{"paper_id":"1210d311-52fa-4ae6-8c9a-7729f80513f3","body_text":"YUHASpace Repository\n0\n538\nCited 0 times in\nCited 21 times in\nEndometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment\n- Authors\n- Ryan M Marquardt ; Tae Hoon Kim ; Jung-Yoon Yoo ; Hanna E Teasley ; Asgerally T Fazleabas ; Steven L Young ; Bruce A Lessey ; Ripla Arora ; Jae-Wook Jeong\n- Citation\n- FASEB JOURNAL, Vol.35(2) : e21209, 2021-02\n- Journal Title\n- FASEB JOURNAL\n- ISSN\n- 0892-6638\n- Issue Date\n- 2021-02\n- MeSH\n- Adult ; Animals ; DNA-Binding Proteins / genetics ; DNA-Binding Proteins / metabolism* ; Embryo Implantation* ; Endometrium / metabolism* ; Female ; Hepatocyte Nuclear Factor 3-beta / genetics ; Hepatocyte Nuclear Factor 3-beta / metabolism ; Humans ; Leukemia Inhibitory Factor / genetics ; Leukemia Inhibitory Factor / metabolism ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Transcription Factors / genetics ; Transcription Factors / metabolism*\n- Keywords\n- ARID1A ; FOXA2 ; endometriosis ; endometrium ; infertility\n- Abstract\n- Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that ARID1A binds and regulates transcription of the Foxa2 gene required for endometrial gland function. Uterine-specific deletion of Arid1a compromises gland development and diminishes Foxa2 and Lif expression. Deletion of Arid1a with Ltf-iCre in the adult mouse endometrial epithelium preserves the gland development while still compromising the gland function. Mice lacking endometrial epithelial Arid1a are severely sub-fertile due to defects in implantation, decidualization, and endometrial receptivity from disruption of the LIF-STAT3-EGR1 pathway. FOXA2 is also reduced in the endometrium of women with endometriosis in correlation with diminished ARID1A, and both ARID1A and FOXA2 are reduced in nonhuman primates induced with endometriosis. Our findings describe a role for ARID1A in the endometrial epithelium supporting early pregnancy establishment through the maintenance of gland function.\n- Appears in Collections:\n- 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers\n- Yonsei Authors\n- Yoo, Jung Yoon(유정윤) https://orcid.org/0000-0001-9366-3863\nItems in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.","source_license":"CC0","license_restricted":false}