{"paper_id":"0d0401d6-c3c3-481e-9ea4-5d93b6d5cfc7","body_text":"Small molecule stabilization of diverse amyloidogenic \nimmunoglobulin light chains revealed by hydrogen-\ndeuterium exchange mass spectrometry \nDaniele Peterle1,a*, Nicholas L. Yan2,b, Elena S. Klimtchuk3, Thomas E. Wales1, Olga Gursky4, Jeffery W. \nKelly2, John R. Engen1,c, Gareth J. Morgan3,5* \n1Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA \n2Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA \n3Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA \n4Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian \nSchool of Medicine, Boston, MA, USA \n5Section of Hematology and Medical Oncology, Department of Medicine, Boston University Chobanian & \nAvedisian School of Medicine, Boston, MA, USA \na Current address: Department of Experimental Biophysics, Peptone Switzerland AG, Bellinzona, \nSwitzerland \nb Current address: Institute for Neurodegenerative Diseases, University of California San Francisco, San \nFrancisco, CA, USA \nc Current address: New Mexico Consortium, Los Alamos, NM, USA \n* Corresponding authors:  \nDaniele Peterle d.peterle@northeastern.edu and Gareth J. Morgan gjmorgan@bu.edu \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nAbstract \nImmunoglobulin light chains, a component of antibodies, can misfold and aggregate to cause systemic \nAL amyloidosis. Aggregation, including amyloid fibril formation, requires unfolding of the full-length light \nchain from its native state, and in most cases aberrant proteolysis. Small molecules that bind to the \nnative state of light chains to stabilize them against conformational excursions and proteolysis are under \ndevelopment as drug candidates for AL amyloidosis. Since each patient has a unique light chain \nsequence, a challenge for candidate stabilizer drugs is to bind multiple light chains and suppress their \ndynamics. Here, we used hydrogen-deuterium exchange measured by mass spectrometry to \ncharacterize the binding of six small molecule stabilizers to eleven different λ light chain proteins. \nDespite structural and dynamic differences among the light chains, the binding of the most efficacious \nstabilizer molecule led to increased protection from hydrogen exchange, consistent with reduced local \nand global unfolding. Protection upon binding was most prominent in residues within complementarity \ndetermining region 3 and framework region 4 of the light chain variable domains, which undergo major \nconformational changes enabling amyloid formation. Stabilizer binding also reduced the rate at which all \nlight chains were cleaved by protease. These data show that these stabilizers suppress the range of \nconformational dynamics associated with light chain aggregation, supporting their therapeutic potential. \nKeywords: Immunoglobulin light chain amyloidosis; AL amyloidosis; amyloid fibrils; Light chain kinetic \nstabilizers; drug design; protein stability and dynamics; HDX-MS; PLIMSTEX analysis.  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nHighlights \n• Small-molecule kinetic stabilizers suppress conformational dynamics and aberrant proteolysis of \ndiverse amyloidogenic full-length λ light chains. \n• HDX-MS indicates conserved protection in regions forming the interface between the two \nvariable domains of the light chain dimer, corresponding to residues that form the core of \npatient-derived amyloid fibrils. \n• PLIMSTEX binding titrations show coupled binding, dimerization and stabilization at sub-\nmicromolar kinetic stabilizer concentrations.  \n• Small molecule kinetic stabilization across different λ sequences supports kinetic stabilizers as a \npromising therapeutic strategy for AL amyloidosis. \n \nDeclaration of interests: NLY, JWK and GJM are authors on a patent that describes the use of kinetic \nstabilizers as a potential therapy for AL amyloidosis. JWK is a founder and board member of Protego \nBiopharma.  \nAbbreviations: AL – amyloid light chain; CDR – complementarity determining region; CL – light chain \nconstant domain; FL – full-length; FR – framework region; HDX – hydrogen-deuterium exchange; GL – \ngermline; LC – immunoglobulin light chain; MM – multiple myeloma; MS – mass spectrometry; SDS \nPAGE – sodium dodecyl sulfate polyacrylamide gel electrophoresis; ThT - thioflavin T; VL – light chain \nvariable domain.  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nIntroduction \nUnfolding and subsequent aberrant proteolysis of full-length (FL) immunoglobulin light chain (LC) \nproteins are generally required for the formation of amyloid light chain (AL) deposits in the disease AL \namyloidosis (Figure 1A), one of a spectrum of systemic amyloidoses (Buxbaum et al. 2024). \nAccumulation of amyloid fibrils derived from normally soluble LCs in multiple tissues leads to \nprogressive and eventually fatal organ dysfunction (Sanchorawala 2024; Merlini et al. 2018). Soluble, \nmisfolded LCs can also contribute to cardiotoxicity that is the major cause of mortality (Merlini et al. \n2018). FL LCs are subunits of antibodies that normally function in the immune system to recognize \nantigens (Del Pozo-Yauner et al. 2023). Antibodies are covalent heterotetramers of two FL LCs and two \nheavy chains, which circulate in blood alongside “free” LC monomers and homodimers— FL LCs are \nproduced in excess to enable efficient antibody secretion (Feige, Hendershot, and Buchner 2010). \nOverproduction of a single monoclonal free LC by an aberrant clonal cell population can cause LC \nfragment accumulation as amyloid fibrils within tissues. Each AL patient has an essentially unique LC \nsequence that forms amyloid (Morgan et al. 2025). The amino acid sequence of each LC appears to \ndefine its propensity to aggregate (Del Pozo-Yauner et al. 2023; Absmeier et al. 2023). Amyloid \nformation is also driven, in part, by increased concentration of the monoclonal free FL LC or fragments \nthereof, so existing therapies kill the clonal cells to reduce the total amyloidogenic LC concentration \n(Sanchorawala 2024; Merlini et al. 2018). Protein conformational control by small molecules that \nmodulate protein assembly, folding and stability have become an important class of drugs, targeting \nproteins associated with multiple disease categories (Chiti and Kelly 2022). Kinetic stabilizers are a \nsubset of these molecules, which selectively bind to the native state and slow the rate of protein \nunfolding. Kinetic stabilization of circulating LCs should protect residual free LCs from misfolding, \naberrant proteolysis and aggregation, thus complementing cytotoxic chemotherapies (Morgan, \nBuxbaum, and Kelly 2021), and this concept is currently being tested in clinical trials. \nThere are two types of LC, κ and λ, of which λ LCs are more frequently involved in AL amyloidosis \n(Kourelis et al. 2017; Merlini et al. 2018; Morgan et al. 2025). FL LCs are secreted as 210–220-residue \nproteins that fold into two independent structural domains (Figure 1A), a variable (V\nL) domain and a \nconstant (CL) domain (Del Pozo-Yauner et al. 2023; Feige, Hendershot, and Buchner 2010). Both domains \nhave a ß-sandwich structure, termed an immunoglobulin (Ig) fold, stabilized by an intramolecular \ndisulfide bond. The N-terminal variable domain (residues 1–113 in the alignment shown in Figures 1B \nand 1C) is involved in antigen binding when incorporated into antibodies via three highly polymorphic \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nloops known as complementarity determining regions (CDR, Figure 1C). Other residue segments, defined \nas framework regions (FR), are more conserved. The C-terminal constant LC domain (residues 114-219) \nhas a structural role within antibodies, and its sequence is highly conserved between LCs. Free FL LCs \ncan form homodimers in circulation. Such free LC dimers have a parallel orientation where the VL and CL \ndomains from one protomer interact with their counterpart in the other protomer (Figure 1A). Residues \nfrom ß-strands CV, C’V, FV and GV form a VL-VL interface, while residues from ß-strands AC, BC, DC and EC \nform the CL-CL interface. A cysteine residue near the C-terminus of CL (referred to here as C218, relative \nto the alignment) can make an intermolecular disulfide bond within the homodimer. In patients, \namyloidogenic FL LCs can form both monomers and homodimers (Connors et al. 2007; Andrich et al. \n2017; Sternke-Hoffmann et al. 2020). \nThe structured cores of patient-derived amyloid fibrils primarily comprise residues from the VL domain \nin non-native, cross-ß-sheet conformations (Radamaker et al. 2019). Isolated VL domains can aggregate \nunder mild conditions in vitro, whereas FL LCs remain soluble for extended periods under the same \nconditions and are much more resistant to aggregation (Morgan and Kelly 2016; Blancas-Mejía et al. \n2015; Blancas-Mejía and Ramirez-Alvarado 2016). Amyloid-associated VL domains tend to unfold and \naggregate more readily than non-AL VL domains (Wall et al. 1999; Hurle et al. 1994; Baden, Randles, et \nal. 2008; Kazman et al. 2020; Absmeier et al. 2023). Furthermore, amyloid-associated FL LCs are \ngenerally less conformationally stable than their non-AL counterparts and are more prone to local or \nglobal unfolding that enables aberrant endoproteolysis, releasing aggregation-prone fragments, \nincluding the VL domain (Klimtchuk et al. 2010; Morgan and Kelly 2016; Oberti et al. 2017; Blancas-Mejía \net al. 2017; Lavatelli et al. 2024). In some cases, proteolysis can occur after aggregation (Lavatelli et al. \n2020). Amyloid fibrils formed by VL domains can accelerate, or seed, the aggregation of full-length LCs \n(Blancas-Mejía and Ramirez-Alvarado 2016). \nCollectively, these data suggest a role for the local conformational dynamics in sensitive protein regions. \nThese regions have been proposed to involve: i) domain-domain interfaces in free LCs, such as the VL-VL \nand VL-CL interfaces (Rennella et al. 2019; Brumshtein et al. 2014; Baden, Owen, et al. 2008); ii) regions \ninvolving the internal disulfide bond in VL, a region that unfolds during amyloid formation (Radamaker et \nal. 2019; Klimtchuk et al. 2023); iii) amyloid-promoting regions (APRs), which are sequence regions with \nhigh intrinsic aggregation propensity that are proposed to initiate protein misfolding (Klimtchuk et al. \n2023; Peterle et al. 2021; Goldschmidt et al. 2010); iv) mutation, misfolding or proteolysis of the C\nL \ndomains (Klimtchuk et al. 2010; Benson, Liepnieks, and Kluve-Beckerman 2015; Morgan, Usher, and \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nKelly 2017; Rottenaicher et al. 2023; Lavatelli et al. 2024).  The roles of these sensitive regions in amyloid \nformation may differ for different LC sequences, complicating their therapeutic targeting.  \nBecause LCs have diverse sequences and no natural small-molecule ligands, historically they epitomized \na challenging drug target (Yan et al. 2023). Nontheless, we carried out a high-throughput screen that \nidentified small molecules that protect folded FL LCs from undergoing conformational excursions \nenabling proteolysis, compounds that we call LC kinetic stabilizers; these molecules bind highly \nconserved residues at the VL-VL interface of the LC homodimer (Morgan et al. 2019) (Figure 1B, colored \nresidues). Subsequent structure-based medicinal chemistry efforts led to more potent kinetic stabilizers \n(Figure 1D) (Yan et al. 2020, 2021, 2022; Yan, Wilson, and Kelly 2023; Lederberg et al. 2024). Screening \nand optimization of hit molecules was mainly carried out using a single full-length LC protein, termed \nWIL-FL. A key challenge for ongoing drug development is to identify kinetic stabilizers that bind tightly \nand specifically to multiple LCs with diverse sequences. These kinetic stabilizers slow LC unfolding by \nstrengthening the VL-VL domain interface within the LC homodimer, which is expected to decelerate \nproteolysis and aggregation. However, the effects of small-molecule kinetic stabilizers on localized \nunfolding and proteolysis of a broader collection of FL LCs associated with amyloidosis have not been \nscrutinized experimentally. \nTo explore the conformational dynamics of multiple FL LCs we used hydrogen-deuterium exchange \n(HDX) mass spectrometry (MS). Previously, we used HDX-MS to investigate the native structure and \ndynamics of isolated VL domains, FL LCs, and IgG proteins to identify specific regions that potentially \ncontribute to protein misfolding enabling aberrant proteolysis (Peterle et al. 2021; Klimtchuk et al. 2023, \n2024). In the current study we investigated localized unfolding in nine different FL LCs and the influence \nthat the binding of small-molecule kinetic stabilizers have on these dynamics. The stabilizers explored \nwere either screening hits (e.g. P1 and P5, Figure 1D) or structure-based designed stabilizers (e.g. B20, \nM63, M53 and M83. We provide molecular details about stabilizers’ mechanism of action and gain \ninsights to guide the development of novel therapies for the treatment of AL amyloidosis.  \nMaterials and Methods \nProtein selection, expression and purification \nNine LC proteins selected for analysis are listed in Table 1. Amino acid sequences of these LCs are listed \nin the Supplementary Information. All residues are numbered according to the sequence alignment \nshown in Figure 1C. Domain boundaries and CDR residues are defined according to the IMunoGeneTics \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n(IMGT) system (Lefranc et al. 2003). Cysteine 218 in the alignment, which forms an intermolecular \ndisulphide bond, corresponds to residue 214 in the Kabat numbering system (Kabat et al. 1987) and \nresidue 127 of the C-region in the IMGT numbering system. Variable and constant germline genes were \nassigned using IMGT’s tools for peptide and nucleotide analysis (Lefranc et al. 2018), as appropriate. \nEach LC listed in Table 1 was expressed as a full-length protein containing Cys218, which predominantly \nforms disulfide-linked dimers when expressed in E. coli (Peterle et al. 2021). We refer to these tabulated \nLCs as “AL LC”, “MCG LC”, etc. We also explored two additional proteins: the stand-alone VL domain of \nthe AL sequence (AL VL) and the AL C218S variant (Kabat: C214), where replacement of the cysteine \nprevents formation of the intermolecular disulfide bond. In total, 11 proteins were studied. Unless \notherwise specified, experiments were carried out in phosphate buffered saline (PBS), defined here as \n20 mM sodium phosphate buffer, pH 7.4, containing 150 mM NaCl. For proteins where no crystal \nstructure was available, a model was generated using the AlphaFold 3 algorithm, implemented via \nwww.alphafoldserver.com (Abramson et al. 2024). The relative orientations of the V\nL domains within \neach model were similar but the “elbow” angle between the VL and CL domains varied; for clarity, only \nthe VL domains are shown when multiple structures are compared. \nVariants of AL, MM and JTO LCs were expressed in E. coli with N-terminal polyhistidine tags and purified \nby affinity chromatography as previously described (Peterle et al. 2021). Untagged MCG, H3, H6, H7, H9 \nand H16 were expressed as inclusion bodies and purified by ion exchange and size exclusion \nchromatography, as previously described (Oberti et al. 2017; Yan, Wilson, and Kelly 2023). Protein purity \nwas 95%+ verified by SDS-PAGE (Figure S1). Protein molar concentration is reported as monomer \nequivalents. For LCs characterized to date, stabilizers bind with a stoichiometry of one small molecule to \ntwo LC monomers. \nSmall-molecule stabilizers \nWe tested six small-molecule kinetic stabilizers shown in Figure 1D and described in our previous work \n(Yan et al. 2023): P1, P5, B20, M53, M63 and M83. Numbering corresponds to that from the original \npaper (Yan et al. 2021). Letters indicate the origin of the molecules: P1 and P5 were originally identified \nas hits in a high-throughput screen (Morgan et al. 2019); B20, M53, M63 and M83 were designed and \nsynthesized during medicinal chemistry efforts to improve stabilization efficacy (Yan et al. 2021, 2022). \nThese molecules are elaborations on the coumarin scaffold of P1. B20 and M53 retain the original \ndiethylamino substitution in position 7 of the coumarin heterocycle. M63 and M83 incorporate \nphenylethoxy modifications that were optimized for binding within the core of the LC dimer. Synthesis \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nand purification of these molecules was carried out as previously described (Yan et al. 2021). Small \nmolecules were solubilized in dimethyl sulfoxide (DMSO) vehicle and diluted to the desired \nconcentration. DMSO concentrations were 1.5% during equilibration and 0.15% during deuterium \nlabeling unless otherwise specified. \nSequence analysis \nAll AL-associated λ LCs with complete VL domain sequences were taken from AL-Base, available via \nhttps://wwwapp.bumc.bu.edu/BEDAC_ALBase/, and aligned according to the IMGT numbering system. \nFully conserved gaps, which are used to facilitate structural comparisons between different types of \nimmunoglobulin domains, were removed from the alignment, leaving 113 occupied positions. This \nalignment was visualized using the ggseqlogo (Wagih 2017) package in R v 4.2.2 (R Core Team 2022), and \nthe binding site residues were highlighted manually. \nThe sequence-based consensus method AmylPred2 (Tsolis et al. 2013) was used to predict the \namyloidogenic sequence propensities of the nine LCs under study. APRs are defined as segments \npredicted by 6 or more of the 10 algorithms available via the AmlyPred2 website. \nHydrogen deuterium exchange mass spectrometry (HDX-MS)  \nAt least two independent HDX-MS replicates were measured for each LC in accordance with current \nrecommendations (Masson et al. 2019; Engen and Wales 2015). HDX-MS data have been deposited to \nthe ProteomeXchange Consortium via the PRIDE repository (Perez-Riverol et al. 2019) with the dataset \nidentifier PXD068745.  \nDeuterium labeling \nLCs were freshly diluted to 30 μM in biological replicates from stock concentrations in PBS, pH 7.4, \nprepared in H2O. Before labeling, the protein solutions were mixed 1-fold with a 300 μM solution of \nstabilizer molecule in PBS containing 3% (v/v) DMSO. Deuterium labeling commenced with a 10-fold \ndilution (18 μL) of the D2O labeling buffer (10 mM sodium phosphate, 150 mM NaCl, pD 7.4, 99.9% D2O) \nadded to 2 μL of each 15 μM protein solution. After each labeling time (10 seconds, 1 minute, 10 \nminutes, 1 hour, 4 hours, 16 hours) at 20 °C, the labeling reaction was quenched with the addition of 20 \nμL of ice-cold quenching buffer [200 mM sodium phosphate, 4 M guanidine hydrochloride (GdnHCl), \n0.72 M TCEP, pH 2.37, H2O] and analyzed immediately by liquid chromatography coupled mass \nspectrometry (LC-MS). The maximally deuterated samples of each protein that were used for back-\nexchange correction were prepared as described (Peterle, Wales, and Engen 2022). Protein solutions (15 \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nμL at 15 μM) were lyophilized, resuspended in 7 M GdnHCl containing 50 mM DTT (15 μL), and heated at \n90 °C for 5 min. After cooling to 20 °C, 18 μL of labeling buffer (as above) was added to 2 μL of cooled, \ndenatured protein solution, and the exchange reaction was allowed to proceed at 50 °C for 10 min. \nThese maximally deuterated protein samples were then cooled to 0 °C, exchange quenched with the \naddition of 20 μL of ice-cold quenching buffer (as above) and analyzed immediately by LC-MS.  \nMass spectrometry \nLC-MS was performed with a Waters HDX system containing an HDX unit and two Acquity I-class UPLC \npumps (Wales et al. 2008). Deuterated and control samples were digested online in the HDX cooling \nunit, where the digestion chamber was held at 15 °C, using an AffiPro Pepsin column (AffiPro, AP-PC-\n001, 2.1 mm × 20 mm). Peptides were trapped and desalted on a VanGuard PreColumn trap [2.1 mm × 5 \nmm, ACQUITY UPLC BEH C18, 1.7 μm, (Waters, 186002346)] for 3 minutes at 100 μL/min. Peptides were \nthen eluted from the trap using a 5%–35% gradient of acetonitrile over 6 minutes at a flow rate of 100 \nμL/min, and separated using an ACQUITY UPLC HSS T3, 1.8 μm, 1.0 mm × 50 mm column (Waters, \n186003535). The main cooling chamber of the Waters HDX unit, which housed all the chromatographic \nelements, was held at 0.0 ± 0.1 °C for the entire time of the measurements. The back pressure averaged \n~9000 psi at 0 °C and 5% acetonitrile 95% water, 0.1% formic acid. To eliminate peptide carryover, a \nwash solution (1.5 M GdnHCl, 0.8% formic acid and 4% acetonitrile) was injected over the pepsin column \nduring each analytical run. Mass spectra were acquired using a Waters Synapt XS HDMSE mass \nspectrometer operated in ion mobility mode. The mass spectrometer was calibrated with direct infusion \nof a solution of Glu-fibrinopeptide (Sigma, F3261) at 200 femtomole/μL at a flow rate of 5 μL/min prior \nto data collection. A conventional electrospray source was used, and the instrument was scanned over \nthe range 50 to 2000 m/z. The instrument configuration was: capillary voltage 2.5 kV, trap collision \nenergy at 4 V, sampling cone at 35 V, source temperature of 80 °C, and desolvation temperature of \n175 °C. All experiments were done under identical experimental conditions. In this experimental setup, \nthe error in determining peptide deuterium levels was ±0.20 Da, as established using deuterated \npeptide standards.  \nData processing \nPeptides were identified using PLGS 3.0.1 software (Waters, 720001408EN) with replicates of \nundeuterated samples used as controls. Raw MS data were imported into DynamX 3.0 (Waters, \n720005145EN) and filtered with minimum consecutive products of 2 and minimum number of products \nper amino acid of 0.25. The peptides meeting the filtering criteria were further processed automatically \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nby DynamX followed by manual inspection of all spectra and data processing. The amount of deuterium \nin each peptide was determined by subtracting the centroid mass of the undeuterated form of each \npeptide from that of the deuterated form, at each time point, for each condition. Correction for back \nexchange to report percent deuteration (%D) was done as described (Zhang and Smith 1993) according \nto the equation: \n%𝐷𝐷\n𝑙𝑙𝑙𝑙𝑙𝑙𝑙𝑙𝑙𝑙= (𝑚𝑚𝑡𝑡− 𝑚𝑚0)\n(𝑚𝑚𝑚𝑚𝑚𝑚𝑚𝑚𝑚𝑚− 𝑚𝑚0) \nwhere mt is the observed peptide centroid mass at a given labeling time-point t, m0 is the undeuterated \npeptide centroid mass, and mmaxD is the maximally deuterated peptide centroid mass.  \nPeptide-level “chiclet” plot heatmaps were used to visualize the HDX-MS data (Kerres et al. 2017). These \nvisualizations directly show the acquired data, but because the analyzed peptides may not be equivalent \nbetween different proteins it can be difficult to make direct comparisons. To more easily visualize \ndifferences between LCs, we used the PyHDX web server to reduce the peptide deuteration level \ninformation to the single amino acid level (Smit et al. 2021). We assumed that both subunits of the LC \ndimers were equivalent. All measured and processed values can be found in the Excel supplemental data \nfile. Residue-level percent deuteration values, corrected for back-exchange, were used to generate \nskyline plots, heat maps, difference heat maps and structural images. Data were plotted onto structural \nmodels of the appropriate LC using PyMOL (Schrödinger LLC). For a simple comparison between LCs, we \ncalculated the area under the exchange curve (AUC) over the residues with measurable HDX data in all \nexperiments, using a trapezoidal method. \nPLIMSTEX analysis of binding affinity \nBinding affinity between small-molecule stabilizers and proteins was measured by HDX-MS using the \nPLIMSTEX approach (Zhu et al. 2003). Binding isotherms were generated by incubating 5 μM of protein \n(AL LC, C218S, or VL) with 2-fold serial dilutions of stabilizer molecules (500 to 1.9 μM) at 20°C in 10 mM \nsodium phosphate buffer, pH 7.4, containing 150 mM NaCl and 5% DMSO (v/v). After 30 minutes of \nequilibration at room temperature, 3 μL of the protein-ligand mixture was diluted with 57 μL of \ndeuterium labeling buffer (10 mM sodium phosphate, 150 mM NaCl, pD 7.4, 99.9% D\n2O, final DMSO \n0.25% v/v) and incubated for 1 hour and 30 minutes at 20°C.  After dilution, protein concentration was \n0.25 μM and small-molecule stabilizers ranged in concentration from 0.095 to 25 μM. The reaction was \nacid-quenched and immediately injected into the mass spectrometer for analysis. All experiments were \nperformed in duplicate. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nPLIMSTEX experiments were conducted on a Waters SELECT Series CyclicIMS system coupled to two I-\nClass UPLC pumps (Waters). The separation gradient was 5-35% acetonitrile over 3 minutes at a 100 \nμL/min flow rate. The mass spectrometer was calibrated using the Major Mix (Waters) and operated \nwith the following parameters: capillary voltage 2.8 kV, trap collision energy 4 V, sampling cone 30 V, \nsource temperature 80°C, and desolvation temperature 175°C.  \nFor the PLIMSTEX data analysis of AL LC titration with M83, the peptide fragment 101NWVFGGGTKL110 \n(numbered according to the sequence alignment, equivalent to residues 98-107 of the AL LC sequence) \nwas selected. This peptide was chosen because it contains residues that form the stabilizer binding site \nin WIL-FL, notably F104 (Morgan et al. 2019). Accordingly, it exhibited one of the strongest responses to \nkinetic stabilizer binding.  \nSize exclusion chromatography \nProtein (AL VL, 0.24 mg/mL, 20 μM) was incubated for 30 minutes at 37°C in the presence or absence of \nM83 (100 μM) in PBS, pH 7.4, containing 1 % (v/v) DMSO. Following incubation, the protein mixture was \nloaded onto a Superdex® 75 10/300 column (Cytiva) equilibrated with PBS, pH 7.4, and eluted using an \nAKTA Pure FPLC system (Cytiva) at a flow rate of 0.5 mL/min, while monitoring the absorbance at 280 \nnm. M83 was added at a 1:5 (mol:mol) ratio. The column was calibrated using protein standards \n(Sigma): blue dextran (2000 kDa), bovine serum albiumin (66 kDa), carbonic anhydrase (29 kDa), \ncytochrome C (12.4 kDa), and aprotinin (6.5 kDa). \nLimited proteolysis  \nLCs (0.2 mg/mL, ~8.3 µM) were incubated in PBS, pH 7.4, containing 1% DMSO at 37°C with agitation at \n450 rpm in the presence or absence of 100 µM of M83. Proteolysis was initiated by adding trypsin \n(Promega, 0.5 mg/mL stock concentration, ~20.8 uM).  