{"paper_id":"120c29e0-f59a-4ab3-971a-61c7e49241d8","body_text":"Abstract\nDiseases and tumors of the appendix vermiformis are very rare, except for acute appendicitis. This study aimed to examine rare findings in the histopathologic examinations of specimens of patients undergoing appendectomy due to the diagnosis of acute appendicitis. The files of 1970 patients undergoing appendectomy due to the diagnosis of acute appendicitis between March 2012 and March 2016 were retrospectively investigated. Rare findings were found in 59 (3 %) patients, and these were evaluated in detail. Patients’ age, gender, pathology reports, and postoperation follow-ups were recorded. The rare histopathological findings of 59 patients were examined. Of these, 31 were female (52.5 %) and 28 were male (47.5 %). The average age was 33.1 ± 18.2 years. The unusual findings were as follows: 16 fibrous obliteration, 11 Enterobius vermicularis, 2 schistosomiasis, 3 appendiceal neuroma, 2 granulomatous appendicitis, 1 Crohn’s disease, 3 chronic appendicitis, 1 endometriosis, 2 hyperplastic polyps, 9 mucinous cystadenoma (+mucocele), 8 carcinoid tumors, and 1 lymphoma. All of the malignant tumors were localized in the distal end of the appendix, and all of the patients were treated with appendectomy. Patients with parasitic diseases also underwent anthelmintic treatment, while chemotherapy was administered to the patient with lymphoma. All of the patients diagnosed with malignancy were alive reported no problems at their follow-ups. Although all of the appendectomy samples were normal macroscopically, data from this study suggest that all specimens should be sent for routine investigation.\nSimilar content being viewed by others\nReferences\nFlum DR, Koepsell T (2002) The clinical and economic correlates of misdiagnosed appendicitis: nationwide analysis. Arch Surg 137(7):799–804\nAkbulut S, Tas M, Sogutcu N, Arikanoglu Z, Basbug M, Ulku A, Semur H, Yagmur Y (2011) Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol 17(15):1961–1970\nEmre A, Akbulut S, Bozdag Z, Yilmaz M, Kanlioz M, Emre R et al (2013) Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients. Int Surg 98(4):354–362\nMatthyssens LE, Ziol M, Barrat C, Champault GG (2006) Routine surgical pathology in general surgery. Br J Surg 93(3):362–368\nThe Royal College of Pathologists 2005 Histopathology and Cytopathology of limited or no clinical value 2nd edition. London. [http://www.rcpath.org/publications]\nChan W, Fu KH (1987) Value of routine histopathological examination of appendices in Hong Kong. J Clin Pathol 40(4):429–433\nNemeth L, Reen DJ, O’Briain D, McDermott M, Pui P (2001) Evidence of an inflammatory pathologic condition in “normal” appendices following emergency appendectomy. Arch Path Lab Med 125(6):759–764\nConnor SJ, Hanna GB, Frizell FA (1998) Appendiceal tumors. Dis Colon rectum 41(1):75–80\nKozar RA, Roslyn JJ (1999) The appendix. In: Schwartz SI (ed) Principles of surgery. McGraw-Hill, New York\nRussell RC, Williams NS, Bulstrode CJ (2000) The vermiform appendix. In: Russell RC, Williams NS, Bulstrode CJ (eds) Bailey and Love’s short practice of surgery, 23 th edn. Arnold Publishers, London, pp. 1076–1092\nDuzgun AP, Moran M, Uzun S, Ozmen MM, Ozer VM, Seckin S, Coskun F (2004) Unusual findings in appendicectomy specimens: evaluation of 2458 cases and review of the literature. Indian J Surg 66(4):221–226\nJones AE, Phillips AW, Jarvis JR, Sargen K (2007) The value of routine histopathological examination of appendicectomy specimens. BMC Surg 7:17\nChamisa I (2009) A clinicopathological review of 324 appendices removed for acute appendicitis in Durban, South Africa: a retrospective analysis. Ann R Coll Surg Engl 91(8):688–692\nYabanoglu H, Caliskan K, Ozgur Aytac H, Turk E, Karagulle E, Kayaselcuk F et al (2014) Unusual findings in appendectomy specimens of adults: retrospective analyses of 1466 patients and a review of literature. Iran Red Crescent Med J 16(2):1–6\nLadu R (2014) Schistosomiasis as a rare cause of recurrent acute appendicitis: a case report. Int J Surg Case Report 5(3):159–160\nSteinmann P, Keiser J, Boss R, Tanner M, Utzinger J (2006) Schistosomiasis and water resources development: systemic review, meta-analysis and estimates of people at risk. Lancet Infect Dis 6(7):411–425\nGali BM, Nggada HA (2006) Schistosomiasis of the appendix in Maiduguri. Trop Doctor 36(3):162–163\nGupta K, Solanki A, Vasishta RK (2011) Appendiceal neuroma: report of an elusive neuroma. Trop Gastroenterol 32(4):332–333\nPatel AV, Friedman M, MacDermott RP (2010) Crohn’s disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (fibrous obliteration of the appendix). Inflamm Bowel Dis 16(7):1093–1094\nAbdullGaffar B (2010) Granulomatous diseases and granulomas of the appendix. Int J Surg Pathol 18(1):14–20\nTucker ON, Healy V, Jeffers M, Keane FB (2003) Granulomatous appendicitis. Surgeon 1(5):286–289\nShivakumar P, Shanmugam RP, Mani CS (2010) Idiopathic granulomatous appendicitis: a rare appendicular pseudo tumor. Trop Gastroenterol 31(2):130–131\nShapiro R, Eldar S, Sadot E, Papa MZ, Zippel DB (2011) Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg 201(6):805–808\nIn’t Hof KH, van der Wal HC, Kazemier G, Lange JF (2008) Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg 12(8):1436–1438\nDemetrashvili Z, Chkhaidze M, Khutsishvili K, Topchishvili G, Javakhishvili T, Pipia I (2012) Mucocele of the appendix: case report and review of literature. Int Surg 97(3):266–269\nLimaiem F, Bouraoui S, Bouahmed S, Sahraoui G, Lahmar A, Mzabi-Regaya S (2015) Appendiceal hyperplastic polyp: case report. J Interdiscipl Histopathol 3(1):36–38\nKothadia JP, Katz S, Ginzburg L (2015) Chronic appendicitis: uncommon cause of chronic abdominal pain. Therap Adv Gastroenterol 8(3):160–162\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nThis study was approved by the local ethics committee.\nConflict of Interest\nThe authors declare that they have no conflict of interest.\nInformed Consent\nWritten informed consent was obtained from the patient.\nFunding\nThe authors declared that this case has received no financial support.\nRights and permissions\nAbout this article\nCite this article\nDincel, O., Göksu, M., Türk, B.A. et al. Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients. Indian J Surg 80, 48–53 (2018). https://doi.org/10.1007/s12262-016-1557-z\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s12262-016-1557-z","source_license":"public-domain-us","license_restricted":false}