{"paper_id":"0cb5815b-fe9f-4dc4-9b2f-5ef069f3e8ea","body_text":"- Login\n- Register\n- Home/Current Issue\n- About the journal\n- Editorial board\n- Online submission\n- Instructions for authors\n- Subscriptions\n- Foundation Acta Endocrinologica\n- Archive\n- Contact\nRomanian Academy\nThe Publishing House of the Romanian Academy\nACTA ENDOCRINOLOGICA (BUC)\nThe International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List\nActa Endocrinologica(Bucharest) is live in PubMed Central\nJournal Impact Factor - click here.\nThis Article\nServices\nGoogle Scholar\nPubMed\nActa Endocrinologica (Buc)\nHosseini E, Nikmard F, Aflatoonian B, Vesali S, Alenabi T, Aflatoonian A, Mehraein F, Aflatoonian R\nControlled Ovarian Stimulation in Endometriosis Patients Can Be Individualized by Anti-Mullerian Hormone Levels\nActa Endo (Buc) 2017, 13 (2): 195-202doi: 10.4183/aeb.2017.195\nContext. Anti-Mullerian hormone (AMH) assay\nis becoming the best indicator of successful IVF treatment\nresponse to fertility drugs and could be a useful marker of\nembryo implantation potential. Various protocols are being\nused for controlled ovarian stimulation (COS), but there is an\nuncertainty regarding the implementation of the best protocol\nfor endometriosis patients and also little evidence is available\nconcerning the clinical value of AMH levels in endometriosis.\nObjective. This study aimed to evaluate the\nprognostic value of serum AMH levels for pregnancy\nin COS using GnRH-agonist(GnRH-a) and GnRHantagonist(\nGnRH-ant) protocols in endometriosis patients.\nDesign. This is a cross-sectional study between\nMarch 2012 and November 2015.\nSubjects and Methods. Data were collected from\n249 COS cycles of endometriosis patients, including 129\ncycles with GnRH-a and 120 cycles with GnRH-ant. Patients\nin each group were classified into three subgroups based on\ntheir serum AMH levels. The outcomes of ICSI program\nwere evaluated.\nResults. The ROC curve analysis showed that\nembryo and oocyte counts and AMH were equally predictive\nfor pregnancy, as demonstrated by a similar area under\nthe curve (AUC) of 0.69, 0.66 and 0.64, respectively.\nThe sensitivity and specificity for prediction of positive\npregnancy were 70.91% and 67.01% for embryo counts,\n70.91% and 67.53% for oocyte counts at the cutoff values\nof 5 and 7, respectively, and 83.64% and 52.58% for AMH\nlevels at the cutoff values of 1.3ng/mL.\nConclusions. This study demonstrates that AMH\nas a single test has substantial accuracy in the prediction of\npregnancy using the GnRH antagonist protocol for patients\nwith endometriosis. In other words, AMH assay prior\nto ovarian stimulation initiation guides the clinicians to\nchoose the antagonist stimulation protocol for the patients\nwith two extreme AMH levels. AMH levels can be used to\nindividualize control ovarian stimulation in endometriosis\npatients.\nKeywords: Anti-Mullerian hormone, Ovarian induction, Endometriosis, Gonadotropin releasing hormone\nCorrespondence: Fereshteh Mehraein MD, PhD, Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Hemmat highway, 1449614525, Tehran, Iran, E-mail: femehra@yahoo.com","source_license":"CC0","license_restricted":false}