{"paper_id":"111d2cd4-3dec-44d4-9fd5-a1b736c826f2","body_text":"Print ISSN: 1021-335X\nOnline ISSN: 1791-2431\nInternational Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.\nInternational Journal of Oncology is an international journal devoted to oncology research and cancer treatment.\nCovers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.\nOncology Reports is an international journal devoted to fundamental and applied research in Oncology.\nExperimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.\nOncology Letters is an international journal devoted to Experimental and Clinical Oncology.\nExplores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.\nInternational journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.\nMultidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.\nOpen-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.\nPublishes open-access research on using epigenetics to advance understanding and treatment of human disease.\nAn International Open Access Journal Devoted to General Medicine.\nArticle\n- Authors:\n-\nPages: 939-983|Published online on: July 1, 1998https://doi.org/10.3892/or.5.4.939\n- Expand metrics +\nThe records of 41 patients diagnosed with adenosarcoma of the female genital tract between 1982 and 1996 were reviewed. The median age at diagnosis is 51 years (range, 14-84). The most common symptom is vaginal bleeding (71%). Clinical signs at presentation include pelvic mass (37%), uterine polyps (29%), and enlarged uterus (22%). In 71% of patients, the tumor originates from the uterus. Other sites include ovary (15%), pelvis (12%), cervix (2%). A history of thyroid cancer, benign ovarian cyst, and polycystic ovarian disease is found more frequently than expected in this patient population, whereas no relationship to endometriosis is observed. Surgery is the mainstay of treatment, but platin-based chemotherapy given upfront in inoperable patient has definite efficacy. An overall response rate of 92.5% was observed after primary therapy (surgery with or without radiotherapy, and/or chemotherapy), with a median survival of 48 months (range, 1-174). Thirty-eight percent of patients had recurrent disease. The median time to recurrence is 12 months (range, 5-132). Although 60% of patients with recurrence achieved a complete remission after treatment, only 1 (8%) is alive without disease, and 3 (22%), with disease at the time of this analysis. In our series, histologic sarcomatous overgrowth is a predictor of poor prognosis (p<0.03), however myometrial invasion and stage of disease seem to be of less prognostic significance. Adenosarcoma is a tumor with a fair prognosis. Most tumor can be cured with surgery, but recurrence carries a bad prognosis.\nCopy and paste a formatted citation\nSpandidos Publications style\nVerschraegen C, Vasuratna A, Edwards C, Freedman R, Kudelka A, Tornos C and Kavanagh J: Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.. Oncol Rep 5: 939-983, 1998.\nAPA\nVerschraegen, C., Vasuratna, A., Edwards, C., Freedman, R., Kudelka, A., Tornos, C., & Kavanagh, J. (1998). Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.. Oncology Reports, 5, 939-983. https://doi.org/10.3892/or.5.4.939\nMLA\nVerschraegen, C., Vasuratna, A., Edwards, C., Freedman, R., Kudelka, A., Tornos, C., Kavanagh, J.\"Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.\". Oncology Reports 5.4 (1998): 939-983.\nChicago\nVerschraegen, C., Vasuratna, A., Edwards, C., Freedman, R., Kudelka, A., Tornos, C., Kavanagh, J.\"Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience.\". Oncology Reports 5, no. 4 (1998): 939-983. https://doi.org/10.3892/or.5.4.939","source_license":"public-domain-us","license_restricted":false}