{"paper_id":"06ee5501-75c2-47c5-93de-776fc8ba6dba","body_text":"Abstract\nThis chapter discusses the role of assisted conception, i.e. in vitro fertilisation (IVF), gamete intra-fallopian transfer (GIFT), and zygote intra-fallopian transfer (ZIFT) in the management of male infertility. In vitro fertilisation was initially developed as a treatment for female infertility secondary to bilateral fallopian tube occlusion. Indications for its use have broadened and it is now being employed successfully for other causes of infertility such as endometriosis, unexplained infertility and male factor infertility (Rogers 1989; Yates and De Kretser 1987). Pregnancy rates have gradually improved from 16.5% in earlier series to approximately 30% in later series (Edwards et al. 1984).\nPreview\nUnable to display preview. Download preview PDF.\nSimilar content being viewed by others\nReferences\nAbdalla HI, Ahuja KK, Leonard T, Morris NN (1988) The value of IVF-ET in patients undergoing treatment by the GIFT procedure. Human Reprod 3:944–947\nAcosta AA, Chillik CF, Brugo S et al. (1986) In vitro fertilisation and the male factor. Urology 28:1–9\nAitken RJ, Best FSM, Richardson DW, Djahanbacklich O, Templeton A, Lees MM (1982) An analysis of semen quality and sperm function in cases of oligospermia. Fertil Steril 38:705–711\nAl-Shawaf T, Ah-Moye M, Junk S, Brinsden P, Craft I (1990) Fertilisation of supernumerary oocytes following gamete intra-fallopian transfer (GIFT). Correlation with outcome of GIFT treatment. J IVF-ET 2:98–102\nAsch RH, Ellsworth LR, Balmaceda JP, Wong PC (1984) Pregnancy after translaparoscopic gamete intrafallopian transfer. Lancet ii:1034–1035\nAsch RH, Ellsworth LR, Balmaceda JP, Wong PC (1985) Gamete intra-fallopian transfer (GIFT). A new treatment for infertility. Int J Fertil 30:41–45\nAsch RH, Balmaceda JP, Ellsworth LR, Wong PC (1986) Preliminary experiences with gamete intra-fallopian transfer (GIFT). Fertil Steril 45:366–371\nAwadalla SG, Friedman CI, Schmidt G, Chin K, Kim MH (1987) In vitro fertilisation and embryo transfer as a treatment for male factor infertility. Fertil Steril 47:807–811\nBalmaceda JP, Gastaldi C, Remohi J, Bornero C, Ord T, Asch R (1988) Tubal embryo transfer as a treatment for infertility due to male factor. Fertil Steril 50:476–479\nBalmaceda JP, Remohi J, Ord T, Patrizio P, Asch RH (1989) Tubal embryo transfer (TET): results in cases of oligoasthenozoopsermia and failed GIFT. Abstracts VI world congress on in vitro fertilisation and alternate assisted conception, Jerusalem, Israel, 1989, p 43\nBelaisch-Allart JC, Hazout A, Guillet-Russo F, Glissant M, Testart J, Frydman R (1985) Various techniques for oocyte recovery in an in vitro fertilisation and embryo transfer programme. J IVF-ET 2:99–104\nBerger T, Marrs RP, Majer DL (1985) Comparison of techniques for selection of motile spermatozoa. Fertil Steril 43:268–273\nBlackledge DG, Matson PL, Wilcox DC, Yovich JM, Turner SR, Richardson PA (1986) Pronuclear stage transfer and modified gamete intra-fallopian transfer techniques for oligospermic cases. Med J Aust 145:173–174\nBongso TA, Ng SC, Mok H, Lim MN, Teo HL, Wong PC, Ratnam SS (1987) Effect of sperm motility on human in vitro fertilisation. Arch Androl 22:185–190\nBorrero C, Ord T, Balmaceda JP, Rojas FJ, Asch RH (1988) The GIFT experience: an evaluation of outcome of 115 cases. Hum Reprod 3:227–230\nCohen J, Alikani M, Maker HE, Adler A, Talansky BE, Rosenwaks Z (1991) Partial zona dissection or subzonal sperm insertion: microsurgical fertilisation alternatives based on evaluation of sperm embryo morphology. Fertil Steril 56:696–706\nCohen J, Alikani M, Adler A et al. (1993) Microsurgical fertilization procedures: absence of stringent criteria for patient selection. (in press)\nCohen J, Weber RFA, van der Vijver JCM, Zeilmaker GH (1982) In vitro fertilising capacity of human spermatozoa with the use of zona-free hamster ova: inter-assay variation and prognostic