{"paper_id":"060adcfe-a7fe-4856-ae3d-ec220fe10bd6","body_text":"Altered Notch Pathway-Related Protein Expression in Cord Blood of Preeclampsia Offspring | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Altered Notch Pathway-Related Protein Expression in Cord Blood of Preeclampsia Offspring Ouxuan Jin, Yixin Wu, Liwei Tang, Jingyun Yang, Meixian Zhang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8591375/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 15 Apr, 2026 Read the published version in BMC Pregnancy and Childbirth → Version 1 posted 24 You are reading this latest preprint version Abstract Objective: This study aims to investigate the differential expression of NCOR2, DLL-4, and Jagged-1 proteins in cord blood samples from offspring of mothers with preeclampsia (PE), gestational hypertension (GH), and healthy controls, to understand the impact of these conditions on offspring health. Methods: This is a prospective cohort study, including 17 mother-offspring pairs with gestational hypertension, 17 mother-offspring pairs with preeclampsia, and 34 healthy mother-offspring pairs as controls. Standardized questionnaires were used to collect family and birth information, medical records were used to collect clinical data, and Western blot was employed to measure the expression levels of NCOR2, DLL-4, and Jagged-1 in cord blood. We analyzed the differences in offspring cord blood proteins among the three groups. Results: Protein expression levels of NCOR2, DLL-4, and Jagged-1 differed significantly among the control, GH, and PE groups: ①NCOR2: 1.36±0.44 (control), 1.00±0.12 (GH), 0.94±0.15 (PE) ( p =0.001), with the GH and PE significantly lower than control group. ②DLL-4: 0.82±0.28 (control), 0.98±0.17 (GH), 1.27±0.40 (PE) ( p =0.001), with the PE significantly higher than GH, and GH higher than control group. ③Jagged-1: 1.36±0.28 (control), 1.02±0.12 (GH), 0.87±0.18 (PE) ( p <0.001), with the PE significantly lower than GH, and GH lower than control group. Conclusion: The offspring cord blood levels of NCOR2 and Jagged-1 proteins were significantly increased in offspring of PE and GH, while DLL-4 protein expression was significantly decreased. Preeclampsia NCOR2 DLL-4 Jagged-1 Figures Figure 1 Introduction Preeclampsia and gestational hypertension represent two prevalent forms of hypertensive disorders in pregnancy [1] . Preeclampsia (PE) is a major contributor to maternal and neonatal mortality [2] . Epidemiological data from 2019 indicate that PE affects approximately 2%-5% of pregnancies and is a leading cause of perinatal mortality in both mothers and offspring [3] . Globally, an estimated 4 million women are diagnosed with PE annually, resulting in over 70,000 maternal and 500,000 infant deaths [3, 4] .Studies suggest that offspring of preeclamptic pregnancies face significantly elevated risks of metabolic, neurological, and cardiovascular diseases in adulthood, with neurodevelopmental impairments being particularly prominent [3, 5, 6] . Accumulating evidence indicates that fetal and early-life neurodevelopment progresses at an unparalleled pace compared to other life stages, marking this period as critical for lifelong health [7, 8] . However, the impact of PE on offspring neurodevelopment remains underinvestigated, and its underlying mechanisms are poorly understood. Research on PE-associated neurodevelopmental impairments has proposed several hypotheses, with angiogenic dysfunction emerging as a key mechanism. Studies demonstrate disrupted balance between pro- and anti-angiogenic factors in the fetal-placental circulation of preeclamptic pregnancies [9] . Clinical studies further reveal that PE offspring exhibit significantly reduced total vascular density by 3 months of age [10] and decreased cerebral blood flow in parietal and occipital lobes during school age (7–10 years) [11] . Animal models corroborate these observations, showing impaired cerebral perfusion and microvascular reactivity in PE offspring as early as postnatal day 5, likely linked to aberrant expression of angiogenesis-related proteins [12] . Collectively, these findings suggest that aberrant angiogenesis in the offspring brain may underlie neurodevelopmental deficits. However, the molecular mechanisms connecting PE to dysregulated cerebral angiogenesis and their interplay with key signaling pathways remain unclear. The Notch signaling pathway, an evolutionarily conserved system regulating cell fate determination, proliferation, and apoptosis, plays a pivotal role in angiogenesis and neurogenesis [13] . Jagged-1 and DLL-4 and two ligands of Notch receptor, which exert opposing effects on angiogenesis: Jagged-1 knockout mice display reduced dermal vascular branching, while its overexpression enhances neovascularization [14] . Conversely, the DLL-4/Notch axis regulates vascular sprouting by modulating tip cell numbers—pathway inhibition increases tip cells and branching, whereas activation suppresses both [15] . Nuclear receptor corepressor 2 (NCOR2, also known as SMRT) is a transcriptional suppressor of Notch signaling, which mediates gene silencing and participates in diverse biological processes, including hematopoiesis and endothelial cell development [16, 17] . Notably, analysis of the GEO dataset (GSE58885) identifies NCOR2 as a key epigenetic locus in fetal brain development [18] . Emerging evidence implicates NCOR2 as a candidate gene for neurodevelopmental disorders, with its downregulation predicting long-term neurobehavioral deficits [19, 20] . In the present study, it is hypothesized that there exists differential expression of NCOR2, DLL-4, and Jagged-1 in cord blood. This study adopts a prospective cohort design, recruiting mothers with preeclampsia (PE), gestational hypertension (GH), and normotensive pregnancies from the obstetric department of our institution. Through the analysis of cord blood and clinical data, the aim is to characterize the differences in the expression of proteins related to the Notch pathway. Methods Participants This study enrolled 17 mother-offspring pairs with gestational hypertension, 17 mother-offspring pairs with preeclampsia, and 34 healthy mother-offspring pairs as controls. The inclusion criteria comprised late-term pregnant women admitted for delivery at our hospital's obstetrics department. The diagnostic criteria for preeclampsia and gestational hypertension were defined by the Chinese Guidelines for the Management of Hypertensive Disorders in Pregnancy [2] . Preeclampsia was defined as high blood pressure (> 140/90 mmHg) after 20 weeks of pregnancy and excess protein in urine (≥ 0.3 g in 24 hours, or urinary protein/creatinine ratio ≥ 0.3, or random urine protein ≥ 1+). In the absence of proteinuria, preeclampsia is diagnosed if the woman has any one of the following organ or system dysfunctions: involvement of major organs (heart, lungs, liver, kidneys), or hematologic, digestive, or neurological abnormalities, or placental-fetal complications [2] .Gestational hypertension was defined as high blood pressure (> 140/90 mmHg) after 20 weeks of pregnancy with no detectable proteinuria [2] . Exclusion criteria included pre-existing type 1 or type 2 diabetes mellitus, pre-existing chronic hypertension, other severe pregnancy-associated complications, active infectious diseases, and multiple gestation. Data collection Data were collected through standardized questionnaires(Supplementary file 1) and medical record systems. After explaining the study purpose, questionnaire completion methods, and data confidentiality measures to the participating mothers and their families, informed consent was obtained and questionnaires were administered. Simultaneously, relevant clinical data were collected form medical records. The questionnaire primarily included family information: (1) General demographic characteristics of the mothers (date of birth, education level, occupation, annual household income, etc.), obstetric history, pre-pregnancy height and weight, gestational weight gain, smoking exposure during pregnancy (active/passive), folic acid supplementation, and medication use; (2) Neonatal information: gestational age, birth weight, length, Apgar scores, and delivery mode. Data collection was performed by uniformly trained postgraduate students specializing in pediatrics. Cord blood collection and protein analysis Immediately after placental delivery, 2ml of cord blood was collected into EDTA-anticoagulated tubes subsequently and stored at -80°C for preservation. Protein expression levels of NCOR2, DLL-4, and Jagged-1 were analyzed by Western blotting. Statistical analysis Categorical variables were presented as frequencies (percentages). Differences among the control, GH (gestational hypertension), and PE (preeclampsia) groups were assessed using the chi-square (χ²) test . Continuous variables were expressed as mean ± standard deviation (Mean ± SD). Difference between three groups was analyzed with one-way ANOVA, with LSD post hoc test for pairwise comparisons. Associations between protein levels and continuous variables were examined using Pearson correlation analysis. Inter-group protein differences across categorical variables were examined using t-tests. Multivariate linear regression was used to analyze influencing factors of umbilical cord blood proteins. All statistical analyses were performed using IBM SPSS Statistics 30.0 (IBM Corp, Armonk, NY, USA). Missing data were excluded from the analysis. A two-sided p -value < 0.05 was considered statistically significant. Results Patient demographics We studied 17 (PE), 17 (GH) and 34 (control) mother-offspring pairs (Table 1). The three groups exhibited statistically significant differences in weight-related parameters (including pre-pregnancy weight, pre-pregnancy BMI, pre-delivery weight, and pre-delivery BMI), history of iron supplementation during pregnancy, and antenatal dexamethasone administration. Table1. Demographic characteristics of PE, GH and control groups Total (n = 68) Control （n=34） GH （n=17） PE (n = 17) p Maternal Age (years) 30.15±4.52 29.94±4.58 30.08±3.91 30.63±5.15 0.878 Height (m) 1.60±0.06 1.60±0.06 1.60±0.08 1.62±0.04 0.603 Pre-pregnancy weight (kg) 61.33±13.79 56.64±8.73 71.78±19.07 60.26±10.53 0.014 Pre-pregnancy BMI (kg/m 2 ） b 23.80±4.77 22.20±4.77 27.70±5.35 23.10±4.12 <0.001 Gestational weight gain (kg) 12.20±6.38 12.50±4.48 9.59±8.30 14.22±6.93 0.097 Pre-delivery weight (kg) 73.54±12.85 69.14±10.33 81.37±16.40 74.49±9.77 0.004 Pre-delivery BMI (kg/m 2 ) 28.58±4.70 27.09±4.28 31.62±5.15 28.51±3.67 0.004 Gravidity 1.96±1.45 1.91±1.60 2.29±1.49 1.71±1.05 0.488 Parity 1.37±0.75 1.47±0.93 1.29±0.59 1.24±0.44 0.521 Educational Level 0.228 High school/technical secondary school and below 22(32.4) 8(23.5) 8(47.1) 6(35.3) University/College and above 46(67.6) 26(76.5) 9(52.9) 11(64.7) Residential area 0.597 Urban 24(35.3) 10(29.4) 7(41.2) 7(41.2) Rural 44(64.7) 24(70.6) 10(58.8) 10(58.8) Family annual income 0.124 a Below 100,000 yuan 14(20.6) 4(11.8) 6(35.3) 4(23.5) Above 100,000 yuan 54(79.4) 30(88.2) 11(64.7) 13(76.5) Exposure to secondhand smoke during pregnancy 0.591 a Yes 9(13.2) 6(17.6) 1(5.9) 2(11.8) No 59(59.8) 28(82.4) 16(94.1) 15(88.2) （Continued Table 1） Folic acid supplementation in the first trimester 0.278 a Yes 63(92.6) 33(97.1) 15(88.2) 15(88.2) No 5(7.4) 1(2.9) 2(11.8) 2(11.8) Iodine supplementation during pregnancy 0.265 a Yes 14(20.6) 6(17.6) 2(11.8) 6(35.3) No 54(79.4) 28(82.4) 15(88.2) 11(64.7) Iron supplementation during pregnancy 0.006 a Yes 49(72.1) 30(88.2) 8(47.1) 11(64.7) No 19(27.9) 4(11.8) 9(52.9) 6(35.3) Antenatal dexamethasone administration 0.041 a Yes 17(25) 5(14.7) 4(23.5) 8(47.1) No 51(75) 29(85.3) 13(76.5) 9(52.9) Maternal hemoglobin (g/L) 117.16±13.21 116.97±10.54 119.88±17.95 114.82±12.88 0.539 Neonatal Gestational age (week) 37.30±1.84 37.61±1.71 36.95±1.99 37.03±1.95 0.383 Neonatal gender 0.914 Male 39(57.4) 20(58.8) 9(52.9) 10(58.8) Female 29(42.6) 14(41.2) 8(47.1) 7(41.2) Mode of delivery 0.078 Natural birth 48(70.6) 6(17.6) 8(47.1) 6(35.3) Caesarean section 20(29.4) 28(82.4) 9(52.9) 11(64.7) Amniotic fluid index (mm) 99.01±38.44 99.53±46.89 94.47±15.51 102.75±37.03 0.652 Birth weight (g) 2918±641 2946±526 2992±844 2786±640 0.608 Birth length (cm) 47.87±3.11 48.32±2.48 47.47±4.06 47.35±3.20 0.484 PI（kg/m 3 ） c 26.29±3.81 25.95±3.47 27.27±3.80 25.98±4.47 0.473 Apgar (1 min) 9.88±0.44 9.85±0.50 9.82±0.53 10.00±0.00 0.442 Apgar (5 min) 9.99±0.12 10.00±0.00 9.94±0.24 10.00±0.00 0.226 Apgar (10 min) 10.00±0.00 10.00±0.00 10.00±0.00 10.00±0.00 - a. Statistical analysis was performed using Fisher's exact test. b. Body mass index (BMI) was calculated as weight (kg) divided by