At designated time intervals, aliquots (10 µg) of \neach proteolysis mixture were quenched with 0.2 % v/v formic acid and separated by denaturing \nelectrophoresis on 10-20% acrylamide gradient Tris-Glycine gels under reducing conditions, followed by \nCoomassie staining. Intact LCs was quantified by densitometric analysis of the gel bands (Gel Analyzer \nv23.1, Istvan Lazar Jr. and Istvan Lazar Sr., available at www.gelanalyzer.com). Residual LC fractions were \ncalculated for each time point. Proteolysis kinetics were measured over 24 h. Proteolysis rates were \ncalculated by fitting the data to a single exponential decay, and areas under the curve (AUC) calculated \nusing a trapezoidal method. These data were used to optimize a single timepoint experiment to \ndetermine the maximum protection afforded by kinetic stabilizer binding. Enzyme to substrate (E:S) \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nratios ranged from 1:16 to 1:64 (w:w) and incubation times from 5 hours to 24 hours, depending on the \ninherent proteolytic susceptibility of each LC variant.  \nResults \nStructural dynamics vary among different full-length light chains  \nWe investigated seven FL λ LC proteins whose sequences were originally identified in patients with AL \namyloidosis, along with two FL λ LC control sequences (Figure 1, Table 1). These sequences are derived \nfrom germline genes which are over-represented in AL amyloidosis compared to the normal repertoire \n(Morgan et al. 2025; Kourelis et al. 2017). As in our prior study (Peterle et al. 2021), our controls were \ntwo non-amyloidogenic λ LCs: MM, originally identified in a patient with multiple myeloma but without \namyloid deposition; and GL, the protein with the precursor germline sequence from which the AL and \nMM sequences are derived, IGLV6-57.  \nTo identify APRs within the FL LC sequences we used the AmylPred2 server (Tsolis et al. 2013), which \ncombines the results of multiple algorithms, producing a consensus score from 0 to 10. Similar regions \nof sequences were identified in each FL LC, although the strength of the predictions varied between \nsequences (Figure 2A). VL domains harbored two (H6) to six (GL, MM, H16 and MCG) APRs (AmylPred2 \nscore > 5). Two segments in the CL domain, common to all nine FL LCs, were also predicted as APRs. \nThese segments predominantly form ß-strands within the native LC structure (Figure 2A) but may drive \nself-association upon local or global unfolding. \nWe first employed HDX-MS to investigate the local backbone conformational dynamics of FL LCs under \nidentical conditions in the absence of kinetic stabilizer small molecules. HDX-MS provides detailed \ninsights into solvent exposure and hydrogen bond stability by monitoring the exchange of backbone \namide hydrogens with deuterons in the solvent (Konermann, Pan, and Liu 2011). The exchange was \ninitiated under native-like conditions where the protein was folded. Greater deuterium incorporation \nreflected greater conformational dynamics and/or solvent exposure. Exchange was quenched at specific \ntimepoints, from 10 sec to 16 h, by denaturation of the protein at acidic pH, where the average intrinsic \nrate of backbone amide HDX is minimal, followed by peptic digestion to generate peptides for LC-MS \nanalysis. The extent of exchange at different time points was determined by measuring deuterium \nincorporation relative to that of the undeuterated protein, and was normalized relative to the \nexperimental maximal deuterium uptake (maxD) observed  for each peptide, as previously described \n(Peterle, Wales, and Engen 2022). For each LC, sequence coverage exceeded 95% (Figure S2).  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nTo facilitate comparisons among different isoforms, HDX-MS results were visualized as skyline plots, \nwhich show percent deuteration at each residue interpolated from peptide-level exchange data. Figure \n2B shows the data for 1 minute of exchange and Figure S3 shows other timepoints. No systemic \ndifferences between FL LCs with a histidine tag (AL, MM and GL) compared to other (untagged) FL LCs \nwere observed by HDX (Figure 2B and S3). Figure 2C compares deuterium uptake kinetics for \nrepresentative peptides in specific regions of interest, including CDR1, CDR2, CDR3, and the residue \nsegment 133-139 from CL. The latter segment was selected because it partially overlaps with the \namyloidogenic region 136-145 and encompasses a known proteolytic hotspot whose cleavage can \ngenerate a VL-containing LC fragment found in human amyloid deposits (Lavatelli et al. 2020; Mazzini et \nal. 2022; Lavatelli et al. 2024). We observed large variations in HDX within and between the FL LCs, \nmainly in the VL domains, reflecting their variable sequences. As expected, the solvent-exposed CDR \nloops exhibit more deuteration, corresponding to the low structural protection of amides from HDX, as \ncompared to the FRs, which contain more hydrogen-bonded β-sheets. The deuteration level in each \nregion varied among different LCs. The least protected regions were adjacent to the APRs identified by \nAmylPred2. However, portions of these APRs showed low exchange indicating high protection by the \nnative LC structure. This included high protection in C21 and C140 that are located in amyloidogenic \nsegments and form internal disulfides in the VL and CL domains, respectively. The counterpart cysteine \nresidues in the intermolecular disulfide bonds, C92 and C200, respectively, are located in regions of \nvariable solvent exposure: C92 resides in a relatively exposed area near CDR3, whereas C200 is \npositioned within a more protected region. \nAs expected, the extent of C\nL deuterium incorporation is similar for the nine LCs studied, reflecting the \nsequence and structural conservation of CL. Most differences in HDX were observed in the first 20 \nresidues of CL which are adjacent to the VL domain. Within these residues, segments from AL, MM, GL, \nH3 and H16 showed lower structural protection (greater exchange) after 1 minute than those of H6, H7, \nH9 and MCG. These differences may be associated with differential interactions between the two \ndomains. \nOverall, no clear and strict correlation was identified between the observed deuteration levels in specific \nregions and the amyloid-forming properties of the LCs under study. However, compared to the non-\namyloidogenic isoforms GL and MM, which share a very similar HDX profile, all amyloidogenic \ncounterparts showed lower protection in the V\nL domain, but not in the CL domain. AL, H3, H9, and H16 \nexhibited generally rapid exchange across the entire VL, particularly in the CDRs. MCG showed greater \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\ndeprotection in CDR1 and CDR3 at shorter time points, while FR3 exchanged to a greater extent at \nlonger time points. H6 and H7 were more difficult to compare due to differences in peptide lengths and \npositions, but they exhibited increased uptake in FR4, FR1, and FR3 while remaining more protected in \nCDR1 and CDR2. \nStabilizer binding reduces FL AL LC deuterium incorporation \nWe next investigated the effects of stabilizer molecules on deuterium uptake of AL LC. HDX-MS was \ncarried out using 1.5 µM AL LC in the presence of 15 µM stabilizer. These concentrations are comparable \nwith the circulating concentrations of free LCs (Katzmann et al. 2002) and an approved kinetic stabilizer \ndrug for transthyretin amyloidosis (Cho et al. 2015). Figure 3A shows differences in normalized \ndeuterium uptake of AL LC peptic peptides in the presence of P1, P5, B20, M53, M63 and M83, \ncompared with the vehicle control (0.15% v/v DMSO), presented as peptide-level heatmaps (“chiclet \nplots”) across all labeling times. For clarity, only peptides from the VL domain are shown; complete data \nare shown in Figure S4. Example data for the peptide covering residues 101–110 (101NWVFGGGTKL110, \nnumbered according to the sequence alignment in Figure 1, corresponding to sequential positions 98–\n107 of AL LC) is shown in Figure 3B. This peptide comprises residues in CDR3 and FR4 and also forms part \nof the VL-VL interface. No differences were detected at short labeling times; at longer times, increased \nstabilizer-induced protection from HDX was detected for four out of six stabilizer molecules (M83, B20, \nM53, P1). The region with the greatest change in protection from HDX was residues 92–110 (equivalent \nto sequential positions 89–107), which extends from C92 of the intra-domain disulfide bond through \nCDR3 to FR4. An additional site exhibiting less increased protection from HDX was observed between \nresidues 34 and 48 (Figure 3A).  Only minor stabilizer-induced changes were detected in CL domain, \nwhich were most evident for residues 165-180 in the presence of M83 (Figure S4). Stabilizer molecules \nP5 and M63 did not alter deuterium uptake. The other four stabilizers resulted in increased protection \nfrom HDX in the order M83>B20>M53>P1. This is the same order as the small-molecules’ efficacy \ndetermined in the assay that was originally used for drug optimization, which measured protection of \nthe WIL-FL LC from endoproteolysis (Morgan et al. 2019; Yan et al. 2021). Similar residues were \nprotected from exchange by all four kinetic stabilizers. \nTo determine the relative efficacy of the small-molecule stabilizers, we measured deuterium uptake by \nAL LC (0.25 µM) as a function of stabilizer concentration. M83, B20, M53, and P1 were titrated from 0.2 \nto 25 µM. We analyzed the data using the PLIMSTEX approach (Protein Ligand Interaction by Mass \nSpectrometry, Titration, and EXchange) (Zhu et al. 2003; Zhu, Rempel, and Gross 2004). In a PLIMSTEX \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nexperiment the labeling time is fixed, and protein-ligand interaction is monitored through changes in \ndeuterium incorporation across a titration series of the ligand. AL LC peptide 101NWVFGGGTKL110, \ndescribed above, was selected for PLIMSTEX analysis. This peptide exhibits a large change in deuterium \nuptake upon stabilizer binding. The analysis was conducted at a labeling time of 1 hour and 30 minutes, \nchosen to capture the maximum observable protection from exchange while allowing the system to \napproach the near steady-state equilibrium of the exchangeable hydrogens (Zhu, Rempel, and Gross \n2004). PLIMSTEX analysis of the HDX data indicated that M83 decreases deuterium uptake at \nconcentrations 100-fold lower than that of the other stabilizer molecules (Figure 3C). \nWe chose to focus the remainder of our studies on M83, the most efficacious stabilizer, in order to \ninvestigate the mechanism by which M83 protects AL LC from exchange.  We used two additional forms \nof the AL protein: AL LC C218S, which cannot form the intermolecular disulfide linking the CL domains; \nand AL VL, the stand-alone VL domain. Both these proteins equilibrate between monomer and non-\ncovalent dimer in solution. At the concentrations used in HDX-MS, AL C218S is primarily dimeric and AL \nVL is primarily monomeric (Peterle et al. 2021).  \nFigures 4A–4C show HDX-MS data from AL LC, AL C218S and AL VL, respectively, in the presence or \nabsence of M83. Consistent with our previous studies, unliganded AL LC exhibited greater protection \nfrom HDX than AL C218S or AL VL (difference heatmaps in the right-most columns of Figures 4B and 4C). \nThese data are consistent with progressive stabilization associated with the presence of the CL domain \nand intramolecular disulfide bond that has been observed in other FL LCs (Peterle et al. 2021; Klimtchuk \net al. 2023; Rennella et al. 2019; Puri, Gadda, et al. 2025). Figure S5 shows the same data as peptide-\nlevel chiclet plots. Binding of the stabilizer molecule led to a large decrease in deuteration (i.e., an \nincrease in HDX protection) observed from middle to long exchange times. For VL, this change in \ndeuteration was no longer apparent at 16 hours, likely because both bound and unbound states of the \nprotein had reached equilibrium with the solvent. Notably, this increased protection from HDX was \nobserved in similar V\nL segments of all three protein constructs. These segments were also more \nprotected in AL LC than in AL C218S or AL VL, indicating that stabilizer binding mimics the effect of \nincreased dimer formation that was previously observed for these proteins (Peterle et al. 2021). Unlike \nVL, the CL domain showed only a small increase in protection upon stabilizer binding to FL LCs, mainly in \nresidues 165–180, which are also more protected in AL LC than in AL C218S. The observed deuterium \nincorporation was only slightly reduced in M83-bound AL LC compared to M83-bound AL C218S. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nAccordingly, the change in deuterium incorporation upon M83 binding observed for AL C218S was \ngreater than that observed for AL LC.  \nWe mapped the differences in AL LC deuteration in the presence and absence of M83 onto an \nAlphaFold3 model of AL LC, since no experimental structure of this FL LC is available (Figure 4D). \nMultiple backbone regions exhibited increased protection from HDX in the presence of M83. The \ngreatest increase in protection was observed in peptides that form the VL-VL interface. Altered exchange \nin this region is consistent with M83 binding in a similar site to that observed for other stabilizer \nmolecules in co-crystal structures with LCs (Morgan et al. 2019; Yan et al. 2020, 2021; Yan, Wilson, and \nKelly 2023; Lederberg et al. 2024). In addition, residues from the solvent-exposed ß-strands CV, C’V, FV \nand HV, of the VL domain also show increased protection upon M83 binding. CL residues 165–180, which \nshow a small increase in protection upon stabilizer binding, form the CL-CL interface and are located \nclose to the CL-VL domain interface. \nKinetic stabilizer binding enhances self-association of VL domains \nTo further investigate the interaction between stabilizer binding, dimerization and HDX, we applied the \nPLIMSTEX approach, as above, to measure the apparent affinity of M83 for the three AL constructs. We \nasked whether binding of M83 could force AL C218S and AL VL to form a dimeric molecule with \nprotection from HDX equivalent to that of the unbound or bound disulfide-linked dimer. M83 was \ntitrated against each AL construct and the deuterium incorporation measured after 90 minutes. Raw \nmass spectra of peptide 101NWVFGGGTKL110 at varying concentrations of M83 are presented in Figure \n5A, and the averaged centroid values of the spectra plotted against concentration of M83 are shown in \nFigure 5B. Without M83, deuterium incorporation for peptide 101NWVFGGGTKL110 differed significantly \namong the three AL constructs, reflecting differences in their intrinsic stabilities shown, consistent with \nprevious experiments (Peterle et al. 2021). AL VL exhibited the highest deuterium uptake (D0 = 6.34 Da, \nFigure 5A), AL C218S showed intermediate uptake (D0 = 5.20 Da), and AL LC showed the lowest uptake \n(D0 = 3.73 Da). M83 titration resulted in a concentration-dependent reduction in deuterium uptake \nacross all three protein constructs, confirming specific binding. The maximum reduction in deuterium \nincorporation (ΔD, measured between the centroids of the m/z distributions) was observed at 25 µM \nM83, the highest stabilizer concentration investigated and 100-fold in excess of protein. The ΔD values \nfor AL LC, AL C218S and AL VL were -1.37 Da, -2.85 Da and 2.61, respectively. The change in deuteration \nwas greater for the non-covalent constructs than for AL LC upon M83 binding. However, this \nquantitative analysis showed that neither AL C218S nor AL VL reached the same protection from \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nexchange as M83-bound AL LC. M83 binding was sufficient to reduce uptake of deuterium by AL C218S, \nbut not AL VL, to below the level measured for unliganded AL LC. Fitting the observed ΔD to a unimolar \nbinding model (1:1 LC dimer:ligand) yielded protection midpoints (EC50, the concentration of 50% \nmaximal effect) of 0.65 μM for AL LC, 1.8 μM for AL C214S and 2.2 μM for AL VL (Figure 5C; reported \nvalues are the mean of two independent measurements). These values are not directly comparable \nbecause the dimerization equilibria and exchange endpoints are different for the three AL constructs \nand hence, these values should not be treated as dissociation constants. \nThe distributions of discrete m/z states observed in each experiment for peptide 101NWVFGGGTKL110 \nreport on the ensembles of species within the exchange reaction, averaged over the 90-minute \ntimecourse. AL LC spectra had similar distributions of peaks at all concentrations of M83, consistent with \nhomogeneous exchange. The spectra of AL C218S and AL VL were more complex, indicating the presence \nof multiple populations of exchanged species. Unliganded AL C218S had a broad distribution of states \nthat becomes narrower as the concentration of M83 increases. AL VL exhibited different behavior, \nwhere increasing M83 led to the appearance of a population with less incorporation of deuterium. We \nhypothesize that this behavior reflects ligand-induced dimerization of both non-covalent species. Under \nthe maximum concentration of M83 tested, only a sub-population of AL VL is stabilized. \nWe next asked whether kinetic stabilizer binding could enhance VL domain dimerization. M83 increases \nthe equilibrium population of VL dimer, as determined by analytical size exclusion chromatography \n(Figure 5C). This observation is consistent with drug binding in the VL-VL interfacial cavity, and with the \nprevious observation that P1 binding favors dimerization of WIL-FL C218S (Morgan et al. 2019).  \nStabilizer molecules reduce hydrogen exchange and endoproteolysis of diverse LCs \nWe next asked whether binding of M83 alters the stability and dynamics of other FL LCs. We measured \nHDX kinetics for each FL LC (1.5 µM) in the presence and absence of 15 µM M83. Figure 6A shows the \ndifference in deuteration between FL LCs with and without M83 as residue-level heatmaps, while Figure \n6B shows the data mapped onto the dimeric VL domains of structural models. All FL LCs exhibited \nreduced deuteration in the presence of M83, particularly between 1 to 4 hours of exchange (further \ndata are provided in Figures S6 and S7). The protein segments showing the most significant stabilizer-\ninduced protection from HDX were consistent across eight of the nine proteins, with the strongest \neffects observed in FR4 and, in some cases, CDR3. An exception was H6, which exhibited increased \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nprotection primarily within FR2. Only AL LC and GL LC exhibited increased protection within the CL \ndomain.  \nTo further assess the structural impact of M83, we conducted limited proteolysis experiments using \ntrypsin at neutral pH on FL LCs in the presence or absence of M83 (Figure 7). We initially measured \ntimecourses for each FL LC under identical conditions, with timepoints ranging from 1 minute to 24 \nhours (Figure 7A and Figure S8). Although we were able to fit data for some FL LCs to exponential decay \nmodels (Figure 7A–B and Figure S8), this was not successful for all FL LCs. Therefore we calculated the \narea under the curve (AUC) for these data to define a simple metric for protease sensitivity (Figure 7A \nand Figure S8). For comparison, we calculated an equivalent AUC for HDX data (Figure 7B and Figure S8). \nSince the intrinsic proteolysis rates and the magnitude of M83-induced protection varied across the FL \nLCs, we tailored single timepoint proteolysis experiments by selecting optimized conditions for each FL \nLC (Figure 7D). The protease sensitivity of the FL LCs and the effect of M83 varied substantially. There \nwas only a weak correlation between the intrinsic protease resistance of each FL LC and its protection \nfrom HDX (Pearson’s correlation coefficient R = 0.14, Figure 7E). Furthermore, the extent of protection \nfrom protease and HDX were weakly correlated, both when comparing the AUC for the proteolysis \ntimecourses (R = -0.3, Figure 7F) and the optimized, single timepoint data (R = 0 069, Figure 7G). These \nobservations indicate that limited trypsin proteolysis and HDX measure different aspects of stability, \nlikely due to differential cleavage of unstructured peptide bonds within the folded states. However, both \nmethods demonstrated stabilization of all FL LCs upon binding to M83. \nDiscussion  \nThis work demonstrates the ability of small-molecule kinetic stabilizers to bind to multiple LCs and \nthereby suppress their dynamics and proteolytic susceptibility. LC dynamics, including local and global \nunfolding, enable self-association of non-native LCs to form amyloid, as well as proteolytic cleavage that \nyields more amyloidogenic VL-containing LC fragments. Binding of the most potent small molecule, M83, \nleads to a reduction in exchange of amide hydrogens with the solvent and decreased susceptibility to \nproteolytic cleavage for all nine LCs studied (Figures 6 and 7), despite their distinct sequences and \ndynamics (Figure 2). These data are consistent with the previous observation that small molecule \nbinding stabilizes WIL-FL, the IGLV6-57-derived LC that was used for the high throughput screen and hit \noptimization to generate M83. The precursor germline genes represented by the LCs studied here, \nIGLV1-44, IGLV1-51, IGLV2-8, IGLV2-14 and IGLV6-57 together account for 386/847 (46%) of all \namyloidogenic LCs and 386/621 (62%) of amyloidogenic λ LCs in the AL-Base repository (Morgan et al. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n2025). By demonstrating that M83 stabilizes several LCs derived from the most commonly observed λ LC \ngenes, our results support the hypothesis that pharmacologic stabilization of LCs is a promising \ntherapeutic strategy that could complement existing and emerging approaches. \nConsistent with our previous studies (Rennella et al. 2019; Peterle et al. 2021; Klimtchuk et al. 2023, \n2024) and those of other groups (Puri, Gadda, et al. 2025; Weber et al. 2020; Rottenaicher et al. 2021; \nPuri, Palkar, et al. 2025), the extent of amide exchange varies across the sequence of the LCs. The VL \ndomains of the seven amyloidogenic proteins have distinct patterns of deuterium uptake. There are no \nclear patterns that could represent a “signature” of amyloid propensity other than our previous \nobservations that AL LC is less protected from exchange than the non-amyloidogenic IGLV6-57-derived \nMM LC or GL LC. None of the LCs investigated here exhibited increased exchange in the C\nV and CV’ \nstrands (residues 38-49) that were identified as rapidly exchanging in the amyloidogenic IGLV6-57-\nderived LC AL55 which may be related to the altered VL–VL interface observed for this specific LC (Puri, \nGadda, et al. 2025). Instead, we observed more rapid HDX in the region encompassing CDR2 and strand \nDV (Figure 2). In contrast, similar patterns of deuterium uptake were observed in all nine CL domains, \nconsistent with their similar sequences and structures. CL domain mutations have been associated with \ninstability and amyloid formation (Benson, Liepnieks, and Kluve-Beckerman 2015; Rottenaicher et al. \n2023; Rennella et al. 2019), but our data suggest that in the absence of such mutations, the dynamics of \nthe unmutated CL sequences are indistinguishable within free LC dimers. Overall, these results and our \nprevious study of κ LCs (Klimtchuk et al. 2023) are consistent with the hypothesis that multiple types of \nsequence and structural changes can lead to amyloidogenic LCs. \nWe asked whether stabilizer binding would lead to similar structural changes in LCs with different local \ndynamics. The stabilization imparted to all tested LCs is consistent with similar modes of binding \nbetween LCs, as observed in co-crystal structures of stabilizers with MM and H9 (Yan et al. 2021; \nLederberg et al. 2024; Yan, Wilson, and Kelly 2023). However, our analysis only measures the effect of \nstabilizer binding on HDX and cannot directly report on the conformation of the LC or small molecule. It \nis possible that M83 can bind in different conformations to that observed for other stabilizers and LCs, \nparticularly in the case of H6, which has a different pattern of differentially-protected regions than the \nother LCs (Figure 6).  \nWe hypothesize that stabilizer binding enhances structural coupling between the constituent domains of \na full-length LC dimer (Rennella et al. 2019), so that both global and local structural fluctuations are \nreduced. In agreement with this idea, stabilizer binding enhances dimerization and increases protection \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nin both the residues that define the binding pocket and residues forming the dimeric interface, such as \nstrand A, FR2, strands E and F, CDR3 and J-region of the VL domain as well as strand E of the CL domain \n(Figures 4–6). On the other hand, relatively little change in protection was observed for the most labile \nprotons in the loops of CDR1 and CDR2, indicating that these residues do not form new hydrogen bonds. \nHowever, the global protection from protease digestion afforded by stabilizer binding indicates that \nthese mobile regions are not susceptible to trypsin proteolysis without local or global unfolding. \nImportantly, M83 binding increased local protection in CDR3 and FR4 regions in all proteins but H6 (Fig. \n6A). CDR3 is adjacent to C92 that forms an internal disulfide (C21–C92) in V\nL. The structure around this \nconserved disulfide must fully unfold to enable the relative backbone rotation by 180 degrees, from \nparallel in native V\nL to antiparallel in amyloid (Radamaker et al. 2019). This backbone rotation likely \nprovides a major contribution to the kinetic barrier for LC misfolding in amyloid; if so, suppression of \nlocal backbone dynamics in the regions adjacent to the C21–C92 disulfide, particularly the highly \ndynamic CDR1 and CDR3, is expected to decelerate amyloid formation (Klimtchuk et al. 2023). \nTherefore, M83-induced stabilization of CDR3 and adjacent regions in most LCs explored suggests M83 \nshould suppress LC amyloid formation.  \nThe largest reduction in deuterium uptake induced by M83 was observed for AL LC (Figure 6A). Other \namyloidogenic LCs showed a reduced level of stabilization, which may be due to the optimization of \nstabilizers for binding to IGLV6-57-derived LCs. The reduced protection afforded to GL LC and MM LC by \nstabilizer binding appears to be due to their increased stability in the absence of the small molecule. \nBinding of M83 is not sufficient to globally reduce the level of exchange of AL LC to that of the non-\namyloidogenic LCs (Figure 6 and Figures S5–S6). However, the stabilization of AL LC’s structured regions \nby M83 reduced their exchange to a level similar to that observed for equivalent regions of unbound GL \nLC. The M83-bound states of AL LC and AL C218S exhibited similar exchange kinetics (Figure 4A and 5), \nwhere the M83-bound state of AL C218S was slightly less stable than M83-bound AL LC but more stable \nthan unbound AL LC. We therefore suggest that stabilizer binding can compensate for the loss of \nstability associated with reduction of the intermolecular disulfide bond, and that the effect of stabilizers \nwill not be limited to disulfide-linked dimers in patients. \nThe major limitation of our study is that these nine LCs represent only a fraction of the vast potential \ndiversity of light chains. Although we expect that the stabilizer can bind to most λ LCs, it is not clear how \nmuch stabilization will be imparted in each case and whether this will be sufficient for clinical efficacy. \nCoumarin-based stabilizers including M83 bind relatively weakly to κ LCs (Morgan et al. 2019; Yan et al. