{"paper_id":"10d14860-d0a0-440f-8c51-8538bd5c6813","body_text":"WEKO3\nアイテム\nImpact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis\nhttp://hdl.handle.net/10422/0002000041\nhttp://hdl.handle.net/10422/00020000411c4aa969-e1ef-4f52-9fe2-6abc9bb9899b\n| 名前 / ファイル | ライセンス | アクション |\n|---|---|---|\n|\nrmb2.12540.pdf (5.9 MB)\n|\n| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||\n|---|---|---|---|---|---|---|\n| 公開日 | 2023-11-22 | |||||\n| タイトル | ||||||\n| タイトル | Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis | |||||\n| 言語 | en | |||||\n| 言語 | ||||||\n| 言語 | eng | |||||\n| キーワード | ||||||\n| 言語 | en | |||||\n| 主題Scheme | Other | |||||\n| 主題 | CA-125 antigen | |||||\n| キーワード | ||||||\n| 言語 | en | |||||\n| 主題Scheme | Other | |||||\n| 主題 | endometriosis | |||||\n| キーワード | ||||||\n| 言語 | en | |||||\n| 主題Scheme | Other | |||||\n| 主題 | intraperitoneal injections | |||||\n| キーワード | ||||||\n| 言語 | en | |||||\n| 主題Scheme | Other | |||||\n| 主題 | Macaca fascicularis | |||||\n| キーワード | ||||||\n| 言語 | en | |||||\n| 主題Scheme | Other | |||||\n| 主題 | mesenchymal stem cells | |||||\n| 資源タイプ | ||||||\n| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||\n| 資源タイプ | journal article | |||||\n| アクセス権 | ||||||\n| アクセス権 | open access | |||||\n| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||\n| 著者 |\nTSUJI, Ichiro\n× TSUJI, Ichiro× MUKAI, Takeo× TSUCHIYA, Hideaki× IWATANI, Chizuru× NAKAMURA, Akiko× NAGAMURA-INOUE, Tokiko× MURAKAMI, Takashi |\n|||||\n| 著者別名 |\n辻, 俊一郎\n× 辻, 俊一郎× 土屋, 英明× 岩谷, 千鶴× 中村, 暁子× 村上, 節 |\n|||||\n| 抄録 | ||||||\n| 内容記述タイプ | Abstract | |||||\n| 内容記述 | Purpose: This study aimed to explore whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be used as a therapeutic resource for endometriosis. Methods: Of seven cynomolgus monkeys with endometriosis, five were administered UC-MSCs (intervention group) and two were administered saline (control group). First, intravenous US-MSC treatment was administered for three months. Second, weekly intravenous US-MSC administration combined with monthly intraperitoneal US-MSC administration was conducted for 3 months. Finally, weekly intraperitoneal US-MSC administration was conducted for 3 months. The dose of UC-MSCs was set to 2 × 106 cells/kg for all administration routes. Laparoscopic findings and serum cancer antigen 125 (CA125) levels were also evaluated. The Revised American Society for Reproductive Medicine classification was used for laparoscopic evaluation. Results: Laparoscopic findings showed exacerbation of endometriosis after intraperitoneal UC-MSC administration, although no changes were observed in the control group. Intravenous UC-MSC administration decreased the level of CA125 in all monkeys; however, the difference was not significant. Intraperitoneal UC-MSC administration significantly exacerbated endometriosis compared with intravenous administration (p = 0.02). Conclusions: This study revealed that intraperitoneal UC-MSC administration exacerbates endometriosis in a nonhuman primate model of the disease. |\n|||||\n| 言語 | en | |||||\n| 書誌情報 |\nen : Reproductive medicine and biology 巻 22, 号 1, 発行日 2023-08-28 |\n|||||\n| 出版者 | ||||||\n| 出版者 | Japan Society for Reproductive Medicine | |||||\n| 言語 | en | |||||\n| 別言語の出版者 | ||||||\n| 出版者 | 日本生殖医学会 | |||||\n| 言語 | ja | |||||\n| ISSN | ||||||\n| 収録物識別子タイプ | EISSN | |||||\n| 収録物識別子 | 1447-0578 | |||||\n| PMID | ||||||\n| 識別子タイプ | PMID | |||||\n| 関連識別子 | 37693240 | |||||\n| PMCID | ||||||\n| 識別子タイプ | URI | |||||\n| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10491929/ | |||||\n| DOI | ||||||\n| 関連タイプ | isIdenticalTo | |||||\n| 識別子タイプ | DOI | |||||\n| 関連識別子 | https://doi.org/10.1002/rmb2.12540 | |||||\n| 権利 | ||||||\n| 権利情報 | © 2023 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. | |||||\n| 言語 | en | |||||\n| 著者版フラグ | ||||||\n| 出版タイプ | VoR | |||||\n| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |","source_license":"CC0","license_restricted":false}