{"paper_id":"0cddd7e4-1c96-478d-bca6-913822bc4766","body_text":"Abstract\nWe describe a middle-aged Chinese systemic lupus erythematosus (SLE) patient developing steroid refractory and transfusion dependent red cell aplasia. Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy.\nSimilar content being viewed by others\nReferences\nChoi BG, Yoo WH (2002) Successful treatment of pure red cell aplasia with plasmapheresis in a patient with systemic lupus erythematosus. Yonsei Med J 43(2):274–278\nKiely PD, McGuckin CP, Collins DA, Bevan DH et al (1995) Erythrocyte aplasia and systemic lupus erythematosus. Lupus 4:407–411\nLinardaki GD, Boki KA, Fartakis A, Tzioufas AG (1999) Pure red cell aplasia as presentation of systemic lupus erythematosus: Antibodies to erythropoietin. Scand J Rheumatol 28:189–191\nAbkowitz JL, Kadin ME, Powell JS, Adamson JW (1986) Pure red cell aplasia: lymphocyte inhibition of erythropoiesis. Br J Haematol 63:59–67\nClark DA, Dessypris EN, Krantz SB (1984) Studies on pure red cell aplasia. XI. Results of immunosuppressive treatment of 37 patients. Blood 63:277\nWinkler A, Jackson RW, Kay DS (1988) High dose intravenous cyclophosphamide treatment of systemic lupus erythematosus associated aplastic anemia. Arthritis Rheum 31:693\nDuarte-Salazar C, Cazarin-Barrientos J, Goycochea-Robles MV, Collazo-Jaloma J et al (2000) Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with cyclosporin A. Rheumatol 39:1155–1157\nIlan Y, Naparstek Y (1993) Pure red cell aplasia associated with systemic lupus erythematosus: remission after a single course of intravenous immunoglobulin. Acta Haematol 89:152–154\nLippman SM, Durie BGM, Garewal HS, Giordano G et al (1986) Efficacy of danazol in pure red cell aplasia. Am J Hematol 23:373–379\nRoubinian JR, Papoian R, Talal N (1977) Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest 59:1066–1070\nRoubinian JR, Talal N, Greenspan JS, Goodman JR et al (1978) Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med 147:1568–1583\nMichalski JP, McCombs CC, Roubinian JR, Talal N (1983) Effect of androgen therapy on survival and suppressor cell activity in aged NZB/NZW F1 hybrid mice. Clin Exp Immunol 52:229–233\nStein CM (2001) Immunoregulatory drugs. In: Ruddy S (ed) Kelley’s Textbook of Rheumatology. W.B. Saunders, Philadelphia, pp 879–898\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nChan, A.Y., Li, E.K., Tam, L. et al. Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid. Rheumatol Int 25, 388–390 (2005). https://doi.org/10.1007/s00296-004-0521-6\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00296-004-0521-6","source_license":"CC0","license_restricted":false}