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n2021), which account for approximately 20% of AL amyloidosis clones (Morgan et al. 2025). \nFurthermore, it is not clear how the dynamics that are measured by HDX relate to amyloid propensity, \nsince there is no clear correlation between the patterns of exchange protection observed for each LC \nand its pathogenicity. Our data will support further work to identify such mechanistic details. \nStabilization of LCs is a novel and potentially valuable therapeutic approach that could complement \nexisting therapies. This work demonstrates that kinetic stabilizers can bind to multiple LCs and reduce \nthe conformational dynamics associated with proteolysis and aggregation, which is essential for their \nbroader utility. In combination with our previous work developing stabilizers with increased affinity (Yan \net al. 2021) and specificity for LCs in blood (Lederberg et al. 2024), the current study supports further \ndevelopment of these molecules as therapeutic candidates.  \nAcknowledgements \nThis work was supported by National Institute of Health Awards R01-GM067260, R01-GM135158 and \nR01-HL157566; the Wildflower Foundation; and the Boston University Amyloid Research Fund.  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigures and legends \n \n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure 1: Kinetic stabilizers to inhibit aggregation of diverse antibody light chains. (A) Schematic \nrepresentation of systemic AL amyloidosis pathogenesis and the mechanism of action of kinetic \nstabilizers. Unstable LCs are overexpressed by abnormal proliferating plasma cells and released into the \nbloodstream as homodimers, composed of a variable V\nL domain (in yellow) and a constant CL domain (in \ngray). An inter-molecular disulfide bond between cysteine residues at position 218 is observed in some \nLCs. Each clone produces a unique LC sequence. LCs can undergo unfolding, oligomerization, and \nproteolysis events, eventually leading to formation of fibrils that accumulate in various organs, most \nfrequently the heart and kidney, resulting in progressive organ damage. Proteolysis can release \naggregation-prone fragments that may act as templates or seeds for intact LCs. Kinetic stabilizers \nprevent fibril formation by stabilizing the dimeric native structure, thus reducing the concentration of \naggregation-competent species. (B) Sequence logo plot of 554 V\nL domains of λ LCs taken from AL-Base. \nThe height of each letter is proportional to its frequency in the alignment and the overall height of the \ncolumn is proportional to the information content at that position. Amino acids interacting with kinetic \nstabilizers are indicated according to the numbering used in the original crystal structure (PDB code \n6MG5) and color-coded according to the substructure of the M83 stabilizer to which they bind (see the \nstructure of M83 in panel (D): red, anchor substructure; blue, aromatic core; green, linker module; \npurple, distal substructure). (C) Multiple sequence alignment of the 9 selected LCs explored in this study. \nThe shading indicates the degree of conservation of amino acid residues. V\nL domain framework regions \n(FR1–4) and complementarity determining regions (CDR1–3) are shown in green and yellow, \nrespectively. Blue and red boxes show the locations of the native secondary structure elements. \nIndividual ß-strands are labeled. Intramolecular disulfide bonds are shown by orange lines. Note that \nthe IMGT regions are defined to allow comparison between different immunoglobulin domains and do \nnot correspond precisely to LC secondary structure elements. (D) Structures of the kinetic stabilizers \nused in this study. M83, the stabilizer molecule that showed the highest potency in LC stabilization, has \nits substructures highlighted. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \nFigure 2: Hydrogen-deuterium exchange profiles of LCs. (A) Sequence alignment of the nine LCs under \nstudy, highlighting in purple the residues with amyloidogenic propensity as predicted by the AmylPred2 \nwebserver. The shading represents the number of algorithms within AmylPred2 that identified each \nresidue as amyloidogenic. (B) Skyline plot showing the percent of deuterium incorporation (%D) across \nthe aligned LC amino acid sequences at 1-minute labeling time point. Gray shading represents CDRs 1, 2 \nand 3 within V\nL and residues 133-139 within CL. Top, middle, and bottom panels correspond to LCs \nderived from variable gene families IGLV6, IGLV1 and IGLV2, respectively. Dashed lines show the \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nboundary between the variable and constant domains. The secondary structure scheme is shown at the \ntop of the panels, with blue boxes representing ß-sheets and red indicating α-helices. Intramolecular \ndisulfide bonds are shown by orange lines. (C) Deuterium uptake plots (%D) are shown for specific \npeptides covering regions of interest, including CDR1, CDR2, CDR3, and the constant region (CL). Each \nline corresponds to a specific LC variant, with peptide sequence numbers indicated. Note that these \nplots are not directly comparable due to sequence differences between the peptides. Complete HDX-MS \nresults for all proteins and labeling times are reported in Figures S3, S6 and S7. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure 3: Differential stabilization of 1.5 µM AL LC by six small molecule stabilizers. (A) Peptide-level \nchiclet plot of deuterium uptake of FL AL LC in the presence or absence of 15 µM kinetic stabilizers. Only \npeptides originating from the VL domain are shown; complete data are provided in Figure S4. “N” and \n“C” indicate the N- and C-termini, respectively, of the peptic peptides, numbered according to the \nsequence of AL LC. The AL LC peptide 101NWVFGGGTKL110 (corresponding to sequential positions 98-107) \nis highlighted with a red arrow. Vehicle (Veh) represents DMSO at 0.15% v/v during exchange. (B) \nDeuterium uptake curves for peptide 101NWVFGGGTKL110. (C) PLIMSTEX curves for peptide \n101NWVFGGGTKL110 titrated with P1 (blue), B20 (green), M53 (magenta), and M83 (red) are shown as a \nfunction of the stabilizer molecule concentration. \n   \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \nFigure 4: Effects of the kinetic stabilizer M83 binding to AL constructs monitored by HDX-MS. Residue-\nlevel heatmaps display percent deuterium incorporation (%D) for the proteins in the presence or \nabsence of M83, as well as the corresponding differences in deuterium uptake (Δ%D). “Veh” represents \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nDMSO vehicle at 0.15% v/v during exchange. Horizontal lines indicate the boundaries between the \nvariable (VL) and constant (CL) domains. (A) AL LC. (B) AL C218S. (C) AL VL. Peptide-level data are \nprovided in the Figure S5. Differences between constructs in the absence of M83 (C218S – LC and \nVL – LC) are also shown. The protection induced by the kinetic stabilizer is greatest at peptides \ncorresponding to the dimeric interface regions, but is not restricted to these residues. (D) Change in \ndeuteration (Δ%D [(AL LC + M83) - AL LC]) after 1 hour of labeling mapped onto an AlphaFold 3 model of \nthe AL LC dimeric structure. Regions of increased protection are shown in shades of blue. The names of \nthe β-strands within the V\nL domain are shown for one monomer.  \n \n \nFigure 5: Stabilizer binding promotes LC dimerization. (A) Raw mass spectra of peptide \n101NWVFGGGTKL110 from AL LC, AL C218S, and AL VL in the presence of varying concentrations of M83 at \na single time point of 90 minutes. Proteins concentration was 0.25 µM monomer equivalent. The blue \npeaks represent the isotopic distribution of the peptide, with centroid shifts from the undeuterated \nstate indicating the average extent of deuterium incorporation (ΔD) (B) PLIMSTEX titration data for \npeptide \n101NWVFGGGTKL110 from AL LC (red), AL C218S (black), and AL VL (teal), showing measured \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\ndeuterium uptake values (average of duplicates, where error bars show the range of the measurements) \nwith corresponding fitted curves. (C) Size exclusion chromatography (SEC) of AL VL in the absence (black) \nand presence (red) of 100 µM M83, illustrating its effect on dimer formation. M and D labels refer to the \nelution volume of the peaks corresponding to the monomeric and dimeric form of VL. Peaks \ncorresponding to molecular weight standards are shown above. \n \nFigure 6: Effect of M83 binding on multiple LC proteins monitored by HDX-MS. (A) Single-residue \naligned heatmaps of percent deuterium difference (Δ%D) across the nine LCs. The solid horizontal line \nindicates the boundary between the VL and CL. Protection from deuterium exchange is observed for all \nLCs upon incubation with M83. Complete data are provided in Figure S6 and S7. (B) Structural mapping \nof Δ%D onto VL dimer structures for each isoform highlights regions of stabilization upon M83 binding \nafter 1 hour of exchange. The relative orientation of the VL and CL domains differs between the models, \nso for clarity only VL is shown. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \nFigure 7: Effect of M83 binding on multiple LC proteins monitored by limited proteolysis. (A) Kinetics \nof digestion of H16 LC by trypsin in the presence (red) or absence (black) of M83, analyzed by SDS-PAGE. \nData were analyzed by fitting to a single-exponential decay and by calculating the area under the curve \n(AUC). Data for other LCs are provided in Figure S8. (C) Proteolysis rates from fits of timecourse data to \nsingle exponential models. Hollow symbols and bars represent rates and fitting errors for successful fits \n(see Figure S8), solid symbols show data for which no rate could be determined. (B) AUC analysis of H16 \nHDX in the presence and absence of M83 for comparison with (A). (D) Single point proteolysis using \noptimized conditions to determine the maximal protection from protease afforded by M83 binding. \nQuantitation of the data is shown by the bars. (E–G) Correlations between proteolysis and HDX \nmeasurements of the intrinsic LC stability or stabilization imparted by M83. The blue dashed lines \nindicate linear regression lines with associated Pearson correlation coefficients (R) and significance \nvalues (p). \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nTable \nName \n(alternative \nnames) \nGermline \nvariable gene  \nGermline \nconstant gene \nSequence \nNCBI \naccession \nPDB \ncode \nReference Disease \nAL (AL-150L; \n01-095) \nIGLV6-57 IGLC2 EF589390 N/A (Peterle et al. \n2021) \nAL \nMCG IGLV2-8 IGLC1 3MCG_1 3MCG (Schiffer et al. \n1973) \nAL \nH3 (AL30) IGLV1-44 IGLC3 KC433670 5MTL (Oberti et al. \n2017) \nAL \nH6 (AL50) IGLV1-51 IGLC2 KY471433 5MUD (Oberti et al. \n2017) \nAL \nH7 (AL48) IGLV1-51 IGLC3 KC433671 5MUH (Oberti et al. \n2017) \nAL \nH9 (AL52) IGLV2-8 IGLC2 KY471435 5M6A (Oberti et al. \n2017) \nAL \nH16 (AL54) IGLV2-14 IGLC3 KY471437 N/A (Oberti et al. \n2017) \nAL \nMM (JTO) IGLV6-57 IGLC3 6MG4_A 6MG4; \n1CD0 \n(Wall et al. \n1999) \nMM \nGL (6aJL2) IGLV6-57 IGLC2 2W0K_A (VJ \nonly) \n2W0K (Peterle et al. \n2021) \nGermline \nsequence \n \nTable 1: LC proteins used in the current study. 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Gross. 2004. “Modeling Data from Titration, Amide H/D \nExchange, and Mass Spectrometry to Obtain Protein-Ligand Binding Constants.” Journal of the \nAmerican Society for Mass Spectrometry 15 (3): 388–97. \nhttps://doi.org/10.1016/j.jasms.2003.11.007. \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nSmall molecule stabilization of diverse amyloidogenic \nimmunoglobulin light chains revealed by hydrogen-deuterium \nexchange mass spectrometry \nDaniele Peterle, Nicholas L. Yan, Elena S. Klimtchuk, Thomas E. Wales, Olga Gursky, Jeffery W. Kelly, John \nR. Engen, Gareth J. Morgan \nSupplementary Appendix \nProtein sequences \nSupplementary Figures S1-S8 \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nProtein sequences \n>AL \nNFMLTQPHSVSESPGKTVTISCTRSSGSIASTYVQWYQQRPGSAPTNVIFEDNERPSGVPDRFSGSIDSSSNSAYLTISGLKTED\nEADYYCQSYGTNNWVFGGGTKLTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSY\nSCQVTHEGSTVEKTVAPTECS \n>GL \nNFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTED\nEADYYCQSYDSSNWVFGGGTKLTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSY\nSCQVTHEGSTVEKTVAPTECS \n>MM \nNFMLNQPHSVSESPGKTVTISCTRSSGNIDSNYVQWYQQRPGSAPITVIYEDNQRPSGVPDRFAGSIDRSSNSASLTISGLKTED\nEADYYCQSYDARNVVFGGGTRLTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSY\nSCQVTHEGSTVEKTVAPTECS \n>H3 \nQSVLTQPPSTSGTPGQRVTISCSGSSSNIETNTVNWYQQLPGTAPKLVMHTNNQRPSGVPDRFSGSRSGTSASLAIGGLQSEDEA\nDYFCAAWDDNLNGVIFGGGTKLTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSY\nSCQVTHEGSTVEKTVAPTECS \n>H6 \nQSVLTQPPSVSAAPGQKVTISCSGNNSNIGKNYVSWYQQLPGRTPKVIMYENNKRSSGIPDRFSGSKSGTSATLGITGLQTGDEA\nDYYCGVWDSSLSGGVFGGGTKVTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSY\nSCQVTHEGSTVEKTVAPTECS \n>H7 \nQSVLTQPPSVSAAPGQKVTISCSNVGKNFVSWYQQFPGTAPKVVIYDTDKRPSDIPDRFSGSKSGTSATLDITGLQTGDEADYYC\nGTWDSGLNGGVFGGGTKVTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSY\nSCQVTHEGSTVEKTVAPTECS \n>H9 \nQSALTQPPSASGSPGQSVTISCTGTSSDVGGSDSVSWYQQHPGKAPKLIIYEVSQRPSGVPNRFSGSKSGNTASLTVSGLQAEDD\nADYYCSSYGGDNNLFFGGGTKVTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSY\nSCQVTHEGSTVEKTVAPTECS \n>H16 \nQSALTQPASVSGSPGLSITISCTGTSSDIGGYNSVSWYQQHPGKAPKLIIYEVSNRPSGISNRFSGSKSGYTASLTISGLQAEDE\nADYYCSSYTNSGILFGGGTELTVL \nGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSY\nSCQVTHEGSTVEKTVAPTECS \n>MCG \nQSALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDE\nADYYCSSYEGSDNFVFGTGTKVTVL \nGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSY\nSCQVTHEGSTVEKTVAPTECS  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nSupplementary Figures \n \n  \n \nFigure S1.  SDS-PAGE characterization of the nine full-length LCs used in this study. Proteins were run on \na 10–20% acrylamide gel under reducing conditions and the gels were stained with Coomassie. 7 μg of \neach protein sample was loaded per lane. Molecular weight markers are indicated on the left. The \nsecondary bands underneath the main LC band appear to be alternative conformers the main LC \nprotein, since no truncated species were observed by mass spectrometry.  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S2. Sequence coverage maps of LCs constructs used in this study. Horizontal purple bars below LC \nsequence indicate the peptides for which HDX was followed. Vertical lines mark the separation between \nthe VL and the CL. The number of peptides, sequence coverage (%), and average redundancy values are \nreported for each LC.  \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \nVL CL\nVL CL\nVL CL\nVL CL\nVL CL\nVL CL\n \n1 min\n10 min\n1 hr\n4 hr\n16 hr\n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S3. Single-residue aligned skyline plots for all light chains (LCs) at six different labeling time \npoints: 10 seconds, 1 minute, 10 minutes, 1 hour, 4 hours, and 16 hours. Percent deuterium \nincorporation (%D) is plotted against amino acid number, with vertical dashed lines indicating the \nboundary between V\nL and CL domains. Gray boxes indicate the CDR regions. Each line represents a \nspecific LC isoform, defined in the legend on the right. \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S4. HDX-MS screening of six different kinetic stabilizers. Peptide chiclet plots display differences \nin the percent deuterium uptake across the sequence of AL LC upon binding of each compound. The \ncompounds screened were P1, B20, M53, M83, P5, and M63. On the left, the absolute uptake of AL LC \n(no compound) serves as the baseline for comparison. M83 shows the most significant protection, \nfollowed by B20, M53, and P1, with decreasing levels of protection. P5 and M63 do not show notable \ndifferences in HDX. The horizontal line separates the variable (VL) and constant (CL) domains. Regions \nwith no data (peach) or no change (gray) are indicated. The AL LC peptide 101NWVFGGGTKL110 \n(corresponding to sequential positions 98-107) is highlighted with a red arrow. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S5. Binding of the kinetic stabilizer M83 to AL LC, C214S, and VL monitored by HDX-MS. This figure \npresents the same data as Figure 3, displayed in a peptide-resolution chiclet plot format instead of \nresidue-level heatmaps. Percent deuterium incorporation (%D) is shown for the protein in 0.15% DMSO \nvehicle and in the presence of M83, alongside the differences in deuterium uptake (Δ%D). Comparisons \nbetween constructs (C214S-LC and VL-LC) are also shown. Horizontal lines separate VL and CL domains. \nRegions with no data (peach) or no change (gray) are indicated. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n10 s\n1 m\n10 m\n1 h\n4 h\n16 h\n0.324 0.4595 0.6183 0.7667 0.8747 0.9163\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.3359 0.4698 0.6167 0.7599 0.8655 0.9132\n0.5975 0.7566 0.8428 0.9588 0.987 0.9855\n0.5975 0.7566 0.8428 0.9588 0.987 0.9855\n0.5975 0.7566 0.8428 0.9588 0.987 0.9855\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.6854 0.8616 0.9095 0.976 0.9909 0.9893\n0.3161 0.3933 0.5027 0.6023 0.7217 0.8051\n0.3338 0.4158 0.5223 0.617 0.7287 0.8076\n0.3338 0.4158 0.5223 0.617 0.7287 0.8076\n0.3338 0.4158 0.5223 0.617 0.7287 0.8076\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3937 0.4973 0.6445 0.7501 0.8252 0.8776\n0.3703 0.475 0.6512 0.7817 0.8589 0.9014\n0.4178 0.6092 0.8033 0.9156 0.9514 0.9648\n0.4515 0.647 0.8197 0.9256 0.9626 0.9726\n0.4767 0.6883 0.8446 0.9381 0.9716 0.9786\n0.4966 0.6845 0.8277 0.9305 0.9699 0.9812\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4951 0.6788 0.8201 0.9248 0.9668 0.9792\n0.4763 0.6418 0.7824 0.8957 0.9561 0.9742\n0.4769 0.6224 0.7501 0.8692 0.9394 0.9646\n0.4763 0.5997 0.7093 0.8396 0.9233 0.9554\n0.4763 0.5997 0.7093 0.8396 0.9233 0.9554\n0.4763 0.5997 0.7093 0.8396 0.9233 0.9554\n0.4775 0.582 0.678 0.8101 0.9021 0.9401\n0.4264 0.5065 0.5897 0.7306 0.8518 0.9126\n0.4264 0.5065 0.5897 0.7306 0.8518 0.9126\n0.4264 0.5065 0.5897 0.7306 0.8518 0.9126\n0.4264 0.5065 0.5897 0.7306 0.8518 0.9126\n0.4264 0.5065 0.5897 0.7306 0.8518 0.9126\n0.4137 0.4886 0.57 0.714 0.8406 0.9057\n0.1368 0.2252 0.3598 0.4703 0.6516 0.7789\n0.1903 0.2413 0.3448 0.4419 0.6132 0.7602\n0.1994 0.2479 0.3502 0.4467 0.6155 0.754\n0.1994 0.2479 0.3502 0.4467 0.6155 0.754\n0.1994 0.2479 0.3502 0.4467 0.6155 0.754\n0.1994 0.2479 0.3502 0.4467 0.6155 0.754\n0.2389 0.2782 0.3696 0.4638 0.6225 0.7579\n0.2378 0.2709 0.3471 0.4336 0.5823 0.7303\n0.2488 0.2779 0.3516 0.4414 0.5833 0.7223\n0.2488 0.2779 0.3516 0.4414 0.5833 0.7223\n0.242 0.2681 0.3356 0.4238 0.5634 0.7085\n0.2359 0.2564 0.3183 0.4026 0.535 0.685\n0.2359 0.2564 0.3183 0.4026 0.535 0.685\n0.2282 0.2408 0.277 0.3442 0.4631 0.6507\n0.4617 0.5621 0.6694 0.7585 0.8468 0.8916\n0.4898 0.5804 0.6961 0.7849 0.8659 0.9129\n0.4898 0.5804 0.6961 0.7849 0.8659 0.9129\n0.4898 0.5804 0.6961 0.7849 0.8659 0.9129\n0.4898 0.5804 0.6961 0.7849 0.8659 0.9129\n0.4655 0.5586 0.6772 0.776 0.8636 0.91\n0.4655 0.5586 0.6772 0.776 0.8636 0.91\n0.4655 0.5586 0.6772 0.776 0.8636 0.91\n0.4655 0.5586 0.6772 0.776 0.8636 0.91\n0.3203 0.4363 0.5762 0.7152 0.8405 0.8795\n0.2047 0.3306 0.501 0.6719 0.8095 0.8618\n0.1853 0.2956 0.4628 0.6411 0.7854 0.8425\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.1723 0.2816 0.4567 0.6345 0.7789 0.8357\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4619 0.5903 0.6922 0.7867 0.8615 0.9054\n0.4421 0.5718 0.6796 0.7743 0.8465 0.8929\n0.4283 0.5642 0.6792 0.7759 0.8459 0.8916\n0.4255 0.566 0.6823 0.7766 0.8427 0.887\n0.4255 0.566 0.6823 0.7766 0.8427 0.887\n0.4255 0.566 0.6823 0.7766 0.8427 0.887\n0.4261 0.5729 0.692 0.7845 0.8478 0.8891\n0.3749 0.5602 0.7234 0.8167 0.8564 0.8879\n0.3405 0.5389 0.7325 0.8311 0.8548 0.8777\n0.3114 0.5092 0.7274 0.8346 0.8493 0.8665\n0.286 0.4677 0.7046 0.8217 0.8332 0.8491\n0.2728 0.454 0.7023 0.8225 0.8299 0.8442\n0.2728 0.454 0.7023 0.8225 0.8299 0.8442\n0.2728 0.454 0.7023 0.8225 0.8299 0.8442\n0.2728 0.454 0.7023 0.8225 0.8299 0.8442\n0.2728 0.454 0.7023 0.8225 0.8299 0.8442\n0.3082 0.3223 0.4368 0.5703 0.6333 0.7185\n0.3419 0.3679 0.485 0.6135 0.6826 0.7781\n0.3419 0.3679 0.485 0.6135 0.6826 0.7781\n0.3419 0.3679 0.485 0.6135 0.6826 0.7781\n0.4126 0.4449 0.5526 0.6702 0.7341 0.8273\n0.4126 0.4449 0.5526 0.6702 0.7341 0.8273\n0.4126 0.4449 0.5526 0.6702 0.7341 0.8273\n0.4126 0.4449 0.5526 0.6702 0.7341 0.8273\n0.4126 0.4449 0.5526 0.6702 0.7341 0.8273\n0.375 0.4096 0.5091 0.6118 0.6707 0.765\n0.4063 0.5023 0.6497 0.7569 0.8001 0.8488\n0.4228 0.5547 0.7293 0.8338 0.8712 0.893\n0.443 0.5821 0.7529 0.8627 0.8972 0.9114\n0.443 0.5821 0.7529 0.8627 0.8972 0.9114\n0.443 0.5821 0.7529 0.8627 0.8972 0.9114\n0.443 0.5821 0.7529 0.8627 0.8972 0.9114\n0.443 0.5821 0.7529 0.8627 0.8972 0.9114\n0.4769 0.6168 0.7909 0.8847 0.9152 0.9277\n0.4769 0.6168 0.7909 0.8847 0.9152 0.9277\n0.4769 0.6168 0.7909 0.8847 0.9152 0.9277\n0.481 0.6273 0.8034 0.8924 0.9242 0.9319\n0.4595 0.5989 0.7725 0.8652 0.9027 0.9154\n0.4595 0.5989 0.7725 0.8652 0.9027 0.9154\n0.3014 0.3951 0.5444 0.6645 0.7387 0.7896\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2743 0.3537 0.4673 0.5846 0.6728 0.7472\n0.2693 0.3508 0.4549 0.568 0.6511 0.7288\n0.2115 0.3011 0.5911 0.77 0.8629 0.9524\n0.2097 0.2978 0.5825 0.7585 0.8427 0.9189\n0.2097 0.2978 0.5825 0.7585 0.8427 0.9189\n0.2097 0.2978 0.5825 0.7585 0.8427 0.9189\n0.2097 0.2978 0.5825 0.7585 0.8427 0.9189\n0.2097 0.2978 0.5825 0.7585 0.8427 0.9189\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1895 0.2711 0.4204 0.544 0.6202 0.7026\n0.1991 0.2748 0.4418 0.5631 0.6293 0.703\n0.4583 0.557 0.6089 0.6595 0.6974 0.7806\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4815 0.5896 0.66 0.7134 0.7518 0.8328\n0.4826 0.61 0.6737 0.7299 0.7911 0.8798\n0.4644 0.6187 0.6812 0.7373 0.8312 0.9322\n0.513 0.6541 0.712 0.7643 0.8487 0.9423\n0.513 0.6541 0.712 0.7643 0.8487 0.9423\n0.513 0.6541 0.712 0.7643 0.8487 0.9423\n0.5396 0.677 0.7275 0.7807 0.8646 0.9554\n0.5396 0.677 0.7275 0.7807 0.8646 0.9554\n0.5842 0.7039 0.7557 0.8008 0.8705 0.9517\n0.5842 0.7039 0.7557 0.8008 0.8705 0.9517\n0.3155 0.4347 0.5691 0.6919 0.737 0.8187\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.312 0.4376 0.5737 0.7035 0.7474 0.8111\n0.3119 0.4462 0.5989 0.7312 0.7791 0.8269\n0.295 0.4409 0.6131 0.7589 0.8165 0.8367\n0.3545 0.5243 0.7116 0.8365 0.8819 0.8966\n0.3767 0.558 0.7589 0.876 0.9185 0.9256\n0.3767 0.558 0.7589 0.876 0.9185 0.9256\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.4198 0.6234 0.8244 0.9211 0.94 0.9485\n0.412 0.6183 0.813 0.9111 0.944 0.9449\n0.2622 0.3269 0.4223 0.5139 0.556 0.5748\n0.2668 0.3315 0.4301 0.5217 0.563 0.5832\n0.2668 0.3315 0.4301 0.5217 0.563 0.5832\n0.2668 0.3315 0.4301 0.5217 0.563 0.5832\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3219 0.4016 0.5243 0.6236 0.662 0.6926\n0.3028 0.3785 0.494 0.5932 0.6355 0.6733\n0.3108 0.3816 0.5011 0.6322 0.7043 0.7592\n0.319 0.3888 0.5311 0.6876 0.7729 0.8342\n0.338 0.4031 0.5513 0.7167 0.81 0.8756\n0.3682 0.4349 0.5877 0.7562 0.8471 0.907\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.3748 0.4401 0.5888 0.7514 0.8374 0.8961\n0.36 0.4259 0.5756 0.7294 0.8072 0.8621\n0.3651 0.4287 0.5674 0.7156 0.7904 0.8477\n0.3864 0.4426 0.5612 0.7045 0.7761 0.8383\n0.3864 0.4426 0.5612 0.7045 0.7761 0.8383\n0.3864 0.4426 0.5612 0.7045 0.7761 0.8383\n0.3947 0.4458 0.5416 0.6674 0.7351 0.7984\n0.3575 0.4002 0.4793 0.5874 0.6536 0.7333\n0.3575 0.4002 0.4793 0.5874 0.6536 0.7333\n0.3575 0.4002 0.4793 0.5874 0.6536 0.7333\n0.3575 0.4002 0.4793 0.5874 0.6536 0.7333\n0.3575 0.4002 0.4793 0.5874 0.6536 0.7333\n0.2827 0.3229 0.4037 0.4914 0.5613 0.6515\n0.2484 0.2846 0.3555 0.4286 0.4973 0.5951\n0.2004 0.2387 0.3196 0.3789 0.4419 0.5455\n0.2314 0.2738 0.3595 0.4207 0.4884 0.5874\n0.2534 0.2933 0.3827 0.4435 0.4995 0.5887\n0.2534 0.2933 0.3827 0.4435 0.4995 0.5887\n0.2534 0.2933 0.3827 0.4435 0.4995 0.5887\n0.2796 0.32 0.408 0.4713 0.5236 0.6057\n0.2796 0.32 0.408 0.4713 0.5236 0.6057\n0.2796 0.32 0.408 0.4713 0.5236 0.6057\n0.2796 0.32 0.408 0.4713 0.5236 0.6057\n0.2556 0.296 0.3729 0.4411 0.4991 0.5786\n0.2414 0.2799 0.3535 0.4275 0.4863 0.5508\n0.2414 0.2799 0.3535 0.4275 0.4863 0.5508\n0.235 0.276 0.3509 0.4592 0.521 0.5693\n0.3141 0.3774 0.5281 0.6765 0.7387 0.7639\n0.3141 0.3774 0.5281 0.6765 0.7387 0.7639\n0.3141 0.3774 0.5281 0.6765 0.7387 0.7639\n0.3141 0.3774 0.5281 0.6765 0.7387 0.7639\n0.3141 0.3774 0.5281 0.6765 0.7387 0.7639\n0.295 0.3848 0.5531 0.6968 0.7577 0.7857\n0.295 0.3848 0.5531 0.6968 0.7577 0.7857\n0.295 0.3848 0.5531 0.6968 0.7577 0.7857\n0.295 0.3848 0.5531 0.6968 0.7577 0.7857\n0.189 0.2585 0.4036 0.5678 0.6114 0.7301\n0.1691 0.2292 0.3732 0.5359 0.5971 0.7119\n0.1607 0.2164 0.3568 0.5116 0.5864 0.7013\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.1524 0.2049 0.3413 0.4943 0.5752 0.6913\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4531 0.5611 0.6831 0.779 0.8374 0.9072\n0.4309 0.5366 0.6658 0.7642 0.8195 0.8836\n0.4135 0.5214 0.6641 0.7669 0.8191 0.8815\n0.4113 0.5239 0.6687 0.7702 0.8135 0.8732\n0.4113 0.5239 0.6687 0.7702 0.8135 0.8732\n0.4113 0.5239 0.6687 0.7702 0.8135 0.8732\n0.4113 0.5239 0.6687 0.7702 0.8135 0.8732\n0.3449 0.5225 0.7166 0.8248 0.8427 0.8772\n0.3027 0.507 0.7291 0.8501 0.8515 0.8712\n0.2663 0.4701 0.7167 0.8551 0.8445 0.8578\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.2441 0.423 0.6837 0.835 0.8266 0.8389\n0.3539 0.3854 0.4747 0.6277 0.6934 0.7765\n0.3539 0.3854 0.4747 0.6277 0.6934 0.7765\n0.3539 0.3854 0.4747 0.6277 0.6934 0.7765\n0.434 0.4619 0.5566 0.6932 0.7443 0.8347\n0.434 0.4619 0.5566 0.6932 0.7443 0.8347\n0.434 0.4619 0.5566 0.6932 0.7443 0.8347\n0.434 0.4619 0.5566 0.6932 0.7443 0.8347\n0.434 0.4619 0.5566 0.6932 0.7443 0.8347\n0.3848 0.4168 0.4924 0.6218 0.6696 0.7402\n0.3893 0.4777 0.6104 0.7224 0.7643 0.8129\n0.392 0.514 0.6806 0.7823 0.8207 0.8562\n0.4258 0.5538 0.7188 0.8347 0.8658 0.902\n0.4258 0.5538 0.7188 0.8347 0.8658 0.902\n0.4258 0.5538 0.7188 0.8347 0.8658 0.902\n0.4258 0.5538 0.7188 0.8347 0.8658 0.902\n0.4258 0.5538 0.7188 0.8347 0.8658 0.902\n0.4653 0.6121 0.7805 0.8845 0.8992 0.9245\n0.4653 0.6121 0.7805 0.8845 0.8992 0.9245\n0.4653 0.6121 0.7805 0.8845 0.8992 0.9245\n0.4731 0.625 0.7898 0.8987 0.9086 0.9344\n0.446 0.5895 0.7518 0.8646 0.8827 0.9146\n0.446 0.5895 0.7518 0.8646 0.8827 0.9146\n0.3131 0.4176 0.5614 0.6939 0.7507 0.812\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2785 0.3633 0.477 0.6152 0.6845 0.7586\n0.2226 0.3065 0.4618 0.604 0.6682 0.7417\n0.2153 0.316 0.5752 0.719 0.7688 0.8613\n0.2301 0.3272 0.5767 0.7253 0.782 0.8703\n0.2301 0.3272 0.5767 0.7253 