height squared (m²). c. Ponderal index (PI) was calculated as weight (kg) divided by height cubed (m³). Comparison of cord blood NCOR2, DLL-4, and Jagged-1 among control, GH, and PE groups The expression levels of cord blood NCOR2, DLL-4, and Jagged-1 proteins in the control, GH, and PE groups are presented in Figures 1. The three groups showed significant differences in protein expression levels: (1) NCOR2 expression levels were 1.36±0.44, 1.00±0.12, and 0.94±0.15 ( p =0.001) in the control, GH, and PE groups respectively, with the expression levels in both the GH and PE groups being significantly lower than those in the control group; (2) DLL-4 expression levels were 0.82±0.28, 0.98±0.17, and 1.27±0.40 ( p =0.001) in the three groups respectively, showing that the PE group was significantly higher than the GH group, and the GH group was significantly higher than the control group; (3) Jagged-1 expression levels were 1.36±0.28, 1.02±0.12, and 0.87±0.18 ( p <0.001) respectively, demonstrating that the PE group was significantly lower than the GH group, and the GH group was significantly lower than the control group. Figure 1. Differences of NCOR2, DLL-4 and Jagged-1 levels in control, GH, and PE groups Univariate analysis of Notch pathway-related proteins in cord blood The correlation coefficients between continuous variables and Notch pathway-associated proteins in cord blood are shown in Table 2. Maternal weight, maternal BMI, amniotic fluid index, and Apgar(1min) were negatively associated with NCOR2 levels. Birth length was negatively associated with DLL-4 levels. Parity, gestational age, and birth height were positively associated with Jagged-1 levels. Independent t-tests(Table 3) revealed significantly lower DLL-4 levels in offspring cord blood among: (1) mothers with prenatal iron supplementation history ( p =0.014), and (2) mothers without antenatal dexamethasone exposure ( p =0.038). Table 2. Correlation coefficiency between continuous variables and Notch pathway-associated proteins in cord blood NCOR2 DLL-4 Jagged-1 r p r p r p Maternal Age (years) -0.230 0.094 -0.103 0.401 0.114 0.356 Height (m) -0.231 0.093 0.030 0.809 -0.228 0.061 Pre-pregnancy weight (kg) -0.336 0.013 -0.036 0.771 -0.121 0.324 Pre-pregnancy BMI (kg/m 2 ) -0.307 0.024 -0.058 0.639 -0.037 0.766 Gestational weight gain (kg) -0.060 0.667 0.128 0.330 0.048 0.697 Pre-delivery weight (kg) -0.389 0.004 0.025 0.841 -0.106 0.388 Pre-delivery BMI (kg/m 2 ) -0.343 0.011 -0.001 0.995 0.006 0.962 Gravidity -0.156 0.260 -0.088 0.474 0.151 0.219 Parity -0.079 0.568 -0.195 0.111 0.327 0.006 Maternal hemoglobin (g/L) 0.080 0.564 0.039 0.751 -0.005 0.970 Neonatal Gestational age (week) -0.151 0.276 -0.220 0.072 0.259 0.033 Amniotic fluid index (mm) -0.274 0.047 -0.007 0.954 0.133 0.285 Birth weight (g) -0.243 0.076 -0.204 0.095 0.192 0.116 Birth length (cm) -0.201 0.144 -0.242 0.047 0.243 0.046 PI (kg/m 3 ) -0.180 0.194 -0.026 0.833 0.023 0.851 Apgar (1 min) -0.556 <0.001 -0.028 0.822 0.041 0.741 Apgar (5 min) 0.043 0.760 -0.011 0.930 -0.024 0.848 Apgar (10 min) - - - - - - Table 3. Variations in Notch pathway-related proteins in neonatal cord blood across different categorical subgroups n NCOR2 Mean±SD DLL-4 Mean±SD Jagged-1 Mean±SD Maternal Educational Level High school/technical secondary school and below 22 1.06±0.37 1.00±0.32 1.10±0.30 University/College and above 46 1.14±0.33 0.96±0.36 1.19±0.32 t=-0.807 t=0.472 t=-1.074 p=0.423 p =0.639 p =0.287 Residential area Urban 24 1.09±0.27 1.02±0.43 1.17±0.31 Rural 44 1.13±0.38 0.94±0.29 1.15±0.32 t=-0.372 t=0.871 t=0.285 p =0.712 p =0.387 p =0.777 Family annual income Below 100,000 yuan 14 1.03±0.19 1.00±0.37 1.06±0.34 Above 100,000 yuan 54 1.14±0.37 0.96±0.34 1.18±0.30 t=-0.931 t=0.330 t=-1.311 p =0.356 p =0.742 p =0.195 Exposure to secondhand smoke during pregnancy Yes 9 1.07±0.11 0.98±0.28 1.23±0.25 No 59 1.12±0.36 0.97±0.36 1.15±0.32 t=-0.323 t=0.111 t=0.761 p =0.748 p =0.912 p =0.449 Folic acid supplementation in the first trimester Yes 63 1.12±0.35 0.96±0.33 1.17±0.31 No 5 1.02±0.16 1.13±0.53 1.04±0.40 t=0.575 t=-1.059 t=0.847 p =0.568 p =0.294 p =0.400 Iodine supplementation during pregnancy Yes 14 1.03±0.21 0.98±0.42 1.16±0.29 No 54 1.13±0.36 0.97±0.33 1.16±0.32 t=-0.815 t=0.077 t=0.012 p =0.419 p =0.939 p =0.990 (Continued Table 3) Iron supplementation during pregnancy Yes 49 1.14±0.33 0.91±0.32 1.19±0.30 No 19 1.07±0.38 1.14±0.37 1.06±0.35 t=0.683 t=-2.529 t=1.594 p =0.498 p =0.014 p =0.116 Antenatal dexamethasone administration Yes 17 1.06±0.39 1.12±0.40 1.05±0.28 No 51 1.14±0.32 0.92±0.32 1.19±0.32 t=-0.842 t=2.117 t=-1.702 p =0.403 p =0.038 p =0.094 Neonatal Neonatal gender Male 39 1.08±0.31 0.94±0.37 1.17±0.33 Female 29 1.15±0.38 1.02±0.32 1.14±0.29 t=-0.725 t=-0.960 t=0.469 p =0.472 p =0.341 p =0.641 Mode of delivery Natural birth 48 1.12±0.29 0.95±0.37 1.18±0.32 Caesarean section 20 1.11±0.44 1.03±0.28 1.09±0.30 t=0.020 t=-0.871 t=1.129 p =0.984 p =0.387 p =0.263 Multivariate analysis of Notch pathway-related proteins in cord blood Result from linear regression modelling were displayed in Table 4-Table 6. We found that NCOR2 levels were negatively influenced by GH(β=-0.419, p =0.002, Model 2), PE(β=-0.390, p =0.001, Model 2), amniotic fluid index(β=-0.197, p =0.049, Model 2), and 1-minute Apgar score(β=-0.425, p<0.001, Model 2). DLL-4 levels were only positively influenced by PE(β=-0.493, p <0.001, Model 2). Jagged-1 levels were negatively influenced by GH(β=-0.463, p <0.001, Model 2), PE(β=-0.650, p =0.001, Model 2), while showing positive correlations with parity (β=0.313, p <0.001) and gestational age (β=0.295, p=0.032).\" Table 4. Multivariable linear regression analysis of factors associated with NCOR2 levels Model 1（R 2 =0.608） Model 2（R 2 =0.614） β p 95%CI β p 95%CI HDP GH -0.396 0.002 -0.463, -0.114 -0.419 0.002 -0.488, -0.122 PE -0.390 0.001 -0.454, -0.123 -0.390 0.002 -0.466, -0.112 Pre-pregnancy weight (kg) 0.069 0.754 -0.008, 0.012 0.045 0.844 -0.009, 0.011 Pre-delivery weight (kg) -0.251 0.248 -0.017, 0.004 -0.257 0.245 -0.017, 0.004 Amniotic fluid index (mm) -0.199 0.041 -0.003, 0.000 -0.197 0.049 -0.003,0.000 Apgar (1min) -0.442 <0.001 -0.439, -0.172 -0.425 <0.001 -0.437, 0.150 Iron supplementation during pregnancy No vs Yes - - - 0.096 0.452 -0.115, 0.255 Antenatal dexamethasone administration No vs Yes - - - 0.075 0.503 -0.110, 0.221 Table 5. Multivariable linear regression analysis of factors associated with DLL-4 levels Model 1（R 2 =0.344） Model 2（R 2 =0.364） β p 95%CI β p 95%CI HDP GH 0.109 0.359 -0.101, 0.275 0.094 0.433 -0.115, 0.264 PE 0.516 <0.001 0.227, 0.594 0.493 <0.001 0.206, 0.578 Parity - - - -0.153 0.177 -0.174, 0.033 Gestational age (week) - - - -0.110 0.524 -0.085, 0.044 Birth length (cm) -0.164 0.168 -0.044, 0.008 -0.098 0.535 -0.046, 0.024 Iron supplementation during pregnancy No vs Yes 0.197 0.109 -0.034, 0.336 0.171 0.168 -0.057, 0.319 Antenatal dexamethasone administration No vs Yes 0.053 0.685 -0.164, 0.248 0.045 0.743 -0.181, 0.252 Table 6. Multivariable linear regression analysis of factors associated with Jagged-1 levels Model 1（R 2 =0.597） Model 2（R 2 =0.610） β p 95%CI β p 95%CI HDP GH -0.425 <0.001 -0.431, -0.180 -0.463 <0.001 -0.467, -0.199 PE -0.617 <0.001 -0.570, -0.318 -0.650 <0.001 -0.599, -0.335 Parity 0.302 <0.001 0.054, 0.198 0.313 <0.001 0.057, 0.204 Gestational age (week) 0.244 0.060 -0.002, 0.085 0.295 0.032 0.005, 0.096 Birth length (cm) -0.010 0.937 -0.026, 0.024 -0.003 0.984 -0.025, 0.025 Iron supplementation during pregnancy No vs Yes - - - 0.109 0.260 -0.057, 0.209 Antenatal dexamethasone administration No vs Yes - - - -0.053 0.623 -0.191, 0.116 Discussion The offspring of preeclampsia patients exhibited altered expression levels of DLL-4 and Jagged-1 proteins In this study, offspring of preeclampsia patients exhibited significantly higher DLL-4 and lower Jagged-1 in cord blood versus controls. As two key ligands of the Notch signaling pathway, DLL-4 and Jagged-1 proteins exhibit significant functional antagonism [21] . Specifically, DLL-4 primarily inhibits angiogenesis through Notch signaling activation, with its upregulation leading to reduced tip cell formation and vascular branching [15] . In contrast, Jagged-1 promotes vascular formation and branching [14] while antagonizing DLL-4 effects [21] . The pathogenesis of preeclampsia involves similar angiogenic mechanisms, with its hallmark pathological features including inadequate uterine spiral artery remodeling and vascular endothelial dysfunction, which ultimately cause placental hypoperfusion and compromise fetal oxygen/nutrient supply [22] . As critical regulators of angiogenesis, DLL-4 and Jagged-1 are closely associated with preeclampsia development. Our study demonstrated progressively decreasing cord blood Jagged-1 expression levels across control, GH, and PE groups, consistent with previous placental and cord blood studies. Research has confirmed that DLL-4 and Jagged-1 modulate proliferation and differentiation of cord blood endothelial progenitor cells [23, 24] . Animal studies revealed their expression in both maternal/fetal endothelial cells and trophoblasts, with dynamic level changes during placental development [25] . Human placental immunohistochemistry showed that Jagged-1 expression significantly increases during term gestation in healthy pregnancies but decreases markedly in preeclamptic placentas [26] . Further spatial analysis identified deficient Jagged-1 signaling in preeclamptic placental vasculature [27] , suggesting its crucial role in spiral artery remodeling and underscoring Notch signaling's importance in vascular development and preeclampsia. Interestingly, while existing literature lacks direct evidence of DLL-4 upregulation in preeclamptic cord blood or placenta, our study revealed progressively increasing DLL-4 expression across control, GH, and PE groups - a pattern contrasting sharply with Jagged-1's expression trend. This inverse relationship aligns with their opposing biological effects and suggests novel mechanisms in hypertensive pregnancy disorders. Although this may reflect their functional antagonism in Notch signaling [28] , the precise interaction mechanisms in preeclampsia offspring cord blood require further investigation. The offspring of preeclampsia patients exhibited altered expression levels of NCOR2 protein In this study, offspring of preeclampsia patients exhibited significantly lower NCOR2 in cord blood versus controls. NCOR2, as a key regulatory factor in the Notch signaling pathway, participates in the regulation of various biological processes by mediating transcriptional silencing of target genes [16] . Studies have found that both NCOR2 and Notch receptors can interact with the downstream transcription factor CSL to regulate target gene expression [16] . Upon ligand binding, the intracellular domain of Notch receptor (NICD) is released and interacts with CSL to activate target gene transcription; in the absence of NICD binding, CSL recruits multiple corepressor proteins (including NCOR2) to downregulate target gene expression [16] . Thus, NCOR2 modulates the downstream biological effects of the Notch pathway, and alterations in NCOR2 may be associated with changes in other pathway proteins. Our study found that NCOR2 protein expression progressively decreased across the control, GH, and PE groups, while DLL-4 protein showed an opposite trend among these groups, reflecting the antagonistic biological effects of NCOR2 and the DLL-4/Notch signaling pathway—that is, NCOR2 expression exhibited an inverse relationship with the development of hypertensive disorders of pregnancy. A 2014 study demonstrated that NCOR2 knockdown led to upregulation of DLL-4 protein, promoting arterial endothelial cell fate and ultimately inhibiting their differentiation [17] , which aligns with the observed changes in these two proteins in our study. Given the established association between the Notch pathway and hypertensive disorders of pregnancy, we reasonably hypothesize that NCOR2 is also linked to these conditions, though mechanistic studies in this area remain limited. In November 2024, a recent study analyzing the Gene Expression Omnibus (GEO) database identified NCOR2 as associated with preeclampsia for the first time. However, they reported significantly elevated NCOR2 expression in the serum and placental tissues of preeclamptic mothers [27] , which contradicts our findings and appears inconsistent with the known biological effects of Notch signaling. Therefore, further mechanistic studies based on our results are warranted to clarify these discrepancies. Other factors influencing NCOR2 and Notch ligand (DLL-4/Jagged-1) levels Independent