{"paper_id":"0ca4066d-7f8c-4090-8f68-59e627b2accd","body_text":"Abstract\nDuring the past 50 years, the medical management of endometriosis has evolved from a primitive clinical art utilizing agents with poor specificity, to a scientific endeavour utilizing pharmacological compounds that are highly specific in their molecular actions and extensively studied in randomized clinical trials. The first medical regimens developed to treat endometriosis utilized high-dose testosterone propionate1 or high-dose diethylstilboesterol2. These regimens were moderately effective in the treatment of endometriosis, but they were associated with major unwanted side-effects, such as virilization in the case of testosterone proprionate therapy1. In the late 1950s Kistner introduced progestin-only3 and pseudopregnancy4 regimens for the treatment of endometriosis. These regimens remained the standard medical therapy until danazol (Figure 13.1) was approved for use in 1976. 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Endocrinol., 29, 45–51\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 1991 Springer Science+Business Media Dordrecht\nAbout this chapter\nCite this chapter\nBarbieri, R.L. (1991). The use of danazol as a treatment of endometriosis. In: Thomas, E.J., Rock, J.A. (eds) Modern Approaches to Endometriosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3864-2_13\nDownload citation\nDOI: https://doi.org/10.1007/978-94-011-3864-2_13\nPublisher Name: Springer, Dordrecht\nPrint ISBN: 978-94-010-5719-6\nOnline ISBN: 978-94-011-3864-2\neBook Packages: Springer Book Archive\nKeywords\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}