{"paper_id":"0f5327d1-6721-4ce7-932b-dd0de8e0d7a9","body_text":"Abstract\nPurpose\nA reduced oocyte competence has been claimed as one of the factors underlying infertility in women with endometriosis. This idea has justified the hypothesis that intracytoplasmic sperm injection (ICSI), rather than conventional IVF (c-IVF), may overcome oocyte impairment and ensure better assisted reproduction technology (ART) outcomes; however, data from the literature are controversial. Thus, the aim of this study was to compare ART success rates following (c-IVF) between women with and without endometriosis in the presence of normozoospermic partners.\nMethods\nThis is a retrospective, matched case–control study of 314 patients who underwent c-IVF cycles between January 2014 and December 2020. Women with endometriosis were matched in a 1:1 ratio with patients undergoing ART for other indications, considering age (± 6 months), number of oocytes retrieved (± 1), and study period. The main outcome measures included total fertilization failure, fertilization rate, embryo quality, cumulative clinical pregnancy, and live birth rates.\nResults\nThe fertilization rate and the proportion of women with total fertilization failure did not differ between women with and without endometriosis. Similarly, all other embryological variables did not also differ, except for the number of top-quality cleavage stage embryos which was higher in the endometriosis group. Cumulative clinical pregnancy and live birth rates were similar between women with and without endometriosis.\nConclusion\nA diagnosis of endometriosis does not negatively affect the performance of c-IVF; thus, c-IVF can be efficiently used in women affected, unless a male factor is also involved. This issue holds clinical relevance to help operators on their insemination technique decision-making.\nSimilar content being viewed by others\nData availability\nThe database analysed during the current study is available from the corresponding author on reasonable request.\nReferences\nLee D, Kim SK, Lee JR, Jee BC. Management of endometriosis-related infertility: considerations and treatment options. Clin Exp Reprod Med. 2020;47(1):1–11. https://doi.org/10.5653/cerm.2019.02971.\nAmerican Society of Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98(3):591–8. https://doi.org/10.1016/j.fertnstert.2012.05.031.\nTaylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. The Lancet. 2021;397(10276):839–52. https://doi.org/10.1016/s0140-6736(21)00389-5.\nCoddington CC, Oehninger S, Cunningham DS, Hansen K, Sueldo CE, Hodgen GD. 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M.C. acknowledges the support of Coordenação de Aperfeiçoamento de Pessoal do Nível Superior-Brasil (CAPES) - Finance Code 001.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of interest\nE.S. declares honoraria and grants from Theramex, Merck-Serono and Ferring. All the other authors have nothing to declare.\nAdditional information\nPublisher's note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nSupplementary information\nBelow is the link to the electronic supplementary material.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nViganò, P., Reschini, M., Ciaffaglione, M. et al. Conventional IVF performs similarly in women with and without endometriosis. J Assist Reprod Genet 40, 599–607 (2023). https://doi.org/10.1007/s10815-022-02700-z\nReceived:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s10815-022-02700-z","source_license":"CC0","license_restricted":false}