of preeclampsia effects, hypoxic exposure showed a potential association with lower NCOR2 levels. This study found that hypoxia (indicated by low amniotic fluid index and low Apgar scores) may lead to upregulation of NCOR2. Previous research suggests this may be associated with the CUL4B protein. Under hypoxic conditions, HIF1α transcription increases and positively regulates CUL4B expression, while CUL4B can interact with the NCOR/SMRT pathway, thereby promoting angiogenesis [29] .However, direct evidence demonstrating hypoxia-induced upregulation of NCOR2 remains lacking. We also found that Jagged-1 levels showed progressive increases with advancing gestational age and higher parity. The positive association between gestational age and Jagged-1 levels may reflect dynamic temporal regulation of Notch signaling during progressive stages of pregnancy [30] , potentially facilitating placental vascular maturation. However, gestational age-dependent changes in Jagged-1 protein have not been previously reported in human cord blood studies. Similarly, the potential relationship between parity and Jagged-1 expression appears understudied in existing literature. Conclusion In conclusion, this study demonstrates that preeclampsia significantly alters the expression of key developmental regulators in offspring cord blood, including downregulation of NCOR2 and Jagged-1; upregulation of DLL-4. The coordinated dysregulation of these molecules—particularly the opposing effects on Notch ligands DLL4 and Jagged-1—suggests potential dysregulated angiogenic mechanisms in PE-exposed fetuses. Further studies should validate these associations and explore their long-term developmental consequences. Declarations Ethics approval and consent to participate Data were collected after obtaining written informed consent from all participating mothers. This study was approved by the Ethics Committee of Taizhou Hospital, Zhejiang Province (Approval No. K20230639). All procedures were conducted in strict adherence to the guidelines of our institutional ethics committee and were in full compliance with the ethical principles set forth by the Declaration of Helsinki, as outlined by the World Medical Association. Consent for publication Not applicable. Availability of data and materials The data that support the findings of this study are available on request from the corresponding author, upon reasonable request. Competing interests The authors declare that they have no competing interests. Funding This study is supported by Zhejiang Province Clinical Research Center for Pediatric Diseases (ZJEK2306Y). Authors' contributions OXJ and YXW were accountable for the collection of patient data and the composition of the manuscript. LWT and JYY conducted the Western blotting experiment. LZW and MXZ undertook the responsibility of guiding and overseeing the research process. All authors reviewed and endorsed the final manuscript. Acknowledgements Not applicable. References Wu P, Green M, Myers JE. Hypertensive disorders of pregnancy [J]. BMJ (Clinical Res ed). 2023;381:e071653. Yang Z, Weiyaun Z. Diagnosis and treatment of hypertension and pre-eclampsia in pregnancy:a clinical practice guideline in China(2020) [J]. Chin J Obstet Gynecol, 2020, 55(4). Poon LC, Shennan A, Hyett JA et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention [J]. Int J Gynaecol Obstet, 2019, 145 Suppl 1(Suppl 1). Magee LA, Brown MA, Hall DR, et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice [J]. Pregnancy Hypertens. 2022;27:148–69. Pittara T, Vyrides A, Lamnisos D, et al. Pre-eclampsia and long-term health outcomes for mother and infant: an umbrella review [J]. BJOG: Int J Obstet Gynecol. 2021;128(9):1421–30. Abdelmageed WA, Lapointe A, Brown R, et al. Association between maternal hypertension and infant neurodevelopment in extremely preterm infants [J]. J Perinatology: Official J Calif Perinat Association. 2024;44(4):539–47. McCoy DC, Seiden J, Cuartas J, et al. Estimates of a multidimensional index of nurturing care in the next 1000 days of life for children in low-income and middle-income countries: a modelling study [J]. Lancet Child Adolesc Health. 2022;6(5):324–34. Black MM, Walker SP, Fernald LCH, et al. Early childhood development coming of age: science through the life course [J]. Lancet (London England). 2017;389(10064):77–90. Flint EJ, Cerdeira AS, Redman CW, et al. The role of angiogenic factors in the management of preeclampsia [J]. Acta Obstet Gynecol Scand. 2019;98(6):700–7. Yu GZ, Reilly S, Lewandowski AJ, et al. Neonatal Micro-RNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies [J]. Hypertension. 2018;72(4):937–45. Rätsep MT, Paolozza A, Hickman AF, et al. Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study [J]. AJNR Am J Neuroradiol. 2016;37(5):939–45. Lara E, Rivera N, González-Bernal A, et al. Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model [J]. J Cereb Blood Flow Metab. 2022;42(12):2318–32. Zhou B, Lin W, Long Y, et al. Notch signaling pathway: architecture, disease, and therapeutics [J]. Signal Transduct Target Ther. 2022;7(1):95. Benedito R, Roca C, Sörensen I, et al. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis [J]. Cell. 2009;137(6):1124–35. Hellström M, Phng L-K, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis [J]. Nature. 2007;445(7129):776–80. Kim GS, Park H-S, Lee YC. OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor [J]. Mol Cells. 2018;41(9):842–52. Wei Y, Ma D, Gao Y, et al. Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish [J]. Blood. 2014;124(10):1578–85. Spiers H, Hannon E, Schalkwyk LC, et al. Methylomic trajectories across human fetal brain development [J]. Genome Res. 2015;25(3):338–52. Prasun P. NCOR2 Is a Candidate Gene for Neurodevelopmental Disorders [J]. Pediatr Neurol. 2024;156:1–3. Finik J, Buthmann J, Zhang W, et al. Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood [J]. J Abnorm Child Psychol. 2020;48(6):783–95. Pedrosa AR, Trindade A, Fernandes AC et al. Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1 [J]. (1524–4636 (Electronic)). Dimitriadis EA-O, Rolnik DA-O, Zhou W et al. Pre-eclampsia [J]. (2056-676X (Electronic)). Ishige-Wada M, Kwon SM, Eguchi M et al. Jagged-1 Signaling in the Bone Marrow Microenvironment Promotes Endothelial Progenitor Cell Expansion and Commitment of CD133 + Human Cord Blood Cells for Postnatal Vasculogenesis [J]. (1932–6203 (Electronic)). Liu X, Luo Q, Zheng Y et al. The role of Delta-like 4 ligand/Notch-ephrin-B2 cascade in the pathogenesis of preeclampsia by regulating functions of endothelial progenitor cell [J]. (1532–3102 (Electronic)). Levin HI, Sullivan-Pyke CS, Papaioannou VE et al. Dynamic maternal and fetal Notch activity and expression in placentation [J]. (1532–3102 (Electronic)). Cobellis L, Mastrogiacomo A, Fau - Federico E, Federico E, Fau - Schettino MT et al. Distribution of Notch protein members in normal and preeclampsia-complicated placentas [J]. (0302-766X (Print)). Hunkapiller NM, Gasperowicz M, Fau - Kapidzic M, Kapidzic M, Fau - Plaks V et al. A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia [J]. (1477–9129 (Electronic)). Pedrosa AR, Trindade A, Fernandes AC, et al. Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1 [J]. Arterioscler Thromb Vasc Biol. 2015;35(5):1134–46. Huang W, Zhang J, Huo M et al. CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway [J]. (2198–3844 (Electronic)). Huang Z, Huang S, Song T, et al. Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients [J]. Adv Nutr. 2021;12(6):2415–34. Additional Declarations No competing interests reported. Supplementary Files Supplementaryfile1questionnaire.doc Supplementaryfile2Westernblotimages.pptx Cite Share Download PDF Status: Published Journal Publication published 15 Apr, 2026 Read the published version in BMC Pregnancy and Childbirth → Version 1 posted Editorial decision: Revision requested 13 Feb, 2026 Reviews received at journal 11 Feb, 2026 Reviews received at journal 10 Feb, 2026 Reviewers agreed at journal 10 Feb, 2026 Reviews received at journal 07 Feb, 2026 Reviews received at journal 07 Feb, 2026 Reviewers agreed at journal 07 Feb, 2026 Reviewers agreed at journal 07 Feb, 2026 Reviews received at journal 06 Feb, 2026 Reviews received at journal 06 Feb, 2026 Reviewers agreed at journal 06 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviews received at journal 05 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviews received at journal 05 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviewers agreed at journal 05 Feb, 2026 Reviewers invited by journal 05 Feb, 2026 Editor invited by journal 21 Jan, 2026 Editor assigned by journal 21 Jan, 2026 Submission checks completed at journal 20 Jan, 2026 First submitted to journal 20 Jan, 2026 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {\"props\":{\"pageProps\":{\"initialData\":{\"identity\":\"rs-8591375\",\"acceptedTermsAndConditions\":true,\"allowDirectSubmit\":false,\"archivedVersions\":[],\"articleType\":\"Research Article\",\"associatedPublications\":[],\"authors\":[{\"id\":587608507,\"identity\":\"8db28e41-4127-4da1-a45b-eebcaf6d956d\",\"order_by\":0,\"name\":\"Ouxuan Jin\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Zhejiang Taizhou Hospital\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Ouxuan\",\"middleName\":\"\",\"lastName\":\"Jin\",\"suffix\":\"\"},{\"id\":587608508,\"identity\":\"66b23888-9ef3-48bd-ab0f-f1b879e45770\",\"order_by\":1,\"name\":\"Yixin 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17:16:28\",\"extension\":\"doc\",\"order_by\":0,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"supplement\",\"size\":58368,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Supplementaryfile1questionnaire.doc\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8591375/v1/64b0c236f6cbb9c1b34e78c2.doc\"},{\"id\":102242764,\"identity\":\"1028a9bf-97c1-4791-97e2-b6415e3cfa4c\",\"added_by\":\"auto\",\"created_at\":\"2026-02-09 17:16:30\",\"extension\":\"pptx\",\"order_by\":1,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"supplement\",\"size\":39487208,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"Supplementaryfile2Westernblotimages.pptx\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-8591375/v1/5b7da35b1cae8dd42a20b4df.pptx\"}],\"financialInterests\":\"No competing interests reported.\",\"formattedTitle\":\"Altered Notch Pathway-Related Protein Expression in Cord Blood of Preeclampsia Offspring\",\"fulltext\":[{\"header\":\"Introduction\",\"content\":\"\\u003cp\\u003ePreeclampsia and gestational hypertension represent two prevalent forms of hypertensive disorders in pregnancy\\u003csup\\u003e[1]\\u003c/sup\\u003e. Preeclampsia (PE) is a major contributor to maternal and neonatal mortality\\u003csup\\u003e[2]\\u003c/sup\\u003e. Epidemiological data from 2019 indicate that PE affects approximately 2%-5% of pregnancies and is a leading cause of perinatal mortality in both mothers and offspring\\u003csup\\u003e[3]\\u003c/sup\\u003e. Globally, an estimated 4 million women are diagnosed with PE annually, resulting in over 70,000 maternal and 500,000 infant deaths\\u003csup\\u003e[3, 4]\\u003c/sup\\u003e.Studies suggest that offspring of preeclamptic pregnancies face significantly elevated risks of metabolic, neurological, and cardiovascular diseases in adulthood, with neurodevelopmental impairments being particularly prominent\\u003csup\\u003e[3, 5, 6]\\u003c/sup\\u003e. Accumulating evidence indicates that fetal and early-life neurodevelopment progresses at an unparalleled pace compared to other life stages, marking this period as critical for lifelong health\\u003csup\\u003e[7, 8]\\u003c/sup\\u003e. However, the impact of PE on offspring neurodevelopment remains underinvestigated, and its underlying mechanisms are poorly understood.\\u003c/p\\u003e\\n\\u003cp\\u003eResearch on PE-associated neurodevelopmental impairments has proposed several hypotheses, with angiogenic dysfunction emerging as a key mechanism. Studies demonstrate disrupted balance between pro- and anti-angiogenic factors in the fetal-placental circulation of preeclamptic pregnancies\\u003csup\\u003e[9]\\u003c/sup\\u003e. Clinical studies further reveal that PE offspring exhibit significantly reduced total vascular density by 3 months of age\\u003csup\\u003e[10]\\u003c/sup\\u003e and decreased cerebral blood flow in parietal and occipital lobes during school age (7\\u0026ndash;10 years)\\u003csup\\u003e[11]\\u003c/sup\\u003e. Animal models corroborate these observations, showing impaired cerebral perfusion and microvascular reactivity in PE offspring as early as postnatal day 5, likely linked to aberrant expression of angiogenesis-related proteins\\u003csup\\u003e[12]\\u003c/sup\\u003e. Collectively, these findings suggest that aberrant angiogenesis in the offspring brain may underlie neurodevelopmental deficits. However, the molecular mechanisms connecting PE to dysregulated cerebral angiogenesis and their interplay with key signaling pathways remain unclear.