value. Fertil Steril 37:565–572\nCohen J, Edwards RG, Fehilly CB et al. (1984) Treatment of male infertility by in vitro fertilisation: factors affecting fertilisation and pregnancy. Acta Eur Fertil 15:455–465\nCohen J, Edwards RG, Fehilly CB, Fishel SB, Hewitt J, Purdy J (1985). In vitro fertilisation: a treatment for male infertility. Fertil Steril 43:422–432\nCohen J, Malter H, Wright G, Kort H, Massey J, Mitchell D (1989) Partial zona disection of human oocytes when failure of zona pellucida penetration is anticipated. Human Reprod 4:435–442\nCorson SL, Batzer F, Eisenburg E, English ME, White SM, Laberge Y, Go KJ (1986). Early experience with the GIFT procedure. J Reprod Med 31:219–223\nCraft I, Brinsden PR, Simons EG, Lewis PM (1988). Limitations of GIFT. Lancet i:183\nCritchlow JD, Matson PL, Troup SA, Ibrahim ZHZ, Burslem RW, Buck P Lieberman BA (1990) Fertilisation in vitro of supernumerary oocyte following gamete intra-fallopian transfer (GIFT). Hum Reprod 5:853–856\nDe Kretser DM, Dennis P, Hudson B et al. (1973) Transfer of a human zygote. Lancet 2:728–729\nDe Kretser DM, Yates CA, Kovacs GT (1985) The use of IVF in the management of male infertility. Clin Obstet Gynecol 12:767–773\nDevroey P (1990) Zygote intra-fallopian transfer (ZIFT). Hum Reprod abstracts of the II joint ESCO-ESHRE meeting, Milan, 1990 p 55\nDevroey P, Braeckmans P, Smitz J et al. (1986) Pregnancy after translaparoscopic zygote intrafallopian transfer in a patient with sperm antibodies. Lancet i:1329\nDevroey P, Staessen C, Camus M (1989a) Results of zygote intrafallopian tube transfer. Abstracts VI world congress in vitro fertilisation and alternate assisted reproduction, Jerusalem, Israel, 1989, p 155\nDevroey P, Staessen C, Camus M, De Grauwe E, Wisanto A, Van Steirteghem AC (1989b) Zygote intrafallopian tube transfer as a successful treatment for unexplained infertility. Fertil Steril 52:246\nDiamond MP, Rogers BJ, Vaughn WK, Wentz AC (1985) Effect of the number of inseminating sperm and the follicular stimulation protocol on in vitro fertilisation of human oocytes in male factor and non-male factor couples. Fertil Steril 1985 44:449\nDiedrich K, Bauer O, vander Ven H, Al-Hasanii S, Krebs D (1990) The transvaginal intratubal embryo transfer: a new treatment of male infertility. Hum Reprod abstracts of the II joint ESCO-ESHRE meeting, Milan, 1990, p 55\nEdwards RG, Fishel SB, Cohen J et al. (1984) Factors influencing the success of in vitro fertilisation alleviating human infertility. J. IVF-ET 1:3–23\nEdwards RG, Steptoe PC, Purdy JM (1970) Fertilisation and cleavage in vitro of pre-ovulatory human oocytes. Nature 227:1307–1309\nFishel S, Jackson P, Antinori S, Johnson J Grossi S, Versaci C (1990) Subzonal insemination for the alleviation of infertility. Fertil Steril 54:828\nFormigli L, Coglitore MT, Roccio C, Belotti G, Stangalini A, Formigli G (1990) One hundred and six gamete intra-fallopian transfer procedures with donor semen. Hum Reprod 5:549–552\nGellert-Mortimer ST, Clarke GN, Naker HWG, Hyne RV, Johnson WCH (1988) Evaluation of Nycodenz and percoll density gradients for the selection of motile human spermatozoa. Fertil Steril 49:335–341\nGibbons W (1987) In vitro fertilisation as therapy for male factor infertility. Urol Clin North Am 14:563–567\nGordon JW (1990) Zona drilling: a new approach to male infertility. J IVF-ET 9:223–228\nGuzick DS, Balmaceda JP, Ord T, Asch (1989) The importance of egg and sperm factors in predicting the likelihood of pregnancy from gamete intrafallopian transfer. Fertil Steril 52:795–800\nHammitt DG, Syrop CH, Hahn SJ, Walker DL, Butkowski CR, Donovan JF (1990) Comparison of concurrent pregnancy rates for in vitro fertilisation embryo transfer, pronuclear stage tubal transfer and gamete intra-fallopian transfer. Hum Reprod 5:947–954\nHamori M, Stuckensen JA, Rumpf D, Knewald T, Kniewald A, Marquez MA (1988) Zygote intrafallopian transfer (ZIFT): evaluation of 42 cases. Fertil Steril 