{"paper_id":"10360bb3-96c4-4af7-8cec-f652bf662e90","body_text":"Abstract\nPurpose\nFindings from studies on the association between the p53 Arg72Pro polymorphism and endometriosis susceptibility have so far been inconsistent. Therefore, we undertook a meta-analysis to clarify the association of p53 Arg72Pro polymorphism with the risk of endometriosis.\nMethods\nRelevant studies were chosen by searching PubMed, Embase, the Cochrane Library databases, CNKI, Wanfang database, and CBM for articles published before and up to April 30, 2015. Two independent reviewers performed the eligibility evaluation and data extraction. The odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated for the overall risk estimate.\nResults\nEleven case–control studies involving 1834 endometriosis cases and 2331 controls were included. Pooled data analysis suggested that the p53 72Pro variant is a significant endometriosis risk factors in comparison to the 72Arg variant (Pro vs. Arg: OR = 1.298, 95 % CI 1.082–1.558; Pro/Pro vs. Arg/Arg: OR = 1.751, 95 % CI 1.130–2.711; Pro/Arg vs. Arg/Arg: OR = 1.530, 95 % CI 1.174–1.994), which was strengthened in the dominant model (Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 1.570, 95 % CI = 1.181–2.087). In the stratified analysis by ethnicity and Hardy–Weinberg equilibrium (HWE) in the controls, we found strong associations in Asians and in studies that were consistent with HWE. However, the analyses of the revised American Fertility Society (rAFS) stage and the menopausal status subgroup did not reveal any significant associations.\nConclusion\nIn conclusion, the p53 Arg72Pro polymorphism was closely related to the risk of endometriosis, especially in Asian populations.\nSimilar content being viewed by others\nReferences\nAgorastos T, Masouridou S, Lambropoulos AF, Chrisafi S, Miliaras D, Pantazis K, Constantinides TC, Kotsis A, Bontis I (2004) P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women. Eur J Cancer Prev 13(4):277–280\nAmmendola M, Gloria-Bottini F, Sesti F, Piccione E, Bottini E (2008) Association of p53 codon 72 polymorphism with endometriosis. Fertil Steril 90(2):406–408\nBianco B, Christofolini DM, Brandes A, Lerner TG, Goncalves-Filho RP, Souza AM, Barbosa CP (2011) Analysis of codon 72 polymorphism of the TP53 gene in infertile women with and without endometriosis. Rev Bras Ginecol Obstet 33(1):37–42\nBrady CA, Attardi LD (2010) p53 at a glance. J Cell Sci 123(Pt 15):2527–2532\nBrosens I, Benagiano G (2011) Endometriosis, a modern syndrome. Indian J Med Res 133:581–593\nBushe CJ, Bradley AJ, Wildgust HJ, Hodgson RE (2009) Schizophrenia and breast cancer incidence: a systematic review of clinical studies. Schizophr Res 114(1–3):6–16\nChang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC (2002) The proline form of p53 codon 72 polymorphism is associated with endometriosis. Fertil Steril 77(1):43–45\nde Ziegler D, Borghese B, Chapron C (2010) Endometriosis and infertility: pathophysiology and management. Lancet 376(9742):730–738\nDerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188\nDumont P, Leu JI, Della Pietra AC 3rd, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat Genet 33(3):357–365\nDun EC, Taylor RN, Wieser F (2010) Advances in the genetics of endometriosis. Genome Med 2(10):75\nEgger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634\nFerrero S, Remorgida V, Maganza C, Venturini PL, Salvatore S, Papaleo E, Candiani M, Leone Roberti Maggiore U (2014) Aromatase and endometriosis: estrogens play a role. Ann N Y Acad Sci 1317:17–23\nGallegos-Arreola MP, Figuera-Villanueva LE, Puebla-Perez AM, Montoya-Fuentes H, Suarez-Rincon AE, Zuniga-Gonzalez GM (2012) Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women. Genet Mol Res 11(2):1401–1408\nGloria-Bottini F, Ammendola M, Saccucci P, Neri A, Magrini A, Bottini E (2015) The effect of ACP, ADA and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis. Arch Gynecol Obstet\nHe XF, Su J, Zhang Y, Huang X, Liu Y, Ding DP, Wang W, Arparkorn K (2011) Association between the p53 polymorphisms and breast cancer risk: meta-analysis based on case-control study. Breast Cancer Res Treat 130(2):517–529\nHiggins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558\nHong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K, Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460(7259):1132–1135\nHosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF (2004) Detection of genotyping errors by Hardy-Weinberg equilibrium testing. Eur J Hum Genet 12(5):395–399\nHsieh YY, Lin CS (2006) P53 codon 11, 72, and 248 gene polymorphisms in endometriosis. Int J Biol Sci 2(4):188–193\nHuang Y, Zong L, Lin J, Fu Y, Liu Z, Mao T, Zeng J, Wang Y, Zhao X (2013) Association of P53 gene polymorphisms with susceptibility to endometriosis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(3):335–339\nIoannidis JP, Trikalinos TA (2005) Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 58(6):543–549\nJia S, Xu L, Chan Y, Wu X, Yang S, Yu H, Yang H, Luo Y, Tang W (2012) p53 codon 72 polymorphism and endometriosis: a meta-analysis. Arch Gynecol Obstet 285(6):1657–1661\nJoerger AC, Fersht AR (2007) Structure-function-rescue: the diverse nature of common p53 cancer mutants. Oncogene 26(15):2226–2242\nLattuada D, Vigano P, Somigliana E, Abbiati A, Candiani M, Di Blasio AM (2004) Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis. Mol Hum Reprod 10(9):651–654\nMantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748\nMarte B (2002) Cancer: super p53. Nature 420(6913):279\nMitchell AA, Cutler DJ, Chakravarti A (2003) Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test. Am J Hum Genet 72(3):598–610\nNikbakht Dastjerdi M, Aboutorabi R, Eslami Farsani B (2013) Association of TP53 gene codon 72 polymorphism with endometriosis risk in Isfahan. Iran J Reprod Med 11(6):473–478\nOmori S, Yoshida S, Kennedy SH, Negoro K, Hamana S, Barlow DH, Maruo T (2004) Polymorphism at codon 72 of the p53 gene is not associated with endometriosis in a Japanese population. J Soc Gynecol Investig 11(4):232–236\nPiao JM, Kim HN, Song HR, Kweon SS, Choi JS, Yun WJ, Kim YC, Oh IJ, Kim KS, Shin MH (2011) p53 codon 72 polymorphism and the risk of lung cancer in a Korean population. Lung Cancer 73(3):264–267\nPim D, Banks L (2004) p53 polymorphic variants at codon 72 exert different effects on cell cycle progression. Int J Cancer 108(2):196–199\nSaadat M (2011) Significance of the Hardy-Weinberg equilibrium in genetic association studies. Psychiatry Res 190(1):165\nSiddique M, Sabapathy K (2006) Trp53-dependent DNA-repair is affected by the codon 72 polymorphism. Oncogene 25(25):3489–3500\nSoave I, Caserta D, Wenger JM, Dessole S, Perino A, Marci R (2015) Environment and Endometriosis: a toxic relationship. Eur Rev Med Pharmacol Sci 19(11):1964–1972\nSong HR, Kweon SS, Kim HN, Piao JM, Yun WJ, Choi JS, Hwang JE, Yoon JY, Kim HR, Park YK, Kim SH, Choi YD, Shin MH (2011) p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population. Gastric Cancer 14(3):242–248\nSzczepanska M, Wirstlein P, Holysz H, Skrzypczak J, Jagodzinski PP (2013) The FCRL3 -169T>C polymorphism and the risk of endometriosis-related infertility in a Polish population. Arch Gynecol Obstet 288(4):799–804\nVietri MT, Molinari AM, Iannella I, Cioffi M, Bontempo P, Ardovino M, Scaffa C, Colacurci N, Cobellis L (2007) Arg72Pro p53 polymorphism in Italian women: no association with endometriosis. Fertil Steril 88(5):1468–1469\nYe F, Zhang J, Cheng Q, Shen J, Chen H (2010) p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population. Cancer Lett 287(1):117–121\nYing TH, Tseng CJ, Tsai SJ, Hsieh SC, Lee HZ, Hsieh YH, Bau DT (2011) Association of p53 and CDKN1A genotypes with endometriosis. Anticancer Res 31(12):4301–4306\nZintzaras E (2010) Impact of Hardy-Weinberg equilibrium deviation on allele-based risk effect of genetic association studies and meta-analysis. Eur J Epidemiol 25(8):553–560\nAcknowledgments\nThis study was not supported by any kind of funding.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nThe authors declare that they have no financial relationship with the organization that sponsored the research. The authors also state that they have had full control of all primary data and agree to allow the Journal to review their data if requested.\nRights and permissions\nAbout this article\nCite this article\nLao, X., Chen, Z. & Qin, A. p53 Arg72Pro polymorphism confers the susceptibility to endometriosis among Asian and Caucasian populations. Arch Gynecol Obstet 293, 1023–1031 (2016). https://doi.org/10.1007/s00404-015-3923-7\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-015-3923-7","source_license":"CC0","license_restricted":false}