\\u003c/p\\u003e\\n\\u003cp\\u003eThe Notch signaling pathway, an evolutionarily conserved system regulating cell fate determination, proliferation, and apoptosis, plays a pivotal role in angiogenesis and neurogenesis\\u003csup\\u003e[13]\\u003c/sup\\u003e. Jagged-1 and DLL-4 and two ligands of Notch receptor, which exert opposing effects on angiogenesis: Jagged-1 knockout mice display reduced dermal vascular branching, while its overexpression enhances neovascularization\\u003csup\\u003e[14]\\u003c/sup\\u003e. Conversely, the DLL-4/Notch axis regulates vascular sprouting by modulating tip cell numbers\\u0026mdash;pathway inhibition increases tip cells and branching, whereas activation suppresses both\\u003csup\\u003e[15]\\u003c/sup\\u003e. Nuclear receptor corepressor 2 (NCOR2, also known as SMRT) is a transcriptional suppressor of Notch signaling, which mediates gene silencing and participates in diverse biological processes, including hematopoiesis and endothelial cell development\\u003csup\\u003e[16, 17]\\u003c/sup\\u003e. Notably, analysis of the GEO dataset (GSE58885) identifies NCOR2 as a key epigenetic locus in fetal brain development\\u003csup\\u003e[18]\\u003c/sup\\u003e. Emerging evidence implicates NCOR2 as a candidate gene for neurodevelopmental disorders, with its downregulation predicting long-term neurobehavioral deficits\\u003csup\\u003e[19, 20]\\u003c/sup\\u003e.\\u003c/p\\u003e\\n\\u003cp\\u003eIn the present study, it is hypothesized that there exists differential expression of NCOR2, DLL-4, and Jagged-1 in cord blood. This study adopts a prospective cohort design, recruiting mothers with preeclampsia (PE), gestational hypertension (GH), and normotensive pregnancies from the obstetric department of our institution. Through the analysis of cord blood and clinical data, the aim is to characterize the differences in the expression of proteins related to the Notch pathway.\\u0026nbsp;\\u003c/p\\u003e\"},{\"header\":\"Methods\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003eParticipants\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThis study enrolled 17 mother-offspring pairs with gestational hypertension, 17 mother-offspring pairs with preeclampsia, and 34 healthy mother-offspring pairs as controls.\\u003c/p\\u003e\\n\\u003cp\\u003eThe inclusion criteria comprised late-term pregnant women admitted for delivery at our hospital\\u0026apos;s obstetrics department. The diagnostic criteria for preeclampsia and gestational hypertension were defined by the Chinese Guidelines for the Management of Hypertensive Disorders in Pregnancy\\u003csup\\u003e[2]\\u003c/sup\\u003e. Preeclampsia was defined as high blood pressure (\\u0026gt; 140/90 mmHg) after 20 weeks of pregnancy and excess protein in urine (\\u0026ge; 0.3 g in 24 hours, or urinary protein/creatinine ratio \\u0026ge; 0.3, or random urine protein \\u0026ge; 1+). In the absence of proteinuria, preeclampsia is diagnosed if the woman has any one of the following organ or system dysfunctions: involvement of major organs (heart, lungs, liver, kidneys), or hematologic, digestive, or neurological abnormalities, or placental-fetal complications\\u003csup\\u003e[2]\\u003c/sup\\u003e.Gestational hypertension was defined as high blood pressure (\\u0026gt; 140/90 mmHg) after 20 weeks of pregnancy with no detectable proteinuria\\u003csup\\u003e[2]\\u003c/sup\\u003e. Exclusion criteria included pre-existing type 1 or type 2 diabetes mellitus, pre-existing chronic hypertension, other severe pregnancy-associated complications, active infectious diseases, and multiple gestation.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eData collection\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eData were collected through standardized questionnaires(Supplementary file 1) and medical record systems. After explaining the study purpose, questionnaire completion methods, and data confidentiality measures to the participating mothers and their families, informed consent was obtained and questionnaires were administered. Simultaneously, relevant clinical data were collected form medical records.\\u003c/p\\u003e\\n\\u003cp\\u003eThe questionnaire primarily included family information: (1) General demographic characteristics of the mothers (date of birth, education level, occupation, annual household income, etc.), obstetric history, pre-pregnancy height and weight, gestational weight gain, smoking exposure during pregnancy (active/passive), folic acid supplementation, and medication use; (2) Neonatal information: gestational age, birth weight, length, Apgar scores, and delivery mode. Data collection was performed by uniformly trained postgraduate students specializing in pediatrics.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eCord blood collection and protein analysis\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eImmediately after placental delivery, 2ml of cord blood was collected into EDTA-anticoagulated tubes subsequently and stored at -80\\u0026deg;C for preservation. Protein expression levels of NCOR2, DLL-4, and Jagged-1 were analyzed by Western blotting.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eStatistical analysis\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eCategorical variables were presented as frequencies (percentages). Differences among the control, GH (gestational hypertension), and PE (preeclampsia) groups were assessed using the chi-square (\\u0026chi;\\u0026sup2;) test . Continuous variables were expressed as mean \\u0026plusmn; standard deviation (Mean \\u0026plusmn; SD). Difference between three groups was analyzed with one-way ANOVA, with LSD post hoc test for pairwise comparisons. Associations between protein levels and continuous variables were examined using Pearson correlation analysis. Inter-group protein differences across categorical variables were examined using t-tests. Multivariate linear regression was used to analyze influencing factors of umbilical cord blood proteins.\\u003c/p\\u003e\\n\\u003cp\\u003eAll statistical analyses were performed using IBM SPSS Statistics 30.0 (IBM Corp, Armonk, NY, USA). Missing data were excluded from the analysis. A two-sided \\u003cem\\u003ep\\u003c/em\\u003e-value \\u0026lt; 0.05 was considered statistically significant.\\u003c/p\\u003e\"},{\"header\":\"Results\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003ePatient demographics\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eWe studied 17 (PE), 17 (GH) and 34 (control) mother-offspring pairs (Table 1). The three groups exhibited statistically significant differences in weight-related parameters (including pre-pregnancy weight, pre-pregnancy BMI, pre-delivery weight, and pre-delivery BMI), history of iron supplementation during pregnancy, and antenatal dexamethasone administration.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eTable1. Demographic characteristics of PE, GH and control groups\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"649\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003eTotal\\u003c/p\\u003e\\n \\u003cp\\u003e(n = 68)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003eControl\\u003c/p\\u003e\\n \\u003cp\\u003e（n=34）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003eGH\\u003c/p\\u003e\\n \\u003cp\\u003e（n=17）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003ePE\\u003c/p\\u003e\\n \\u003cp\\u003e(n = 17)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eMaternal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eAge (years)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e30.15\\u0026plusmn;4.52\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e29.94\\u0026plusmn;4.58\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e30.08\\u0026plusmn;3.91\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e30.63\\u0026plusmn;5.15\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.878\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eHeight (m)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.60\\u0026plusmn;0.06\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.60\\u0026plusmn;0.06\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.60\\u0026plusmn;0.08\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.62\\u0026plusmn;0.04\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.603\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003ePre-pregnancy weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e61.33\\u0026plusmn;13.79\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e56.64\\u0026plusmn;8.73\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e71.78\\u0026plusmn;19.07\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e60.26\\u0026plusmn;10.53\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.014\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003ePre-pregnancy BMI (kg/m\\u003csup\\u003e2\\u003c/sup\\u003e）\\u003csup\\u003eb\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e23.80\\u0026plusmn;4.77\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e22.20\\u0026plusmn;4.77\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e27.70\\u0026plusmn;5.35\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e23.10\\u0026plusmn;4.12\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eGestational weight gain (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e12.20\\u0026plusmn;6.38\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e12.50\\u0026plusmn;4.48\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.59\\u0026plusmn;8.30\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e14.22\\u0026plusmn;6.93\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.097\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003ePre-delivery weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e73.54\\u0026plusmn;12.85\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e69.14\\u0026plusmn;10.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e81.37\\u0026plusmn;16.40\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e74.49\\u0026plusmn;9.77\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.004\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003ePre-delivery BMI (kg/m\\u003csup\\u003e2\\u003c/sup\\u003e)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e28.58\\u0026plusmn;4.70\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e27.09\\u0026plusmn;4.28\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e31.62\\u0026plusmn;5.15\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e28.51\\u0026plusmn;3.67\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.004\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eGravidity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.96\\u0026plusmn;1.45\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.91\\u0026plusmn;1.60\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2.29\\u0026plusmn;1.49\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.71\\u0026plusmn;1.05\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.488\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eParity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.37\\u0026plusmn;0.75\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.47\\u0026plusmn;0.93\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.29\\u0026plusmn;0.59\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1.24\\u0026plusmn;0.44\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.521\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eEducational Level\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.228\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp; High school/technical secondary school and below\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e22(32.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(23.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(47.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp; \\u0026nbsp; \\u0026nbsp;University/College and above\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e46(67.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e26(76.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(52.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e11(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eResidential area\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.597\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eUrban\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e24(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10(29.