50:519–521\nHargreave TB, Aitken RJ, Elton RA (1988) Prognostic significance of the zona-free hamster egg test. Br J Urol 62:603–608\nHinting A, Comhaire F, Schoonjam F (1988) Capacity of objectively assessed sperm motility characteristics in differentiating between semen of fertile and subfertile men. Fertil Steril 50:635–639\nHinting A, Comhaire F, Vermeulen L, Dhout M, Vermeulen A, Vandekerckhove D (1990) Possibilities and limitation of techniques of assisted reproduction for the treatment of male infertility. Hum Reprod 5:544–548\nHirsch I, Gibbons WE, Lipshultz L (1986) In vitro fertilisation in couples with male factor infertility. Fertil Steril 45:659–664\nHonda I, Kobayashi Y, Inoue M, Murahami M, Fujii A (1987) Result of 106 gamete intra-fallopian transfers. In: Progress in clinical and biological research, vol 302. Sperm measures and reproductive success. Alan R Liss, New York, pp 181–186\nHyne RV, Stajanoff A, Clarke GN, Lopata A, Johnston WIH (1986) Pregnancy from in vitro fertilisation of human eggs after separation of motile spermatozoa by density gradient centrifugation. Fertil Steril 45:93–96\nJean M, Barriere P, Sagot P, L’Hermite A, Lopes P (1992) Utility of zona pellucida drilling in cases of severe semen alterations in man. Fertil Steril 57:591–596\nJeulin C, Feneux D, Serres C, Jouannet D, Guillet-Rosso F, Belaisch-Allart J, Testart J (1986) Sperm factors related to failure of human in vitro fertilisation. J Reprod Fertil 76:735–744\nJohnson JP, Alexander NJ (1984) Hamster egg penetration: comparison of preincubation periods. Fertil Steril 41:599–602\nKhan I, Camus M, Staessen C, Wisanto A, Devroey D, Van Steirteghem AC (1988) Success rate in gamete intra-fallopian transfer using low and high concentration washed spermatozoa. Fertil Steril 50:922–927\nKruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehmger S (1988) Predictive value of abnormal sperm morphology in in vitro fertilisation. Fertil Steril 49:112–117\nKruger TF, Menkveld R, Stander FSH et al. (1986) Sperm morphologic features as a prognostic factor in in vitro fertilisation. Fertil Steril 46:1118–1123\nLacham O, Sakkas D, Trounson AO (1990) Improved fertilisation rates after microinjection of human male factor sperm under the zona pellucida. Proceedings of the 9th annual scientific meeting, Fertility Society of Australia, 26–29 September 1990, Perth, abstract 8\nLay G, Bayers SP, Decherney AH (1988) Hyaluronidase removal of cumulus oophorus increases in vitro fertilisation. J IVF-ET 5:257–260\nLeeton J, Rogers P, Caro C, Healy D, Yates C (1987) A controlled study between the use of gamete intra-fallopian transfer management of idiopathic and male infertility. Fertil Steril 48:605–607\nLippi J, Turner M, Jansen RPS (1990) Pregnancies after in vitro fertilisation by sperm microinjection into the perivitelline spaces. Proceedings of the 9th annual scientific meeting, Fertility Society of Australia, 26–29 September 1990, Perth, abstract 9\nLiu DY, Du Plessis YP, Narjadu PC, Johnson WIH, Baker HWG (1988) The use of in vitro fertilisation to evaluate putative test of human sperm function. Fertil Steril 49:272–277\nLucena E, Lucena C, Gomez M (1989) Recovery of motile sperm using migration sedimentation technique in an in vitro fertilisation embryo transfer programme. Hum Reprod 4:163–165\nMahedevan MM, Trounson AO (1984) The influence of seminal characteristics on the success rate of human in vitro fertilisation. Fertil Steril 42:400–405\nMahadevan MM, Trounson AO (1985) Removal of the cumulus oophorus from the human oocyte in vitro fertilization. Fertil Steril 43:263–267\nMalter HE, Cohen J (1989) Partial zona dissection of the human oocyte: a non-traumatic method using micromanipulation to assist zona pellucida penetration. Fertil Steril 51:139–148\nMargalioth EJ, Navot D, Laufer N, Lewin A, Rabinowitz R, Schenker JG (1986) Correlation between free hamster egg sperm penetration assay and human in vitro fertilisation. Fertil Steril 