{"paper_id":"102ec3a4-0f01-4f97-9ddd-3bba721dcb0c","body_text":"Abstract\nPurpose\nTo examine the possible roles of various immunological factors in recurrent miscarriage and unexplained infertility.\nMethods\nThe synthesis and review of the relevant current literature in English language.\nResults\nSubstantial evidence suggests that antiphospholipid antibodies, lupus anticoagulant, antisperm antibodies, antithyroid antibodies, anti-endometrial antibodies, antiovarian antibodies, anti-C trachomatis antibodies, cytokines, and immunological events in endometriosis and premature ovarian failure due to immunologic factors may contribute to reproductive failure including unexplained infertility and/or non-chromosomal recurrent miscarriage.\nConclusions\nElimination or suppression of the immunological factors related with reproductive failure might occupy an important place in the treatment of unexplained infertility and non-chromosomal recurrent miscarriage.\nSimilar content being viewed by others\nReferences\nBurney RO, Schust DJ, Yao MWM (2007) Infertility. 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Arch Gynecol Obstet 286, 1283–1289 (2012). https://doi.org/10.1007/s00404-012-2480-6\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-012-2480-6","source_license":"public-domain-us","license_restricted":false}