{"paper_id":"0b52e94d-84d4-43ba-be92-38028290f31e","body_text":"Abstract\nPurpose\nThe glutathione family (GST) genes appear to play a role in the genesis of endometriosis. This case–control study aimed to compare the frequencies of GSTM1 and GSTT1 polymorphisms in women with endometriosis and women without endometriosis.\nMethods\nPolymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97).\nResult(s)\nNo differences in the frequencies of GSTM1 polymorphism (null genotype) were observed between the cases and controls: odds ratio (OR) = 1.13; 95 % CI 0.656–1.93 (p = 0.659). The GSTT1 polymorphism (null genotype) was more prevalent in the endometriosis group than in the control group (OR = 0.53; 95 % CI 0.94–0.29 (p = 0.039). No relationship between menstrual cycle interval and GSTM1 null genotype frequency was observed in either cases or controls (p = 0.370 and p = 0.664, respectively). In addition, no relationship between menstrual cycle interval and GSTT1 null genotype was observed in cases (p = 0.797) or controls (p = 0.052).\nConclusions\nGSTM1 null genotype frequency was similar between cases and controls. The GSTT1 null genotype was more frequent in the control group.\nSimilar content being viewed by others\nAbbreviations\n- CEP-HUJM:\n-\nResearch Ethics Committee—Julio Muller Hospital University\n- DNA:\n-\nDeoxyribonucleic acid\n- GSH:\n-\nGlutathione\n- GSTM1:\n-\nGene mu (μ) 1 the glutathione S-transferase system\n- GSTT1:\n-\nGene theta (θ) 1 the glutathione S-transferase system\n- BMI:\n-\nBody mass index\n- bp:\n-\nBase pairs\n- PCR:\n-\nPolymerase chain reaction\n- UFMT:\n-\nFederal University of Mato Grosso\n- USA:\n-\nUnited States of America\nReferences\nOlive DL, Schwartz LB. Endometriosis. N Engl J Med. 1993;328:1759–69.\nKennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G, Greb R, et al. ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–704.\nMeyer R. 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Fertil Steril. 2008;90 Suppl 3:S260–9.\nAcknowledgments\nThis study was supported by the National Council of Research and Development (CNPq) and the Mato Grosso Foundation for Research (FAPEMAT).\nConflict of interest\nThere is no conflict of interest in connection with this article for any of the authors.\nInformed consent\nInformed consent was obtained from all individual participants included in the study.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAdditional information\nCapsule\nGSTT1 null polymorphism may protect against endometriosis development in mixed-race Brazilian women.\nRights and permissions\nAbout this article\nCite this article\nKubiszeski, E.H., de Medeiros, S.F., da Silva Seidel, J.A. et al. Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis. J Assist Reprod Genet 32, 1531–1535 (2015). https://doi.org/10.1007/s10815-015-0554-7\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s10815-015-0554-7","source_license":"CC0","license_restricted":false}