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e7(41.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e7(41.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eRural\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e44(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e24(70.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10(58.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10(58.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eFamily annual income\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.124\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eBelow 100,000 yuan\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e14(20.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e4(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e4(23.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eAbove 100,000 yuan\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e54(79.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e30(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e11(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e13(76.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eExposure to secondhand smoke during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.591\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(13.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(17.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1(5.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e59(59.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e28(82.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e16(94.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e15(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp; （Continued Table 1）\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"649\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eFolic acid supplementation in the first trimester\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.278\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e63(92.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e33(97.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e15(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e15(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e5(7.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e1(2.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eIodine supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.265\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e14(20.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(17.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e54(79.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e28(82.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e15(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e11(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eIron supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.006\\u003c/strong\\u003e\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e49(72.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e30(88.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(47.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e11(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e19(27.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e4(11.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(52.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eAntenatal dexamethasone administration\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.041\\u003c/strong\\u003e\\u003csup\\u003ea\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e17(25)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e5(14.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e4(23.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(47.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e51(75)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e29(85.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e13(76.5)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(52.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eMaternal hemoglobin (g/L)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e117.16\\u0026plusmn;13.21\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e116.97\\u0026plusmn;10.54\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e119.88\\u0026plusmn;17.95\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e114.82\\u0026plusmn;12.88\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.539\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNeonatal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eGestational age (week)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e37.30\\u0026plusmn;1.84\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e37.61\\u0026plusmn;1.71\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e36.95\\u0026plusmn;1.99\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e37.03\\u0026plusmn;1.95\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.383\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNeonatal gender\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.914\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eMale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e39(57.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e20(58.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(52.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10(58.8)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eFemale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e29(42.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e14(41.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(47.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e7(41.2)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eMode of delivery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.078\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eNatural birth\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e48(70.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(17.6)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e8(47.1)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e6(35.3)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eCaesarean section\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e20(29.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e28(82.4)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9(52.9)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e11(64.7)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eAmniotic fluid index (mm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e99.01\\u0026plusmn;38.44\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e99.53\\u0026plusmn;46.89\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e94.47\\u0026plusmn;15.51\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e102.75\\u0026plusmn;37.03\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.652\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eBirth weight (g)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2918\\u0026plusmn;641\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2946\\u0026plusmn;526\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2992\\u0026plusmn;844\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e2786\\u0026plusmn;640\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.608\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eBirth length (cm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e47.87\\u0026plusmn;3.11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e48.32\\u0026plusmn;2.48\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e47.47\\u0026plusmn;4.06\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e47.35\\u0026plusmn;3.20\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.484\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003ePI（kg/m\\u003csup\\u003e3\\u003c/sup\\u003e）\\u003csup\\u003ec\\u003c/sup\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e26.29\\u0026plusmn;3.81\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e25.95\\u0026plusmn;3.47\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e27.27\\u0026plusmn;3.80\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e25.98\\u0026plusmn;4.47\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.473\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eApgar (1 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.88\\u0026plusmn;0.44\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.85\\u0026plusmn;0.50\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.82\\u0026plusmn;0.53\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.442\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eApgar (5 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.99\\u0026plusmn;0.12\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e9.94\\u0026plusmn;0.24\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e0.226\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 189px;\\\"\\u003e\\n \\u003cp\\u003eApgar (10 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 101px;\\\"\\u003e\\n \\u003cp\\u003e10.00\\u0026plusmn;0.00\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 55px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003ea. Statistical analysis was performed using Fisher\\u0026apos;s exact test.\\u003c/p\\u003e\\n\\u003cp\\u003eb. Body mass index (BMI) was calculated as weight (kg) divided by height squared (m\\u0026sup2;).\\u003c/p\\u003e\\n\\u003cp\\u003ec. Ponderal index (PI) was calculated as weight (kg) divided by height cubed (m\\u0026sup3;).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eComparison of cord blood NCOR2, DLL-4, and Jagged-1 among control, GH, and PE groups\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThe expression levels of cord blood NCOR2, DLL-4, and Jagged-1 proteins in the control, GH, and PE groups are presented in Figures 1. The three groups showed significant differences in protein expression levels:\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e(1) NCOR2 expression levels were 1.36\\u0026plusmn;0.44, 1.00\\u0026plusmn;0.12, and 0.94\\u0026plusmn;0.15 (\\u003cem\\u003ep\\u003c/em\\u003e=0.001) in the control, GH, and PE groups respectively, with the expression levels in both the GH and PE groups being significantly lower than those in the control group;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;(2) DLL-4 expression levels were 0.82\\u0026plusmn;0.28, 0.98\\u0026plusmn;0.17, and 1.27\\u0026plusmn;0.40 (\\u003cem\\u003ep\\u003c/em\\u003e=0.001) in the three groups respectively, showing that the PE group was significantly higher than the GH group, and the GH group was significantly higher than the control group;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;(3) Jagged-1 expression levels were 1.36\\u0026plusmn;0.28, 1.02\\u0026plusmn;0.12, and 0.87\\u0026plusmn;0.18 (\\u003cem\\u003ep\\u003c/em\\u003e\\u0026lt;0.001) respectively, demonstrating that the PE group was significantly lower than the GH group, and the GH group was significantly lower than the control group.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;Figure 1. Differences of NCOR2, DLL-4 and Jagged-1 levels in control, GH, and PE groups\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eUnivariate analysis of Notch pathway-related proteins in cord blood\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThe correlation coefficients between continuous variables and Notch pathway-associated proteins in cord blood are shown in Table 2. Maternal weight, maternal BMI, amniotic fluid index, and Apgar(1min) were negatively associated with NCOR2 levels. Birth length was negatively associated with DLL-4 levels. Parity, gestational age, and birth height were positively associated with Jagged-1 levels.\\u003c/p\\u003e\\n\\u003cp\\u003eIndependent t-tests(Table 3) revealed significantly lower DLL-4 levels in offspring cord blood among: (1) mothers with prenatal iron supplementation history (\\u003cem\\u003ep\\u003c/em\\u003e=0.014), and (2) mothers without antenatal dexamethasone exposure (\\u003cem\\u003ep\\u003c/em\\u003e=0.038).