{"paper_id":"0995d1b1-ece1-4b6c-90d0-bed27ca138d3","body_text":"Evolving T-Cells to Outsmart Cancer | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 14 April 2025 V1 Latest version Share on Evolving T-Cells to Outsmart Cancer Author : Ememobong Eka 0009-0000-6997-0329 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174466176.61258809/v1 404 views 86 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Are modern treatments enough? There are treatments such as radiation therapy and chemotherapy, however, they cannot fully treat the ailment. Nevertheless, there are limitations with those cancer treatments because they target all cells and are not specific, have severe side effects, and have limited persistence. The promising nature of immunotherapy, especially for blood cancers, could have the same effect on solid tumors if refined and enhanced. Therefore, this concept of adaptive T-cell evolution would solve the obstacle of tumor immune evasion by allowing T-cells to evolve in real time, similar to how bacteria adapt under selective pressure. Self-editing T-cells would continuously reinforce their receptors and functions to counteract emerging tumor mutations and improve their effectiveness and longevity. This approach could create a universal and reliable approach to cancer treatment and more adequate personalized therapies. Moreover, this could usher in a new path of fully curing cancer as a whole. In a study by Dimitri et al., CRISPR-Cas9 technology has led to a surge in applying genome editing approaches to combat genetic disorders and cancers. The technology can induce specific mutations in the setting of in vitro and in vivo experimental disease models to study various interventional strategies. (Dimitri et al., 2022) This concept can be promising and change the trajectory of cancer treatment to be improved. Evolving T-Cells to Outsmart Cancer Cancer is an inflammatory disease and is a constant challenge for many people regardless of age, ethnicity, country of origin, or lifestyle. Immune cells already help to rid the body of potential threats. For instance, immune cells help to break down ink particles in tattoos over time. This same function of immune cells is utilized against cancerous cells. Unfortunately, there is no sure way of avoiding cancer as it is prevalent, and there is a dire need for better Supplementary Material File (evolving t-cells to outsmart cancer (5).pdf) Download 141.19 KB Information & Authors Information Version history V1 Version 1 14 April 2025 Copyright This work is licensed under a Creative Commons Attribution 4.0 International License Keyword cancer immunotherapy gene editing t-cell therapy crispr immuno-oncology cell therapy precision medicine Authors Affiliations Ememobong Eka 0009-0000-6997-0329 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 404 views 86 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Ememobong Eka. Evolving T-Cells to Outsmart Cancer. Authorea . 14 April 2025. DOI: https://doi.org/10.22541/au.174466176.61258809/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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