0.782 0.8703\n0.2301 0.3272 0.5767 0.7253 0.782 0.8703\n0.2301 0.3272 0.5767 0.7253 0.782 0.8703\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.2234 0.307 0.5242 0.6837 0.7468 0.8173\n0.236 0.3177 0.5244 0.6792 0.7424 0.8146\n0.3557 0.4531 0.5791 0.6733 0.7128 0.8054\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.4411 0.5676 0.6615 0.726 0.7619 0.8654\n0.464 0.597 0.6798 0.7369 0.7726 0.8775\n0.4603 0.613 0.688 0.7423 0.7947 0.907\n0.4476 0.6169 0.6844 0.7346 0.8029 0.9247\n0.4924 0.6494 0.7131 0.7632 0.8236 0.9366\n0.4924 0.6494 0.7131 0.7632 0.8236 0.9366\n0.4924 0.6494 0.7131 0.7632 0.8236 0.9366\n0.516 0.6695 0.729 0.7796 0.8366 0.9472\n0.516 0.6695 0.729 0.7796 0.8366 0.9472\n0.5574 0.6944 0.7493 0.8026 0.8452 0.9493\n0.5574 0.6944 0.7493 0.8026 0.8452 0.9493\n0.3317 0.4542 0.5884 0.7077 0.7697 0.8189\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.3562 0.4855 0.6073 0.7309 0.7942 0.8387\n0.4107 0.539 0.7763 0.9125 0.9409 0.9392\n0.4107 0.539 0.7763 0.9125 0.9409 0.9392\n0.4107 0.539 0.7763 0.9125 0.9409 0.9392\n0.4625 0.6262 0.8724 0.9648 0.9694 0.9721\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4625 0.6359 0.8844 0.9716 0.9746 0.9718\n0.4515 0.6515 0.8935 0.9818 0.9756 0.9792\n0.2337 0.2945 0.4094 0.4832 0.5066 0.5224\n0.2336 0.3013 0.4218 0.4954 0.525 0.5373\n0.2336 0.3013 0.4218 0.4954 0.525 0.5373\n0.2336 0.3013 0.4218 0.4954 0.525 0.5373\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2623 0.3469 0.4897 0.5727 0.5997 0.6133\n0.2642 0.3546 0.5026 0.5871 0.6151 0.6281\n0.2642 0.3546 0.5026 0.5871 0.6151 0.6281\n0.2486 0.3343 0.476 0.5634 0.5928 0.6146\n0.3112 0.3751 0.5068 0.6731 0.755 0.8144\n0.3469 0.4009 0.5422 0.743 0.8433 0.9011\n0.3469 0.4009 0.5422 0.743 0.8433 0.9011\n0.3636 0.421 0.5571 0.7517 0.8521 0.9037\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3692 0.4261 0.5575 0.7436 0.8405 0.8912\n0.3538 0.4059 0.5347 0.71 0.7987 0.8539\n0.3624 0.4111 0.5287 0.6918 0.7733 0.833\n0.3636 0.4124 0.5238 0.6798 0.7614 0.8234\n0.3803 0.4265 0.526 0.6686 0.7441 0.8044\n0.3811 0.4307 0.5194 0.6429 0.7097 0.7691\n0.3927 0.442 0.5171 0.62 0.6766 0.7362\n0.348 0.398 0.459 0.5411 0.5942 0.6469\n0.348 0.398 0.459 0.5411 0.5942 0.6469\n0.348 0.398 0.459 0.5411 0.5942 0.6469\n0.348 0.398 0.459 0.5411 0.5942 0.6469\n0.348 0.398 0.459 0.5411 0.5942 0.6469\n0.2868 0.3364 0.4035 0.474 0.5265 0.6049\n0.2621 0.312 0.3708 0.426 0.4723 0.5567\n0.2028 0.2404 0.3123 0.352 0.3981 0.4983\n0.2276 0.2603 0.3463 0.3906 0.4367 0.5494\n0.2355 0.2675 0.3528 0.3963 0.4415 0.5495\n0.2355 0.2675 0.3528 0.3963 0.4415 0.5495\n0.2355 0.2675 0.3528 0.3963 0.4415 0.5495\n0.2723 0.3014 0.3854 0.4326 0.4769 0.5709\n0.2723 0.3014 0.3854 0.4326 0.4769 0.5709\n0.2723 0.3014 0.3854 0.4326 0.4769 0.5709\n0.2723 0.3014 0.3854 0.4326 0.4769 0.5709\n0.2696 0.2988 0.382 0.4309 0.4755 0.5692\n0.2544 0.2815 0.358 0.4129 0.4535 0.5385\n0.2544 0.2815 0.358 0.4129 0.4535 0.5385\n0.235 0.2608 0.3312 0.3983 0.4365 0.5122\n0.3388 0.3809 0.5287 0.6488 0.7161 0.754\n0.3626 0.4148 0.5722 0.7068 0.7693 0.8088\n0.3626 0.4148 0.5722 0.7068 0.7693 0.8088\n0.3626 0.4148 0.5722 0.7068 0.7693 0.8088\n0.3626 0.4148 0.5722 0.7068 0.7693 0.8088\n0.3536 0.4295 0.6465 0.7649 0.8177 0.8559\n0.3267 0.4051 0.6191 0.7356 0.7942 0.8398\n0.3267 0.4051 0.6191 0.7356 0.7942 0.8398\n0.3267 0.4051 0.6191 0.7356 0.7942 0.8398\n0.2892 0.395 0.6681 0.7657 0.8202 0.8723\n0.2428 0.3329 0.5558 0.6518 0.7226 0.7866\n0.2428 0.3329 0.5558 0.6518 0.7226 0.7866\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.1631 0.2295 0.372 0.4702 0.5656 0.6554\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4514 0.5427 0.6712 0.7752 0.8439 0.8914\n0.4315 0.5212 0.6539 0.7603 0.8264 0.8689\n0.4188 0.5122 0.6547 0.7673 0.8271 0.8665\n0.4163 0.5167 0.6629 0.7717 0.8247 0.8601\n0.4758 0.5887 0.7765 0.8931 0.9091 0.9305\n0.4758 0.5887 0.7765 0.8931 0.9091 0.9305\n0.4758 0.5887 0.7765 0.8931 0.9091 0.9305\n0.4441 0.5841 0.7893 0.9062 0.9147 0.93\n0.3351 0.5056 0.711 0.8295 0.851 0.8624\n0.3026 0.4762 0.7048 0.833 0.8462 0.8507\n0.2781 0.4339 0.6779 0.8185 0.8323 0.8342\n0.2646 0.4223 0.6757 0.8203 0.831 0.8304\n0.2646 0.4223 0.6757 0.8203 0.831 0.8304\n0.2646 0.4223 0.6757 0.8203 0.831 0.8304\n0.2646 0.4223 0.6757 0.8203 0.831 0.8304\n0.2646 0.4223 0.6757 0.8203 0.831 0.8304\n0.3192 0.3198 0.4109 0.5469 0.6161 0.6593\n0.375 0.3843 0.4741 0.6001 0.6737 0.7221\n0.375 0.3843 0.4741 0.6001 0.6737 0.7221\n0.375 0.3843 0.4741 0.6001 0.6737 0.7221\n0.4256 0.4351 0.5307 0.6496 0.7114 0.7681\n0.4256 0.4351 0.5307 0.6496 0.7114 0.7681\n0.4256 0.4351 0.5307 0.6496 0.7114 0.7681\n0.4256 0.4351 0.5307 0.6496 0.7114 0.7681\n0.4256 0.4351 0.5307 0.6496 0.7114 0.7681\n0.4206 0.4322 0.5105 0.6264 0.69 0.7288\n0.4047 0.4963 0.6322 0.7398 0.7877 0.8071\n0.4053 0.5311 0.6895 0.7989 0.8445 0.8493\n0.4287 0.5514 0.7145 0.8298 0.8738 0.8816\n0.4287 0.5514 0.7145 0.8298 0.8738 0.8816\n0.4287 0.5514 0.7145 0.8298 0.8738 0.8816\n0.4287 0.5514 0.7145 0.8298 0.8738 0.8816\n0.4287 0.5514 0.7145 0.8298 0.8738 0.8816\n0.4713 0.6023 0.7629 0.8617 0.8989 0.8932\n0.4713 0.6023 0.7629 0.8617 0.8989 0.8932\n0.4713 0.6023 0.7629 0.8617 0.8989 0.8932\n0.4793 0.6102 0.7713 0.8698 0.9056 0.8993\n0.4553 0.5795 0.7355 0.8384 0.8804 0.881\n0.4553 0.5795 0.7355 0.8384 0.8804 0.881\n0.3206 0.404 0.5289 0.6571 0.7309 0.7727\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2915 0.365 0.4722 0.595 0.6774 0.7268\n0.2529 0.3171 0.402 0.5146 0.6031 0.6602\n0.2402 0.3199 0.5755 0.7156 0.7742 0.863\n0.2402 0.3199 0.5755 0.7156 0.7742 0.863\n0.2164 0.3033 0.5558 0.7132 0.7741 0.84\n0.2124 0.3001 0.5548 0.7143 0.7734 0.8313\n0.2124 0.3001 0.5548 0.7143 0.7734 0.8313\n0.1733 0.262 0.4984 0.6694 0.7293 0.7518\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.1979 0.2774 0.4631 0.5977 0.6529 0.6814\n0.2028 0.2768 0.4536 0.5757 0.628 0.6596\n0.3471 0.407 0.5355 0.6176 0.6431 0.6845\n0.4087 0.4863 0.5979 0.6669 0.6986 0.7478\n0.4416 0.5171 0.6053 0.6588 0.6881 0.744\n0.4416 0.5171 0.6053 0.6588 0.6881 0.744\n0.4416 0.5171 0.6053 0.6588 0.6881 0.744\n0.4416 0.5171 0.6053 0.6588 0.6881 0.744\n0.4416 0.5171 0.6053 0.6588 0.6881 0.744\n0.4926 0.5745 0.6561 0.7032 0.7317 0.7927\n0.475 0.581 0.6697 0.7185 0.7652 0.8429\n0.4276 0.5714 0.6701 0.7226 0.7925 0.8948\n0.4889 0.6145 0.7083 0.758 0.8213 0.9131\n0.4889 0.6145 0.7083 0.758 0.8213 0.9131\n0.4889 0.6145 0.7083 0.758 0.8213 0.9131\n0.5155 0.6359 0.729 0.7771 0.8416 0.9312\n0.5155 0.6359 0.729 0.7771 0.8416 0.9312\n0.5804 0.6818 0.7664 0.8139 0.8676 0.9407\n0.5804 0.6818 0.7664 0.8139 0.8676 0.9407\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.2292 0.3186 0.4845 0.6631 0.7541 0.8506\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5445 0.6811 0.8181 0.8981 0.931 0.9582\n0.5689 0.702 0.8282 0.9021 0.9364 0.9614\n0.4487 0.5532 0.6643 0.7036 0.7272 0.7704\n0.4575 0.5548 0.6617 0.6968 0.7292 0.7671\n0.4469 0.5407 0.6457 0.6771 0.7094 0.7485\n0.3876 0.4886 0.5891 0.6298 0.6623 0.7035\n0.3711 0.4731 0.5666 0.6109 0.6475 0.6894\n0.3493 0.4582 0.5981 0.6525 0.6962 0.7485\n0.3493 0.4582 0.5981 0.6525 0.6962 0.7485\n0.2721 0.3935 0.5543 0.6249 0.6758 0.7383\n0.2908 0.4249 0.5603 0.6376 0.6893 0.7431\n0.2934 0.4312 0.5604 0.6434 0.6989 0.75\n0.2934 0.4312 0.5604 0.6434 0.6989 0.75\n0.2615 0.3854 0.4791 0.5922 0.668 0.7166\n0.2615 0.3854 0.4791 0.5922 0.668 0.7166\n0.2615 0.3854 0.4791 0.5922 0.668 0.7166\n0.2615 0.3854 0.4791 0.5922 0.668 0.7166\n0.2615 0.3854 0.4791 0.5922 0.668 0.7166\n0.2209 0.3355 0.4404 0.5929 0.6921 0.7455\n0.2952 0.413 0.5296 0.6714 0.7597 0.8036\n0.495 0.6165 0.7652 0.8803 0.937 0.9522\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5154 0.6375 0.7897 0.9005 0.9559 0.97\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.5196 0.6206 0.7727 0.8857 0.9354 0.9723\n0.4884 0.5791 0.7328 0.8525 0.9066 0.9573\n0.4884 0.5791 0.7328 0.8525 0.9066 0.9573\n0.4776 0.5602 0.712 0.8339 0.888 0.9483\n0.2657 0.3101 0.3528 0.4519 0.5917 0.7474\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.3003 0.3528 0.4075 0.5148 0.6607 0.8088\n0.2984 0.3427 0.4017 0.4963 0.6305 0.7796\n0.2884 0.3277 0.3843 0.4736 0.602 0.7517\n0.2739 0.3076 0.3658 0.4455 0.5626 0.7094\n0.2617 0.2905 0.3483 0.4201 0.5314 0.675\n0.2617 0.2905 0.3483 0.4201 0.5314 0.675\n0.2601 0.2817 0.3421 0.4058 0.5064 0.6452\n0.2414 0.2721 0.3145 0.4106 0.5238 0.6395\n0.3875 0.5587 0.7917 0.8934 0.9182 0.9925\n0.3242 0.447 0.7174 0.8826 0.9343 0.9841\n0.3022 0.4222 0.7146 0.8964 0.9394 0.9782\n0.2811 0.397 0.6859 0.8726 0.9209 0.9632\n0.2811 0.397 0.6859 0.8726 0.9209 0.9632\n0.2811 0.397 0.6859 0.8726 0.9209 0.9632\n0.2463 0.3442 0.6513 0.8658 0.9218 0.9536\n0.217 0.3085 0.5946 0.8114 0.8807 0.923\n0.0983 0.1743 0.3794 0.5984 0.7259 0.8006\n0.0956 0.1671 0.3579 0.5845 0.7215 0.8019\n0.0932 0.1635 0.3446 0.5735 0.7212 0.8012\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.0901 0.158 0.3317 0.5637 0.7162 0.8002\n0.4302 0.5274 0.6392 0.7918 0.8563 0.8903\n0.4302 0.5274 0.6392 0.7918 0.8563 0.8903\n0.4302 0.5274 0.6392 0.7918 0.8563 0.8903\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.451 0.5562 0.6634 0.8035 0.8721 0.9049\n0.4401 0.5468 0.656 0.7949 0.8603 0.8914\n0.4354 0.5445 0.6588 0.7968 0.8634 0.8907\n0.4423 0.5549 0.6709 0.8013 0.8647 0.8912\n0.4423 0.5549 0.6709 0.8013 0.8647 0.8912\n0.4423 0.5549 0.6709 0.8013 0.8647 0.8912\n0.4506 0.57 0.6854 0.8098 0.8739 0.8995\n0.3553 0.514 0.6867 0.8272 0.8543 0.8736\n0.3149 0.4872 0.6813 0.8303 0.8436 0.859\n0.2874 0.4641 0.6807 0.8326 0.8378 0.8481\n0.265 0.4231 0.6581 0.819 0.8255 0.8322\n0.2517 0.4105 0.6555 0.8195 0.8223 0.8279\n0.2517 0.4105 0.6555 0.8195 0.8223 0.8279\n0.2517 0.4105 0.6555 0.8195 0.8223 0.8279\n0.2515 0.4076 0.6579 0.8182 0.821 0.8301\n0.2515 0.4076 0.6579 0.8182 0.821 0.8301\n0.2721 0.306 0.3901 0.4979 0.5494 0.6322\n0.3065 0.3747 0.4652 0.5686 0.6275 0.7297\n0.3065 0.3747 0.4652 0.5686 0.6275 0.7297\n0.3065 0.3747 0.4652 0.5686 0.6275 0.7297\n0.334 0.4321 0.5297 0.6292 0.6779 0.7832\n0.334 0.4321 0.5297 0.6292 0.6779 0.7832\n0.334 0.4321 0.5297 0.6292 0.6779 0.7832\n0.334 0.4321 0.5297 0.6292 0.6779 0.7832\n0.334 0.4321 0.5297 0.6292 0.6779 0.7832\n0.3539 0.4343 0.5151 0.6126 0.6668 0.7625\n0.3731 0.4841 0.624 0.7332 0.7807 0.8157\n0.3859 0.5118 0.6724 0.7885 0.8377 0.8529\n0.4264 0.5662 0.7228 0.8369 0.8814 0.8917\n0.4264 0.5662 0.7228 0.8369 0.8814 0.8917\n0.4264 0.5662 0.7228 0.8369 0.8814 0.8917\n0.4264 0.5662 0.7228 0.8369 0.8814 0.8917\n0.4264 0.5662 0.7228 0.8369 0.8814 0.8917\n0.4599 0.6012 0.7594 0.8765 0.9075 0.916\n0.4599 0.6012 0.7594 0.8765 0.9075 0.916\n0.4599 0.6012 0.7594 0.8765 0.9075 0.916\n0.4671 0.6091 0.7639 0.8827 0.9112 0.9211\n0.4428 0.5769 0.7246 0.8452 0.8818 0.8989\n0.4428 0.5769 0.7246 0.8452 0.8818 0.8989\n0.2994 0.3904 0.5031 0.6273 0.7082 0.756\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2689 0.3403 0.4258 0.5345 0.6294 0.6917\n0.2584 0.325 0.4042 0.5107 0.609 0.6756\n0.2605 0.3337 0.4576 0.5725 0.645 0.7334\n0.2487 0.3304 0.552 0.6818 0.7406 0.8297\n0.2445 0.3197 0.5457 0.6796 0.7363 0.819\n0.2445 0.3197 0.5457 0.6796 0.7363 0.819\n0.2445 0.3197 0.5457 0.6796 0.7363 0.819\n0.2445 0.3197 0.5457 0.6796 0.7363 0.819\n0.2233 0.2839 0.5149 0.667 0.7229 0.7773\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2241 0.2764 0.4781 0.6176 0.6753 0.7174\n0.2362 0.2865 0.4722 0.6023 0.6606 0.6889\n0.3869 0.4842 0.5824 0.6678 0.671 0.7301\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4419 0.5445 0.6411 0.7127 0.7153 0.7696\n0.4796 0.5936 0.6806 0.7472 0.7394 0.7965\n0.4593 0.5961 0.6818 0.7316 0.7461 0.8161\n0.4368 0.5931 0.6829 0.7116 0.7506 0.8352\n0.4725 0.6244 0.7148 0.7427 0.7864 0.8659\n0.4725 0.6244 0.7148 0.7427 0.7864 0.8659\n0.4725 0.6244 0.7148 0.7427 0.7864 0.8659\n0.4725 0.6244 0.7148 0.7427 0.7864 0.8659\n0.4725 0.6244 0.7148 0.7427 0.7864 0.8659\n0.5054 0.6415 0.7363 0.7701 0.8034 0.8791\n0.5054 0.6415 0.7363 0.7701 0.8034 0.8791\n0.4942 0.659 0.7922 0.8207 0.8336 0.912\n0.4942 0.659 0.7922 0.8207 0.8336 0.912\n0.4942 0.659 0.7922 0.8207 0.8336 0.912\n0.4942 0.659 0.7922 0.8207 0.8336 0.912\n0.4599 0.6194 0.7712 0.8144 0.8357 0.9101\n0.4599 0.6194 0.7712 0.8144 0.8357 0.9101\n0.4599 0.6194 0.7712 0.8144 0.8357 0.9101\n0.3555 0.4959 0.7136 0.8066 0.8556 0.9107\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3601 0.481 0.6835 0.7794 0.83 0.8944\n0.3686 0.454 0.6284 0.7298 0.7831 0.8646\n0.3686 0.454 0.6284 0.7298 0.7831 0.8646\n0.3686 0.454 0.6284 0.7298 0.7831 0.8646\n0.3686 0.454 0.6284 0.7298 0.7831 0.8646\n0.3013 0.362 0.5148 0.6044 0.7384 0.8411\n0.3096 0.378 0.5276 0.6116 0.7337 0.8411\n0.3157 0.3835 0.5369 0.6178 0.7336 0.8424\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3304 0.3951 0.5442 0.629 0.7376 0.8461\n0.3086 0.3544 0.4956 0.5978 0.7643 0.8442\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3862 0.4664 0.627 0.708 0.7588 0.8399\n0.3508 0.4248 0.5665 0.6438 0.7013 0.7988\n0.1638 0.2397 0.3196 0.3461 0.4121 0.5321\n0.1638 0.2397 0.3196 0.3461 0.4121 0.5321\n0.1611 0.2316 0.3033 0.3298 0.399 0.5331\n0.2072 0.2738 0.3459 0.3851 0.46 0.617\n0.2072 0.2738 0.3459 0.3851 0.46 0.617\n0.2072 0.2738 0.3459 0.3851 0.46 0.617\n0.2445 0.304 0.3763 0.4252 0.5063 0.6797\n0.3184 0.3656 0.4462 0.5029 0.5808 0.7608\n0.3121 0.3609 0.4363 0.502 0.5823 0.7687\n0.3121 0.3609 0.4363 0.502 0.5823 0.7687\n0.3121 0.3609 0.4363 0.502 0.5823 0.7687\n0.3121 0.3609 0.4363 0.502 0.5823 0.7687\n0.3082 0.3523 0.4254 0.4895 0.5697 0.7572\n0.3082 0.3523 0.4254 0.4895 0.5697 0.7572\n0.2817 0.3293 0.3992 0.4493 0.5311 0.7207\n0.3224 0.3983 0.5728 0.6845 0.7514 0.791\n0.3168 0.3927 0.5687 0.6814 0.7494 0.789\n0.3168 0.3927 0.5687 0.6814 0.7494 0.789\n0.3168 0.3927 0.5687 0.6814 0.7494 0.789\n0.3168 0.3927 0.5687 0.6814 0.7494 0.789\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.2726 0.3226 0.4726 0.5946 0.6841 0.7392\n0.3051 0.3603 0.5118 0.634 0.7185 0.7706\n0.3051 0.3603 0.5118 0.634 0.7185 0.7706\n0.3051 0.3603 0.5118 0.634 0.7185 0.7706\n0.3199 0.3845 0.5343 0.6468 0.7314 0.7885\n0.3542 0.4252 0.5737 0.6803 0.7579 0.8122\n0.3542 0.4252 0.5737 0.6803 0.7579 0.8122\n0.3542 0.4252 0.5737 0.6803 0.7579 0.8122\n0.3542 0.4252 0.5737 0.6803 0.7579 0.8122\n0.3554 0.4218 0.5709 0.6826 0.7577 0.8074\n0.3554 0.4218 0.5709 0.6826 0.7577 0.8074\n0.3587 0.4277 0.5776 0.6885 0.76 0.808\n0.3647 0.4361 0.5891 0.6988 0.768 0.815\n0.3737 0.4481 0.6023 0.7091 0.775 0.8204\n0.3737 0.4481 0.6023 0.7091 0.775 0.8204\n0.3737 0.4481 0.6023 0.7091 0.775 0.8204\n0.3527 0.4322 0.5904 0.6979 0.7666 0.8116\n0.337 0.4637 0.6507 0.7629 0.8052 0.8351\n0.3307 0.4896 0.701 0.8182 0.8382 0.854\n0.2748 0.4538 0.7071 0.8405 0.8402 0.8391\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2524 0.4094 0.677 0.8222 0.8228 0.8244\n0.2276 0.3188 0.412 0.5609 0.6159 0.6792\n0.2723 0.3564 0.469 0.6025 0.679 0.7431\n0.2706 0.3587 0.4847 0.628 0.7205 0.7772\n0.2706 0.3587 0.4847 0.628 0.7205 0.7772\n0.3087 0.4063 0.537 0.6587 0.7537 0.8217\n0.3087 0.4063 0.537 0.6587 0.7537 0.8217\n0.3087 0.4063 0.537 0.6587 0.7537 0.8217\n0.3087 0.4063 0.537 0.6587 0.7537 0.8217\n0.3087 0.4063 0.537 0.6587 0.7537 0.8217\n0.3407 0.4152 0.5156 0.6174 0.6914 0.7361\n0.3908 0.4873 0.6458 0.7585 0.8083 0.833\n0.4087 0.513 0.6922 0.8088 0.85 0.8676\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.4055 0.5067 0.6812 0.8007 0.8447 0.8652\n0.3817 0.4861 0.6517 0.7762 0.8236 0.8496\n0.3817 0.4861 0.6517 0.7762 0.8236 0.8496\n0.3817 0.4861 0.6517 0.7762 0.8236 0.8496\n0.3567 0.4457 0.5899 0.7225 0.7846 0.8218\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2992 0.3719 0.4799 0.616 0.6968 0.7561\n0.2886 0.3577 0.46 0.5954 0.6796 0.7443\n0.2599 0.3228 0.4141 0.5475 0.6322 0.7025\n0.2495 0.3401 0.6012 0.722 0.7799 0.8638\n0.2423 0.3284 0.5934 0.7206 0.7776 0.8507\n0.2423 0.3284 0.5934 0.7206 0.7776 0.8507\n0.2423 0.3284 0.5934 0.7206 0.7776 0.8507\n0.2423 0.3284 0.5934 0.7206 0.7776 0.8507\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2345 0.3117 0.5505 0.6911 0.7426 0.7958\n0.2454 0.3228 0.5422 0.6747 0.7201 0.7677\n0.3652 0.4499 0.5903 0.6687 0.7099 0.7753\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4016 0.495 0.6216 0.694 0.7327 0.7988\n0.4334 0.5323 0.6442 0.7059 0.7449 0.8115\n0.4598 0.5669 0.6715 0.7236 0.7619 0.8344\n0.488 0.6015 0.6963 0.7408 0.7771 0.8514\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.5334 0.636 0.7326 0.775 0.815 0.8925\n0.4341 0.5572 0.707 0.7888 0.8516 0.9024\n0.4341 0.5572 0.707 0.7888 0.8516 0.9024\n0.4341 0.5572 0.707 0.7888 0.8516 0.9024\n0.4052 0.525 0.6821 0.7684 0.8358 0.8928\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.2941 0.3916 0.5292 0.6072 0.6862 0.7959\n0.2941 0.3916 0.5292 0.6072 0.6862 0.7959\n0.2941 0.3916 0.5292 0.6072 0.6862 0.7959\n0.2941 0.3916 0.5292 0.6072 0.6862 0.7959\n0.2941 0.3916 0.5292 0.6072 0.6862 0.7959\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3311 0.4518 0.6168 0.7123 0.7939 0.8558\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.3885 0.506 0.671 0.7589 0.827 0.8837\n0.4341 0.5572 0.707 0.7888 0.8516 0.9024\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1937 0.2817 0.4714 0.5609 0.632 0.6934\n0.1885 0.2661 0.4419 0.5374 0.6091 0.6817\n0.1885 0.2661 0.4419 0.5374 0.6091 0.6817\n0.2 0.2739 0.4449 0.5524 0.6313 0.7139\n0.226 0.297 0.4671 0.5925 0.6755 0.7584\n0.226 0.297 0.4671 0.5925 0.6755 0.7584\n0.3061 0.367 0.5152 0.6465 0.7344 0.8272\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.332 0.3891 0.5275 0.6553 0.7419 0.8356\n0.3572 0.4089 0.5381 0.6651 0.7494 0.8448\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.419 0.4514 0.5504 0.6666 0.7441 0.8263\n0.4323 0.4606 0.5521 0.6676 0.7441 0.8251\n0.4323 0.4606 0.5521 0.6676 0.7441 0.8251\n0.4507 0.4747 0.5579 0.6715 0.7462 0.8258\n0.3181 0.3707 0.4746 0.5658 0.6468 0.7985\n0.2849 0.336 0.4354 0.5027 0.5779 0.7429\n0.2948 0.3471 0.4529 0.5162 0.5899 0.7537\n0.2948 0.3471 0.4529 0.5162 0.5899 0.7537\n0.2948 0.3471 0.4529 0.5162 0.5899 0.7537\n0.2948 0.3471 0.4529 0.5162 0.5899 0.7537\n0.3002 0.3499 0.4536 0.5164 0.5928 0.7571\n0.3002 0.3499 0.4536 0.5164 0.5928 0.7571\n0.3002 0.3499 0.4536 0.5164 0.5928 0.7571\n0.3002 0.3499 0.4536 0.5164 0.5928 0.7571\n0.2955 0.3425 0.4441 0.5014 0.575 0.7362\n0.2955 0.3425 0.4441 0.5014 0.575 0.7362\n0.2643 0.3134 0.4035 0.446 0.5159 0.6688\n0.3578 0.4277 0.5619 0.6822 0.7734 0.8367\n0.3578 0.4277 0.5619 0.6822 0.7734 0.8367\n0.3578 0.4277 0.5619 0.6822 0.7734 0.8367\n0.3578 0.4277 0.5619 0.6822 0.7734 0.8367\n0.3578 0.4277 0.5619 0.6822 0.7734 0.8367\n0.2503 0.3236 0.4741 0.6114 0.7257 0.8054\n0.2503 0.3236 0.4741 0.6114 0.7257 0.8054\n0.2503 0.3236 0.4741 0.6114 0.7257 0.8054\n0.2503 0.3236 0.4741 0.6114 0.7257 0.8054\n0.2503 0.3236 0.4741 0.6114 0.7257 0.8054\n0.2596 0.3328 0.4797 0.6144 0.7242 0.8029\n0.2596 0.3328 0.4797 0.6144 0.7242 0.8029\n0.2596 0.3328 0.4797 0.6144 0.7242 0.8029\n0.2596 0.3328 0.4797 0.6144 0.7242 0.8029\n0.2596 0.3328 0.4797 0.6144 0.7242 0.8029\n0.3105 0.3765 0.5087 0.6415 0.7374 0.8084\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3435 0.4086 0.5375 0.6757 0.7686 0.8308\n0.3178 0.3865 0.5183 0.6471 0.7343 0.8007\n0.4556 0.548 0.7128 0.844 0.8631 0.9004\n0.4556 0.548 0.7128 0.844 0.8631 0.9004\n0.4556 0.548 0.7128 0.844 0.8631 0.9004\n0.4208 0.5456 0.7293 0.86 0.8703 0.9002\n0.2932 0.4612 0.6688 0.7991 0.822 0.8439\n0.2746 0.4581 0.6944 0.8402 0.8447 0.8485\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2754 0.4503 0.6897 0.8362 0.8404 0.8515\n0.2262 0.3119 0.3989 0.5141 0.5792 0.6361\n0.2588 0.3485 0.4402 0.551 0.6118 0.6884\n0.2588 0.3485 0.4402 0.551 0.6118 0.6884\n0.2588 0.3485 0.4402 0.551 0.6118 0.6884\n0.2976 0.4096 0.5162 0.6111 0.6672 0.7447\n0.2976 0.4096 0.5162 0.6111 0.6672 0.7447\n0.2976 0.4096 0.5162 0.6111 0.6672 0.7447\n0.2976 0.4096 0.5162 0.6111 0.6672 0.7447\n0.2976 0.4096 0.5162 0.6111 0.6672 0.7447\n0.3182 0.4103 0.4885 0.5719 0.6176 0.6869\n0.3871 0.4962 0.6213 0.7324 0.7771 0.8122\n0.4153 0.5313 0.6756 0.7979 0.8423 0.8634\n0.4403 0.5523 0.6953 0.8266 0.8655 0.8928\n0.4403 0.5523 0.6953 0.8266 0.8655 0.8928\n0.4403 0.5523 0.6953 0.8266 0.8655 0.8928\n0.4403 0.5523 0.6953 0.8266 0.8655 0.8928\n0.4403 0.5523 0.6953 0.8266 0.8655 0.8928\n0.4795 0.5984 0.7354 0.8594 0.8963 0.9127\n0.4795 0.5984 0.7354 0.8594 0.8963 0.9127\n0.4795 0.5984 0.7354 0.8594 0.8963 0.9127\n0.4852 0.6041 0.737 0.8625 0.9009 0.9172\n0.4852 0.6041 0.737 0.8625 0.9009 0.9172\n0.4852 0.6041 0.737 0.8625 0.9009 0.9172\n0.3403 0.431 0.5405 0.6647 0.7317 0.7856\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2912 0.3652 0.4534 0.5646 0.641 0.7073\n0.2474 0.3094 0.3823 0.4806 0.5632 0.6375\n0.2513 0.3382 0.5902 0.7286 0.7848 0.8705\n0.2554 0.3404 0.5882 0.7257 0.7811 0.86\n0.2449 0.3289 0.5775 0.7216 0.776 0.8515\n0.2449 0.3289 0.5775 0.7216 0.776 0.8515\n0.2449 0.3289 0.5775 0.7216 0.776 0.8515\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.2314 0.3064 0.53 0.6889 0.738 0.7934\n0.242 0.3145 0.528 0.6791 0.7256 0.7785\n0.3025 0.3706 0.549 0.6699 0.7116 0.7607\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.4471 0.5071 0.6452 0.7332 0.7638 0.8171\n0.5238 0.5807 0.6912 0.7575 0.7827 0.8439\n0.5237 0.5948 0.706 0.7593 0.7854 0.8518\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4903 0.5829 0.7023 0.7451 0.7761 0.8495\n0.4138 0.59 0.723 0.8237 0.8813 0.9103\n0.412 0.5822 0.7368 0.8492 0.8919 0.9217\n0.4144 0.5806 0.7158 0.8309 0.8823 0.9145\n0.4144 0.5806 0.7158 0.8309 0.8823 0.9145\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4194 0.5841 0.717 0.8297 0.8824 0.9133\n0.4382 0.5913 0.7185 0.8238 0.8708 0.9049\n0.5568 0.6363 0.7278 0.7863 0.7981 0.8521\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.6349 0.7028 0.7874 0.8305 0.8413 0.8788\n0.5584 0.6394 0.7242 0.7699 0.7814 0.8339\n0.41 0.5051 0.5879 0.6277 0.6463 0.7106\n0.41 0.5051 0.5879 0.6277 0.6463 0.7106\n0.41 0.5051 0.5879 0.6277 0.6463 0.7106\n0.1947 0.3192 0.383 0.4124 0.4387 0.5195\n0.2085 0.3561 0.4439 0.4755 0.4995 0.5769\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.2128 0.3798 0.4795 0.5122 0.5349 0.6151\n0.3476 0.4641 0.6791 0.8211 0.8452 0.8694\n0.3552 0.4686 0.6784 0.8205 0.8459 0.8749\n0.3649 0.4813 0.6903 0.8206 0.8427 0.8728\n0.3761 0.4941 0.6963 0.8197 0.8385 0.8684\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.4 0.5139 0.7 0.8152 0.8306 0.8596\n0.3921 0.5063 0.6912 0.8039 0.8177 0.846\n0.3998 0.5027 0.6584 0.7609 0.7722 0.7973\n0.2935 0.3491 0.4614 0.5593 0.637 0.7686\n0.2935 0.3491 0.4614 0.5593 0.637 0.7686\n0.2935 0.3491 0.4614 0.5593 0.637 0.7686\n0.2935 0.3491 0.4614 0.5593 0.637 0.7686\n0.2935 0.3491 0.4614 0.5593 0.637 0.7686\n0.3201 0.3473 0.4251 0.5029 0.5801 0.7195\n0.3378 0.3526 0.4144 0.482 0.5581 0.6997\n0.3378 0.3526 0.4144 0.482 0.5581 0.6997\n0.3357 0.3413 0.3879 0.4491 0.5269 0.6761\n0.3357 0.3413 0.3879 0.4491 0.5269 0.6761\n0.3357 0.3413 0.3879 0.4491 0.5269 0.6761\n0.3123 0.3216 0.3574 0.4147 0.4891 0.6252\n0.4314 0.658 0.7379 0.8109 0.8473 0.8741\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4583 0.6937 0.7829 0.8584 0.8879 0.9088\n0.4431 0.6714 0.7713 0.856 0.8942 0.9139\n0.1765 0.2474 0.3716 0.5311 0.6292 0.7422\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.1828 0.2558 0.3754 0.5273 0.6195 0.7362\n0.2233 0.2924 0.4192 0.5806 0.6731 0.7736\n0.2908 0.3649 0.5033 0.6605 0.7306 0.8077\n0.3192 0.3962 0.5416 0.6935 0.7542 0.823\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.3539 0.4327 0.5795 0.7235 0.7748 0.833\n0.358 0.437 0.5856 0.7305 0.7796 0.8346\n0.3492 0.4273 0.5743 0.7173 0.767 0.8243\n0.4026 0.497 0.655 0.7973 0.8288 0.8758\n0.4026 0.497 0.655 0.7973 0.8288 0.8758\n0.4112 0.5093 0.6684 0.8087 0.8387 0.8842\n0.4037 0.5294 0.7046 0.8432 0.8623 0.8983\n0.3074 0.4647 0.6644 0.8031 0.8237 0.8494\n0.2737 0.4513 0.6859 0.8328 0.8386 0.848\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2499 0.407 0.658 0.8182 0.824 0.8301\n0.2307 0.3106 0.4088 0.5177 0.5814 0.6599\n0.2816 0.3768 0.4739 0.5841 0.664 0.7505\n0.2785 0.3732 0.4712 0.5888 0.6712 0.7639\n0.2785 0.3732 0.4712 0.5888 0.6712 0.7639\n0.3105 0.4191 0.5244 0.6334 0.7076 0.7993\n0.3105 0.4191 0.5244 0.6334 0.7076 0.7993\n0.3105 0.4191 0.5244 0.6334 0.7076 0.7993\n0.3105 0.4191 0.5244 0.6334 0.7076 0.7993\n0.3105 0.4191 0.5244 0.6334 0.7076 0.7993\n0.3354 0.4322 0.5204 0.6224 0.7011 0.7816\n0.373 0.4894 0.6278 0.7332 0.7835 0.8184\n0.4062 0.5344 0.7023 0.8188 0.8533 0.8717\n0.4373 0.5715 0.7322 0.8559 0.8865 0.9022\n0.4373 0.5715 0.7322 0.8559 0.8865 0.9022\n0.4373 0.5715 0.7322 0.8559 0.8865 0.9022\n0.4373 0.5715 0.7322 0.8559 0.8865 0.9022\n0.4373 0.5715 0.7322 0.8559 0.8865 0.9022\n0.4722 0.606 0.764 0.884 0.9047 0.9229\n0.4722 0.606 0.764 0.884 0.9047 0.9229\n0.4722 0.606 0.764 0.884 0.9047 0.9229\n0.4808 0.6137 0.7683 0.8929 0.9113 0.9309\n0.4581 0.5843 0.7331 0.8589 0.885 0.9089\n0.4581 0.5843 0.7331 0.8589 0.885 0.9089\n0.293 0.3757 0.4885 0.6133 0.6892 0.7436\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2631 0.3346 0.4262 0.5401 0.6255 0.6888\n0.2224 0.2975 0.4346 0.5602 0.633 0.6967\n0.2383 0.3281 0.5759 0.7125 0.7647 0.8476\n0.2306 0.3212 0.5679 0.7106 0.7635 0.846\n0.2306 0.3212 0.5679 0.7106 0.7635 0.846\n0.2306 0.3212 0.5679 0.7106 0.7635 0.846\n0.2306 0.3212 0.5679 0.7106 0.7635 0.846\n0.2174 0.301 0.5176 0.6724 0.7231 0.7904\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2138 0.2923 0.4763 0.6138 0.657 0.7216\n0.2243 0.2984 0.4601 0.5819 0.6193 0.6808\n0.3852 0.4586 0.5632 0.6374 0.6573 0.7143\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4503 0.5283 0.6221 0.6925 0.7101 0.7565\n0.4738 0.5529 0.6364 0.7007 0.715 0.7586\n0.4598 0.5719 0.6535 0.7004 0.7253 0.794\n0.4309 0.583 0.667 0.6958 0.7354 0.8366\n0.4905 0.6258 0.7101 0.7393 0.78 0.8736\n0.4905 0.6258 0.7101 0.7393 0.78 0.8736\n0.4905 0.6258 0.7101 0.7393 0.78 0.8736\n0.4905 0.6258 0.7101 0.7393 0.78 0.8736\n0.4905 0.6258 0.7101 0.7393 0.78 0.8736\n0.538 0.6516 0.7435 0.7774 0.8166 0.8952\n0.538 0.6516 0.7435 0.7774 0.8166 0.8952\n0.4705 0.6368 0.734 0.8257 0.8886 0.9357\n0.4667 0.6263 0.7217 0.8112 0.8788 0.9248\n0.4667 0.6263 0.7217 0.8112 0.8788 0.9248\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4631 0.6209 0.711 0.8026 0.876 0.9221\n0.4659 0.6278 0.7152 0.8059 0.8814 0.9244\n0.4491 0.6174 0.6992 0.7925 0.8734 0.9177\n0.5244 0.6401 0.7233 0.8024 0.8591 0.9003\n0.5921 0.6604 0.7451 0.8112 0.8463 0.8847\n0.6591 0.7142 0.7852 0.8387 0.8721 0.9122\n0.6591 0.7142 0.7852 0.8387 0.8721 0.9122\n0.6591 0.7142 0.7852 0.8387 0.8721 0.9122\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6772 0.7243 0.7866 0.8385 0.8743 0.9189\n0.6652 0.7074 0.7623 0.8139 0.8569 0.9214\n0.6652 0.7074 0.7623 0.8139 0.8569 0.9214\n0.6652 0.7074 0.7623 0.8139 0.8569 0.9214\n0.638 0.6824 0.7348 0.7885 0.8367 0.9084\n0.6354 0.6753 0.7207 0.7704 0.8229 0.9052\n0.6354 0.6753 0.7207 0.7704 0.8229 0.9052\n0.6354 0.6753 0.7207 0.7704 0.8229 0.9052\n0.5431 0.6024 0.6472 0.7022 0.7589 0.8386\n0.3206 0.4338 0.4831 0.5479 0.6102 0.6688\n0.2824 0.438 0.4982 0.5747 0.655 0.6935\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.2753 0.4547 0.5151 0.5875 0.6681 0.7001\n0.1863 0.3491 0.4153 0.5281 0.6479 0.6657\n0.3625 0.5142 0.6632 0.772 0.8371 0.8503\n0.4693 0.6143 0.8134 0.9198 0.9517 0.9622\n0.4679 0.607 0.7939 0.8995 0.9354 0.9516\n0.5355 0.6803 0.8251 0.905 0.9342 0.9561\n0.559 0.6958 0.8282 0.9031 0.933 