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;Table 2. Correlation coefficiency between continuous variables and Notch pathway-associated proteins in cord blood\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"716\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 133px;\\\"\\u003e\\n \\u003cp\\u003eNCOR2\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 133px;\\\"\\u003e\\n \\u003cp\\u003eDLL-4\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" valign=\\\"top\\\" style=\\\"width: 133px;\\\"\\u003e\\n \\u003cp\\u003eJagged-1\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003er\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003er\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003er\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eMaternal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003e\\u0026nbsp;\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003e\\u0026nbsp;\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eAge (years)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.230\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.094\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.103\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.401\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.114\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.356\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eHeight (m)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.231\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.093\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.030\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.809\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.228\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.061\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003ePre-pregnancy weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.336\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.013\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.036\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.771\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.121\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.324\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003ePre-pregnancy BMI (kg/m\\u003csup\\u003e2\\u003c/sup\\u003e)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.307\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.024\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.058\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.639\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.037\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.766\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eGestational weight gain (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.060\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.667\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.128\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.330\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.048\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.697\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003ePre-delivery weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.389\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.004\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.025\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.841\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.106\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.388\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003ePre-delivery BMI (kg/m\\u003csup\\u003e2\\u003c/sup\\u003e)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.343\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.011\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.001\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.995\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.006\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.962\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eGravidity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.156\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.260\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.088\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.474\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.151\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.219\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eParity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.079\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.568\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.195\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.111\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.327\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.006\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eMaternal hemoglobin (g/L)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.080\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.564\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.039\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.751\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.005\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.970\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eNeonatal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eGestational age (week)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.151\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.276\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.220\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.072\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.259\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.033\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 244px;\\\"\\u003e\\n \\u003cp\\u003eAmniotic fluid index (mm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.274\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.047\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 17px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e-0.007\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.954\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 64px;\\\"\\u003e\\n \\u003cp\\u003e0.133\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 69px;\\\"\\u003e\\n \\u003cp\\u003e0.285\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003eBirth weight (g)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.243\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.076\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.204\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.095\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.192\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.116\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003eBirth length (cm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.201\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.144\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.242\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.047\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.243\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.046\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003ePI (kg/m\\u003csup\\u003e3\\u003c/sup\\u003e)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.180\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.194\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.026\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.833\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.023\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.851\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003eApgar (1 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.556\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.028\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.822\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.041\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.741\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003eApgar (5 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.043\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.760\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.011\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.930\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-0.024\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e0.848\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd\\u003e\\n \\u003cp\\u003eApgar (10 min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp; Table 3. Variations in Notch pathway-related proteins in neonatal cord blood across different categorical subgroups\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"110%\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd valign=\\\"top\\\" style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003en\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003eNCOR2\\u003c/p\\u003e\\n \\u003cp\\u003eMean\\u0026plusmn;SD\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003eDLL-4\\u003c/p\\u003e\\n \\u003cp\\u003eMean\\u0026plusmn;SD\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003eJagged-1\\u003c/p\\u003e\\n \\u003cp\\u003eMean\\u0026plusmn;SD\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eMaternal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eEducational Level\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp; High school/technical secondary school and below\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e22\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.06\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.10\\u0026plusmn;0.30\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp; \\u0026nbsp; \\u0026nbsp;University/College and above\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e46\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.96\\u0026plusmn;0.36\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.19\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.807\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.472\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-1.074\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep=0.423\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.639\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.287\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eResidential area\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eUrban\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e24\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.09\\u0026plusmn;0.27\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.02\\u0026plusmn;0.43\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.17\\u0026plusmn;0.31\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eRural\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e44\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.13\\u0026plusmn;0.38\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.94\\u0026plusmn;0.29\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.15\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.372\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.871\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.285\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.712\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.387\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.777\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eFamily annual income\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eBelow 100,000 yuan\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e14\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.03\\u0026plusmn;0.19\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.00\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.06\\u0026plusmn;0.34\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eAbove 100,000 yuan\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e54\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.96\\u0026plusmn;0.34\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.18\\u0026plusmn;0.30\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.931\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.330\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-1.311\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.356\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.742\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.195\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eExposure to secondhand smoke during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e9\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.07\\u0026plusmn;0.11\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.98\\u0026plusmn;0.28\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.23\\u0026plusmn;0.25\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e59\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.12\\u0026plusmn;0.36\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.97\\u0026plusmn;0.36\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.15\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.323\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.111\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.761\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.748\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.912\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.449\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eFolic acid supplementation in the first trimester\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e63\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.12\\u0026plusmn;0.35\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.96\\u0026plusmn;0.