometriosis: novel etiopathogenetic concepts and clinical perspectives. Fertil Steril 78(4):665–678\nGiudice LC, Kao LC (2004) Endometriosis. 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J Biol Chem 266(35):23739–23744\nMorad F, Elsayed EM, Mahmoud SM (1997) Inhibition of steroid sex hormones release in rats by two Ca2+ channel blockers. Pharmacol Res 35(3):177–180\nAcknowledgments\nThis study has been presented as an oral presentation in 27th Annual Meeting of ESHRE - Stockholm 2011.\nConflict of interest\nNone.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nSimsek, Y., Celik, O., Karaer, A. et al. Therapeutic efficiency of Atosiban, an oxytocin receptor blocking agent in the treatment of experimental endometriosis. Arch Gynecol Obstet 286, 777–783 (2012). https://doi.org/10.1007/s00404-012-2390-7\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-012-2390-7","source_license":"CC0","license_restricted":false}