0.9533\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5635 0.6933 0.8223 0.8998 0.9353 0.9569\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.5077 0.6116 0.7322 0.8297 0.8909 0.9279\n0.4897 0.598 0.7216 0.8187 0.8786 0.919\n0.4897 0.598 0.7216 0.8187 0.8786 0.919\n0.4897 0.598 0.7216 0.8187 0.8786 0.919\n0.4684 0.5746 0.6947 0.7913 0.8489 0.8891\n0.2074 0.2669 0.3669 0.4308 0.5344 0.6302\n0.2228 0.2769 0.37 0.4278 0.5366 0.6582\n0.2228 0.2769 0.37 0.4278 0.5366 0.6582\n0.2228 0.2769 0.37 0.4278 0.5366 0.6582\n0.2228 0.2769 0.37 0.4278 0.5366 0.6582\n0.2228 0.2769 0.37 0.4278 0.5366 0.6582\n0.2722 0.3094 0.3753 0.417 0.5032 0.6221\n0.2952 0.3213 0.3706 0.4038 0.4762 0.5874\n0.2813 0.2965 0.3353 0.362 0.4255 0.533\n0.2813 0.2965 0.3353 0.362 0.4255 0.533\n0.2813 0.2965 0.3353 0.362 0.4255 0.533\n0.2813 0.2965 0.3353 0.362 0.4255 0.533\n0.2554 0.2708 0.2962 0.3223 0.3784 0.4809\n0.5043 0.6309 0.7191 0.8041 0.9023 0.9328\n0.5043 0.6309 0.7191 0.8041 0.9023 0.9328\n0.5043 0.6309 0.7191 0.8041 0.9023 0.9328\n0.5043 0.6309 0.7191 0.8041 0.9023 0.9328\n0.5043 0.6309 0.7191 0.8041 0.9023 0.9328\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.5348 0.6461 0.7067 0.8183 0.9137 0.9421\n0.3684 0.4919 0.534 0.6744 0.7595 0.813\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.1833 0.2627 0.3063 0.4222 0.5118 0.5825\n0.39 0.4628 0.5833 0.7341 0.8297 0.8827\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4938 0.572 0.6935 0.8198 0.8753 0.9008\n0.4385 0.5249 0.6517 0.7888 0.8556 0.8848\n0.4385 0.5249 0.6517 0.7888 0.8556 0.8848\n0.4049 0.4938 0.6254 0.7697 0.8423 0.875\n0.4071 0.5002 0.6384 0.776 0.8395 0.8624\n0.4071 0.5002 0.6384 0.776 0.8395 0.8624\n0.4071 0.5002 0.6384 0.776 0.8395 0.8624\n0.4071 0.5002 0.6384 0.776 0.8395 0.8624\n0.3625 0.5056 0.6738 0.8068 0.8511 0.8659\n0.3209 0.498 0.6971 0.8295 0.8548 0.8625\n0.2857 0.4676 0.6873 0.8283 0.8456 0.8517\n0.2607 0.4224 0.6591 0.8133 0.8306 0.8363\n0.2462 0.4096 0.6556 0.8133 0.8276 0.8325\n0.2462 0.4096 0.6556 0.8133 0.8276 0.8325\n0.2462 0.4096 0.6556 0.8133 0.8276 0.8325\n0.2462 0.4096 0.6556 0.8133 0.8276 0.8325\n0.2462 0.4096 0.6556 0.8133 0.8276 0.8325\n0.1989 0.2764 0.3691 0.5075 0.583 0.6466\n0.2494 0.3379 0.4424 0.5686 0.6675 0.7335\n0.2494 0.3379 0.4424 0.5686 0.6675 0.7335\n0.2494 0.3379 0.4424 0.5686 0.6675 0.7335\n0.275 0.3784 0.4957 0.6221 0.7095 0.7849\n0.275 0.3784 0.4957 0.6221 0.7095 0.7849\n0.275 0.3784 0.4957 0.6221 0.7095 0.7849\n0.275 0.3784 0.4957 0.6221 0.7095 0.7849\n0.275 0.3784 0.4957 0.6221 0.7095 0.7849\n0.3007 0.3899 0.4928 0.5987 0.7022 0.7514\n0.3625 0.4778 0.6212 0.7354 0.798 0.8235\n0.3938 0.5182 0.6868 0.8034 0.857 0.8656\n0.3901 0.51 0.672 0.7888 0.8449 0.8594\n0.3901 0.51 0.672 0.7888 0.8449 0.8594\n0.3901 0.51 0.672 0.7888 0.8449 0.8594\n0.3901 0.51 0.672 0.7888 0.8449 0.8594\n0.3901 0.51 0.672 0.7888 0.8449 0.8594\n0.466 0.5899 0.7549 0.8683 0.9068 0.9183\n0.466 0.5899 0.7549 0.8683 0.9068 0.9183\n0.466 0.5899 0.7549 0.8683 0.9068 0.9183\n0.4765 0.5989 0.7622 0.8737 0.9067 0.9262\n0.4452 0.5619 0.7182 0.8315 0.8737 0.9\n0.4452 0.5619 0.7182 0.8315 0.8737 0.9\n0.305 0.3969 0.5183 0.6352 0.7167 0.7711\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2766 0.36 0.4605 0.5697 0.6607 0.7248\n0.2406 0.3152 0.3898 0.4852 0.5851 0.6577\n0.2341 0.3297 0.6059 0.7466 0.8084 0.8921\n0.2341 0.3297 0.6059 0.7466 0.8084 0.8921\n0.2341 0.3297 0.6059 0.7466 0.8084 0.8921\n0.2341 0.3297 0.6059 0.7466 0.8084 0.8921\n0.2341 0.3297 0.6059 0.7466 0.8084 0.8921\n0.2066 0.2843 0.5092 0.6645 0.7285 0.7866\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.23 0.3038 0.4998 0.6358 0.6953 0.7494\n0.2473 0.3168 0.4891 0.6079 0.6662 0.7157\n0.2869 0.3507 0.4899 0.5848 0.6372 0.6841\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4292 0.4915 0.6057 0.6773 0.7103 0.7589\n0.4652 0.5266 0.6258 0.6865 0.7135 0.7614\n0.4763 0.5579 0.6557 0.7066 0.7392 0.7938\n0.4986 0.6206 0.7154 0.747 0.7906 0.8586\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.5645 0.6571 0.7587 0.7989 0.8455 0.9232\n0.326 0.4804 0.6323 0.7385 0.8141 0.8864\n0.3324 0.4911 0.6222 0.7301 0.8093 0.8824\n0.3324 0.4911 0.6222 0.7301 0.8093 0.8824\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.3392 0.498 0.6368 0.74 0.8164 0.8843\n0.4053 0.5434 0.6728 0.7676 0.8274 0.8825\n0.6427 0.7065 0.8019 0.8666 0.8668 0.8762\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.7507 0.8064 0.8871 0.9321 0.9319 0.9386\n0.8049 0.8586 0.9281 0.9544 0.9602 0.9679\n0.1901 0.2494 0.3334 0.3827 0.4049 0.4544\n0.1888 0.251 0.3397 0.3907 0.4129 0.464\n0.1888 0.251 0.3397 0.3907 0.4129 0.464\n0.1888 0.251 0.3397 0.3907 0.4129 0.464\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.1966 0.2752 0.3935 0.4659 0.4927 0.5396\n0.2099 0.2877 0.411 0.4923 0.5265 0.5738\n0.2094 0.2823 0.4014 0.4827 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0.4512 0.5517 0.6004 0.6184\n0.2347 0.3148 0.4512 0.5517 0.6004 0.6184\n0.2347 0.3148 0.4512 0.5517 0.6004 0.6184\n0.2347 0.3148 0.4512 0.5517 0.6004 0.6184\n0.2573 0.3123 0.4027 0.4835 0.5438 0.5772\n0.2804 0.3229 0.3915 0.4628 0.5284 0.5662\n0.2734 0.3032 0.3492 0.4111 0.4845 0.5318\n0.2734 0.3032 0.3492 0.4111 0.4845 0.5318\n0.2734 0.3032 0.3492 0.4111 0.4845 0.5318\n0.2734 0.3032 0.3492 0.4111 0.4845 0.5318\n0.2544 0.2792 0.3203 0.3792 0.446 0.4903\n0.5251 0.7005 0.7921 0.8527 0.8486 0.8517\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.5275 0.7128 0.7952 0.8663 0.8697 0.8729\n0.4446 0.5674 0.6713 0.7459 0.7844 0.8262\n0.1466 0.2393 0.3961 0.4694 0.5629 0.7148\n0.1728 0.2582 0.4077 0.4883 0.5811 0.7242\n0.1728 0.2582 0.4077 0.4883 0.5811 0.7242\n0.1728 0.2582 0.4077 0.4883 0.5811 0.7242\n0.1728 0.2582 0.4077 0.4883 0.5811 0.7242\n0.1728 0.2582 0.4077 0.4883 0.5811 0.7242\n0.1953 0.2658 0.3956 0.4838 0.5807 0.7167\n0.1953 0.2658 0.3956 0.4838 0.5807 0.7167\n0.2286 0.2946 0.4193 0.5212 0.6218 0.7491\n0.2628 0.329 0.4552 0.5619 0.6579 0.7721\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3089 0.3736 0.5004 0.6134 0.7019 0.7963\n0.3136 0.3779 0.5071 0.6231 0.7089 0.7993\n0.2876 0.3525 0.4835 0.5901 0.6724 0.7683\n0.3709 0.4994 0.6847 0.7863 0.8287 0.8726\n0.3709 0.4994 0.6847 0.7863 0.8287 0.8726\n0.3834 0.5199 0.7111 0.812 0.8491 0.8858\n0.3942 0.5432 0.7446 0.8438 0.8746 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0\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n0 0 0 0 0 0\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n-0.0195 -0.0522 -0.0122 -0.022 -0.0248 -0.0175\n-0.0175 -0.0487 -0.0154 -0.0315 -0.0432 -0.0302\n-0.0187 -0.0441 -0.0142 -0.0338 -0.0483 -0.0383\n-0.0176 -0.0413 -0.0129 -0.0375 -0.0566 -0.0445\n-0.0176 -0.0413 -0.0129 -0.0375 -0.0566 -0.0445\n-0.0176 -0.0413 -0.0129 -0.0375 -0.0566 -0.0445\n-0.0169 -0.0373 -0.0131 -0.0401 -0.0643 -0.0556\n-0.0191 -0.0255 -0.015 -0.0505 -0.089 -0.0957\n-0.0191 -0.0255 -0.015 -0.0505 -0.089 -0.0957\n-0.0191 -0.0255 -0.015 -0.0505 -0.089 -0.0957\n-0.0191 -0.0255 -0.015 -0.0505 -0.089 -0.0957\n-0.0191 -0.0255 -0.015 -0.0505 -0.089 -0.0957\n-0.0188 -0.0227 -0.0145 -0.0526 -0.0935 -0.1031\n0.00318 -0.038 -0.0345 -0.078 -0.1759 -0.1859\n-0.0008 -0.017 -0.0207 -0.0688 -0.167 -0.2011\n-0.002 -0.0159 -0.0196 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-0.1701\n-0.0298 -0.0853 -0.1346 -0.1976 -0.2717 -0.2152\n-0.0316 -0.1119 -0.1838 -0.2617 -0.3258 -0.2481\n-0.033 -0.0984 -0.1739 -0.268 -0.341 -0.2606\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n-0.0328 -0.1011 -0.181 -0.2693 -0.3399 -0.2611\n0 0 0 0 0 0\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n0 0 0 0 0 0\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n0 0 0 0 0 0\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0243 -0.0407 -0.0193 -0.0179 -0.0194 -0.0151\n-0.0236 -0.0436 -0.0218 -0.0178 -0.0203 -0.0223\n-0.0224 -0.0471 -0.0232 -0.0169 -0.0217 -0.0245\n-0.0223 -0.0486 -0.0216 -0.0165 -0.0228 -0.0271\n0 0 0 0 0 0\n0 0 0 0 0 0\n-0.0223 -0.0486 -0.0216 -0.0165 -0.0228 -0.0271\n-0.0223 -0.0486 -0.0216 -0.0165 -0.0228 -0.0271\n-0.0221 -0.0471 -0.021 -0.0155 -0.022 -0.0251\n-0.0199 -0.0387 -0.0225 -0.0114 -0.0134 -0.0203\n-0.0205 -0.033 -0.0248 -0.0084 -0.0074 -0.0153\n-0.0199 -0.0303 -0.0263 -0.0049 -0.0024 -0.0125\n-0.0161 -0.0302 -0.0302 -0.0035 -0.0003 -0.012\n-0.0157 -0.0286 -0.0314 -0.0025 0.00162 -0.011\n-0.0157 -0.0286 -0.0314 -0.0025 0.00162 -0.011\n-0.0157 -0.0286 -0.0314 -0.0025 0.00162 -0.011\n-0.0157 -0.0286 -0.0314 -0.0025 0.00162 -0.011\n-0.0157 -0.0286 -0.0314 -0.0025 0.00162 -0.011\n0 0 0 0 0 0\n0 0 0 0 0 0\n0 0 0 0 0 0\n-0.0143 0.00011 -0.0234 -0.0522 -0.0449 -0.0625\n-0.008 0.00019 -0.0262 -0.057 -0.0488 -0.0608\n-0.008 0.00019 -0.0262 -0.057 -0.0488 -0.0608\n-0.008 0.00019 -0.0262 -0.057 -0.0488 -0.0608\n-0.0103 -0.0044 -0.0101 -0.0439 -0.0387 -0.0412\n0 0 0 0 0 0\n-0.0103 -0.0044 -0.0101 -0.0439 -0.0387 -0.0412\n-0.0103 -0.0044 -0.0101 -0.0439 -0.0387 -0.0412\n-0.0103 -0.0044 -0.0101 -0.0439 -0.0387 -0.0412\n-0.0103 -0.0044 -0.0101 -0.0439 -0.0387 -0.0412\n-0.0009 0.00684 -0.0204 -0.0487 -0.0374 -0.0604\n-0.0124 -0.0066 -0.0172 -0.0256 -0.0149 -0.0311\n-0.0188 -0.0115 -0.0181 -0.0134 -0.0022 -0.0124\n-0.0158 -0.0199 -0.0202 -0.0136 -0.0026 -0.0072\n-0.0158 -0.0199 -0.0202 -0.0136 -0.0026 -0.0072\n-0.0158 -0.0199 -0.0202 -0.0136 -0.0026 -0.0072\n-0.0158 -0.0199 -0.0202 -0.0136 -0.0026 -0.0072\n-0.0158 -0.0199 -0.0202 -0.0136 -0.0026 -0.0072\n0 0 0 0 0 0\n-0.0214 -0.0102 -0.025 -0.0108 -0.0016 0.00193\n-0.0214 -0.0102 -0.025 -0.0108 -0.0016 0.00193\n-0.0214 -0.0102 -0.025 -0.0108 -0.0016 0.00193\n-0.0219 -0.0107 -0.03 -0.011 -0.0022 0.00619\n-0.0227 -0.0135 -0.0365 -0.0168 -0.008 -0.0001\n-0.0227 -0.0135 -0.0365 -0.0168 -0.008 -0.0001\n-0.0267 -0.0333 -0.0743 -0.0581 -0.0468 -0.0518\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n0 0 0 0 0 0\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0254 -0.035 -0.0693 -0.067 -0.0575 -0.0722\n-0.0217 -0.0321 -0.0572 -0.0619 -0.0531 -0.0786\n-0.0089 -0.0185 -0.0265 -0.0193 -0.023 -0.0293\n-0.0093 -0.0154 -0.0245 -0.0192 -0.0227 -0.0309\n-0.0093 -0.0154 -0.0245 -0.0192 -0.0227 -0.0309\n0 0 0 0 0 0\n-0.0093 -0.0154 -0.0245 -0.0192 -0.0227 -0.0309\n-0.0093 -0.0154 -0.0245 -0.0192 -0.0227 -0.0309\n-0.0093 -0.0154 -0.0245 -0.0192 -0.0227 -0.0309\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n0.00229 -0.0202 -0.011 -0.0066 -0.0266 -0.0526\n-0.0052 -0.0145 -0.0132 -0.0119 -0.0221 -0.0458\n-0.0181 -0.0128 -0.0014 -0.0125 -0.0148 -0.0272\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0187 -0.0038 0.0008 -0.0095 -0.0126 -0.0217\n-0.0264 -0.0117 -0.0002 -0.0156 -0.0269 -0.0216\n-0.0331 -0.0179 -0.0009 -0.0195 -0.0434 -0.0209\n-0.0355 -0.0162 -0.0021 -0.0187 -0.0391 -0.0192\n-0.0355 -0.0162 -0.0021 -0.0187 -0.0391 -0.0192\n-0.0355 -0.0162 -0.0021 -0.0187 -0.0391 -0.0192\n0 0 0 0 0 0\n-0.0386 -0.0191 -0.0032 -0.0215 -0.042 -0.0206\n-0.0386 -0.0191 -0.0032 -0.0215 -0.042 -0.0206\n-0.0372 -0.0141 -0.0051 -0.016 -0.0315 -0.0186\n-0.0372 -0.0141 -0.0051 -0.016 -0.0315 -0.0186\nVL\nCL\nNt\nCt\n50\n100\n150\n200\nVL\nCL\nNt\nCt\n50\n100\n150\n200\nAL GL MM H3 H6 H7 H9 H16 MGC\nAL GL MM H3 H6 H7 H9 H16 MGC\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\nDeuterium Uptake of LC Isoforms – Percent Deuterium Uptake\n15 30 45 60 75 90 100\nPercent Deuterium Uptake\nNo data\n0\n-25 -15 -10 -5 0 5 10\n% Deuterium Difference\n15 20 25 30\nNo data\n-30 -20\nNo change\n1\n2\n3\nC’\nA\nB\nC\nD\nE\nF\nG\nH\nA\nB\nC\nD\nE\nF\nG\n1\n2\n3\nC’\nA\nB\nC\nD\nE\nF\nG\nH\nA\nB\nC\nD\nE\nF\nG\nEffect of M83 on LC isoforms – Percent Deuterium Difference\n0.3174 0.4367 0.5617 0.6695 0.7476 0.8308\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.3266 0.4515 0.579 0.6834 0.7529 0.8247\n0.5444 0.696 0.7798 0.8606 0.9031 0.9298\n0.5444 0.696 0.7798 0.8606 0.9031 0.9298\n0.5444 0.696 0.7798 0.8606 0.9031 0.9298\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.6227 0.8136 0.8899 0.9381 0.9576 0.976\n0.2742 0.3078 0.4267 0.507 0.5604 0.6083\n0.2885 0.3284 0.4461 0.5246 0.5698 0.6168\n0.2885 0.3284 0.4461 0.5246 0.5698 0.6168\n0.2885 0.3284 0.4461 0.5246 0.5698 0.6168\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.344 0.4007 0.5531 0.659 0.707 0.7405\n0.3226 0.3829 0.5519 0.6877 0.756 0.7861\n0.3933 0.5368 0.7532 0.8758 0.9172 0.9275\n0.4296 0.5847 0.7886 0.8971 0.9386 0.9509\n0.4597 0.6323 0.8326 0.9252 0.9585 0.9691\n0.4766 0.6312 0.8156 0.91 0.9478 0.9658\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4756 0.6265 0.8079 0.9028 0.9421 0.9617\n0.4589 0.5931 0.7669 0.8642 0.9129 0.944\n0.4582 0.5782 0.7359 0.8354 0.8911 0.9263\n0.4587 0.5584 0.6964 0.802 0.8667 0.9109\n0.4587 0.5584 0.6964 0.802 0.8667 0.9109\n0.4587 0.5584 0.6964 0.802 0.8667 0.9109\n0.4606 0.5447 0.6649 0.77 0.8378 0.8845\n0.4073 0.481 0.5747 0.6801 0.7628 0.8169\n0.4073 0.481 0.5747 0.6801 0.7628 0.8169\n0.4073 0.481 0.5747 0.6801 0.7628 0.8169\n0.4073 0.481 0.5747 0.6801 0.7628 0.8169\n0.4073 0.481 0.5747 0.6801 0.7628 0.8169\n0.3949 0.4659 0.5556 0.6614 0.7471 0.8026\n0.14 0.1872 0.3253 0.3923 0.4757 0.593\n0.1895 0.2243 0.3241 0.3731 0.4463 0.5591\n0.1974 0.232 0.3306 0.3776 0.4495 0.563\n0.1974 0.232 0.3306 0.3776 0.4495 0.563\n0.1974 0.232 0.3306 0.3776 0.4495 0.563\n0.1974 0.232 0.3306 0.3776 0.4495 0.563\n0.2341 0.2686 0.3556 0.3995 0.4666 0.5737\n0.2342 0.2582 0.333 0.3728 0.4326 0.5272\n0.243 0.2659 0.3353 0.3741 0.4316 0.5182\n0.243 0.2659 0.3353 0.3741 0.4316 0.5182\n0.2377 0.256 0.3197 0.3566 0.4124 0.4978\n0.2312 0.2434 0.3012 0.3362 0.3879 0.4679\n0.2312 0.2434 0.3012 0.3362 0.3879 0.4679\n0.2271 0.2234 0.261 0.2895 0.3301 0.3877\n0.4265 0.5281 0.608 0.6517 0.6759 0.7266\n0.4492 0.5589 0.6402 0.6811 0.7028 0.7512\n0.4492 0.5589 0.6402 0.6811 0.7028 0.7512\n0.4492 0.5589 0.6402 0.6811 0.7028 0.7512\n0.4492 0.5589 0.6402 0.6811 0.7028 0.7512\n0.4269 0.5266 0.608 0.6548 0.6832 0.7399\n0.4269 0.5266 0.608 0.6548 0.6832 0.7399\n0.4269 0.5266 0.608 0.6548 0.6832 0.7399\n0.4269 0.5266 0.608 0.6548 0.6832 0.7399\n0.2905 0.3511 0.4416 0.5176 0.5688 0.6643\n0.1732 0.2186 0.3172 0.4102 0.4837 0.6137\n0.1523 0.1971 0.2889 0.3731 0.4445 0.5819\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.1395 0.1805 0.2757 0.3652 0.439 0.5746\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4376 0.5496 0.6728 0.7688 0.8421 0.8903\n0.4185 0.5282 0.6578 0.7565 0.8262 0.8706\n0.4059 0.5171 0.6561 0.759 0.8243 0.8671\n0.4032 0.5174 0.6606 0.7601 0.8199 0.8598\n0.4032 0.5174 0.6606 0.7601 0.8199 0.8598\n0.4032 0.5174 0.6606 0.7601 0.8199 0.8598\n0.404 0.5258 0.6709 0.769 0.8258 0.864\n0.3551 0.5215 0.7009 0.8053 0.8429 0.8676\n0.32 0.5059 0.7076 0.8227 0.8474 0.8624\n0.2914 0.4789 0.7011 0.8297 0.8469 0.854\n0.2699 0.4375 0.6744 0.8182 0.8329 0.837\n0.2571 0.4255 0.6709 0.82 0.8315 0.8332\n0.2571 0.4255 0.6709 0.82 0.8315 0.8332\n0.2571 0.4255 0.6709 0.82 0.8315 0.8332\n0.2571 0.4255 0.6709 0.82 0.8315 0.8332\n0.2571 0.4255 0.6709 0.82 0.8315 0.8332\n0.2939 0.3224 0.4134 0.5181 0.5883 0.6559\n0.3339 0.3681 0.4587 0.5565 0.6337 0.7173\n0.3339 0.3681 0.4587 0.5565 0.6337 0.7173\n0.3339 0.3681 0.4587 0.5565 0.6337 0.7173\n0.4022 0.4405 0.5425 0.6263 0.6954 0.786\n0.4022 0.4405 0.5425 0.6263 0.6954 0.786\n0.4022 0.4405 0.5425 0.6263 0.6954 0.786\n0.4022 0.4405 0.5425 0.6263 0.6954 0.786\n0.4022 0.4405 0.5425 0.6263 0.6954 0.786\n0.3741 0.4164 0.4887 0.5631 0.6333 0.7046\n0.3939 0.4957 0.6325 0.7313 0.7851 0.8177\n0.4041 0.5432 0.7112 0.8204 0.869 0.8806\n0.4273 0.5622 0.7327 0.8492 0.8946 0.9042\n0.4273 0.5622 0.7327 0.8492 0.8946 0.9042\n0.4273 0.5622 0.7327 0.8492 0.8946 0.9042\n0.4273 0.5622 0.7327 0.8492 0.8946 0.9042\n0.4273 0.5622 0.7327 0.8492 0.8946 0.9042\n0.4555 0.6065 0.7659 0.8739 0.9136 0.9296\n0.4555 0.6065 0.7659 0.8739 0.9136 0.9296\n0.4555 0.6065 0.7659 0.8739 0.9136 0.9296\n0.4591 0.6165 0.7734 0.8814 0.922 0.9381\n0.4369 0.5854 0.736 0.8484 0.8947 0.9152\n0.4369 0.5854 0.736 0.8484 0.8947 0.9152\n0.2747 0.3618 0.4701 0.6065 0.6919 0.7377\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2489 0.3188 0.398 0.5176 0.6154 0.6749\n0.2475 0.3187 0.3977 0.506 0.598 0.6502\n0.2026 0.2826 0.5645 0.7507 0.8399 0.9231\n0.2004 0.2824 0.558 0.7393 0.82 0.8881\n0.2004 0.2824 0.558 0.7393 0.82 0.8881\n0.2004 0.2824 0.558 0.7393 0.82 0.8881\n0.2004 0.2824 0.558 0.7393 0.82 0.8881\n0.2004 0.2824 0.558 0.7393 0.82 0.8881\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1918 0.2509 0.4094 0.5374 0.5936 0.65\n0.1939 0.2603 0.4286 0.5512 0.6072 0.6572\n0.4402 0.5442 0.6075 0.6471 0.6826 0.7533\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4628 0.5858 0.6608 0.7038 0.7391 0.8111\n0.4562 0.5983 0.6735 0.7143 0.7642 0.8582\n0.4313 0.6008 0.6803 0.7178 0.7879 0.9113\n0.4775 0.6379 0.7099 0.7456 0.8096 0.9231\n0.4775 0.6379 0.7099 0.7456 0.8096 0.9231\n0.4775 0.6379 0.7099 0.7456 0.8096 0.9231\n0.5009 0.6579 0.7243 0.7592 0.8226 0.9348\n0.5009 0.6579 0.7243 0.7592 0.8226 0.9348\n0.547 0.6898 0.7506 0.7849 0.839 0.9331\n0.547 0.6898 0.7506 0.7849 0.839 0.9331\n0.326 0.4353 0.5625 0.6569 0.7002 0.7511\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3255 0.4368 0.5699 0.6675 0.7149 0.7563\n0.3299 0.4507 0.5972 0.6918 0.7407 0.7793\n0.3214 0.4515 0.6157 0.7095 0.7641 0.7927\n0.3822 0.5387 0.7082 0.7986 0.8475 0.8734\n0.4064 0.5765 0.7545 0.8413 0.8883 0.9138\n0.4064 0.5765 0.7545 0.8413 0.8883 0.9138\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4554 0.6526 0.8287 0.898 0.9245 0.9449\n0.4517 0.6419 0.8037 0.8928 0.9355 0.9593\n0.2328 0.2757 0.3939 0.4287 0.4462 0.453\n0.238 0.2818 0.4015 0.4367 0.4538 0.4597\n0.238 0.2818 0.4015 0.4367 0.4538 0.4597\n0.238 0.2818 0.4015 0.4367 0.4538 0.4597\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.285 0.3401 0.4894 0.5353 0.5619 0.5793\n0.2659 0.3187 0.4603 0.5049 0.5339 0.557\n0.2962 0.3492 0.4953 0.5846 0.6467 0.7113\n0.3186 0.3772 0.5413 0.6674 0.7434 0.8197\n0.3444 0.4015 0.5697 0.711 0.7925 0.8723\n0.3856 0.4431 0.6111 0.7562 0.8316 0.9103\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.392 0.4476 0.6097 0.7482 0.8191 0.8965\n0.3746 0.4307 0.592 0.7212 0.7862 0.8566\n0.3793 0.432 0.5823 0.7072 0.7699 0.8407\n0.3992 0.4453 0.573 0.693 0.7548 0.8311\n0.3992 0.4453 0.573 0.693 0.7548 0.8311\n0.3992 0.4453 0.573 0.693 0.7548 0.8311\n0.4077 0.4465 0.548 0.6522 0.7053 0.7842\n0.3663 0.3982 0.4799 0.5658 0.6199 0.709\n0.3663 0.3982 0.4799 0.5658 0.6199 0.709\n0.3663 0.3982 0.4799 0.5658 0.6199 0.709\n0.3663 0.3982 0.4799 0.5658 0.6199 0.709\n0.3663 0.3982 0.4799 0.5658 0.6199 0.709\n0.2891 0.3182 0.4038 0.471 0.5183 0.6141\n0.2527 0.2771 0.3524 0.4062 0.4498 0.5489\n0.2036 0.228 0.3134 0.3407 0.3711 0.4638\n0.2321 0.2601 0.3473 0.3719 0.4038 0.5002\n0.2504 0.2808 0.3685 0.3902 0.4226 0.5037\n0.2504 0.2808 0.3685 0.3902 0.4226 0.5037\n0.2504 0.2808 0.3685 0.3902 0.4226 0.5037\n0.2764 0.307 0.392 0.4145 0.4469 0.5209\n0.2764 0.307 0.392 0.4145 0.4469 0.5209\n0.2764 0.307 0.392 0.4145 0.4469 0.5209\n0.2764 0.307 0.392 0.4145 0.4469 0.5209\n0.2534 0.2801 0.3563 0.3806 0.4078 0.4855\n0.2382 0.2631 0.3316 0.354 0.3848 0.4496\n0.2382 0.2631 0.3316 0.354 0.3848 0.4496\n0.2287 0.2575 0.3178 0.3459 0.3766 0.4357\n0.4012 0.4355 0.5272 0.6555 0.6579 0.6601\n0.4012 0.4355 0.5272 0.6555 0.6579 0.6601\n0.4012 0.4355 0.5272 0.6555 0.6579 0.6601\n0.4012 0.4355 0.5272 0.6555 0.6579 0.6601\n0.4012 0.4355 0.5272 0.6555 0.6579 0.6601\n0.3576 0.4056 0.4759 0.579 0.6029 0.6373\n0.3576 0.4056 0.4759 0.579 0.6029 0.6373\n0.3576 0.4056 0.4759 0.579 0.6029 0.6373\n0.3576 0.4056 0.4759 0.579 0.6029 0.6373\n0.1794 0.2225 0.275 0.3408 0.3887 0.4891\n0.1462 0.1847 0.2429 0.3088 0.3616 0.4676\n0.1315 0.1679 0.2305 0.2937 0.3499 0.4577\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.1211 0.1534 0.2162 0.2795 0.3353 0.4471\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.4629 0.5408 0.6621 0.769 0.8444 0.9002\n0.441 0.5183 0.6416 0.7525 0.8238 0.874\n0.4234 0.5022 0.6382 0.7557 0.8224 0.8671\n0.4217 0.5037 0.6444 0.7584 0.8143 0.8545\n0.4217 0.5037 0.6444 0.7584 0.8143 0.8545\n0.4217 0.5037 0.6444 0.7584 0.8143 0.8545\n0.4217 0.5037 0.6444 0.7584 0.8143 0.8545\n0.3525 0.5062 0.7 0.8139 0.8437 0.8659\n0.3097 0.4941 0.7177 0.8398 0.8519 0.8599\n0.2712 0.4603 0.7074 0.8446 0.8476 0.8469\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.249 0.4129 0.6742 0.8245 0.8283 0.8272\n0.3706 0.383 0.4736 0.5678 0.6472 0.7433\n0.3706 0.383 0.4736 0.5678 0.6472 0.7433\n0.3706 0.383 0.4736 0.5678 0.6472 0.7433\n0.4533 0.4653 0.5636 0.6441 0.7112 0.8104\n0.4533 0.4653 0.5636 0.6441 0.7112 0.8104\n0.4533 0.4653 0.5636 0.6441 0.7112 0.8104\n0.4533 0.4653 0.5636 0.6441 0.7112 0.8104\n0.4533 0.4653 0.5636 0.6441 0.7112 0.8104\n0.4018 0.4098 0.4941 0.568 0.6362 0.7094\n0.4007 0.4681 0.595 0.6924 0.7491 0.7865\n0.4001 0.5029 0.6552 0.7665 0.8163 0.8324\n0.4341 0.5421 0.6928 0.8175 0.864 0.8765\n0.4341 0.5421 0.6928 0.8175 0.864 0.8765\n0.4341 0.5421 0.6928 0.8175 0.864 0.8765\n0.4341 0.5421 0.6928 0.8175 0.864 0.8765\n0.4341 0.5421 0.6928 0.8175 0.864 0.8765\n0.4823 0.6001 0.7482 0.8688 0.8991 0.9076\n0.4823 0.6001 0.7482 0.8688 0.8991 0.9076\n0.4823 0.6001 0.7482 0.8688 0.8991 0.9076\n0.4903 0.6113 0.7526 0.8785 0.9061 0.9157\n0.4587 0.5741 0.7094 0.8384 0.8751 0.8908\n0.4587 0.5741 0.7094 0.8384 0.8751 0.8908\n0.3064 0.3963 0.5094 0.6419 0.7187 0.7626\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2681 0.3449 0.4316 0.5561 0.6462 0.7009\n0.2171 0.2976 0.4355 0.5694 0.6432 0.7038\n0.2264 0.3154 0.5775 0.7131 0.7654 0.8504\n0.2421 0.3288 0.5821 0.7207 0.7771 0.8608\n0.2421 0.3288 0.5821 0.7207 0.7771 0.8608\n0.2421 0.3288 0.5821 0.7207 0.7771 0.8608\n0.2421 0.3288 0.5821 0.7207 0.7771 0.8608\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2331 0.3106 0.5264 0.6796 0.7377 0.8073\n0.2458 0.3225 0.5278 0.6759 0.7316 0.8027\n0.366 0.4499 0.5786 0.6637 0.7073 0.7861\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4553 0.5657 0.6659 0.7246 0.7608 0.8456\n0.4791 0.5944 0.6849 0.7363 0.7715 0.859\n0.4721 0.6008 0.6887 0.7357 0.788 0.8882\n0.4546 0.6 0.684 0.7241 0.7927 0.9072\n0.501 0.6326 0.713 0.7535 0.8155 0.9189\n0.501 0.6326 0.713 0.7535 0.8155 0.9189\n0.501 0.6326 0.713 0.7535 0.8155 0.9189\n0.5263 0.6495 0.7271 0.7689 0.829 0.9289\n0.5263 0.6495 0.7271 0.7689 0.829 0.9289\n0.5704 0.6788 0.7513 0.7934 0.8421 0.9297\n0.5704 0.6788 0.7513 0.7934 0.8421 0.9297\n0.3317 0.4474 0.5866 0.6969 0.7374 0.807\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.3584 0.4747 0.617 0.7287 0.7672 0.8281\n0.4537 0.6111 0.7945 0.919 0.9304 0.9483\n0.4537 0.6111 0.7945 0.919 0.9304 0.9483\n0.4537 0.6111 0.7945 0.919 0.9304 0.9483\n0.5292 0.7189 0.8924 0.9705 0.9741 0.9819\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5243 0.7291 0.899 0.9778 0.9748 0.983\n0.5202 0.7454 0.9064 0.9847 0.9745 0.9816\n0.2257 0.2796 0.3828 0.4401 0.4533 0.4671\n0.2263 0.2836 0.3892 0.4516 0.4658 0.4798\n0.2263 0.2836 0.3892 0.4516 0.4658 0.4798\n0.2263 0.2836 0.3892 0.4516 0.4658 0.4798\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2557 0.3248 0.4511 0.5254 0.543 0.5584\n0.2573 0.3301 0.4589 0.536 0.5561 0.5721\n0.2573 0.3301 0.4589 0.536 0.5561 0.5721\n0.2418 0.3112 0.4337 0.5097 0.5272 0.5465\n0.3089 0.3728 0.5072 0.6548 0.7338 0.8131\n0.3438 0.406 0.5592 0.7372 0.831 0.9164\n0.3438 0.406 0.5592 0.7372 0.831 0.9164\n0.3621 0.4256 0.5764 0.7484 0.836 0.9178\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3676 0.4299 0.5747 0.7404 0.8247 0.906\n0.3503 0.4075 0.5459 0.7057 0.786 0.869\n0.3588 0.4109 0.5363 0.6871 0.7623 0.8493\n0.3608 0.4118 0.53 0.6747 0.7519 0.8403\n0.3765 0.4244 0.5278 0.6636 0.7349 0.8245\n0.3784 0.4262 0.5206 0.6351 0.6992 0.7929\n0.3896 0.4353 0.5146 0.6111 0.6656 0.7635\n0.3403 0.3836 0.4556 0.5377 0.5877 0.6862\n0.3403 0.3836 0.4556 0.5377 0.5877 0.6862\n0.3403 0.3836 0.4556 0.5377 0.5877 0.6862\n0.3403 0.3836 0.4556 0.5377 0.5877 0.6862\n0.3403 0.3836 0.4556 0.5377 0.5877 0.6862\n0.2812 0.3231 0.4006 0.4755 0.5239 0.6276\n0.2569 0.2953 0.3669 0.4284 0.4717 0.5781\n0.1942 0.2269 0.3041 0.3419 0.3902 0.4971\n0.2216 0.2532 0.336 0.3704 0.4173 0.5312\n0.2294 0.2603 0.3418 0.375 0.4189 0.5289\n0.2294 0.2603 0.3418 0.375 0.4189 0.5289\n0.2294 0.2603 0.3418 0.375 0.4189 0.5289\n0.2645 0.2944 0.3724 0.4033 0.4476 0.5548\n0.2645 0.2944 0.3724 0.4033 0.4476 0.5548\n0.2645 0.2944 0.3724 0.4033 0.4476 0.5548\n0.2645 0.2944 0.3724 0.4033 0.4476 0.5548\n0.2619 0.2918 0.3681 0.3989 0.441 0.5491\n0.2453 0.2704 0.339 0.3686 0.4074 0.5085\n0.2453 0.2704 0.339 0.3686 0.4074 0.5085\n0.2246 0.2475 0.3103 0.3382 0.3811 0.4872\n0.3776 0.4223 0.5541 0.6548 0.6711 0.69\n0.4139 0.459 0.5852 0.6994 0.7147 0.7364\n0.4139 0.459 0.5852 0.6994 0.7147 0.7364\n0.4139 0.459 0.5852 0.6994 0.7147 0.7364\n0.4139 0.459 0.5852 0.6994 0.7147 0.7364\n0.424 0.5032 0.6309 0.7285 0.7566 0.7978\n0.3903 0.4754 0.5955 0.6881 0.7254 0.7811\n0.3903 0.4754 0.5955 0.6881 0.7254 0.7811\n0.3903 0.4754 0.5955 0.6881 0.7254 0.7811\n0.3656 0.4926 0.6063 0.6762 0.7366 0.8277\n0.2811 0.382 0.4811 0.5512 0.6284 0.7296\n0.2811 0.382 0.4811 0.5512 0.6284 0.7296\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.1458 0.2086 0.2872 0.3596 0.455 0.583\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4515 0.5325 0.6589 0.7799 0.8424 0.8901\n0.4298 0.5138 0.6452 0.7648 0.8231 0.8663\n0.4165 0.5042 0.6467 0.7707 0.8245 0.8631\n0.4138 0.5095 0.6551 0.7731 0.8214 0.8542\n0.48 0.5869 0.7637 0.8961 0.9048 0.9324\n0.48 0.5869 0.7637 0.8961 0.9048 0.9324\n0.48 0.5869 0.7637 0.8961 0.9048 0.9324\n0.4487 0.5828 0.7772 0.909 0.9099 0.9325\n0.3348 0.5016 0.7049 0.8295 0.8441 0.8609\n0.3023 0.4743 0.6983 0.8318 0.8383 0.8512\n0.2773 0.4317 0.6731 0.8175 0.8223 0.8332\n0.2642 0.4205 0.6709 0.8191 0.8204 0.8295\n0.2642 0.4205 0.6709 0.8191 0.8204 0.8295\n0.2642 0.4205 0.6709 0.8191 0.8204 0.8295\n0.2642 0.4205 0.6709 0.8191 0.8204 0.8295\n0.2642 0.4205 0.6709 0.8191 0.8204 0.8295\n0.3177 0.3251 0.4233 0.5221 0.5828 0.6515\n0.3701 0.3913 0.4816 0.5678 0.6404 0.7182\n0.3701 0.3913 0.4816 0.5678 0.6404 0.7182\n0.3701 0.3913 0.4816 0.5678 0.6404 0.7182\n0.4247 0.4425 0.5444 0.6269 0.6881 0.7664\n0.4247 0.4425 0.5444 0.6269 0.6881 0.7664\n0.4247 0.4425 0.5444 0.6269 0.6881 0.7664\n0.4247 0.4425 0.5444 0.6269 0.6881 0.7664\n0.4247 0.4425 0.5444 0.6269 0.6881 0.7664\n0.4107 0.4428 0.5198 0.5887 0.6592 0.7308\n0.4005 0.492 0.6245 0.7256 0.7713 0.7986\n0.4054 0.525 0.6773 0.7912 0.8308 0.8423\n0.4311 0.5485 0.7009 0.8184 0.8616 0.8767\n0.4311 0.5485 0.7009 0.8184 0.8616 0.8767\n0.4311 0.5485 0.7009 0.8184 0.8616 0.8767\n0.4311 0.5485 0.7009 0.8184 0.8616 0.8767\n0.4311 0.5485 0.7009 0.8184 0.8616 0.8767\n0.4722 0.5954 0.7448 0.8519 0.8881 0.8879\n0.4722 0.5954 0.7448 0.8519 0.8881 0.8879\n0.4722 0.5954 0.7448 0.8519 0.8881 0.8879\n0.4806 0.6037 0.7504 0.8584 0.8953 0.8945\n0.4545 0.5724 0.7135 0.8251 0.8683 0.8736\n0.4545 0.5724 0.7135 0.8251 0.8683 0.8736\n0.3086 0.3954 0.5033 0.6342 0.7066 0.7517\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2804 0.3579 0.4504 0.5728 0.6497 0.7024\n0.2451 0.3134 0.3868 0.4964 0.5718 0.6317\n0.2395 0.3324 0.5796 0.7164 0.7671 0.8614\n0.2395 0.3324 0.5796 0.7164 0.7671 0.8614\n0.2114 0.3067 0.5566 0.7066 0.7592 0.8416\n0.2079 0.3029 0.5556 0.708 0.7591 0.8313\n0.2079 0.3029 0.5556 0.708 0.7591 0.8313\n0.1671 0.2553 0.4972 0.6571 0.7063 0.7525\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.192 0.2708 0.4619 0.5907 0.633 0.6757\n0.2004 0.2707 0.4516 0.5701 0.6098 0.6484\n0.3453 0.4101 0.5318 0.6152 0.6326 