{"paper_id":"0a4aff96-da0b-4c2b-9476-bdcb38784fcb","body_text":"A Multicenter Retrospective Study on Single-Level Thoracolumbar Corpectomy and Vertebral Body Replacement by Neurosurgeons | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A Multicenter Retrospective Study on Single-Level Thoracolumbar Corpectomy and Vertebral Body Replacement by Neurosurgeons Mohammad Khalil Al-Barbarawi, Valerio di Norcia, Luigi Valentino Berra, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4707605/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Vertebral body replacement (VBR) with expandable cages after corpectomy is a critical procedure in spinal surgery, addressing conditions like fractures and tumors that compromise the anterior column of the spine. The eXtreme Lateral Interbody Fusion (XLIF) approach has revolutionized this technique by minimizing muscle dissection and reducing recovery times compared to traditional approaches. Methods: A retrospective clinical study was conducted on 23 consecutive patients who underwent single-level corpectomy and VBR between 2018 and 2023. Surgical outcomes were evaluated using visual analog scale (VAS) for pain and American Spinal Injury Association (ASIA) for neurological status. Radiological assessments included preoperative and postoperative CT scans to measure regional angulation and stability. Results: Postoperatively, patients showed significant pain reduction (median VAS score decreased from 8 to 2) and neurological improvement (82.6% ASIA E classification). Radiologically, there was a median kyphotic angle correction of 5° post-dorsal stabilization and 9° post-ventral stabilization. Complications included pleural injuries (8.7%) and hypoesthesia (8.7%), with higher incidence in thoracic VBR cases and patients with osteoporosis. Conclusion: VBR via XLIF is a promising technique for treating vertebral fractures and tumors, offering substantial pain relief, neurological recovery, and spinal stability. Despite some complications, the procedure demonstrates significant clinical and radiological benefits, underscoring its efficacy in complex spinal pathologies. Vertebral body replacement eXtreme Lateral Interbody Fusion corpectomy expandable cages spinal surgery neurological outcomes Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {\"props\":{\"pageProps\":{\"initialData\":{\"identity\":\"rs-4707605\",\"acceptedTermsAndConditions\":true,\"allowDirectSubmit\":true,\"archivedVersions\":[],\"articleType\":\"Research Article\",\"associatedPublications\":[],\"authors\":[{\"id\":333992030,\"identity\":\"7089cded-a6f2-4959-85bc-45984440771b\",\"order_by\":0,\"name\":\"Mohammad Khalil Al-Barbarawi\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Städtisches Klinikum 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The eXtreme Lateral Interbody Fusion (XLIF) approach has revolutionized this technique by minimizing muscle dissection and reducing recovery times compared to traditional approaches.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eMethods: \\u003c/strong\\u003eA retrospective clinical study was conducted on 23 consecutive patients who underwent single-level corpectomy and VBR between 2018 and 2023. Surgical outcomes were evaluated using visual analog scale (VAS) for pain and American Spinal Injury Association (ASIA) for neurological status. Radiological assessments included preoperative and postoperative CT scans to measure regional angulation and stability.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eResults: \\u003c/strong\\u003ePostoperatively, patients showed significant pain reduction (median VAS score decreased from 8 to 2) and neurological improvement (82.6% ASIA E classification). 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