{"paper_id":"0717cc27-21d4-47b7-b500-7f4105efb9ea","body_text":"How the therapy for endometriosis affects the hormonal status in female infertility\nDOI:\nhttps://doi.org/10.12775/JEHS.2020.10.08.062Keywords\nendometriosis, pituitary hormones, ovarian hormones, hypothalamic-pituitary-ovarian system, infertility, dienogest, a-GnRH, diferelinAbstract\nAim. To determine changes in the values of pituitary and ovarian hormones in women with endometriosis-associated infertility, as well as to evaluate the impact of endometriosis therapy on hormonal parameters\nMaterials and Methods. Sixty-nine women with small-sized endometriomas with adenomyosis (target group) and 50 women with tubal infertility (controls) were examined. The values of pituitary (luteinizing and follicle-stimulating hormones, prolactin) and ovarian (estradiol, tubular antimullerian hormone) hormones were studied. The comparison of quantitative indicators between the studied groups of women was carried out using the Mann-Whitney U-test, the statistical significance of the results was assessed at a level of not less than 95% (risk of error not more than 5% - p <0.05).\nResults\nInfertile women with endometrioma and adenomyosis have lower AMH levels than infertile women with tubal factor. Among patients with endometriosis, there is an increase in serum FSH, LH, prolactin and estradiol compared with women without endometriosis.\nDienogest moderately inhibits the secretion of FSH and LH; it has almost no effect on blood AMH and estradiol values. The use of dienogest can moderately increase the level of prolactin, It is noteworthy that these indicators are within the reference range. The use of diferelin for the treatment of endometriosis has a more active effect on the hormonal status of patients, given the decrease in such indicators as FSH and LH, AMH, estradiol and prolactin\nConclusions. Women with infertility against the background of endometriosis have minor changes in the hypothalamic-pituitary-ovarian system, which indicates the need to develop medical measures in order to correct them.\nThe use of dienogest compared to diferelin affects the hormonal status of patients with endometriosis to a lesser extent, given the pronounced anti-proliferative effect.\nReferences\nBenagiano G, Brosens I. The history of endometriosis. Gynecol Obstet Invest. 2014;78(1):1-9\nRadzinsky VY, Orazov MR, Ivanov II, Khamoshina MB, Kostin IN, Kavteladze EV, Shustova VB. Implantation failures in women with infertility associated endometriosis. Gynecological Endocrinology. 2019. 35:sup1, 27-30, DOI:10.1080/09513590.2019.1632089\nEisenberg VH, Weil C, Chodick G, Shalev V. Epidemiology of endometriosis: a large population‐based database study from a healthcare provider with 2 million members. BJOG. 2018;125(1):55-62. doi: 10.1111/1471-0528.14711\nMarchenko LA, Il’ina LM. 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Journal of Assisted Reproduction and Genetics.2019;36: 1179–1184\nDownloads\nPublished\nHow to Cite\nIssue\nSection\nLicense\nThe periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0\nStats\nNumber of views and downloads: 1365\nNumber of citations: 0","source_license":"CC0","license_restricted":false}