0.6795\n0.4076 0.4862 0.598 0.6694 0.6863 0.7438\n0.4406 0.5171 0.6053 0.6624 0.6756 0.7409\n0.4406 0.5171 0.6053 0.6624 0.6756 0.7409\n0.4406 0.5171 0.6053 0.6624 0.6756 0.7409\n0.4406 0.5171 0.6053 0.6624 0.6756 0.7409\n0.4406 0.5171 0.6053 0.6624 0.6756 0.7409\n0.4945 0.5763 0.6565 0.7105 0.7175 0.7921\n0.4757 0.5816 0.6731 0.7222 0.7478 0.839\n0.4266 0.5712 0.6795 0.7227 0.773 0.8844\n0.4874 0.6114 0.7131 0.7563 0.804 0.9053\n0.4874 0.6114 0.7131 0.7563 0.804 0.9053\n0.4874 0.6114 0.7131 0.7563 0.804 0.9053\n0.5139 0.6315 0.7319 0.774 0.823 0.9249\n0.5139 0.6315 0.7319 0.774 0.823 0.9249\n0.5799 0.6776 0.7623 0.8081 0.8498 0.9399\n0.5799 0.6776 0.7623 0.8081 0.8498 0.9399\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.2055 0.2559 0.3931 0.5116 0.6373 0.7295\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5217 0.6256 0.7748 0.8511 0.8885 0.9312\n0.5446 0.6469 0.7896 0.8621 0.8965 0.9359\n0.4312 0.5026 0.6326 0.6904 0.7016 0.7145\n0.4415 0.4952 0.6128 0.6908 0.7095 0.7036\n0.4317 0.4806 0.5958 0.6744 0.6916 0.6813\n0.3741 0.4389 0.5592 0.6325 0.6467 0.64\n0.3593 0.4286 0.5454 0.6159 0.6288 0.6249\n0.3373 0.4241 0.5825 0.6572 0.677 0.6954\n0.3373 0.4241 0.5825 0.6572 0.677 0.6954\n0.2621 0.381 0.5699 0.6367 0.6571 0.6965\n0.2863 0.4145 0.59 0.6572 0.6717 0.7011\n0.2887 0.4212 0.5954 0.6669 0.6825 0.7056\n0.2887 0.4212 0.5954 0.6669 0.6825 0.7056\n0.2559 0.3681 0.4971 0.5703 0.6077 0.649\n0.2559 0.3681 0.4971 0.5703 0.6077 0.649\n0.2559 0.3681 0.4971 0.5703 0.6077 0.649\n0.2559 0.3681 0.4971 0.5703 0.6077 0.649\n0.2559 0.3681 0.4971 0.5703 0.6077 0.649\n0.213 0.3172 0.446 0.5388 0.6006 0.6678\n0.2846 0.3962 0.5271 0.6197 0.6761 0.7359\n0.4771 0.607 0.7423 0.8419 0.888 0.9252\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.507 0.6257 0.7619 0.8579 0.9015 0.9404\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.5034 0.6039 0.7405 0.8278 0.8754 0.9233\n0.4676 0.56 0.7001 0.7878 0.8425 0.8967\n0.4676 0.56 0.7001 0.7878 0.8425 0.8967\n0.4564 0.5403 0.679 0.7658 0.8222 0.8795\n0.2549 0.303 0.3416 0.4102 0.5183 0.6309\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2975 0.3471 0.3958 0.4774 0.5911 0.7147\n0.2918 0.3438 0.3869 0.464 0.5693 0.6901\n0.2801 0.3299 0.3701 0.4429 0.5429 0.6615\n0.2669 0.3133 0.3506 0.4182 0.5084 0.6223\n0.2522 0.2973 0.3311 0.3943 0.479 0.5882\n0.2522 0.2973 0.3311 0.3943 0.479 0.5882\n0.246 0.2947 0.3225 0.3841 0.4612 0.5655\n0.2272 0.2646 0.3076 0.376 0.4582 0.5633\n0.3041 0.6399 0.8492 0.9688 1.0073 0.9871\n0.2835 0.5468 0.8049 0.9197 0.9637 0.964\n0.2735 0.5341 0.8086 0.9001 0.9413 0.9503\n0.2552 0.5002 0.7668 0.8602 0.9066 0.9284\n0.2552 0.5002 0.7668 0.8602 0.9066 0.9284\n0.2552 0.5002 0.7668 0.8602 0.9066 0.9284\n0.2392 0.4546 0.7398 0.8248 0.8736 0.9093\n0.2091 0.3948 0.6517 0.7448 0.8062 0.8633\n0.094 0.1693 0.314 0.4363 0.5554 0.6919\n0.088 0.1553 0.2876 0.4041 0.5298 0.6837\n0.0833 0.1481 0.2677 0.3829 0.5133 0.6796\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.0794 0.1398 0.2523 0.3644 0.4989 0.6727\n0.4416 0.5307 0.638 0.7907 0.8546 0.8909\n0.4416 0.5307 0.638 0.7907 0.8546 0.8909\n0.4416 0.5307 0.638 0.7907 0.8546 0.8909\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.464 0.5582 0.661 0.8032 0.8678 0.9065\n0.4525 0.5487 0.6552 0.7925 0.8548 0.8919\n0.4479 0.546 0.6575 0.7962 0.8554 0.8924\n0.4545 0.5559 0.6693 0.8008 0.8567 0.8924\n0.4545 0.5559 0.6693 0.8008 0.8567 0.8924\n0.4545 0.5559 0.6693 0.8008 0.8567 0.8924\n0.4632 0.5706 0.6834 0.8098 0.8651 0.9009\n0.3605 0.5126 0.6837 0.8237 0.8508 0.8735\n0.3169 0.4843 0.6774 0.8253 0.841 0.8569\n0.2875 0.4613 0.6774 0.8294 0.8355 0.8457\n0.2634 0.4207 0.6546 0.8169 0.8213 0.8313\n0.2494 0.4077 0.6517 0.8171 0.818 0.8268\n0.2494 0.4077 0.6517 0.8171 0.818 0.8268\n0.2494 0.4077 0.6517 0.8171 0.818 0.8268\n0.2496 0.4063 0.6545 0.8185 0.8182 0.8279\n0.2496 0.4063 0.6545 0.8185 0.8182 0.8279\n0.2259 0.3023 0.3973 0.495 0.5497 0.6421\n0.2801 0.3716 0.4662 0.5744 0.6334 0.7354\n0.2801 0.3716 0.4662 0.5744 0.6334 0.7354\n0.2801 0.3716 0.4662 0.5744 0.6334 0.7354\n0.3138 0.4288 0.5288 0.6325 0.6868 0.7874\n0.3138 0.4288 0.5288 0.6325 0.6868 0.7874\n0.3138 0.4288 0.5288 0.6325 0.6868 0.7874\n0.3138 0.4288 0.5288 0.6325 0.6868 0.7874\n0.3138 0.4288 0.5288 0.6325 0.6868 0.7874\n0.3329 0.4279 0.5139 0.624 0.6756 0.7625\n0.3732 0.4818 0.6248 0.7359 0.7803 0.8209\n0.3931 0.5112 0.6705 0.7897 0.831 0.8543\n0.4365 0.5651 0.7194 0.8327 0.8695 0.8901\n0.4365 0.5651 0.7194 0.8327 0.8695 0.8901\n0.4365 0.5651 0.7194 0.8327 0.8695 0.8901\n0.4365 0.5651 0.7194 0.8327 0.8695 0.8901\n0.4365 0.5651 0.7194 0.8327 0.8695 0.8901\n0.4729 0.6003 0.7569 0.8758 0.8939 0.9096\n0.4729 0.6003 0.7569 0.8758 0.8939 0.9096\n0.4729 0.6003 0.7569 0.8758 0.8939 0.9096\n0.4796 0.6093 0.7621 0.883 0.899 0.9142\n0.4539 0.5771 0.7245 0.8462 0.8709 0.8945\n0.4539 0.5771 0.7245 0.8462 0.8709 0.8945\n0.2988 0.3921 0.5092 0.6334 0.7094 0.7692\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.2632 0.3425 0.4293 0.5433 0.634 0.7045\n0.253 0.3266 0.4073 0.5202 0.614 0.6891\n0.241 0.3337 0.4606 0.5848 0.6502 0.7457\n0.2334 0.3297 0.5518 0.687 0.738 0.8341\n0.2247 0.3189 0.5507 0.6873 0.7338 0.8266\n0.2247 0.3189 0.5507 0.6873 0.7338 0.8266\n0.2247 0.3189 0.5507 0.6873 0.7338 0.8266\n0.2247 0.3189 0.5507 0.6873 0.7338 0.8266\n0.1966 0.2836 0.5244 0.6764 0.7176 0.7863\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.1949 0.2733 0.4859 0.6258 0.6627 0.7249\n0.2077 0.283 0.4744 0.608 0.6435 0.6915\n0.4084 0.487 0.5899 0.6594 0.678 0.7328\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4572 0.551 0.6424 0.7058 0.72 0.769\n0.4992 0.6014 0.6825 0.7399 0.7484 0.7973\n0.4796 0.6046 0.6892 0.7306 0.7631 0.8191\n0.4562 0.6037 0.6917 0.7182 0.7765 0.8409\n0.4963 0.636 0.7194 0.7492 0.7992 0.8721\n0.4963 0.636 0.7194 0.7492 0.7992 0.8721\n0.4963 0.636 0.7194 0.7492 0.7992 0.8721\n0.4963 0.636 0.7194 0.7492 0.7992 0.8721\n0.4963 0.636 0.7194 0.7492 0.7992 0.8721\n0.5298 0.6531 0.7323 0.7735 0.8045 0.8811\n0.5298 0.6531 0.7323 0.7735 0.8045 0.8811\n0.4776 0.5962 0.6847 0.7829 0.8375 0.912\n0.4776 0.5962 0.6847 0.7829 0.8375 0.912\n0.4776 0.5962 0.6847 0.7829 0.8375 0.912\n0.4776 0.5962 0.6847 0.7829 0.8375 0.912\n0.4633 0.5876 0.6844 0.7795 0.8347 0.909\n0.4633 0.5876 0.6844 0.7795 0.8347 0.909\n0.4633 0.5876 0.6844 0.7795 0.8347 0.909\n0.4216 0.5639 0.6952 0.7834 0.838 0.9052\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.4123 0.5351 0.6836 0.7901 0.8404 0.9136\n0.3954 0.4824 0.6623 0.8023 0.8449 0.9291\n0.3954 0.4824 0.6623 0.8023 0.8449 0.9291\n0.3954 0.4824 0.6623 0.8023 0.8449 0.9291\n0.3954 0.4824 0.6623 0.8023 0.8449 0.9291\n0.2471 0.2994 0.4285 0.5478 0.6171 0.7134\n0.2581 0.3095 0.4375 0.5611 0.6265 0.7114\n0.2669 0.3174 0.4472 0.5683 0.6309 0.7087\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2779 0.3388 0.4629 0.5773 0.6406 0.7119\n0.2451 0.2941 0.417 0.5224 0.6088 0.7273\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3986 0.4927 0.651 0.759 0.8005 0.8792\n0.3611 0.4481 0.5939 0.7035 0.7493 0.8413\n0.1633 0.2279 0.3203 0.3756 0.4124 0.5219\n0.1633 0.2279 0.3203 0.3756 0.4124 0.5219\n0.159 0.2189 0.302 0.35 0.3903 0.5113\n0.2037 0.2662 0.3475 0.3974 0.4449 0.5879\n0.2037 0.2662 0.3475 0.3974 0.4449 0.5879\n0.2037 0.2662 0.3475 0.3974 0.4449 0.5879\n0.2413 0.3051 0.382 0.4316 0.4875 0.6519\n0.3159 0.3608 0.4594 0.5087 0.5595 0.7246\n0.3098 0.3566 0.4529 0.5075 0.5564 0.7204\n0.3098 0.3566 0.4529 0.5075 0.5564 0.7204\n0.3098 0.3566 0.4529 0.5075 0.5564 0.7204\n0.3098 0.3566 0.4529 0.5075 0.5564 0.7204\n0.3057 0.3457 0.4432 0.4951 0.5403 0.699\n0.3057 0.3457 0.4432 0.4951 0.5403 0.699\n0.2729 0.326 0.4014 0.4501 0.4994 0.6545\n0.3292 0.4196 0.5549 0.6516 0.7144 0.7866\n0.3239 0.4148 0.5505 0.6493 0.7115 0.7873\n0.3239 0.4148 0.5505 0.6493 0.7115 0.7873\n0.3239 0.4148 0.5505 0.6493 0.7115 0.7873\n0.3239 0.4148 0.5505 0.6493 0.7115 0.7873\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2568 0.3202 0.451 0.5533 0.6262 0.7306\n0.2947 0.3605 0.4895 0.599 0.6739 0.7641\n0.2947 0.3605 0.4895 0.599 0.6739 0.7641\n0.2947 0.3605 0.4895 0.599 0.6739 0.7641\n0.3054 0.3602 0.4951 0.6098 0.684 0.7653\n0.3413 0.405 0.5415 0.6497 0.7216 0.7998\n0.3413 0.405 0.5415 0.6497 0.7216 0.7998\n0.3413 0.405 0.5415 0.6497 0.7216 0.7998\n0.3413 0.405 0.5415 0.6497 0.7216 0.7998\n0.346 0.4205 0.5533 0.6556 0.7272 0.8108\n0.346 0.4205 0.5533 0.6556 0.7272 0.8108\n0.3508 0.4275 0.5608 0.6628 0.7332 0.8137\n0.3586 0.4372 0.5731 0.6743 0.7424 0.8211\n0.3688 0.4501 0.5873 0.6863 0.7522 0.829\n0.3688 0.4501 0.5873 0.6863 0.7522 0.829\n0.3688 0.4501 0.5873 0.6863 0.7522 0.829\n0.3503 0.4392 0.5765 0.6751 0.7358 0.8102\n0.3334 0.4707 0.6455 0.7483 0.7877 0.8381\n0.3242 0.4933 0.7037 0.813 0.8317 0.8594\n0.2685 0.4574 0.7118 0.8418 0.8398 0.8467\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2466 0.4108 0.682 0.8256 0.8222 0.8313\n0.2362 0.3096 0.425 0.5066 0.5827 0.6641\n0.2721 0.3556 0.4675 0.5594 0.6367 0.7359\n0.2733 0.3568 0.4779 0.5677 0.6537 0.7631\n0.2733 0.3568 0.4779 0.5677 0.6537 0.7631\n0.3039 0.4092 0.5225 0.613 0.697 0.8204\n0.3039 0.4092 0.5225 0.613 0.697 0.8204\n0.3039 0.4092 0.5225 0.613 0.697 0.8204\n0.3039 0.4092 0.5225 0.613 0.697 0.8204\n0.3039 0.4092 0.5225 0.613 0.697 0.8204\n0.3331 0.4104 0.502 0.582 0.6508 0.7259\n0.3849 0.4893 0.6425 0.7433 0.7937 0.8404\n0.4033 0.5174 0.6926 0.8008 0.8446 0.8813\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.4011 0.511 0.6805 0.7919 0.8394 0.8767\n0.3805 0.4882 0.6474 0.7685 0.8151 0.8581\n0.3805 0.4882 0.6474 0.7685 0.8151 0.8581\n0.3805 0.4882 0.6474 0.7685 0.8151 0.8581\n0.353 0.4455 0.5844 0.7091 0.7711 0.8274\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2932 0.3706 0.472 0.5982 0.68 0.7568\n0.2837 0.3572 0.4501 0.5771 0.6652 0.7434\n0.2524 0.3198 0.4054 0.5284 0.6135 0.6998\n0.2534 0.3461 0.6037 0.7301 0.7823 0.8782\n0.2446 0.3352 0.5945 0.7277 0.7781 0.8626\n0.2446 0.3352 0.5945 0.7277 0.7781 0.8626\n0.2446 0.3352 0.5945 0.7277 0.7781 0.8626\n0.2446 0.3352 0.5945 0.7277 0.7781 0.8626\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2365 0.3191 0.5517 0.6961 0.7388 0.8074\n0.2504 0.333 0.5421 0.6789 0.7203 0.7818\n0.3771 0.465 0.5881 0.6793 0.7139 0.7949\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4142 0.5081 0.622 0.6975 0.7349 0.8175\n0.4464 0.5458 0.6438 0.7094 0.7444 0.8292\n0.4701 0.5788 0.6716 0.7251 0.763 0.8469\n0.4986 0.6127 0.6958 0.7407 0.7791 0.8629\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.5421 0.6487 0.7324 0.7779 0.8116 0.9088\n0.395 0.503 0.6624 0.772 0.8109 0.8631\n0.395 0.503 0.6624 0.772 0.8109 0.8631\n0.395 0.503 0.6624 0.772 0.8109 0.8631\n0.3841 0.4809 0.6414 0.7526 0.7964 0.8404\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.2808 0.3788 0.5082 0.5945 0.6699 0.7724\n0.2808 0.3788 0.5082 0.5945 0.6699 0.7724\n0.2808 0.3788 0.5082 0.5945 0.6699 0.7724\n0.2808 0.3788 0.5082 0.5945 0.6699 0.7724\n0.2808 0.3788 0.5082 0.5945 0.6699 0.7724\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3196 0.4237 0.5827 0.6952 0.7484 0.8037\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.3687 0.4673 0.6288 0.7414 0.7869 0.8338\n0.395 0.503 0.6624 0.772 0.8109 0.8631\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.2015 0.2687 0.4332 0.5773 0.6267 0.6577\n0.1923 0.2541 0.4059 0.5451 0.599 0.6366\n0.1923 0.2541 0.4059 0.5451 0.599 0.6366\n0.2015 0.2617 0.4091 0.5549 0.6151 0.6618\n0.2242 0.2851 0.4324 0.5905 0.6609 0.7101\n0.2242 0.2851 0.4324 0.5905 0.6609 0.7101\n0.2978 0.3585 0.4961 0.6468 0.7193 0.7771\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3201 0.3809 0.5107 0.6533 0.7243 0.7848\n0.3431 0.4008 0.5238 0.6623 0.7295 0.7905\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.3963 0.4402 0.536 0.6665 0.7141 0.7783\n0.4076 0.449 0.5391 0.6676 0.7128 0.7778\n0.4076 0.449 0.5391 0.6676 0.7128 0.7778\n0.4233 0.4631 0.5462 0.6714 0.7128 0.7795\n0.3185 0.3508 0.4562 0.575 0.6529 0.7943\n0.2821 0.3203 0.4243 0.5113 0.5914 0.7509\n0.2899 0.3307 0.4394 0.526 0.6025 0.7603\n0.2899 0.3307 0.4394 0.526 0.6025 0.7603\n0.2899 0.3307 0.4394 0.526 0.6025 0.7603\n0.2899 0.3307 0.4394 0.526 0.6025 0.7603\n0.2932 0.334 0.4459 0.5243 0.6033 0.7635\n0.2932 0.334 0.4459 0.5243 0.6033 0.7635\n0.2932 0.334 0.4459 0.5243 0.6033 0.7635\n0.2932 0.334 0.4459 0.5243 0.6033 0.7635\n0.2843 0.3296 0.4423 0.5077 0.5846 0.7428\n0.2843 0.3296 0.4423 0.5077 0.5846 0.7428\n0.2576 0.3038 0.4058 0.4517 0.5318 0.6732\n0.2985 0.3815 0.5086 0.629 0.6968 0.7522\n0.2985 0.3815 0.5086 0.629 0.6968 0.7522\n0.2985 0.3815 0.5086 0.629 0.6968 0.7522\n0.2985 0.3815 0.5086 0.629 0.6968 0.7522\n0.2985 0.3815 0.5086 0.629 0.6968 0.7522\n0.2254 0.292 0.4216 0.5506 0.6268 0.6934\n0.2254 0.292 0.4216 0.5506 0.6268 0.6934\n0.2254 0.292 0.4216 0.5506 0.6268 0.6934\n0.2254 0.292 0.4216 0.5506 0.6268 0.6934\n0.2254 0.292 0.4216 0.5506 0.6268 0.6934\n0.2362 0.3036 0.4324 0.5593 0.6358 0.7004\n0.2362 0.3036 0.4324 0.5593 0.6358 0.7004\n0.2362 0.3036 0.4324 0.5593 0.6358 0.7004\n0.2362 0.3036 0.4324 0.5593 0.6358 0.7004\n0.2362 0.3036 0.4324 0.5593 0.6358 0.7004\n0.2938 0.3591 0.4837 0.6138 0.6938 0.752\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3289 0.3932 0.5173 0.6559 0.7377 0.79\n0.3034 0.3718 0.4966 0.6241 0.6981 0.7513\n0.4349 0.5284 0.6937 0.8287 0.8541 0.8933\n0.4349 0.5284 0.6937 0.8287 0.8541 0.8933\n0.4349 0.5284 0.6937 0.8287 0.8541 0.8933\n0.4061 0.5286 0.7134 0.8492 0.8668 0.8948\n0.2881 0.4545 0.6574 0.7963 0.8168 0.829\n0.2706 0.453 0.6879 0.842 0.8441 0.8445\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2647 0.4419 0.685 0.8396 0.8429 0.8437\n0.2323 0.3098 0.4123 0.5188 0.5785 0.644\n0.2535 0.348 0.4478 0.5537 0.6219 0.6993\n0.2535 0.348 0.4478 0.5537 0.6219 0.6993\n0.2535 0.348 0.4478 0.5537 0.6219 0.6993\n0.2961 0.407 0.5141 0.6117 0.6751 0.756\n0.2961 0.407 0.5141 0.6117 0.6751 0.756\n0.2961 0.407 0.5141 0.6117 0.6751 0.756\n0.2961 0.407 0.5141 0.6117 0.6751 0.756\n0.2961 0.407 0.5141 0.6117 0.6751 0.756\n0.3046 0.4058 0.4819 0.5747 0.632 0.7074\n0.3758 0.4883 0.6104 0.732 0.7819 0.8121\n0.4049 0.522 0.6629 0.7963 0.8432 0.8548\n0.427 0.5477 0.6809 0.8213 0.8694 0.8823\n0.427 0.5477 0.6809 0.8213 0.8694 0.8823\n0.427 0.5477 0.6809 0.8213 0.8694 0.8823\n0.427 0.5477 0.6809 0.8213 0.8694 0.8823\n0.427 0.5477 0.6809 0.8213 0.8694 0.8823\n0.4687 0.5846 0.722 0.8568 0.8942 0.9051\n0.4687 0.5846 0.722 0.8568 0.8942 0.9051\n0.4687 0.5846 0.722 0.8568 0.8942 0.9051\n0.4741 0.5901 0.725 0.8611 0.8976 0.9125\n0.4741 0.5901 0.725 0.8611 0.8976 0.9125\n0.4741 0.5901 0.725 0.8611 0.8976 0.9125\n0.3315 0.4263 0.5389 0.6663 0.7383 0.7806\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2849 0.3619 0.457 0.57 0.649 0.7063\n0.2431 0.3068 0.3887 0.49 0.5715 0.641\n0.2444 0.3342 0.5833 0.7248 0.7823 0.8647\n0.2469 0.337 0.581 0.7222 0.7754 0.8519\n0.2369 0.3263 0.572 0.7169 0.77 0.8416\n0.2369 0.3263 0.572 0.7169 0.77 0.8416\n0.2369 0.3263 0.572 0.7169 0.77 0.8416\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.2225 0.3057 0.5247 0.6824 0.7311 0.7764\n0.232 0.314 0.5235 0.6718 0.7175 0.7601\n0.2891 0.3663 0.5405 0.6665 0.7017 0.7419\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.4311 0.4943 0.6284 0.7348 0.7514 0.7878\n0.5072 0.5624 0.6708 0.7613 0.7729 0.812\n0.5071 0.582 0.6857 0.7626 0.7816 0.8353\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.4745 0.5779 0.6828 0.7483 0.7803 0.8562\n0.377 0.5679 0.699 0.7797 0.8556 0.9176\n0.3837 0.5646 0.7023 0.7908 0.879 0.9355\n0.3902 0.57 0.6829 0.7706 0.861 0.9238\n0.3902 0.57 0.6829 0.7706 0.861 0.9238\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.3953 0.5695 0.6851 0.7728 0.8584 0.9194\n0.406 0.5749 0.6845 0.7697 0.847 0.9017\n0.4733 0.6089 0.6806 0.7499 0.7754 0.7902\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.5416 0.6768 0.7395 0.7906 0.8239 0.84\n0.4783 0.6137 0.6824 0.7329 0.761 0.7773\n0.368 0.4948 0.5604 0.6033 0.6373 0.6571\n0.368 0.4948 0.5604 0.6033 0.6373 0.6571\n0.368 0.4948 0.5604 0.6033 0.6373 0.6571\n0.2107 0.3309 0.38 0.4139 0.4575 0.4791\n0.2343 0.3728 0.4429 0.4816 0.5323 0.5642\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.248 0.3965 0.4797 0.5245 0.5767 0.6138\n0.3117 0.3965 0.6136 0.7359 0.8068 0.8459\n0.3191 0.403 0.6134 0.7445 0.8085 0.8492\n0.3285 0.4138 0.6321 0.7562 0.8138 0.8471\n0.3389 0.4274 0.6477 0.7626 0.8128 0.8432\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3636 0.4551 0.6672 0.7678 0.8088 0.8364\n0.3562 0.4472 0.6605 0.757 0.7977 0.8223\n0.3698 0.4579 0.6471 0.7256 0.7555 0.7781\n0.2863 0.3517 0.4626 0.5627 0.6433 0.7798\n0.2863 0.3517 0.4626 0.5627 0.6433 0.7798\n0.2863 0.3517 0.4626 0.5627 0.6433 0.7798\n0.2863 0.3517 0.4626 0.5627 0.6433 0.7798\n0.2863 0.3517 0.4626 0.5627 0.6433 0.7798\n0.3073 0.3509 0.4244 0.5018 0.5816 0.731\n0.3236 0.3565 0.4137 0.4789 0.5581 0.7114\n0.3236 0.3565 0.4137 0.4789 0.5581 0.7114\n0.3196 0.3443 0.3861 0.4441 0.5245 0.6843\n0.3196 0.3443 0.3861 0.4441 0.5245 0.6843\n0.3196 0.3443 0.3861 0.4441 0.5245 0.6843\n0.2945 0.3213 0.3563 0.4061 0.482 0.6257\n0.3935 0.6173 0.72 0.7477 0.7709 0.7996\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4206 0.6514 0.758 0.7933 0.8138 0.8465\n0.4088 0.6284 0.7313 0.7808 0.8156 0.8575\n0.1578 0.2185 0.3143 0.4075 0.5007 0.6219\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.1637 0.228 0.319 0.4038 0.4872 0.6066\n0.208 0.2742 0.3817 0.4991 0.5927 0.6976\n0.2772 0.3512 0.4745 0.6074 0.6813 0.7581\n0.3073 0.3854 0.5157 0.657 0.7212 0.786\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3424 0.4246 0.5586 0.6995 0.7543 0.808\n0.3467 0.4298 0.5668 0.7101 0.7627 0.8127\n0.3387 0.4205 0.5573 0.6949 0.7476 0.8001\n0.3916 0.4975 0.649 0.7865 0.8216 0.8611\n0.3916 0.4975 0.649 0.7865 0.8216 0.8611\n0.3996 0.5119 0.6646 0.7999 0.8322 0.8716\n0.3926 0.5338 0.7057 0.8375 0.8616 0.8906\n0.2972 0.4647 0.6621 0.7917 0.818 0.8414\n0.2645 0.4547 0.6908 0.8291 0.8398 0.8481\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2427 0.4103 0.6639 0.8151 0.8252 0.8324\n0.2244 0.3131 0.4155 0.5121 0.5741 0.6596\n0.2869 0.3833 0.4825 0.5702 0.6493 0.7509\n0.2743 0.3764 0.4833 0.5737 0.6522 0.7667\n0.2743 0.3764 0.4833 0.5737 0.6522 0.7667\n0.3035 0.4244 0.5356 0.6203 0.6929 0.8022\n0.3035 0.4244 0.5356 0.6203 0.6929 0.8022\n0.3035 0.4244 0.5356 0.6203 0.6929 0.8022\n0.3035 0.4244 0.5356 0.6203 0.6929 0.8022\n0.3035 0.4244 0.5356 0.6203 0.6929 0.8022\n0.349 0.4413 0.5296 0.6043 0.6844 0.783\n0.3721 0.4938 0.6319 0.7291 0.7863 0.8244\n0.4052 0.5418 0.7027 0.8161 0.8576 0.8749\n0.4326 0.5744 0.7346 0.8498 0.8887 0.9033\n0.4326 0.5744 0.7346 0.8498 0.8887 0.9033\n0.4326 0.5744 0.7346 0.8498 0.8887 0.9033\n0.4326 0.5744 0.7346 0.8498 0.8887 0.9033\n0.4326 0.5744 0.7346 0.8498 0.8887 0.9033\n0.4655 0.6153 0.7732 0.8817 0.9115 0.9262\n0.4655 0.6153 0.7732 0.8817 0.9115 0.9262\n0.4655 0.6153 0.7732 0.8817 0.9115 0.9262\n0.4728 0.6236 0.7789 0.8901 0.9178 0.9309\n0.4498 0.5934 0.7423 0.8562 0.8905 0.9098\n0.4498 0.5934 0.7423 0.8562 0.8905 0.9098\n0.2851 0.3801 0.4857 0.6097 0.6935 0.7432\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.2545 0.3392 0.4243 0.5352 0.627 0.6867\n0.213 0.3003 0.4366 0.555 0.632 0.6935\n0.2329 0.332 0.5823 0.7105 0.7665 0.8497\n0.2271 0.3246 0.5721 0.7091 0.7653 0.845\n0.2271 0.3246 0.5721 0.7091 0.7653 0.845\n0.2271 0.3246 0.5721 0.7091 0.7653 0.845\n0.2271 0.3246 0.5721 0.7091 0.7653 0.845\n0.2128 0.302 0.5184 0.6689 0.7234 0.784\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.21 0.2947 0.4747 0.607 0.6571 0.7133\n0.218 0.301 0.4591 0.5728 0.6191 0.6745\n0.3815 0.4667 0.5628 0.6328 0.6608 0.7255\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4465 0.5355 0.6221 0.6896 0.7111 0.7642\n0.4705 0.5607 0.6356 0.6979 0.7156 0.7681\n0.4534 0.5753 0.6542 0.7022 0.7299 0.8001\n0.4202 0.5801 0.6699 0.7033 0.7446 0.8372\n0.4813 0.6249 0.7115 0.7455 0.7869 0.8736\n0.4813 0.6249 0.7115 0.7455 0.7869 0.8736\n0.4813 0.6249 0.7115 0.7455 0.7869 0.8736\n0.4813 0.6249 0.7115 0.7455 0.7869 0.8736\n0.4813 0.6249 0.7115 0.7455 0.7869 0.8736\n0.5315 0.655 0.743 0.7801 0.8175 0.8924\n0.5315 0.655 0.743 0.7801 0.8175 0.8924\n0.442 0.578 0.6886 0.7997 0.8474 0.8828\n0.4333 0.5647 0.6727 0.7893 0.8362 0.8707\n0.4333 0.5647 0.6727 0.7893 0.8362 0.8707\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4348 0.5735 0.6717 0.7831 0.8274 0.8643\n0.4371 0.5836 0.6772 0.789 0.8293 0.8658\n0.4313 0.5965 0.6783 0.776 0.8167 0.8576\n0.5055 0.6169 0.6867 0.7749 0.8062 0.8304\n0.5722 0.6353 0.6943 0.7739 0.7969 0.806\n0.626 0.693 0.7367 0.8065 0.8244 0.8393\n0.626 0.693 0.7367 0.8065 0.8244 0.8393\n0.626 0.693 0.7367 0.8065 0.8244 0.8393\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6487 0.7071 0.7475 0.8091 0.8254 0.8361\n0.6468 0.6908 0.7285 0.7845 0.7945 0.8051\n0.6468 0.6908 0.7285 0.7845 0.7945 0.8051\n0.6468 0.6908 0.7285 0.7845 0.7945 0.8051\n0.6294 0.6667 0.7055 0.7582 0.768 0.7744\n0.6292 0.6626 0.6967 0.7426 0.7495 0.7551\n0.6292 0.6626 0.6967 0.7426 0.7495 0.7551\n0.6292 0.6626 0.6967 0.7426 0.7495 0.7551\n0.5404 0.595 0.6326 0.6813 0.6899 0.6907\n0.3235 0.4368 0.4849 0.5455 0.5603 0.5528\n0.2958 0.4442 0.5054 0.5845 0.6181 0.6308\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.291 0.4593 0.5192 0.6096 0.6411 0.6453\n0.2006 0.3531 0.4163 0.5217 0.5945 0.6488\n0.3404 0.4731 0.6242 0.7458 0.8019 0.8373\n0.425 0.5458 0.7502 0.8816 0.9277 0.9515\n0.4247 0.5435 0.7357 0.8591 0.9067 0.9325\n0.4833 0.6094 0.7891 0.8732 0.9038 0.9319\n0.5155 0.641 0.8012 0.872 0.9008 0.9284\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.5218 0.6446 0.7977 0.8693 0.8996 0.9304\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4718 0.5802 0.7076 0.7873 0.8389 0.8807\n0.4532 0.5609 0.6935 0.7732 0.8263 0.8682\n0.4532 0.5609 0.6935 0.7732 0.8263 0.8682\n0.4532 0.5609 0.6935 0.7732 0.8263 0.8682\n0.4317 0.5383 0.6663 0.7454 0.7986 0.8366\n0.2008 0.2618 0.3651 0.4308 0.5197 0.6042\n0.2216 0.2774 0.3722 0.4371 0.5368 0.6364\n0.2216 0.2774 0.3722 0.4371 0.5368 0.6364\n0.2216 0.2774 0.3722 0.4371 0.5368 0.6364\n0.2216 0.2774 0.3722 0.4371 0.5368 0.6364\n0.2216 0.2774 0.3722 0.4371 0.5368 0.6364\n0.2694 0.3129 0.3761 0.4224 0.502 0.5967\n0.2922 0.3258 0.3718 0.407 0.4739 0.5603\n0.2767 0.3032 0.3367 0.3619 0.4195 0.5058\n0.2767 0.3032 0.3367 0.3619 0.4195 0.5058\n0.2767 0.3032 0.3367 0.3619 0.4195 0.5058\n0.2767 0.3032 0.3367 0.3619 0.4195 0.5058\n0.2567 0.2731 0.2962 0.3212 0.3712 0.4475\n0.4705 0.5914 0.6548 0.6811 0.7095 0.7603\n0.4705 0.5914 0.6548 0.6811 0.7095 0.7603\n0.4705 0.5914 0.6548 0.6811 0.7095 0.7603\n0.4705 0.5914 0.6548 0.6811 0.7095 0.7603\n0.4705 0.5914 0.6548 0.6811 0.7095 0.7603\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.5312 0.6207 0.6685 0.7068 0.7368 0.831\n0.3331 0.4351 0.4918 0.5433 0.54 0.6743\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.1611 0.2344 0.268 0.3043 0.336 0.43\n0.392 0.4549 0.5723 0.7338 0.8266 0.8721\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.4933 0.5638 0.6823 0.8159 0.8695 0.8913\n0.435 0.5146 0.6352 0.7837 0.8474 0.8755\n0.435 0.5146 0.6352 0.7837 0.8474 0.8755\n0.4049 0.4879 0.614 0.7673 0.8356 0.8667\n0.4081 0.4965 0.6282 0.7743 0.8307 0.8563\n0.4081 0.4965 0.6282 0.7743 0.8307 0.8563\n0.4081 0.4965 0.6282 0.7743 0.8307 0.8563\n0.4081 0.4965 0.6282 0.7743 0.8307 0.8563\n0.3651 0.5038 0.6666 0.8067 0.8452 0.8609\n0.3234 0.4983 0.6931 0.8329 0.8499 0.8566\n0.2889 0.4679 0.6863 0.8344 0.841 0.8454\n0.2635 0.4237 0.6606 0.8195 0.8261 0.8295\n0.2494 0.4115 0.658 0.8203 0.8235 0.8256\n0.2494 0.4115 0.658 0.8203 0.8235 0.8256\n0.2494 0.4115 0.658 0.8203 0.8235 0.8256\n0.2494 0.4115 0.658 0.8203 0.8235 0.8256\n0.2494 0.4115 0.658 0.8203 0.8235 0.8256\n0.2079 0.2833 0.3804 0.5006 0.5607 0.6482\n0.2582 0.3485 0.4426 0.5603 0.6319 0.7304\n0.2582 0.3485 0.4426 0.5603 0.6319 0.7304\n0.2582 0.3485 0.4426 0.5603 0.6319 0.7304\n0.2825 0.3928 0.4979 0.6151 0.6818 0.7803\n0.2825 0.3928 0.4979 0.6151 0.6818 0.7803\n0.2825 0.3928 0.4979 0.6151 0.6818 0.7803\n0.2825 0.3928 0.4979 0.6151 0.6818 0.7803\n0.2825 0.3928 0.4979 0.6151 0.6818 0.7803\n0.3126 0.4074 0.489 0.5945 0.657 0.7502\n0.3726 0.4841 0.6223 0.7389 0.7792 0.8119\n0.4036 0.5224 0.6885 0.8092 0.8419 0.8545\n0.3982 0.5136 0.6727 0.7929 0.8313 0.8486\n0.3982 0.5136 0.6727 0.7929 0.8313 0.8486\n0.3982 0.5136 0.6727 0.7929 0.8313 0.8486\n0.3982 0.5136 0.6727 0.7929 0.8313 0.8486\n0.3982 0.5136 0.6727 0.7929 0.8313 0.8486\n0.4787 0.5976 0.7601 0.8712 0.8974 0.9095\n0.4787 0.5976 0.7601 0.8712 0.8974 0.9095\n0.4787 0.5976 0.7601 0.8712 0.8974 0.9095\n0.4882 0.607 0.766 0.8743 0.9027 0.9187\n0.4538 0.5685 0.7205 0.831 0.8691 0.8924\n0.4538 0.5685 0.7205 0.831 0.8691 0.8924\n0.3011 0.3956 0.5118 0.6306 0.7088 0.7617\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2735 0.3581 0.4553 0.5644 0.651 0.7135\n0.2399 0.3126 0.3865 0.4812 0.5721 0.6436\n0.2428 0.3336 0.607 0.7484 0.8066 0.8897\n0.2428 0.3336 0.607 0.7484 0.8066 0.8897\n0.2428 0.3336 0.607 0.7484 0.8066 0.8897\n0.2428 0.3336 0.607 0.7484 0.8066 0.8897\n0.2428 0.3336 0.607 0.7484 0.8066 0.8897\n0.2081 0.2851 0.5104 0.6645 0.7203 0.7733\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2322 0.3024 0.501 0.6352 0.6853 0.7389\n0.2502 0.3144 0.4917 0.6096 0.6547 0.7071\n0.2906 0.3464 0.4919 0.5846 0.6246 0.677\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.434 0.4851 0.6075 0.6846 0.7035 0.7539\n0.4703 0.5192 0.6271 0.6949 0.7062 0.7581\n0.4835 0.555 0.6568 0.715 0.732 0.7898\n0.5099 0.6264 0.7161 0.7553 0.7836 0.8532\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.5723 0.6707 0.7556 0.7965 0.8396 0.9068\n0.3424 0.4592 0.5931 0.7293 0.8038 0.8666\n0.3509 0.4745 0.5999 0.7227 0.7957 0.8639\n0.3509 0.4745 0.5999 0.7227 0.7957 0.8639\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.3549 0.4748 0.6098 0.7303 0.805 0.8669\n0.4137 0.5218 0.6469 0.7623 0.8185 0.8655\n0.6248 0.6902 0.7801 0.8772 0.8672 0.8608\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7312 0.7896 0.8677 0.9425 0.934 0.9346\n0.7858 0.8429 0.9118 0.9681 0.9663 0.9714\n0.2155 0.2495 0.3517 0.3872 0.39 0.4196\n0.2156 0.2511 0.3589 0.3937 0.3984 0.4308\n0.2156 0.2511 0.3589 0.3937 0.3984 0.4308\n0.2156 0.2511 0.3589 0.3937 0.3984 0.4308\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2261 0.2775 0.4163 0.4665 0.4777 0.51\n0.2352 0.2883 0.4303 0.4891 0.5103 0.5461\n0.2313 0.2808 0.4164 0.4769 0.5048 0.5483\n0.3113 0.3821 0.5557 0.6829 0.7667 0.8142\n0.3256 0.3995 0.5743 0.697 0.7755 0.8195\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.338 0.4135 0.5861 0.7032 0.779 0.8202\n0.2402 0.3131 0.4457 0.541 0.5949 0.6186\n0.2402 0.3131 0.4457 0.541 0.5949 0.6186\n0.2402 0.3131 0.4457 0.541 0.5949 0.6186\n0.2402 0.3131 0.4457 0.541 0.5949 0.6186\n0.2402 0.3131 0.4457 0.541 0.5949 0.6186\n0.2597 0.3083 0.398 0.4801 0.537 0.5717\n0.2812 0.3169 0.3876 0.4633 0.5207 0.5582\n0.2726 0.297 0.3449 0.4142 0.4753 0.5206\n0.2726 0.297 0.3449 0.4142 0.4753 0.5206\n0.2726 0.297 0.3449 0.4142 0.4753 0.5206\n0.2726 0.297 0.3449 0.4142 0.4753 0.5206\n0.2523 0.2743 0.3155 0.3826 0.4405 0.4763\n0.4616 0.6411 0.7386 0.765 0.7771 0.8085\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.4643 0.6325 0.7512 0.7832 0.7881 0.8267\n0.3861 0.5276 0.608 0.6687 0.7164 0.7804\n0.1209 0.1612 0.3125 0.4358 0.4951 0.5789\n0.1493 0.1909 0.3318 0.4552 0.5204 0.6044\n0.1493 0.1909 0.3318 0.4552 0.5204 0.6044\n0.1493 0.1909 0.3318 0.4552 0.5204 0.6044\n0.1493 0.1909 