45:665–670\nMatson PL, Blackledge DG, Richardson PA, Turner SR, Yovich JM, Yovich JL (1987) The role of gamete intra-fallopian transfer in the treatment of oligospermic infertility. Fertil Steril 48:608–612\nMatson PL, Turner SR, Yovich JM, Tuvik A (1986) Oligospermic infertility treated by in vitro fertilisation. Aust NZ J Obstet Gynecol 26:84–87\nMcDowell J (1986) Preparation of spermatozoa for insemination in vitro. In: Jones HW et al (eds) In vitro fertilisation (Ells). Hodg Waverly Press, London, p 162–167\nMcKenna KM, McBain JC, Speirs AL, Jones G, Du Plessis Y, Johnston WIH (1988) The fate of supernumerary oocytes in gamete intra-fallopian transfer (GIFT) is not predictive of a poor outcome: the effect of oocyte selection. J IVF-ET 5:261–264\nMedical Research International, Society for Assisted Reproductive Technology. The American Fertility Society (1990) In vitro fertilisation embryo transfer in the United States: 1988 results from the IVF-ET Registry. Fertil Steril 53:13\nMenkveld R, Stander FSH, Kotze TJVW, Kruger TF, Van Zyl JA (1990) The evaluation of morphologic characteristics of human spermatozoa according to stricter criteria. Hum Reprod 5:586–592\nMolloy D, Speirs AL, du Plessis Y, Geliert S, Bourne H, Johnston WIH (1986) The establishment of a successful program of gamete intra-fallopian transfer (GIFT): preliminary result. Aust NZ J Obstet Gynecol 26:206–209\nNg SC, Bongso TA, Ratnam SS et al. (1988) Pregnancy after transfer of multiple sperm under the zona. Lancet ii:790\nOrd T, Patrizio P, Marello E, Balmaceda JP, Asch RH (1990) Mini-percoll: a new method of semen preparation for IVF in severe male factor infertility. Hum Reprod 5:987–989\nPalermo G, Devroey P, Camus M et al. (1989) Zygote intra-fallopian transfer as an alternative treatment for male infertility. Hum Reprod 4:412–415\nPalermo G, Camus M, Joris H, Devroey P, Derdre M, Steirteghem AV (1993) Sperm characteristics and outcome of human assisted fertilisation by subzonal insemination and intracytoplasmic sperm injection. Fertil Steril 59:826–835\nPilikian S, Watrelot A, Dreyfus JM, Ecochard R, Gennaro JD (1990) Gamete intra-fallopian transfer with cryopreserved donor serum following AID failure. Hum Reprod 5:944–946\nPool TB, Ellsworth LR, Garza JR, Martin JE, Miller SS, Alice SH (1990a) Zygote intra fallopian transfer as a treatment for non tubal infertility. A 2 year study. Fertil Steril 54:482–488\nPool TB, Martin JE, Ellsworth LR, Parez JB, Alice SH (1990b) Zygote intra-fallopian transfer with “donor rescue” a new option for severe male factor infertility. Fertil Steril 54:166–168\nPurdy JM (1982) Methods for fertilisation and embryo culture in vitro. In: Edwards RG, Purdy JM (eds) Human conception in vitro. Academic Press, London, p 135\nQuigley MM, Sokoloski JE, Withers DM, Richards SI, Rers JM (1987) Simultaneous in vitro fertilisation and gamete intra-fallopian transfer (GIFT). Fertil Steril 47:797–801\nRamsewak SS, Cooke ID, Li TC, Kumar A Momnks NJ, Lenton EA (1990) Are factors that influence oocyte fertilisation predictive? An assessment of 148 cycles of in vitro fertilisation without gonadotrophin stimulation. Fertil Steril 54:470–474\nRogers BJ (1989) Examination of data from programs of in vitro fertilisation in relation to sperm integrity and reproductive success. In: Progress in clinical and biological research, vol 302. Sperm measures and reproductive success. Alan R Liss, New York, p 69–93\nRogers BJ, Wentz AC (1987) IVF as therapy for infertility secondary to oligospermia. In: Proceedings of the 12th world congress on fertility and sterility, Singapore, 1986, pp 95–99\nSakkas D, Lacham O, Gianavoli L, Trounson A (1992) Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilisation. Fertil Steril 57:1279–1288\nSchlaff WD (1987) New ways to prepare semen for IUI. Contemp Obstet Gynecol 4:79–86\nScholtes MCW, Roozenburg BJ, Alberda AT, Zerlmalcer GH (1990) Transcervical intra-fallopian transfer of zygotes. Fertil Steril 