0.3318 0.4552 0.5204 0.6044\n0.1493 0.1909 0.3318 0.4552 0.5204 0.6044\n0.1756 0.2163 0.3332 0.4549 0.5329 0.6257\n0.1756 0.2163 0.3332 0.4549 0.5329 0.6257\n0.2119 0.2554 0.3654 0.4905 0.5822 0.6786\n0.246 0.2933 0.402 0.5291 0.6223 0.7131\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2926 0.3455 0.45 0.5781 0.6713 0.7535\n0.2979 0.3519 0.4584 0.5874 0.6794 0.7593\n0.2726 0.3249 0.4377 0.5639 0.6445 0.7201\n0.3582 0.4795 0.6511 0.7765 0.815 0.8497\n0.3582 0.4795 0.6511 0.7765 0.815 0.8497\n0.3711 0.5019 0.6798 0.8044 0.8375 0.8668\n0.3822 0.5253 0.7143 0.8391 0.865 0.8877\n0.3656 0.5427 0.7592 0.8967 0.9062 0.9099\n0.2457 0.4135 0.6419 0.8205 0.8329 0.8351\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.223 0.3642 0.6051 0.8022 0.8136 0.8169\n0.2682 0.3207 0.4089 0.4956 0.5233 0.5985\n0.3043 0.3634 0.4487 0.5338 0.5659 0.644\n0.3043 0.3634 0.4487 0.5338 0.5659 0.644\n0.3043 0.3634 0.4487 0.5338 0.5659 0.644\n0.3585 0.4373 0.5281 0.6046 0.6396 0.7177\n0.3585 0.4373 0.5281 0.6046 0.6396 0.7177\n0.3585 0.4373 0.5281 0.6046 0.6396 0.7177\n0.3585 0.4373 0.5281 0.6046 0.6396 0.7177\n0.3585 0.4373 0.5281 0.6046 0.6396 0.7177\n0.3654 0.4179 0.4894 0.5679 0.5988 0.6586\n0.3637 0.4608 0.5805 0.686 0.7264 0.7624\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.3625 0.4904 0.6435 0.7675 0.8146 0.8341\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.4598 0.5939 0.7614 0.8727 0.8956 0.9109\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.3122 0.4113 0.5319 0.6495 0.7149 0.7543\n0.2241 0.3371 0.579 0.7239 0.7524 0.8051\n0.2371 0.3411 0.6143 0.7596 0.7988 0.8663\n0.2354 0.3385 0.6116 0.7588 0.795 0.8563\n0.2354 0.3385 0.6116 0.7588 0.795 0.8563\n0.2221 0.3231 0.5963 0.7484 0.7857 0.8461\n0.2221 0.3231 0.5963 0.7484 0.7857 0.8461\n0.2074 0.307 0.5721 0.7359 0.766 0.8113\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2034 0.3008 0.5464 0.6991 0.7243 0.763\n0.2012 0.2949 0.5295 0.6762 0.6968 0.7337\n0.2012 0.2949 0.5295 0.6762 0.6968 0.7337\n0.2002 0.2891 0.5091 0.6516 0.6713 0.7013\n0.2094 0.2897 0.5079 0.6656 0.6986 0.747\n0.3946 0.4908 0.6216 0.7204 0.7478 0.8087\n0.3946 0.4908 0.6216 0.7204 0.7478 0.8087\n0.4676 0.5678 0.665 0.7393 0.7618 0.8251\n0.4676 0.5678 0.665 0.7393 0.7618 0.8251\n0.4676 0.5678 0.665 0.7393 0.7618 0.8251\n0.4676 0.5678 0.665 0.7393 0.7618 0.8251\n0.5027 0.6075 0.6873 0.7508 0.7741 0.8417\n0.5047 0.6195 0.6993 0.7609 0.7909 0.8563\n0.442 0.578 0.6711 0.7321 0.7789 0.8481\n0.513 0.6342 0.7216 0.7846 0.8381 0.9009\n0.513 0.6342 0.7216 0.7846 0.8381 0.9009\n0.513 0.6342 0.7216 0.7846 0.8381 0.9009\n0.5523 0.6642 0.75 0.8164 0.8682 0.9242\n0.5523 0.6642 0.75 0.8164 0.8682 0.9242\n0.5523 0.6642 0.75 0.8164 0.8682 0.9242\n0.5523 0.6642 0.75 0.8164 0.8682 0.9242\n1\n2\n3\nC’\nA\nB\nC\nD\nE\nF\nG\nH\nA\nB\nC\nD\nE\nF\nG\nAL GL MM H3 H6 H7 H9 H16 MGC\nDeuterium Uptake of LC Isoforms + M83 – Percent Deuterium Uptake\nVL\nCL\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\nNt\nCt\n50\n100\n150\n200\n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S6. Single residue aligned heatmaps of LC isoforms with and without M83. Top panels: Percent \ndeuterium uptake (%D) for all nine LC isoforms in the absence of M83. Middle panels: Percent \ndeuterium uptake (%D) for LC isoforms in the presence of M83. Levels of deuterium uptake is color-\ncoded as per legend, with red indicating high uptake (low protection) and blue indicating low uptake \n(high protection). Bottom Panels: Percent deuterium difference (Δ%D) plots showing the effect of M83 \non deuterium uptake for each LC isoform. Blue regions indicate areas of increased protection upon M83 \nbinding, while green regions represent areas with reduced protection. The solid horizontal line indicates \nthe boundary between VL and CL domains. \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \nAL GL MM H3 H6 H7 H9 H16 MGC\n-0.6527 -2.2877 -5.656 -9.7348 -12.726 -8.5525\n-1.2689 -1.5382 -2.1978 -5.9423 -10.118 -9.3657\n-5.3146 -6.0593 -6.2951 -9.8071 -8.3952 -5.5635\n-6.9897 -3.8743 1.27941 0.71019 0.45979 1.82762\n-4.2073 -8.8321 -6.6803 -8.8155 -15.729 -19.909\n-3.8015 -7.8453 -8.0349 -9.6825 -15.871 -18.695\n-5.1393 -9.1071 -7.6768 -8.734 -15.478 -18.021\n-6.439 -12.371 -11.018 -9.987 -11.062 -12.393\n-5.9752 -10.522 -10.544 -9.4477 -9.2883 -10.224\n-4.1576 -8.7871 -10.854 -9.2273 -6.8521 -7.1593\n-2.8886 -8.9555 -3.0179 -0.9784 -0.5657 -1.5857\n-1.9075 -4.1409 1.18826 1.13811 3.50257 3.41468\n-0.7894 -5.0318 -1.7114 -1.2475 -1.2518 -1.891\n-2.3719 -5.1918 -0.1041 -0.7691 1.06753 0.61679\n-3.3643 -5.5252 -1.9717 -2.8779 -2.8757 -1.7616\n-1.8344 -5.4696 -1.3792 -2.5231 -3.5896 -1.2664\n-2.0566 -5.1061 -1.0963 -3.4787 -3.3372 -1.3395\n-0.5769 -4.1767 -1.2837 -2.6312 -4.8704 -3.3192\n-1.4879 -4.8133 -1.5172 -3.7841 -5.766 -4.2865\n-2.0672 -5.2251 -1.8868 -2.7732 -4.1936 -1.9887\n-1.1903 -5.174 -1.4845 -4.1802 -6.5294 -4.9882\n-1.5555 -3.4663 -1.3727 -4.4032 -7.3922 -7.1383\n-1.1318 -3.5248 -1.3254 -4.558 -6.6654 -5.0823\n-2.6109 -1.6682 -0.7131 -4.7186 -7.8564 -8.6813\n-2.3868 -0.0227 -1.8989 -7.2908 -14.198 -18.17\n0.79338 -3.8835 -3.9933 -8.6963 -20.251 -21.586\n0.55418 -1.5222 -0.5254 -3.3466 -14.096 -19.868\n-1.2322 -1.1543 -1.7722 -6.7928 -15.515 -17.484\n-0.3069 -0.8367 -1.1217 -7.014 -16.645 -18.568\n-0.738 -0.7302 -2.6227 -9.1999 -17.141 -20.643\n-0.529 -0.1945 -1.845 -6.9874 -15.096 -22.585\n-1.0988 -0.8025 -1.1393 -7.1405 -15.861 -11.599\n0.13445 -2.5523 -1.4665 -4.6395 -12.332 -28.312\n-4.1707 -0.1344 -3.3418 -9.6443 -14.89 -17.208\n-2.4275 -4.8685 -5.9628 -6.717 -14.696 -12.822\n-3.8533 2.23595 -2.5018 -7.74 -12.592 -13.266\n-4.1441 -7.2673 -12.025 -19.866 -25.754 -21.714\n-2.8271 -8.5576 -13.721 -20.951 -26.853 -21.262\n-3.0791 -12.534 -20.946 -30.917 -39.708 -29.997\n-3.0667 -13.463 -21.987 -28.234 -33.158 -24.258\n-3.6813 -6.3628 -14.827 -28.412 -38.009 -29.28\n-3.2098 -10.943 -20.291 -27.341 -33.652 -26.265\n-2.7663 -2.6492 -0.7141 -1.8769 -1.5128 1.98426\n-2.9146 -2.8391 -1.5909 -2.1567 -1.4181 -1.2387\n-2.2761 -4.1064 -2.9159 -1.8677 -1.7301 -1.4196\n-2.3291 -5.4372 -2.4017 -2.0258 -2.5937 -3.5068\n-2.3486 -4.7405 -2.3335 -1.4815 -2.5864 -2.7368\n-2.2976 -4.9052 -2.2202 -1.7245 -2.3303 -2.8468\n-2.2114 -4.5579 -1.9907 -1.8505 -2.0093 -2.2962\n-2.0311 -4.8695 -1.6806 -1.43 -2.1637 -2.3156\n-2.074 -4.4073 -2.2466 -1.0689 -1.6991 -2.2093\n-1.6832 -2.3107 -2.792 -0.4292 -0.0628 -1.3588\n-2.3495 -2.6301 -2.9754 -0.4982 0.05217 -0.8885\n-1.9164 -2.9097 -2.7422 -0.085 0.39983 -0.9074\n-0.5327 -2.9983 -4.1316 0.04473 0.56473 -1.0668\n-0.4932 1.03083 -1.0188 -3.5743 -2.6136 -4.1613\n-0.7657 -0.4604 -3.2749 -6.6898 -6.0406 -5.8485\n-0.098 0.67402 -2.04 -4.8678 -3.7334 -6.0398\n-1.4201 -1.2082 1.71154 -2.1836 -2.166 -0.8475\n-1.9033 -0.7824 -0.2346 -0.9971 0.06391 -1.7402\n-1.4071 -1.2696 -1.8281 -0.6688 0.12011 -0.1751\n-2.1095 -0.7769 -2.4151 -1.0166 0.29846 -0.046\n-0.6159 -4.706 -2.7032 -1.4224 -0.3931 0.96451\n-3.427 1.20739 -3.5837 -0.4455 0.04659 2.29783\n-2.2875 -2.9259 -5.0226 -4.7232 -3.204 -5.2426\n-2.645 -3.2373 -8.4417 -5.8723 -4.8859 -4.417\n-2.7686 -3.844 -7.0504 -7.6242 -6.5119 -8.045\n-2.1163 -3.3662 -6.0819 -6.9741 -6.4322 -9.2591\n-1.0326 -1.9788 -3.1524 -2.3214 -2.7324 -2.4851\n-0.5587 -1.5047 -1.4162 -0.9675 -1.2356 -4.0461\n-1.0706 -0.5148 -1.7751 -1.8761 -2.1534 -3.6037\n2.03403 -3.4157 -0.5748 0.62796 -3.7696 -6.9175\n0.04651 -1.4839 -1.9916 -1.6303 -2.7191 -5.3187\n-0.7486 -2.3516 0.91526 0.521 -2.1632 -4.7493\n-1.8552 -0.7858 -0.4811 -1.9155 0.13012 -1.3815\n-2.0081 1.03545 0.28895 -0.8628 -0.145 -1.8289\n-1.8493 -0.0718 0.37792 -0.3394 -2.3454 -1.1763\n-2.595 -1.0705 -0.3408 -1.4914 -3.7089 -3.1298\n-4.1823 -3.0088 0.11607 -3.371 -6.5005 -2.5062\n-3.6622 -1.9128 -0.5795 -1.5991 -3.3766 -1.7052\n-4.2205 -1.1598 -0.5242 -1.6135 -2.7124 -1.4469\n32.396 45.949 61.837 76.676 87.48 91.627\n34.694 47.934 61.532 75.358 85.686 91.038\n59.755 75.66 84.281 95.884 98.711 98.555\n75.141 94.046 95.951 98.898 99.39 99.226\n32.943 41.161 51.062 59.997 70.836 80.033\n30.163 37.344 49.404 60.491 73.606 81.033\n36.51 45.567 55.694 64.29 74.105 81.196\n50.932 63.433 78.225 85.749 88.92 92.362\n43.505 54.114 70.442 82.798 88.884 92.618\n34.934 48.008 71.91 87.495 92.616 94.834\n46.511 69.717 85.945 95.408 95.935 97.219\n54.184 77.644 92.489 99.3 99.842 98.915\n44.295 69.081 89.766 96.824 99.479 98.992\n58.05 78.338 90.702 100.28 100.4 100.35\n50.739 69.866 86.817 96.115 98.805 99.734\n46.882 66.528 81.397 93.226 99.253 100.09\n47.621 63.664 78.416 91.536 97.519 99.694\n44.08 59.72 72.978 84.654 92.074 94.602\n46.782 61.149 72.492 84.675 92.237 95.06\n55.305 68.518 78.647 89.655 96.353 98.143\n47.01 59.873 70.414 83.729 92.366 95.089\n44.689 55.936 66.639 79.809 88.869 92.897\n47.118 58.806 69.971 83.513 91.859 94.726\n47.999 50.678 55.799 71.109 83.961 90.726\n31.714 34.49 40.062 56.047 74.406 85.367\n5.6023 13.807 27.981 38.482 58.977 73.978\n19.128 24.087 32.818 40.083 57.798 76.38\n27.906 32.17 42.261 51.942 67.208 78.376\n26.631 31.411 40.359 50.727 67.539 80.152\n22.162 25.276 34.8 46.927 61.822 75.054\n21.882 24.234 32.412 41.538 55.81 72.071\n26.763 29.761 39.106 48.283 63.239 70.775\n23.322 23.991 25.167 30.582 41.188 61.306\n47.557 55.358 65.85 74.916 82.861 89.652\n51.28 63.385 72.555 78.285 86.858 88.789\n54.974 61.939 75.297 84.135 90.655 95.812\n34.177 45.001 59.007 73.318 84.387 88.829\n34.182 44.753 58.117 73.071 85.17 89.522\n12.126 24.394 43.134 63.433 80.567 85.669\n13.358 28.239 47.389 64.178 77.151 83.395\n13.528 20.523 36.412 56.148 72.328 79.254\n13.215 23.897 43.803 61.429 75.885 81.486\n55.895 68.096 75.343 84.77 93.531 96.674\n50.368 60.578 68.153 76.706 84.891 89.875\n43.92 55.709 66.743 77.349 85.845 90.962\n42.329 53.891 64.393 74.519 82.273 87.866\n44.38 55.49 66.022 75.732 83.307 88.126\n43.5 56.676 67.897 77.309 84.265 88.882\n42.043 57.2 69.571 78.7 84.7 88.929\n43.301 62.034 73.008 81.266 87.017 90.328\n38.364 55.227 70.872 80.595 85.179 88.398\n28.634 52.472 76.516 86.271 86.418 88.067\n29.784 49.727 72.965 83.961 84.447 85.677\n27.683 45.409 70.052 82.457 83.338 84.539\n21.407 34.979 63.987 78.514 78.749 79.94\n30.824 32.232 43.682 57.03 63.324 71.849\n34.536 37.524 50.84 65.323 73.581 84.156\n37.508 40.965 50.913 61.187 67.074 76.5\n53.129 57.413 66.616 76.523 82.062 90.997\n45.813 56.948 73.453 85.012 87.5 90.898\n41.32 56.309 75.168 85.01 89.05 89.939\n42.705 57.55 76.133 85.35 89.553 90.378\n50.84 67.073 82.904 95.637 98.104 97.071\n55.495 69.678 87.847 93.552 95.693 96.547\n32.862 43.876 58.238 69.772 75.502 80.295\n28.519 36.885 52.165 64.465 72.89 78.159\n27.262 34.529 43.99 55.842 65.731 74.502\n23.763 30.397 38.686 49.874 59.565 68.925\n22.639 31.84 62.845 81.43 91.497 100.62\n17.43 25.778 49.762 65.928 73.306 81.802\n20.382 28.689 55.466 72.115 77.653 80.957\n16.625 26.2 36.813 49.753 59.797 70.163\n14.825 21.079 33.421 43.399 50.466 58.319\n32.413 40.761 44.506 50.256 56.456 66.749\n49.551 59.163 64.786 69.745 70.302 77.452\n59.907 68.875 77.419 83.64 84.306 90.164\n36.792 52.902 62.708 67.476 76.174 87.087\n51.482 63.276 68.993 73.645 81.245 89.91\n44.185 61.811 66.566 73.667 85.161 96.351\n53.921 67.916 73.727 78.569 86.707 95.564\n64.783 75.241 79.717 83.906 89.693 97.031\n31.547 43.465 56.919 69.189 73.7 81.875\n33.885 46.668 60.096 71.804 75.095 81.71\n27.73 40.726 54.706 69.932 75.469 79.622\n31.154 47.238 67.479 81.465 87.422 87.449\n40.006 57.571 78.102 89.626 93.291 95.155\n41.198 61.82 81.295 91.103 94.389 94.483\n50.945 75.972 96.095 101.52 98.463 99.616\n28.732 35.494 46.002 54.756 58.67 59.315\n25.98 31.957 42.133 51.82 55.893 58.777\n23.548 30.2 37.954 47 51.694 53.952\n27.961 34.43 45.169 54.34 58.256 60.658\n43.929 54.694 71.718 82.425 84.28 85.453\n37.842 47.186 61.927 73.253 75.336 79.459\n33.147 41.898 54.738 64.522 68.039 71.179\n29.248 36.726 48.823 58.525 63.837 67.388\n29.896 37.183 47.634 57.863 64.705 72.477\n33.908 40.997 54.035 72.88 84.019 91.377\n38.15 45.554 59.546 79.634 90.487 97.319\n30.06 38.142 52.851 71.319 81.156 88.424\n43.975 47.823 64.538 81.139 92.747 99.574\n18.546 27.969 54.427 70.484 75.658 78.556\n45.852 53.183 67.653 85.659 94.453 100.64\n32.958 38.792 52.338 70.689 80.604 87.53\n39.663 48.003 66.864 81.812 91.885 94.884\n34.958 41.285 56.449 74.971 85.097 91.195\n38.341 45.364 62.072 78.979 85.457 90.448\n41.451 48.019 65.039 80.827 86.443 92.652\n36.59 41.1 52.845 67.442 76.351 83.283\n34.257 39.178 50.311 64.23 72.798 79.519\n38.953 44.008 56.072 70.64 79.167 85.352\n42.154 48.178 58.964 72.891 78.899 85.862\n38.56 44.446 55.375 68.688 75.401 81.385\n42.709 48.699 60.285 72.97 79.508 85.011\n39.491 44.958 56.221 68.944 75.134 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51.966 76.646 90.589 93.7 93.605\n41.501 55.993 78.702 91.965 94.522 94.256\n53.293 68.25 94.936 99.467 100.05 97.915\n46.724 70.334 94.11 101.52 98.064 101.7\n46.258 66.815 92.433 99.456 99.192 97.049\n24.965 29.569 40.288 47.649 49.692 51.427\n23.45 31.021 43.297 50.397 52.656 53.395\n21.204 27.567 39.241 46.914 49.768 52.048\n24.78 33.026 46.256 53.297 57.414 57.387\n21.776 29.108 41.581 49.238 52.856 54.38\n34.192 46.214 65.751 75.211 77.014 77.029\n29.009 39.414 56.531 66.301 69.505 71.222\n25.647 34.882 49.112 58.458 60.599 63.761\n35.358 41.256 54.913 77.552 88.824 96.216\n39.05 45.389 60.835 83.686 95.152 99.034\n28.65 34.73 48.843 69.334 80.478 87.746\n35.246 40.035 56.899 78.868 86.992 91.102\n45.138 52.823 65.088 83.281 94.997 96.659\n32.261 37.805 54.166 74.351 83.878 90.218\n32.382 37.233 50.864 70.962 82.152 89.111\n34.648 40.019 54.739 75.414 85.654 90.523\n36.697 41.269 52.387 66.864 76.162 82.196\n39.147 43.963 55.092 70.392 78.782 83.866\n33.333 37.857 47.145 61.542 68.951 75.549\n38.982 44.885 54.431 68.481 74.733 79.475\n43.205 48.382 57.803 70.278 77.005 81.324\n39.427 44.683 54.211 65.45 72.736 77.037\n42.132 44.694 48.744 56.661 59.95 69.008\n38.453 44.809 49.247 53.78 56.95 62.53\n18.689 24.002 25.004 25.736 29.792 32.543\n4.0608 8.8535 18.037 20.39 25.398 43.593\n28.785 31.592 40.49 44.237 48.522 58.077\n27.601 30.457 39.555 43.313 48.088 59.526\n32.342 36.164 46.373 49.924 55.648 66.587\n23.047 25.776 33.41 38.754 42.988 52.811\n21.895 24.518 31.676 37.927 42.04 49.328\n26.143 29.086 37.569 42.988 47.593 58.137\n24.983 27.519 34.449 41.599 45.132 52.958\n29.898 32.583 40.499 44.206 48.017 55.015\n33.879 38.089 52.878 64.881 71.617 75.398\n38.366 44.485 61.083 75.83 81.643 85.743\n33.868 45.382 76.927 86.087 89.76 93.373\n20.448 29.432 49.444 60.245 68.751 76.679\n15.875 22.053 35.282 44.582 54.594 63.165\n14.584 20.397 32.524 42.252 51.95 61.766\n53.632 63.422 74.496 83.848 91.804 98.702\n47.868 55.443 65.067 73.443 82.365 87.753\n42.668 49.824 62.924 75.335 83.462 88.632\n43.307 49.755 63.04 74.583 80.843 84.845\n42.208 50.684 64.724 76.012 81.869 85.828\n40.717 51.416 66.78 77.294 82.43 86.214\n42.881 56.357 70.291 79.806 84.626 87.729\n37.767 50.662 68.099 79.562 83.32 85.712\n54.29 66.988 90.484 103 100.44 100.98\n28.584 51.011 75.52 87.273 87.775 87.893\n29.124 47.271 70.546 84.238 84.778 84.358\n25.714 41.187 67.26 81.791 82.419 82.329\n20.86 31.375 60.182 77.718 79.264 78.754\n31.919 31.985 41.091 54.7 61.612 65.935\n34.752 36.099 46.875 60.309 69.774 76.67\n43.607 45.108 52.698 65.468 72.694 75.12\n40.339 41.121 49.218 59.502 64.883 70.377\n53.89 54.877 65.734 76.032 79.569 87.12\n43.634 56.726 72.618 82.609 86.908 86.624\n42.977 57.49 75.642 86.888 90.341 89.236\n51.058 64.23 83.328 95.879 98.787 99.222\n56.664 71.618 87.126 93.317 95.486 91.918\n34.211 44.013 57.519 69.567 76.023 79.34\n32.049 41.538 54.325 66.272 72.133 75.656\n38.291 46.228 58.77 71.766 78.764 82.324\n26.569 33.606 45.238 58.947 68.076 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55.569 69.818 78.367 88.341\n42.452 46.806 57.114 68.691 76.847 86.555\n53.96 53.435 57.419 66.962 73.389 79.013\n32.501 38.906 50.34 59.497 68.618 86.658\n26.137 30.597 39.379 45.522 52.135 66.834\n28.143 32.605 42.811 49.675 56.738 74.296\n26.437 31.343 40.35 44.605 51.587 66.89\n32.993 38.662 51.538 56.429 63.273 79.243\n31.507 35.774 45.55 51.688 60.076 76.648\n35.053 43.267 57.45 68.703 77.618 83.946\n8.1288 16.529 34.954 50.335 65.923 76.554\n35.763 41.709 54.52 67.331 77.401 84.266\n24.827 31.083 44.756 59.731 71.776 80.566\n37.31 42.953 55.503 68.22 76.684 82.383\n28.345 34.639 48.524 62.811 72.548 79.663\n28.271 36.273 51.088 64.543 74.062 80.618\n42.743 49.003 61.054 76.255 84.812 88.76\n33.495 40.818 52.543 63.869 71.235 78.245\n53.733 64.392 82.816 96.082 93.958 95.953\n28.234 50.308 73.775 86.594 86.609 87.768\n29.12 47.061 70.242 83.913 84.414 84.612\n25.416 41.2 65.364 82.11 82.842 82.781\n27.702 43.276 67.88 82.69 83.051 85.816\n22.614 31.191 39.898 51.41 57.921 63.611\n24.013 33.151 43.823 56.707 63.615 73.593\n31.817 41.026 48.843 57.194 61.758 68.684\n36.3 51.244 64.386 71.212 76.029 83.939\n45.485 57.323 72.834 84.58 87.616 89.255\n44.166 57.371 73.29 86.496 90.699 90.762\n53.854 65.095 80.574 95.992 97.297 100.41\n56.719 70.158 82.501 93.274 96.525 95.703\n33.358 43.068 54.252 66.433 73.448 78.66\n31.981 41.174 52.283 63.767 70.28 75.281\n36.492 44.868 55.46 68.938 75.528 81.404\n20.874 25.479 30.733 39.69 48.884 57.604\n27.067 37.166 66.796 78.387 84.835 96.209\n18.555 27.13 53.864 73.14 79.175 85.786\n16.716 24.546 49.926 68.364 74.047 80.341\n17.618 25.344 50.773 69.499 74.286 79.543\n27.313 33.962 52.446 66.459 70.031 76.131\n29.451 36.106 56.887 69.791 74.561 75.929\n29.178 35.456 51.828 63.349 67.398 73.89\n37.211 45.179 59.541 68.396 72.665 79.126\n63.904 68.824 77.276 81.707 83.299 89.2\n52.344 61.978 73.23 76.225 79.008 86.585\n-1.4978 0.30795 -0.7279 -0.8119 1.41377 0.6439\n0.42723 -0.7718 -1.8467 -1.6538 -5.5954 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83.634 88.694\n45.02 55.107 62.889 66.298 67.451 72.802\n14.308 26.358 34.283 37.179 40.308 48.887\n14.496 28.06 32.796 35.605 38.388 47.028\n23.425 42.492 55.726 59.327 61.271 68.383\n22.347 43.921 56.886 60.4 62.368 71.078\n34.769 46.41 67.902 82.106 84.514 86.938\n36.205 47.279 67.784 82.001 84.655 87.991\n38.363 50.546 71.312 82.064 83.664 86.864\n40.722 52.983 71.303 81.727 82.684 85.62\n46.772 58.305 75.79 86.077 87.368 90.189\n41.54 52.313 69.186 80.26 81.242 84.268\n39.979 50.28 65.839 76.095 77.216 79.73\n25.58 32.758 46.426 57.941 66.051 79.154\n34.565 39.665 51.697 60.903 67.867 79.125\n29.791 34.12 42.659 52.31 60.404 75.582\n28.62 32.932 41.029 48.396 56.34 70.277\n38.823 36.789 40.818 45.57 53.608 70.174\n32.768 31.706 32.646 37.426 44.576 57.978\n44.067 67.764 74.928 81.422 84.316 87.102\n42.114 63.652 72.546 80.724 85.171 87.733\n50.079 74.714 83.366 90.258 91.736 93.424\n46.324 70.362 81.332 90.069 93.322 94.746\n10.716 18.391 30.203 43.236 52.874 66.189\n10.193 18.586 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70.295 79.656 84.701\n34.495 42.48 60.01 74.9 82.122 85.259\n36.945 45.314 62.204 75.081 80.796 83.892\n38.854 47.151 62.512 73.975 80.14 82.989\n17.084 27.234 44.46 56.139 60.173 61.875\n30.38 38.947 53.489 63.785 67.706 68.246\n23.996 30.011 40.091 48.708 55.552 58.706\n23.834 28.722 37.526 45.518 51.489 54.179\n31.75 33.753 36.005 41.29 49.819 55.81\n26.388 27.452 28.84 33.498 40.57 46.027\n50.18 69.782 79.185 86.54 85.573 85.915\n55.066 70.344 79.216 83.843 84.067 84.343\n53.178 73.376 80.067 88.965 90.59 90.925\n9.3605 23.178 45.013 50.414 58.234 75.033\n7.2825 15.968 30.848 34.6 42.954 59.741\n5.454 12.792 25.134 32.935 45.938 66.306\n24.211 30.77 44.039 56.913 67.665 79.341\n27.367 34.178 45.03 54.042 64.867 77.339\n26.96 32.465 43.561 55.166 65.511 77.286\n26.646 32.858 46.393 57.145 65.867 76.179\n28.278 35.67 49.333 59.804 68.062 77.724\n30.416 34.764 46.455 57.752 66.123 76.069\n28.544 37.292 51.688 61.469 69.224 78.041\n29.927 35.947 48.359 59.252 67.235 76.351\n43.565 50.327 63.698 76.764 84.013 88.827\n45.707 65.154 89.306 98.939 99.051 98.046\n27.483 45.545 66.877 83.153 84.503 84.788\n23.703 39.115 61.996 81.013 81.987 82.504\n18.641 28.847 54.392 76.43 78.547 78.389\n25.92 32.277 40.719 51.298 56.784 65.292\n27.427 36.004 44.69 55.985 63.577 74.161\n36.124 42.547 49.501 57.276 63.055 70.332\n43.089 55.563 64.821 74.582 77.651 85.918\n41.021 56.257 75.886 87.548 90.147 90.611\n52.82 69.635 88.529 95.867 95.962 95.761\n33.223 43.066 56.723 68.36 76.229 80.66\n31.719 41.315 54.622 66.626 73.126 77.679\n25 36.987 67.305 78.755 83.338 94.436\n22.315 34.81 66.51 86.618 91.41 98.137\n21.624 32.028 62.46 77.295 79.706 86.441\n20.608 31.743 57.455 70.879 73.728 79.759\n20.998 30.618 58.218 74.015 77.902 83.99\n19.045 28.034 53.825 68.71 72.056 77.826\n22.918 32.343 59.664 75.296 76.269 78.143\n8.9201 16.868 44.557 63.974 67.603 75.767\n29.208 36.981 55.48 67.335 69.771 75.251\n19.524 27.976 43.024 52.119 52.333 56.238\n38.326 47.589 61.292 69.71 74.002 79.685\n63.22 71.76 76.12 81.9 83.68 90.54\n39.465 54.882 63.105 69.608 77.742 86.55\n51.34 65.374 72.817 79.886 85.727 90.64\n62.639 73.021 81.116 89.121 95.682 98.811\n1.64943 -2.1107 -3.9139 -0.9226 -1.0344 -1.9849\n2.04622 -1.2218 -0.6477 -0.5741 -1.6635 -1.7371\n1.11647 -3.3748 -3.4763 -1.3448 -0.7866 -1.5732\n-1.7876 -1.6374 -2.1782 1.05152 0.03004 -1.5472\n-2.0931 -1.8163 -2.0239 0.70922 0 -0.1038\n-1.9152 -1.5715 -1.6206 1.37502 0.62203 0.36012\n2.54403 0 1.82147 0.4516 -1.4903 -3.4773\n2.8046 0.01533 2.00766 0.13793 -1.4253 -3.1724\n3.61638 0.72682 3.26183 0.51409 -0.5495 -1.6309\n3.46445 0.36088 2.63443 -0.1624 -2.2916 -4.1321\n0.58814 -0.7025 -0.1797 -1.7481 -2.4342 -2.2382\n-0.7949 -1.2816 -0.8436 -3.2609 -2.547 -1.233\n-0.7802 -0.9462 -0.415 -1.6932 -0.7968 -0.7636\n-0.9015 -1.1226 -0.2211 -1.9391 -1.0886 -0.6464\n-0.9497 -1.1829 -0.0167 -1.6161 -1.0996 -0.7164\n0.77226 0.37825 -0.7565 -1.8125 -0.3467 0.34673\n0.67922 -0.494 -0.3087 -0.8645 -0.247 0.30874\n0.4227 -0.5853 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0.53024 -1.6239 -1.8227\n-1.44 -2.34 -1.12 -0.64 -2.42 -3.44\n-1.6303 -1.7544 -0.6557 -2.0202 -4.2176 -4.4303\n-0.4343 -0.8537 -0.3145 -1.6325 -3.0253 -1.8721\n-0.1204 -0.7373 -0.963 -2.3623 -2.5128 -0.3611\n34.247 45.918 59.309 72.924 80.375 86.651\n35.875 48.874 60.621 71.662 78.816 86.133\n36.133 47.539 62.586 74.27 82.022 87.173\n62.476 69.01 78.008 87.712 86.706 86.075\n77.288 82.633 90.278 97.544 96.212 96.454\n78.573 84.285 91.177 96.808 96.628 97.135\n21.557 24.944 35.165 38.717 39.003 41.969\n21.563 25.272 36.567 39.969 40.628 44.138\n24.747 31.182 47.332 52.721 52.757 53.909\n20.137 25.839 40.888 45.706 47.167 52.039\n27.577 34.161 51.299 62.49 68.845 73.746\n30.808 37.459 54.186 67.034 77.109 83.469\n33.715 41.534 59.595 73.207 81.325 84.495\n36.044 44.191 61.983 73.142 79.707 83.245\n37.904 45.968 62.496 72.359 79.04 82.273\n17.857 27.612 43.704 54.326 59.827 62.222\n31.059 38.453 53.18 62.921 67.459 68.555\n24.419 29.426 39.457 48.057 54.576 58.202\n23.818 28.546 37.096 45.104 50.486 53.622\n31.559 32.933 35.795 42.11 48.407 54.722\n26.065 26.768 28.308 34.259 40.304 44.144\n45.289 62.123 74.768 77.573 78.578 81.024\n47.102 66.294 72.863 75.322 76.75 80.653\n46.893 61.758 77.278 81.444 80.685 85.787\n5.7157 10.172 32.654 45.659 47.647 52.982\n4.2087 7.2352 21.501 32.361 35.151 43.112\n3.5845 5.8055 18.541 30.812 40.174 53.078\n22.387 26.932 37.765 50.749 61.894 73.054\n25.291 29.707 38.704 50.817 60.95 70.944\n25.559 30.229 38.975 51.557 61.945 71.795\n25.027 29.183 41.127 54.306 62.726 70.694\n26.632 32.137 44.211 57.364 65.011 72.56\n28.981 33.005 42.53 54.91 63.506 71.286\n26.987 34.123 47.031 59.003 66.524 73.412\n28.651 34.255 44.403 56.772 64.799 72.338\n41.881 48.518 58.731 72.436 82.538 88.757\n44.688 63.94 87.198 99.651 99.162 98.381\n26.523 44.989 66.742 83.123 84.383 84.563\n22.866 38.171 61.966 81.105 82.337 82.595\n18.641 28.483 54.581 77.283 78.262 78.752\n26.823 32.063 40.9 49.557 52.332 59.855\n28.759 35.785 45.164 54.051 57.737 67.281\n36.542 41.79 48.938 56.793 59.884 65.856\n44.941 56.147 66.152 72.357 76.352 84.164\n40.696 56.009 74.184 87.162 90.255 90.456\n54.423 68.389 86.391 96.414 96.604 97.756\n31.912 42.007 54.046 65.813 72.819 76.736\n30.492 40.227 52.307 64.05 70.106 74.061\n26.349 36.864 66.478 78.387 84.12 94.451\n21.847 34.222 66.649 86.173 91.998 97.115\n20.471 33.02 61.804 77.313 78.89 85.945\n20.171 30.974 56.721 71.561 74.095 78.168\n20.465 29.89 57.632 74.281 77.316 82.268\n18.611 27.329 52.957 68.62 71.622 76.216\n22.051 31.583 58.762 75.225 76.145 76.905\n8.2721 16.112 43.607 63.909 68.834 73.844\n28.241 35.852 54.746 67.926 69.663 73.764\n18.286 26.905 41.524 51.19 51.167 51.714\n37.349 46.363 60.365 70.24 72.378 77.862\n61.78 69.42 75 81.26 81.26 87.1\n37.834 53.128 62.449 67.588 73.525 82.119\n50.906 64.52 72.503 78.254 82.702 88.767\n62.519 72.284 80.153 86.759 93.169 98.45\n42.632 53.558 65.132 76.129 82.032 85.842\n47.807 61.809 72.639 84.441 87.97 91.27\n40.93 52.814 62.924 76.107 80.519 83.731\n41.985 58.441 69.118 79.583 84.396 87.889\n44.065 60.628 66.788 75.984 79.457 84.033\n63.07 68.967 75.615 84.758 87.377 88.49\n74.054 82.104 85.248 92.624 93.712 97.046\n57.334 62.869 68.228 75.319 77.742 78.476\n67.912 72.573 75.192 80.013 81.737 82.775\n75.526 77.326 79.817 82.147 83.015 82.083\n46.125 54.36 59.669 66.69 68.217 69.002\n64.086 63.788 66.677 70.43 69.362 70.43\n51.307 59.814 63.3 68.831 70.183 70.754\n20.147 33.657 38.8 44.717 46.224 44.421\n33.339 52.743 60.532 68.913 71.758 72.519\n27.768 50.168 55.772 67.974 70.532 68.596\n20.065 35.317 41.626 52.168 59.446 64.87\n44.899 57.96 81.782 96.739 99.282 100.66\n62.646 78.21 99.925 103.08 100.54 102.35\n68.533 83.391 97.962 100.1 99.612 100.39\n41.503 52.797 70.094 81.418 88.282 91.851\n38.569 49.415 66.031 77.277 83.846 87.123\n60.816 72.141 81.029 89.079 93.112 97.161\n42.365 53.462 68.068 77.388 82.705 86.043\n49.187 60.963 75.13 81.754 87.305 91.444\n44.66 55.959 68.973 75.829 80.749 85.002\n50.644 61.657 73.398 80.937 86.071 90.647\n42.74 53.558 65.332 71.916 76.453 79.958\n45.627 56.161 67.1 74.301 80.039 84.168\n50.611 60.373 73.434 80.66 84.662 90.972\n44.341 53.785 64.205 70.878 75.786 80.043\n5.2983 10.068 22.57 30.218 41.079 49.882\n19.55 24.801 33.696 40.762 50.342 60.536\n23.597 31.344 42.802 50.054 62.084 74.455\n35.375 41.547 51.106 58.608 68.971 77.618\n25.485 31.391 39.063 42.529 50.762 60.408\n27.426 31.377 38.164 42.541 51.311 62.066\n25.763 29.631 34.745 39.939 47.083 55.841\n31.598 33.301 34.01 35.1 39.005 47.33\n25.616 25.96 26.648 27.564 31.309 38.281\n47.048 59.145 65.48 68.114 70.954 76.029\n65.581 72.236 75.742 79.642 84.258 94.204\n33.308 43.506 49.176 54.321 53.998 67.432\n8.1735 14.189 16.478 19.398 24.194 31.735\n80.919 83.044 93.77 99.046 98.945 97.673\n38.004 44.235 55.846 72.731 83.817 89.427\n60.883 66.887 75.816 87.823 91.564 92.618\n41.389 49.12 60.189 77.299 85.453 88.79\n40.705 45.999 57.554 73.407 81.811 85.625\n39.296 46.742 58.846 74.286 81.942 85.771\n43.555 48.935 61.867 77.649 82.033 84.744\n41.364 49.663 62.639 77.39 82.918 84.941\n40.1 50.809 65.025 78.797 83.822 85.598\n42.146 56.04 68.916 81.036 85.557 87.371\n37.162 50.678 67.285 81.137 84.281 85.691\n27.491 49.679 72.612 86.532 86.751 86.722\n27.248 46.615 69.254 84.192 83.966 84.026\n24.105 40.145 65.277 81.936 81.559 81.921\n19.155 29.848 58.753 77.72 78.395 78.442\n20.79 28.335 38.045 50.064 56.065 64.82\n21.127 30.718 41.947 55.57 65.269 77.002\n32.659 42.265 51.502 61.96 68.53 78.843\n29.698 39.039 46.033 56.673 62.557 70.771\n33.678 49.177 62.141 73.765 79.367 89.199\n44.559 56.506 73.916 86.03 87.871 87.749\n42.337 55.802 74.992 87.504 89.975 90.444\n61.483 73.978 90.78 100.36 100.92 101.25\n32.813 42.974 55.808 67.38 74.064 78.283\n30.968 40.762 52.926 64.41 70.247 74.441\n36.278 45.56 56.775 68.511 76.067 80.901\n23.811 32.709 43.509 55.934 65.813 72.735\n20.265 26.184 31.045 39.426 50.253 58.98\n28.186 38.821 71.584 84.31 90.385 102.09\n17.919 26.693 52.836 71.039 77.49 83.18\n16.375 24.599 49.125 66.312 71.885 77.169\n25.615 31.809 51.157 63.436 69.047 73.365\n27.6 34.255 50.901 62.087 66.155 71.864\n32.971 37.241 46.304 51.682 54.32 59.94\n59.768 64.336 73.933 79.864 79.343 84.172\n50.995 62.633 71.608 75.527 78.355 85.31\n62.082 70.515 78.626 82.873 88.316 94.848\n37.702 56.789 69.908 77.977 85.559 91.764\n39.002 56.148 70.543 80.102 90.087 95.206\n40.174 57.957 64.826 73.478 82.884 90.29\n40.704 56.837 69.014 77.798 85.25 90.948\n66.496 79.976 85.067 90.313 94.635 96.207\n47.328 60.883 68.063 75 77.535 79.022\n52.906 66.516 73.38 77.705 80.578 82.047\n40.742 54.159 60.616 64.199 67.309 69.376\n16.97 28.102 34.096 37.023 41.476 44.076\n17.317 29.534 33.086 36.763 41.486 43.35\n27.836 45.103 56.014 60.767 67.177 72.272\n28.216 45.569 57.172 63.175 68.791 73.802\n31.172 39.648 61.356 73.583 80.67 84.592\n32.602 40.904 61.319 75.256 81.023 85.234\n34.656 43.439 66.805 77.85 82.372 84.295\n36.782 46.531 69.121 78.038 81.005 83.234\n42.897 52.961 74.336 82.841 85.691 88.526\n37.801 47.354 67.633 76.283 79.468 81.622\n36.979 45.796 64.702 72.565 75.549 77.822\n24.771 33.033 46.319 58.552 66.753 80.254\n33.933 40.392 52.076 61.33 68.798 81.652\n28.559 34.052 42.642 51.916 60.9 76.078\n28.467 32.796 41.385 48.837 56.561 70.005\n37.219 37.766 40.465 45.492 53.608 72.208\n30.01 31.726 32.278 35.812 43.33 58.243\n40.232 63.441 73.734 75.796 76.773 79.052\n38.383 59.883 70.096 73.639 77.426 80.931\n45.789 70.67 82.328 84.684 85.229 87.814\n43.168 65.55 75.924 82.179 85.354 90.166\n8.099 13.068 20.053 22.423 29.178 43.66\n7.5665 14.555 19.511 21.51 27.54 42.491\n4.9544 9.3111 16.436 23.325 38.031 54.781\n4.8213 9.5964 19.886 34.35 47.643 62.369\n28.953 36.039 45.811 56.962 65.224 75.025\n27.583 33.892 45.758 58.903 65.937 74.179\n29.817 35.95 47.395 60.326 67.167 74.917\n29.368 37.235 48.796 61.028 67.771 75.23\n30.674 36.454 47.888 61.162 68.099 75.849\n29.304 38.646 51.722 63.533 69.955 76.827\n30.126 37.582 49.629 62.505 69.249 76.588\n39.872 49.065 62.849 80.901 86.077 89.453\n30.364 39.472 52.352 64.573 70.984 77.61\n38.418 45.153 61.223 77.707 81.69 83.059\n40.691 48.201 63.121 78.641 82.067 85.08\n28.977 41.372 56.053 68.393 73.378 78.653\n40.14 49.302 63.947 78.461 81.923 85.777\n38.478 49.993 66.225 80.276 83.754 86.447\n51.668 67.964 86.63 100.35 99.693 100.57\n28.332 50.78 74.551 86.834 88.055 88.099\n26.93 47.082 70.608 84.407 84.848 85.456\n24.007 40.831 66.353 81.737 82.373 83.055\n18.905 30.077 59.744 78.065 78.917 79.375\n22.452 31.312 41.552 51.216 57.413 65.96\n23.754 34.764 46.248 56.436 65.675 77.78\n37.238 47.315 56.253 63.754 72.13 83.611\n23.463 35.466 48.572 58.478 66.124 81.634\n32.326 40.595 49.308 56.734 64.35 72.396\n38.978 56.613 69.007 75.784 81.319 90.66\n43.011 57.542 74.537 84.08 88.097 90.308\n41.051 56.58 74.808 86.337 90.055 91.106\n44.377 57.745 74.421 87.76 89.585 90.297\n53.148 69.214 84.967 97.15 100.08 100.58\n54.816 71.835 87.003 96.189 96.884 98.361\n32.127 43.088 54.984 66.508 74.844 77.499\n30.853 41.132 52.525 63.577 70.618 74.064\n24.848 32.994 42.216 55.954 65.19 72.495\n19.405 25.847 30.294 38.81 49.573 57.518\n25.552 36.944 67.843 78.862 84.815 96.596\n18.107 28.309 52.287 67.888 72.866 78.685\n18.705 27.944 53.421 70.586 77.025 83.115\n17.204 25.681 49.938 65.895 72.004 77.952\n18.826 27.504 50.326 69.921 75.69 81.341\n25.336 33.303 51.373 62.354 67.486 73.318\n14.461 21.762 33.208 43.994 48.351 52.402\n26.895 34.666 50.175 60.548 65.107 72.127\n32.09 39.673 44.796 50 53.247 58.895\n34.906 44.93 58.084 66.159 69.73 76.478\n51.541 60.624 65.814 70.517 71.256 78.122\n59.464 69.24 75.731 81.919 82.564 85.245\n38.095 56.482 64.864 67.648 72.578 83.614\n49.047 63.665 72.246 74.955 78.223 85.896\n60.329 71.405 79.448 82.979 87.113 94.613\n24.034 33.189 43.043 48.922 58.777 73.978\n22.492 33.958 49.38 60.626 67.42 74.573\n39.506 50.294 66.243 77.195 81.087 86.303\n37.502 46.23 62.374 73.634 78.42 82.141\n34.17 44.351 60.669 72.19 77.029 82.218\n23.146 31.647 52.248 68.267 71.722 72.633\n16.384 23.074 39.613 51.482 54.939 55.899\n14.732 20.585 35.318 47.01 50.547 54.653\n14.42 20.145 35.204 51.726 57.977 61.983\n22.119 29.532 45.434 61.456 70.214 76.072\n30.752 37.069 51.113 65.752 72.429 78.166\n29.179 34.514 48.709 63.971 71.27 76.542\n27.032 32.608 46.092 61.582 68.175 72.749\n38.558 43.962 55.413 69.453 76.038 82.884\n39.967 46.105 56.264 67.623 74.212 81.251\n50.025 51.697 55.96 67.47 68.421 75.455\n33.988 35.695 46.486 61.186 70.123 87.19\n25.443 29.261 38.98 46.269 53.332 68.136\n26.626 32.027 42.829 50.018 57.84 75.271\n25.751 30.383 40.573 45.171 53.182 67.319\n31.766 36.796 49.326 57.829 64.207 79.364\n30.221 34.298 46.383 51.98 60.573 77.247\n27.182 36.783 49.891 60.941 66.895 72.382\n7.9535 13.245 26.953 40.006 47.96 56.567\n31.54 38.814 51.285 64.068 72.599 78.404\n24.459 29.413 41.755 55.81 65.35 72.81\n33.436 40.23 52.358 65.623 72.066 77.428\n27.711 33.314 45.787 59.729 67.262 73.052\n27.727 35.299 48.368 61.537 69.067 74.377\n41.821 47.985 60.256 76.297 84.95 88.664\n32.426 39.749 52.03 63.043 70.908 75.809\n51.297 62.14 81.077 95.027 94.685 97.749\n28.205 49.281 72.895 86.653 86.976 86.536\n28.391 46.924 69.117 84.308 84.323 84.566\n25.004 40.788 65.303 82.186 82.476 82.705\n25.132 41.664 67.811 83.426 84.023 84.176\n23.221 30.977 41.227 51.886 57.839 64.398\n23.154 33.553 45.212 56.78 65.26 74.196\n30.458 40.573 48.179 57.469 63.198 70.74\n36.762 50.622 62.552 70.925 76.443 85.136\n44.468 56.063 70.891 83.822 87.934 87.251\n42.895 56.572 72.114 86.543 90.198 90.903\n51.582 65.832 77.964 94.395 98.219 98.802\n56.196 66.708 81.392 93.636 94.956 95.591\n32.584 42.442 53.969 66.85 73.879 78.168\n31.127 40.605 51.804 64.306 70.699 75.236\n35.495 44.644 55.698 68.536 76.599 80.512\n20.668 25.4 31.967 40.829 49.929 58.158\n26.414 36.56 66.206 78.263 84.416 96.551\n18.123 26.95 52.981 72.816 78.977 84.741\n16.05 25.083 49.315 67.271 73.732 78.971\n17.081 25.579 51.327 68.257 73.446 77.377\n26.653 33.394 51.694 65.891 70.123 74.464\n27.177 36.421 55.851 69.699 70.974 72.879\n28.143 34.938 51.739 62.279 67.879 72.356\n35.906 43.94 57.817 68.982 72.079 78.222\n61.944 66.415 74.52 82.544 81.727 84.871\n50.696 61.691 71.219 76.482 79.704 87.689\n48.872 60.209 67.777 77.711 83.283 91.139\n43.773 57.501 70.96 80.427 85.494 91.466\n40.826 55.47 68.333 76.624 82.393 89.729\n39.544 48.249 66.24 80.228 84.491 92.916\n24.899 30.418 43.903 57.087 62.472 70.076\n24.509 29.419 41.701 52.241 60.885 72.725\n27.691 32.697 45.301 58.396 64.261 70.809\n28.847 33.64 47.046 58.574 64.141 70.221\n28.089 36.94 47.846 57.601 65.994 70.265\n30.773 37.222 49.448 60.531 65.05 73.048\n50.221 61.586 80.882 91.22 94.194 98.407\n40.638 50.102 67.768 80.943 84.728 92.095\n32.608 42.137 55.222 66.39 70.689 80.373\n35.905 43.739 57.475 66.268 72.528 82.501\n33.839 41.241 53.903 63.531 67.881 78.452\n5.0859 10.809 20.704 25.845 27.176 32.774\n7.8648 13.602 18.634 20.115 25.277 41.725\n21.286 26.528 32.42 36.411 40.893 56.684\n32.136 39.959 47.861 53.935 60.728 82.042\n26.081 31.029 38.37 43.022 49.109 65.902\n27.097 33.905 41.761 46.738 53.179 71.355\n27.286 32.589 40.141 45.008 49.941 65.447\n43.545 41.53 57.631 60.56 63.097 78.19\n28.629 34.034 42.82 50.274 54.465 70.418\n9.7538 15.11 28.957 36.121 42.581 58.938\n29.498 34.593 47.359 57.881 66.29 77.942\n27.146 32.851 43.6 54.56 63.945 73.893\n25.989 31.294 43.542 55.761 64.808 74.438\n33.02 41.268 54.207 63.977 70.855 78.453\n32.942 41.876 55.29 65.089 71.203 78.336\n32.805 42.794 57.053 66.486 72.315 79.201\n30.857 40.081 53.792 64.265 70.307 78.943\n27.401 32.085 45.029 57.131 64.731 73.272\n29.209 33.845 46.658 58.376 65.842 74.772\n29.448 35.247 48.182 59.617 66.593 76.762\n29.312 36.86 51.277 62.419 68.957 76.923\n32.769 35.983 50.703 63.242 70.531 76.786\n47.32 54.407 68.417 77.505 85.401 93.53\n48.569 61.671 76.261 83.64 87.989 92.691\n27.125 49.563 74.505 86.307 86.423 86.874\n28.693 47.229 72.021 84.5 84.227 85.456\n25.03 41.459 67.857 82.264 81.869 82.264\n19.677 30.489 61.422 78.882 78.218 79.642\n23.622 30.968 42.497 50.658 58.271 66.4\n25.515 35.254 47.766 58.836 67.335 80.777\n27.602 35.975 50.242 58.709 69.396 82.693\n33.301 41.036 50.201 58.209 65.075 72.584\n37.726 53.468 62.935 72.161 80.065 95.774\n44.579 56.034 75.234 84.266 89.235 91.704\n43.078 56.642 76.271 87.699 89.554 91.441\n35.578 45.815 61.57 73.632 77.672 84.405\n34.155 43.852 57.603 69.661 76.938 82.536\n32.748 42.07 55.443 67.61 73.433 79.538\n38.4 46.208 58.899 72.421 80.036 84.177\n24.312 31.055 37.217 50.352 61.07 70.917\n21.222 26.606 32.588 44.962 54.912 64.877\n26.096 36.772 68.113 79.179 85.75 97.44\n20.743 29.152 56.333 73.482 77.495 86.41\n18.565 26.931 52.332 68.476 72.891 79.939\n21.733 29.835 57.294 71.749 76.667 83.993\n21.731 30.559 55.909 72.343 76.311 78.706\n27.643 34.691 52.913 64.636 69.417 76.749\n28.99 36.468 51.822 62.7 66.117 74.636\n37.331 46.989 59.411 68.082 72.113 80.01\n51.866 62.464 67.98 74.091 76.262 84.77\n51.934 63.009 71.835 74.902 79.434 88.158\n51.16 63.664 72.025 75.264 79.572 87.798\n62.232 71.515 79.982 84.654 87.164 99.365\n33.175 44.747 58.663 69.693 73.742 80.692\n38.31 50.009 64.518 75.83 79.501 84.771\n44.797 59.782 78.604 91.789 92.942 94.726\n45.983 62.55 80.378 92.015 93.161 94.937\n59.204 78.52 96.441 100.47 100.96 101.35\n58.041 81.817 96.923 101.51 100.48 100.07\n50.791 76.311 92.12 100.2 97.709 98.665\n24.447 28.981 39.84 45.494 45.452 46.711\n22.697 28.735 39.371 44.951 47.317 48.823\n19.975 25.792 35.076 41.07 43.037 44.402\n24.076 30.711 42.004 49.357 51.131 52.431\n21.232 27.027 37.568 44.138 45.498 47.116\n33.591 43.123 60.57 70.23 73.021 73.851\n28.287 36.816 51.465 60.499 62.448 64.295\n25.311 32.293 45.614 53.701 55.394 58.108\n35.326 42.512 56.82 76.153 87.218 98.235\n38.968 46.29 63.866 83.03 93.841 101.15\n29.15 35.589 50.735 68.897 79.369 89.372\n34.218 40.367 58.717 78.774 84.732 92.224\n45.891 53.388 69.103 84.677 91.452 97.067\n31.974 37.884 56.588 73.682 82.794 89.756\n32.16 37.565 52.718 70.709 81.756 90.046\n34.599 40.458 56.053 75.073 84.388 91.61\n36.06 41.518 52.2 66.864 74.747 85.072\n38.376 43.885 55.659 70.077 77.743 86.432\n32.206 37.737 47.25 59.949 69.056 78.058\n38.902 44.439 54.686 67.542 72.49 81.48\n42.453 48.743 57.908 69.722 75.847 84.47\n39.715 43.896 54.347 65.601 71.054 77.931\n41.736 43.455 47.041 55.934 60.033 71.438\n38.627 43.367 49.104 51.894 55.35 66.429\n16.288 19.787 24.368 27.39 30.746 40.814\n4.3335 7.9638 17.951 22.5 26.704 39.188\n27.949 30.979 39.728 42.878 48.567 58.779\n27.117 30.537 38.748 42.216 47.411 57.993\n31.85 36.317 46.475 49.635 54.272 68.048\n22.262 24.681 31.857 34.309 39.081 49.591\n20.955 23.223 29.409 31.449 36.081 46.397\n25.208 28.064 35.405 39.837 44.2 55.523\n23.851 26.166 32.522 36.004 39.976 50.879\n29.136 31.734 38.819 41.122 43.184 51.048\n37.753 42.238 55.404 65.493 67.116 68.999\n44.623 49.151 61.282 73.902 75.34 77.773\n44.063 57.616 70.63 77.631 82.579 89.91\n23.687 34.911 43.459 50.444 58.358 70.511\n12.817 18.203 25.459 32.494 43.251 55.196\n11.361 15.82 23.797 31.332 40.78 54.511\n54.394 61.25 71.703 84.398 92.467 99.125\n47.938 54.952 63.973 74.285 81.804 87.837\n42.499 48.767 62.051 76.292 83.42 89.055\n43.077 48.733 62.061 74.827 80.743 84.139\n42.06 49.669 63.826 76.188 81.486 85.121\n40.703 50.989 65.884 77.152 82.017 85.247\n42.271 55.72 69.778 80 84.363 87.452\n37.483 50.311 67.64 79.819 82.685 85.577\n55.467 67.426 88.629 103.5 99.894 102.07\n28.791 50.583 74.812 87.435 87.303 87.819\n29.214 47.001 70.081 83.968 83.548 84.538\n25.699 41.471 66.408 81.328 81.537 82.538\n20.612 31.081 60.152 77.718 77.687 78.212\n31.772 32.509 42.335 52.211 58.287 65.149\n34.824 36.297 46.875 57.328 65.984 75.629\n43.062 47.137 54.199 60.997 68.916 76.588\n38.853 41.121 49.521 56.515 62.6 69.179\n54.696 55.7 68.482 75.917 79.487 87.399\n43.544 55.872 72.019 82.31 85.65 85.905\n43.335 57.085 74.491 86.312 89.703 89.516\n52.862 65.148 82.053 94.339 98.414 99.829\n56.412 70.029 84.302 92.687 94.755 91.3\n34.3 43.552 55.228 67.574 73.583 77.837\n31.465 41.043 52.151 64.848 69.915 73.617\n36.186 45.077 56.316 69.131 76.416 80.551\n24.799 32.465 42.195 56.181 65.457 70.856\n20.805 26.172 31.492 41.531 50.387 57.601\n27.803 38.466 65.582 79.529 84.998 96.67\n16.114 24.273 49.65 65.672 70.7 77.514\n14.267 27.083 52.25 71.2 76.917 83.583\n17.189 24.141 50.033 66.105 71.641 76.759\n18.458 27.714 54.907 71.693 75.863 76.33\n18.507 23.387 36.547 45.667 49.027 52.4\n13.351 20.671 34.89 45.73 49.061 52.37\n30.341 36.815 47.216 52.287 55.934 59.193\n33.793 38.51 45.815 52.286 54.665 59.82\n54.153 60.365 65.926 71.271 69.411 77.916\n61.108 67.723 76.39 81.769 81.71 87.647\n36.124 51.563 62.392 67.179 71.312 81.222\n39.646 54.963 67.77 71.335 77.539 89.817\n51.424 64.057 72.334 77.301 81.477 92.095\n63.089 70.649 79.262 83.546 87.711 95.449\n6.1844 8.8073 21.963 35.74 52.319 63.791\n50.127 60.656 76.159 84.129 88.129 92.694\n54.456 64.686 78.956 86.216 89.645 93.587\n43.815 49.138 62.065 68.283 68.908 70.091\n45.649 48.428 58.421 69.142 72.103 68.793\n25.792 40.799 71.592 80.572 85.024 94.875\n35.042 44.587 56.981 60.949 61.876 61.917\n23.971 34.578 48.2 53.429 53.945 54.557\n26.76 36.448 45.986 51.338 51.818 53.177\n20.835 31.402 44.384 51.168 51.95 51.82\n36.676 53.033 68.07 72.569 72.946 73.73\n29.643 42.233 56.855 66.528 66.625 67.703\n30.353 46.213 62.864 72.61 74.889 73.361\n7.3518 12.005 20.782 29.723 45.322 66.053\n26.756 37.006 49.503 62.421 70.365 75.113\n57.906 72.673 84.976 93.908 96.646 99.367\n52.48 65.998 80.743 89.949 94.493 98.375\n61.445 71.269 84.4 92.743 95.804 99.325\n47.866 60.443 74.934 84.472 88.618 92.482\n49.151 59.321 73.871 83.565 88.523 93.48\n49.405 54.627 68.392 74.834 80.658 87.826\n28.176 34.392 38.617 45.912 58.556 71.201\n36.719 43.379 49.581 60.038 73.991 87.565\n35.122 40.935 46.301 56.473 69.518 83.273\n34.371 39.626 45.204 54.252 66.173 79.966\n24.645 28.543 32.821 38.916 48.811 60.175\n22.546 26.301 29.196 36.229 45.378 54.511\n28.479 31.958 37.227 44.424 54.962 67.667\n25.332 28.98 33.17 39.682 49.057 60.283\n22.719 26.465 30.767 37.6 45.82 56.33\n26.066 32.579 33.874 39.155 45.128 55.715\n30.417 63.995 84.926 96.888 100.74 98.712\n30.763 55.289 89.713 100.74 101.57 100.5\n30.78 61.869 96.324 99.466 101.38 100.04\n17.332 28.472 47.592 58.895 72.858 80.91\n13.16 25.164 44.242 55.408 63.517 74.836\n10.035 21.316 41.239 52.241 61.192 74.289\n5.5417 9.0072 20.184 33.703 46.222 62.879\n5.7348 9.8021 18.357 31.354 45.785 61.618\n6.8013 10.909 20.084 29.815 44.545 65.657\n6.5983 12.124 19.283 30.333 45.131 66.416\n6.3364 10.606 18.964 28.901 44.021 64.473\n53.701 61.859 69.807 87.104 95.08 99.874\n48.066 56.497 64.149 77.002 85.093 88.933\n41.054 49.05 59.06 76.996 84.807 89.219\n40.062 46.472 58.241 74.499 80.488 83.995\n42.872 48.988 60.613 76.113 81.608 85.324\n41.492 50.015 62.408 77.164 82.245 85.037\n40.296 51.201 64.796 78.665 83.297 86.434\n56.394 66.982 74.595 85.042 91.879 96.052\n42.476 56.996 68.726 81.413 85.952 88.354\n54.712 67.241 76.538 85.806 92.568 98.035\n36.766 50.25 66.473 80.227 84.046 86.044\n24.848 41.221 64.277 81.273 81.744 82.336\n28.915 51.487 73.768 87.577 86.716 88.204\n25.129 41.684 66.51 82.352 81.866 82.17\n19.247 30.081 58.754 78.017 77.954 78.902\n22.596 30.237 39.74 49.506 54.974 64.213\n23.91 33.81 44.67 56.127 63.638 77.231\n34.691 45.342 52.938 65.91 70.952 79.432\n31.735 39.945 49.663 58.483 63.775 72.691\n38.925 55.652 66.874 76.25 80.611 90.379\n44.373 56.083 73.397 84.437 87.178 88.975\n41.987 55.706 74.604 87.365 89.829 90.174\n57.054 73.165 87.071 96.539 98.82 100.06\n55.404 67.868 84.044 97.181 94.841 95.306\n33.551 45.531 58.496 70.665 77.503 81.399\n32.89 42.557 55.181 67.332 74.176 78.95\n30.767 40.475 51.972 64.159 70.582 74.908\n25.128 32.298 42.793 55.648 64.932 73.969\n23.631 30.407 35.699 45.916 57.219 65.953\n20.129 25.757 30.281 40.385 50.772 58.811\n26.987 37.156 48.644 60.207 66.064 79.002\n25.261 35.78 66.593 78.409 83.249 95.16\n16.862 27.108 51.797 68.943 73.533 78.353\n18.03 28.232 52.806 71.011 78.171 83.817\n16.502 24.314 49.14 66.575 70.838 77.79\n12.636 20.218 52.1 66.126 67.582 83.397\n18.489 27.5 54.712 71.513 75.426 77.221\n25.411 32.38 50.929 63.349 66.137 73.284\n12.024 17.629 33.725 47.042 48.527 53.605\n27.078 34.183 50 61.034 65.45 71.561\n31.473 36.826 46.22 52.26 56.676 60.008\n36.943 47.573 60.697 69.462 74.051 77.864\n53.479 61.15 67.228 72.3 69.627 75.778\n57.667 68.905 75.882 81.785 81.501 83.732\n50.766 61.335 68.63 72.031 75.67 81.402\n49.28 63.468 70.487 74.233 76.623 83.59\n40.087 58.709 68.267 67.991 78.419 84.627\n50.473 63.941 72.328 75.951 79.333 86.908\n61.088 72.803 79.843 83.763 86.401 96.095\n32.603 43.529 56.247 65.685 70.021 75.108\n34.877 46.37 59.633 69.257 73.64 78.154\n29.806 40.757 54.752 65.011 70.578 73.285\n34.308 49.269 67.953 76.496 81.858 84.85\n41.885 58.798 77.341 85.929 90.449 92.778\n45.159 64.194 80.368 89.28 93.54 95.929\n55.742 81.145 98.355 101.61 100 100.99\n25.435 30.303 43.182 46.928 48.246 48.709\n22.984 27.338 38.816 42.483 44.359 44.569\n21.113 24.609 35.601 38.553 40.675 42.13\n25.246 29.899 42.276 45.892 47.475 47.817\n39.974 47.044 67.125 72.935 75.297 75.051\n33.647 40.286 57.442 62.607 65.08 65.572\n29.839 35.478 50.398 55.562 57.627 60.335\n25.494 30.691 45.344 50.123 54.353 59.564\n23.845 29.979 45.704 50.84 56.808 62.582\n36.218 41.282 56.962 72.975 83.623 95.063\n40.405 46.371 62.962 80.092 89.359 98.611\n32.049 39.176 56.391 70.818 80.138 89.458\n45.58 49.574 67.387 84.037 92.551 100.51\n19.275 28.325 54.036 70.644 74.947 77.365\n48.875 55.531 71.045 85.531 91.592 100.84\n33.842 39 55.761 70.432 81.745 89.876\n42.326 48.324 70.858 82.326 88.629 93.408\n36.426 42.051 59.237 75.461 83.744 91.391\n39.613 46.24 62.634 78.252 84.647 90.762\n42.715 48.565 66.989 79.532 84.93 92.059\n37.785 42.518 54.008 66.932 74.247 83.968\n35.085 39.385 50.995 62.606 69.724 78.978\n40.084 44.557 57.429 69.767 76.728 85.126\n43.498 48 60.049 70.834 75.709 83.822\n39.647 44.203 56.186 67.018 71.85 79.196\n44.559 49.091 61.289 71.229 76.309 84.117\n40.653 45.429 56.629 66.478 71.332 78.322\n40.134 42.942 52.233 61.927 66.378 72.89\n42.513 44.507 48.662 56.922 60.944 68.473\n24.175 25.315 27.56 30.668 36.367 48.334\n3.4435 6.3177 17.287 18.87 22.036 36.115\n28.117 31.295 40.148 42.116 45.627 54.162\n18.085 18.789 25.682 27.66 29.997 36.095\n27.241 29.51 38.68 41.122 43.028 52.529\n32.874 36.362 47.193 50.332 54.817 64.884\n31.799 35.807 46.185 49.58 51.103 64.228\n35.652 40.445 51.663 52.298 57.242 59.283\n21.97 24.57 31.175 34.04 37.202 45.215\n20.794 22.851 28.811 31.725 35.068 42.015\n28.156 30.748 38.372 39.834 44.302 52.658\n22.211 25.312 31.514 34.529 38.427 45.34\n27.921 30.48 38.899 40.116 42.34 47.6\n25.226 28.601 34.532 37.072 39.151 43.259\n40.126 43.556 52.725 65.546 65.784 66.004\n29.459 36.255 40.191 46.848 52.352 60.44\n9.9641 12.549 18.707 25.242 29.533 40.934\n9.6255 12.776 19.461 26.076 32.079 43.542\n9.9316 13.113 20.344 26.04 32.439 43.592\n9.2472 11.378 17.721 24.063 29.529 41.801\n53.757 61.752 73.185 82.553 91.467 98.925\n49.007 56.332 65.122 74.348 82.772 89.322\n42.696 49.893 62.545 74.996 83.893 89.305\n43.41 49.355 62.665 74.583 80.629 84.747\n42.143 50.467 64.327 75.798 81.392 85.458\n40.797 51.427 66.575 77.306 82.419 86.256\n28.435 50.271 75.011 86.714 87.095 87.403\n28.606 47.703 71.333 84.705 84.827 84.613\n24.808 41.265 66.902 82.499 82.898 82.653\n19.845 30.504 59.867 77.875 78.445 78.223\n34.552 36.17 45.709 56.773 65.595 77.045\n40.185 40.981 49.399 56.792 63.617 70.929\n54.643 55.777 66.488 72.987 78.318 88.592\n45.33 55.933 73.229 83.366 87.397 87.848\n52.72 65.183 81.079 96.285 99.263 98.511\n56.79 70.293 84.642 95.962 96.151 96.277\n33.041 43.124 55.48 68.444 75.067 78.423\n31.245 40.738 52.745 64.975 71.135 74.364\n35.959 45.065 57.346 69.193 76.367 80.994\n25.237 33.16 42.774 57.73 67.329 72.878\n23.807 30.136 35.71 47.582 58.593 65.368\n20.21 25.932 31.144 42.174 52.455 59.324\n25.838 36.136 68.21 79.452 84.79 95.701\n18.124 27.734 51.069 67.444 72.549 79.332\n18.167 26.263 52.082 69.431 76.21 82.598\n16.445 24.147 48.312 64.501 69.538 76.967\n34.924 42.009 61.356 77.257 85.749 93.238\n26.115 33.116 51.016 62.876 67.356 73.631\n27.907 34.338 49.718 61.328 64.676 71.987\n60.069 68.94 77.02 81.933 81.811 87.475\n34.4 52.74 62.579 65.835 73.142 85.657\n50.862 61.718 68.911 72.639 77.632 87.157\n52.186 63.978 71.451 76.607 81.066 91.169\n41.036 57.277 66.323 70.428 79.46 92.685\n52.789 65.801 73.42 77.422 83.48 93.649\n65.014 73.726 80.638 84.788 88.862 95.621\n31.743 43.661 56.181 66.941 74.754 83.074\n33.425 46.396 59.334 69.416 75.568 81.672\n54.44 69.601 77.986 86.077 90.316 92.992\n68.152 90.172 97.231 99.609 99.849 101.05\n28.735 32.329 44.381 51.182 55.107 60.124\n26.362 29.499 41.369 50.808 57.735 62.339\n31.371 36.46 48.017 55.556 58.628 63.175\n44.493 51.062 67.207 75.762 77.859 79.969\n37.53 43.592 59.898 73.35 79.596 82.394\n30.776 39.221 61.056 78.267 85.764 87.675\n43.622 60.761 82.927 94.43 95.369 95.633\n52.277 73.503 93.678 100.44 103.35 102.33\n43.506 64.049 88.055 95.577 98.227 97.101\n55.678 73.146 90.598 99.516 101.47 100.97\n47.375 64.34 84.845 93.237 95.929 97.973\n45.048 61.058 80.017 90.703 95.663 98.82\n45.564 58.558 77.32 88.058 94.182 98.355\n43.503 55.543 71.694 82.023 87.204 91.283\n45.294 56.336 70.975 80.891 86.471 90.773\n53.238 63.293 76.76 86.882 92.159 96.154\n45.819 54.699 68.93 79.548 85.836 90.1\n43.134 52.469 65.267 75.406 81.477 85.759\n45.986 55.281 68.646 78.955 85.194 89.644\n45.388 49.01 55.085 66.39 76.104 82.044\n29.327 34.468 38.163 48.756 60.209 67.197\n6.3957 9.9233 23.988 29.785 38.727 52.393\n19.682 22.565 32.293 36.736 43.702 56.512\n26.674 31.016 40.489 45.15 51.693 60.893\n26.324 30.575 39.237 43.713 50.894 61.584\n21.424 24.546 32.177 37.727 44.681 54.41\n21.353 24.04 30.567 34.55 40.714 49.486\n25.664 28.958 37.966 41.143 47.378 59.176\n23.456 21.439 23.701 25.943 28.857 32.994\n43.387 55.224 62.508 65.272 67.971 72.444\n48.852 58.517 66.592 71.568 72.162 75.967\n51.121 64.175 72.796 76.395 78.063 82.545\n30.033 37.733 46.982 53.452 58.634 67.115\n31.355 36.195 44.396 52.12 58.317 68.26\n9.0469 11.859 22.188 32.516 40.859 55.672\n10.291 14.776 25.402 35.944 43.993 59.137\n9.8471 14.161 21.584 27.737 34.319 49.974\n10.005 12.955 23.513 34.087 42.232 55.22\n53.129 65.447 74.629 82.893 92.019 98.658\n47.454 57.739 66.563 74.55 83.473 88.637\n41.644 51.603 63.827 75.481 84.115 89.543\n40 48.454 61.992 72.493 79.68 84.359\n42.032 50.749 63.689 74.251 80.72 85.389\n41.202 51.771 65.677 75.584 81.934 86.036\n39.831 52.642 67.581 76.849 82.691 86.632\n41.269 57.165 71.328 79.836 84.853 88.013\n36.29 50.819 68.626 79.526 83.48 86.188\n26.951 50.161 73.724 85.842 86.356 86.708\n27.435 47.096 69.989 83.463 84.499 84.789\n25.767 42.499 67.309 82.372 83.738 83.632\n20.875 31.98 59.855 78.559 79.314 78.874\n30.331 33.262 42.663 53.456 60.711 67.688\n33.77 37.064 47.565 58.633 67.54 78.307\n37.41 41.639 48.873 56.319 63.341 70.46\n51.709 56.205 68.328 74.339 79.896 90.15\n43.91 56.165 73.218 84.015 87.564 89.158\n39.912 55.04 73.34 84.341 89.17 89.764\n40.595 56.773 73.718 84.333 89.851 90.332\n50.224 62.367 80.201 94.215 97.711 98.036\n52.068 70.886 84.263 93.106 95.74 98.845\n30.575 40.95 53.215 65.049 72.298 75.052\n25.874 33.648 43.723 58.593 68.004 73.742\n24.493 30.685 36.939 48.218 59.219 66.457\n21.647 27.031 32.604 42.9 53.133 59.666\n21.606 29.861 59.693 79.109 88.765 98.137\n16.871 24.273 48.346 64.961 72.071 77.755\n19.312 28.174 53.691 70.239 75.499 77.354\n18.659 22.784 36.239 50.381 56.027 63.246\n14.871 19.595 31.429 41.769 47.746 53.001\n31.664 38.41 45.421 50.777 54.293 61.999\n47.696 58.377 64.305 67.829 70.432 76.071\n57.899 69.91 77.708 82.777 84.161 88.335\n34.943 52.831 63.086 67.137 73.829 85.911\n48.887 62.205 68.652 72.153 77.536 86.78\n40.003 58.802 66.682 70.296 78.66 93.845\n50.258 66.003 73.147 76.97 83.331 93.859\n60.563 74.081 79.192 82.292 86.98 95.584\nAL GL MM H3 H6 H7 H9 H16 MGC\nAL GL MM H3 H6 H7 H9 H16 MGC\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\n10 sec\n1 min\n10 min\n1 hr\n4 hrs\n16 hrs\nTime in D2O\n15 30 45 60 75 90 100\nPercent Deuterium Uptake\nNo data\n0\n-25 -15 -10 -5 0 5 10\n% Deuterium Difference\n15 20 25 30\nNo data\n-30 -20\nNo change\n15 30 45 60 75 90 100\nPercent Deuterium Uptake\nNo data\n0\nVL\nCL\nVL\nCL\nVL\nCL\nVL\nCL\nVL\nCL\nVL\nCL\nDeuterium Uptake of LC Isoforms – Percent Deuterium Uptake\nEffect of M83 on LC isoforms – Percent Deuterium Difference\nDeuterium Uptake of LC Isoforms + M83 – Percent Deuterium Uptake\n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S7. Peptide chiclet plots showing deuterium uptake of various LCs and the effect of M83. Top \npanel: Percent deuterium uptake (%D) for all nine LC isoforms in the absence of M83. Levels of \ndeuterium uptake are color-coded as per the legend, with red indicating high uptake (low protection) \nand blue indicating low uptake (high protection). Middle panel: Percent deuterium uptake (%D) for all \nnine LC isoforms in the presence of M83. Bottom panel: Percent deuterium difference (Δ%D) plots \nshowing the effect of M83 on deuterium uptake for each LC isoform. Blue regions indicate areas of \nincreased protection upon M83 binding, while green regions represent areas with reduced protection. \nThe solid horizontal line indicates the boundary between the variable domain (V\nL) and the constant \ndomain (CL).  \n  \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\n \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint \n\nFigure S8. Limited proteolysis assay of FL LCs with and without M83 monitored by SDS-PAGE. FL LCs \nwere tested at a concentration of 8.3 μM, with M83 at 50 μM (1:6 molar ratio) in 10 mM phosphate \nbuffer, pH 7.4, 150 mM NaCl, at 37°C and 450 rpm. Proteolysis reaction was initiated by addition of \ntrypsin at 0.232 μM. Time points (0, 1, 30, 180 minutes, and 24 hours) are shown for digestion \nexperiments. \"+\" and \"-\" refer to digestion in the presence and absence of M83, respectively. Gels (10-\n20%) were run under reducing conditions and stained with Coomassie Blue. Alcohol dehydrogenase was \nincluded as a loading control (not shown). Data were fitted to a single exponential decay model and the \narea under the curve (AUC) was calculated. Dashed lines show data where the fits did not converge. For \ncomparison, the average AUC for all residues was calculated for each FL LC. \n.CC-BY 4.0 International licenseavailable under a \n(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made \nThe copyright holder for this preprintthis version posted January 8, 2026. ; https://doi.org/10.64898/2026.01.07.698275doi: bioRxiv preprint","source_license":"CC-BY-4.0","license_restricted":false}