54:5–9\nSherman JK (1986) Cryopreservation of spermatozoa. In: Insler V and Lunennfeld B. (eds) Infertility: male and female. Churchill Livingstone, Edinburgh, pp 590–606\nThanki KH, Gagliardi CL, Schmidt CL (1992) Poor in vitro fertilisation outcome with semen yielding low sperm density “swim ups” is not because of altered sperm motion parameters. Fertil Steril 58:770–775\nTournaye H, Devroey P, Joris H, Lui J, Nagy P. Van steirteghem AC (1993) Microsurgical epididymal sperm aspiration and intracytoplasmic sperm injection: a winning team. In: Ombelet W (ed) Andrology in the nineties; international symposium on male infertility and assisted reproduction. Abstract number 93, Wyeth 2130 AG Hoofddorp, The Netherlands\nTur-Kaspa I, Dudkrewkz A, Confino E, Grenchen N (1990) Pooled sequential ejaculates: a way to increase the total number of sperm from oligospermic men. Fertil Steril 54:906–909\nVan der Ven HH, Hoebbel K, Al-Hasani S, Diedrich K, Krebs O (1989) Fertilisation of human oocytes in capillary tubes with very small numbers of spermatozoa. Hum Reprod 4:72–76\nWiedemann R, Noss U, Hepp H (1989) Gamete intra-fallopian transfer in male subfertility. Hum Reprod 4:8–11\nWolf DP, Byrd W, Dandekar P, Quigley MM (1984) Sperm concentration and the fertilisation of human eggs in vitro. Biol Reprod 31:837–848\nWHO (1987) World Health Organization laboratory manual for the examination of human semen and semen cervical mucus interaction. Cambridge University Press, Cambridge\nWong PC, Ng SC, Hamilton MPR, Anandakumar C, Wong YC, Ratnam SS (1988a) Eighty consecutive cases of gamete intra-fallopian transfer. Hum Reprod 3:321–323\nWong PC, Bongso A, Ng SE et al. (1988b) Pregnancies after human tubal embryo (TET): a new method of infertility treatment. Singapore J Obstet Gynecol 19:41–43\nYanagimachi R, Yanagimachi H, Rogers BJ (1976) The use of zona-free animal ova as a test system for the assessment of fertilising capacity of human spermatozoa. Biol Reprod 15:471–476\nYates CA, De Kretser DM (1987) Male factor infertility and in vitro fertilisation. J IVF-ET 4:141–147\nYee B, Cummings LM (1988) Modification of the sperm penetration assay using human follicular fluid to minimise false negative results. Fertil Steril 50:123–128\nYee B, Rosen GF, Chacou RR, Soubra S, Stone S (1989) Gamete intra-fallopian transfer: the effect of the number of eggs used and the depth of gamete placement on pregnancy initiation. Fertil Steril 52:639–644\nYovich JL, Stanger JD (1984) The limitations of in vitro fertilisation from males with severe oligospermia and anormal morphology. J IVF-ET 1:172–179\nYovich JM, Edirisinghe WR, Cummins JM, Yovich JL (1988a) Preliminary results using pentoxifylline in a pronuclear stage tubal transfer (PROST) program for severe male factor infertility. Fertil Steril 50:179–181\nYovich JL, Matson PL, Blackledge DG et al. (1988b) The treatment of normospermic infertility by gamete intra-fallopian transfer (GIFT). Br J Obstet Gynaecol 95:361–366\nYovich JL, Draper RR, Turner SR, Cummins JM (1990) Transcervical tubal embryo stage transfer (TC-TEST). J In Vitro Fertil Embryo Transf 7:137–140\nYovich JL, Yovich JM, Edirisinghe WR (1988c) The relative chance of pregnancy following tubal or uterine transfer procedures. Fertil Steril 49:858–864\nEditor information\nEditors and Affiliations\nRights and permissions\nCopyright information\n© 1994 Springer-Verlag London Limited\nAbout this chapter\nCite this chapter\nWong, P.C., Kamal, A. (1994). The Role of Assisted Conception in Male Infertility. In: Hargreave, T.B. (eds) Male Infertility. Springer, London. https://doi.org/10.1007/978-1-4471-1029-3_20\nDownload citation\nDOI: https://doi.org/10.1007/978-1-4471-1029-3_20\nPublisher Name: Springer, London\nPrint ISBN: 978-3-540-76216-4\nOnline ISBN: 978-1-4471-1029-3\neBook Packages: Springer Book Archive\nKeywords\nThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.","source_license":"CC0","license_restricted":false}