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.17\\u0026plusmn;0.31\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e5\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.02\\u0026plusmn;0.16\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.13\\u0026plusmn;0.53\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.04\\u0026plusmn;0.40\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=0.575\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-1.059\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.847\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.568\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.294\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.400\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eIodine supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e14\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.03\\u0026plusmn;0.21\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.98\\u0026plusmn;0.42\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.16\\u0026plusmn;0.29\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e54\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.13\\u0026plusmn;0.36\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.97\\u0026plusmn;0.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.16\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.815\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.077\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.012\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.419\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.939\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.990\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp; (Continued Table 3)\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"110%\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eIron supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e49\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.91\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.19\\u0026plusmn;0.30\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e19\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.07\\u0026plusmn;0.38\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.06\\u0026plusmn;0.35\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=0.683\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-2.529\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=1.594\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.498\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/strong\\u003e\\u003cstrong\\u003e=0.014\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.116\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eAntenatal dexamethasone administration\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eYes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e17\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.06\\u0026plusmn;0.39\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.12\\u0026plusmn;0.40\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.05\\u0026plusmn;0.28\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNo\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e51\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.92\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.19\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.842\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=2.117\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-1.702\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.403\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/strong\\u003e\\u003cstrong\\u003e=0.038\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.094\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNeonatal\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNeonatal gender\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eMale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e39\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.08\\u0026plusmn;0.31\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.94\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.17\\u0026plusmn;0.33\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eFemale\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e29\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.15\\u0026plusmn;0.38\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.02\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.14\\u0026plusmn;0.29\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=-0.725\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-0.960\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=0.469\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.472\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.341\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.641\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eMode of delivery\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eNatural birth\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e48\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.12\\u0026plusmn;0.29\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e0.95\\u0026plusmn;0.37\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.18\\u0026plusmn;0.32\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003eCaesarean section\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e20\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e1.11\\u0026plusmn;0.44\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.03\\u0026plusmn;0.28\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e1.09\\u0026plusmn;0.30\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003et=0.020\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=-0.871\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003et=1.129\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 33px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 5px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 19px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.984\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.387\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 20px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e=0.263\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eMultivariate analysis of Notch pathway-related proteins in cord blood\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eResult from linear regression modelling were displayed in Table 4-Table 6. We found that NCOR2 levels were negatively influenced by GH(\\u0026beta;=-0.419, \\u003cem\\u003ep\\u003c/em\\u003e=0.002, Model 2), PE(\\u0026beta;=-0.390, \\u003cem\\u003ep\\u003c/em\\u003e=0.001, Model 2), amniotic fluid index(\\u0026beta;=-0.197, \\u003cem\\u003ep\\u003c/em\\u003e=0.049, Model 2), and 1-minute Apgar score(\\u0026beta;=-0.425, \\u003cem\\u003ep\\u0026lt;0.001,\\u0026nbsp;\\u003c/em\\u003eModel 2). DLL-4 levels were only positively influenced by PE(\\u0026beta;=-0.493, \\u003cem\\u003ep\\u003c/em\\u003e\\u0026lt;0.001, Model 2). Jagged-1 levels were negatively influenced by GH(\\u0026beta;=-0.463, \\u003cem\\u003ep\\u003c/em\\u003e\\u0026lt;0.001, Model 2), PE(\\u0026beta;=-0.650, \\u003cem\\u003ep\\u003c/em\\u003e=0.001, Model 2), while showing positive correlations with parity (\\u0026beta;=0.313, \\u003cem\\u003ep\\u003c/em\\u003e\\u0026lt;0.001) and gestational age (\\u0026beta;=0.295, p=0.032).\\u0026quot;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;Table 4. Multivariable linear regression analysis of factors associated with NCOR2 levels\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"678\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003eModel 1（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.608）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003eModel 2（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.614）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eHDP\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eGH\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.396\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.002\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.463, -0.114\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.419\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.002\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.488, -0.122\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003ePE\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.390\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.454, -0.123\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.390\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.002\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.466, -0.112\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003ePre-pregnancy weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.069\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.754\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.008, 0.012\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.045\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.844\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.009, 0.011\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003ePre-delivery weight (kg)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.251\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.248\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.017, 0.004\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.257\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.245\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.017, 0.004\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eAmniotic fluid index (mm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.199\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.041\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.003, 0.000\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.197\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.049\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.003,0.000\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eApgar (1min)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.442\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.439, -0.172\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.425\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.437, 0.150\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eIron supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.096\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.452\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.115, 0.255\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eAntenatal dexamethasone administration\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.075\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.503\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.110, 0.221\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eTable 5. Multivariable linear regression analysis of factors associated with DLL-4 levels\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"678\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003eModel 1（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.344）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 243px;\\\"\\u003e\\n \\u003cp\\u003eModel 2（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.364）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eHDP\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eGH\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.109\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.359\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.101, 0.275\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.094\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.433\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.115, 0.264\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003ePE\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.516\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e0.227, 0.594\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.493\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e0.206, 0.578\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eParity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.153\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.177\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.174, 0.033\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eGestational age (week)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.110\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.524\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.085, 0.044\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eBirth length (cm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.164\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.168\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.044, 0.008\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.098\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.535\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.046, 0.024\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eIron supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.197\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.109\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.034, 0.336\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.171\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.168\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.057, 0.319\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eAntenatal dexamethasone administration\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.053\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.685\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.164, 0.248\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.045\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.743\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.181, 0.252\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\\n\\u003cp\\u003e\\u003cbr\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eTable 6. Multivariable linear regression analysis of factors associated with Jagged-1 levels\\u003c/p\\u003e\\n\\u003ctable border=\\\"1\\\" cellspacing=\\\"0\\\" cellpadding=\\\"0\\\" width=\\\"678\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003eModel 1（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.597）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width: 242px;\\\"\\u003e\\n \\u003cp\\u003eModel 2（R\\u003csup\\u003e2\\u003c/sup\\u003e=0.610）\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026beta;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cem\\u003ep\\u003c/em\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e95%CI\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eHDP\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eGH\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.425\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.431, -0.180\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.463\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.467, -0.199\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003ePE\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.617\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.570, -0.318\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.650\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.599, -0.335\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eParity\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.302\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e0.054, 0.198\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.313\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e\\u0026lt;0.001\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e0.057, 0.204\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eGestational age (week)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.244\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.060\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.002, 0.085\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.295\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e0.032\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e0.005, 0.096\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eBirth length (cm)\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.010\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.937\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.026, 0.024\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.003\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.984\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.025, 0.025\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eIron supplementation during pregnancy\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.109\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.260\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.057, 0.209\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eAntenatal dexamethasone administration\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width: 193px;\\\"\\u003e\\n \\u003cp\\u003eNo vs Yes\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e\\u003cstrong\\u003e-\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e-0.053\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 62px;\\\"\\u003e\\n \\u003cp\\u003e0.623\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 118px;\\\"\\u003e\\n \\u003cp\\u003e-0.191, 0.116\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n\\u003c/table\\u003e\"},{\"header\":\"Discussion\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003eThe offspring of preeclampsia patients exhibited altered expression levels of DLL-4 and Jagged-1 proteins\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eIn this study, offspring of preeclampsia patients exhibited significantly higher DLL-4 and lower Jagged-1 in cord blood versus controls. As two key ligands of the Notch signaling pathway, DLL-4 and Jagged-1 proteins exhibit significant functional antagonism\\u003csup\\u003e[21]\\u003c/sup\\u003e. Specifically, DLL-4 primarily inhibits angiogenesis through Notch signaling activation, with its upregulation leading to reduced tip cell formation and vascular branching\\u003csup\\u003e[15]\\u003c/sup\\u003e. In contrast, Jagged-1 promotes vascular formation and branching\\u003csup\\u003e[14]\\u003c/sup\\u003e while antagonizing DLL-4 effects\\u003csup\\u003e[21]\\u003c/sup\\u003e. The pathogenesis of preeclampsia involves similar angiogenic mechanisms, with its hallmark pathological features including inadequate uterine spiral artery remodeling and vascular endothelial dysfunction, which ultimately cause placental hypoperfusion and compromise fetal oxygen/nutrient supply\\u003csup\\u003e[22]\\u003c/sup\\u003e.\\u003c/p\\u003e\\n\\u003cp\\u003eAs critical regulators of angiogenesis, DLL-4 and Jagged-1 are closely associated with preeclampsia development. Our study demonstrated progressively decreasing cord blood Jagged-1 expression levels across control, GH, and PE groups, consistent with previous placental and cord blood studies. Research has confirmed that DLL-4 and Jagged-1 modulate proliferation and differentiation of cord blood endothelial progenitor cells\\u003csup\\u003e[23, 24]\\u003c/sup\\u003e. Animal studies revealed their expression in both maternal/fetal endothelial cells and trophoblasts, with dynamic level changes during placental development\\u003csup\\u003e[25]\\u003c/sup\\u003e. Human placental immunohistochemistry showed that Jagged-1 expression significantly increases during term gestation in healthy pregnancies but decreases markedly in preeclamptic placentas\\u003csup\\u003e[26]\\u003c/sup\\u003e. Further spatial analysis identified deficient Jagged-1 signaling in preeclamptic placental vasculature\\u003csup\\u003e[27]\\u003c/sup\\u003e, suggesting its crucial role in spiral artery remodeling and underscoring Notch signaling\\u0026apos;s importance in vascular development and preeclampsia.\\u003c/p\\u003e\\n\\u003cp\\u003eInterestingly, while existing literature lacks direct evidence of DLL-4 upregulation in preeclamptic cord blood or placenta, our study revealed progressively increasing DLL-4 expression across control, GH, and PE groups - a pattern contrasting sharply with Jagged-1\\u0026apos;s expression trend. This inverse relationship aligns with their opposing biological effects and suggests novel mechanisms in hypertensive pregnancy disorders. Although this may reflect their functional antagonism in Notch signaling\\u003csup\\u003e[28]\\u003c/sup\\u003e, the precise interaction mechanisms in preeclampsia offspring cord blood require further investigation.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eThe offspring of preeclampsia patients exhibited altered expression levels of NCOR2 protein\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eIn this study, offspring of preeclampsia patients exhibited significantly lower NCOR2 in cord blood versus controls. NCOR2, as a key regulatory factor in the Notch signaling pathway, participates in the regulation of various biological processes by mediating transcriptional silencing of target genes\\u003csup\\u003e[16]\\u003c/sup\\u003e. Studies have found that both NCOR2 and Notch receptors can interact with the downstream transcription factor CSL to regulate target gene expression\\u003csup\\u003e[16]\\u003c/sup\\u003e. Upon ligand binding, the intracellular domain of Notch receptor (NICD) is released and interacts with CSL to activate target gene transcription; in the absence of NICD binding, CSL recruits multiple corepressor proteins (including NCOR2) to downregulate target gene expression\\u003csup\\u003e[16]\\u003c/sup\\u003e. Thus, NCOR2 modulates the downstream biological effects of the Notch pathway, and alterations in NCOR2 may be associated with changes in other pathway proteins.\\u003c/p\\u003e\\n\\u003cp\\u003eOur study found that NCOR2 protein expression progressively decreased across the control, GH, and PE groups, while DLL-4 protein showed an opposite trend among these groups, reflecting the antagonistic biological effects of NCOR2 and the DLL-4/Notch signaling pathway\\u0026mdash;that is, NCOR2 expression exhibited an inverse relationship with the development of hypertensive disorders of pregnancy. A 2014 study demonstrated that NCOR2 knockdown led to upregulation of DLL-4 protein, promoting arterial endothelial cell fate and ultimately inhibiting their differentiation\\u003csup\\u003e[17]\\u003c/sup\\u003e, which aligns with the observed changes in these two proteins in our study. Given the established association between the Notch pathway and hypertensive disorders of pregnancy, we reasonably hypothesize that NCOR2 is also linked to these conditions, though mechanistic studies in this area remain limited.\\u003c/p\\u003e\\n\\u003cp\\u003eIn November 2024, a recent study analyzing the Gene Expression Omnibus (GEO) database identified NCOR2 as associated with preeclampsia for the first time. However, they reported significantly elevated NCOR2 expression in the serum and placental tissues of preeclamptic mothers\\u003csup\\u003e[27]\\u003c/sup\\u003e, which contradicts our findings and appears inconsistent with the known biological effects of Notch signaling. Therefore, further mechanistic studies based on our results are warranted to clarify these discrepancies.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eOther factors influencing NCOR2 and Notch ligand (DLL-4/Jagged-1) levels\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eIndependent of preeclampsia effects, hypoxic exposure showed a potential association with lower NCOR2 levels. This study found that hypoxia (indicated by low amniotic fluid index and low Apgar scores) may lead to upregulation of NCOR2. Previous research suggests this may be associated with the CUL4B protein. Under hypoxic conditions, HIF1\\u0026alpha; transcription increases and positively regulates CUL4B expression, while CUL4B can interact with the NCOR/SMRT pathway, thereby promoting angiogenesis\\u003csup\\u003e[29]\\u003c/sup\\u003e.However, direct evidence demonstrating hypoxia-induced upregulation of NCOR2 remains lacking.\\u003c/p\\u003e\\n\\u003cp\\u003eWe also found that Jagged-1 levels showed progressive increases with advancing gestational age and higher parity. The positive association between gestational age and Jagged-1 levels may reflect dynamic temporal regulation of Notch signaling during progressive stages of pregnancy\\u003csup\\u003e[30]\\u003c/sup\\u003e, potentially facilitating placental vascular maturation. However, gestational age-dependent changes in Jagged-1 protein have not been previously reported in human cord blood studies. Similarly, the potential relationship between parity and Jagged-1 expression appears understudied in existing literature.\\u003c/p\\u003e\"},{\"header\":\"Conclusion\",\"content\":\"\\u003cp\\u003eIn conclusion, this study demonstrates that preeclampsia significantly alters the expression of key developmental regulators in offspring cord blood, including downregulation of NCOR2 and Jagged-1; upregulation of DLL-4. The coordinated dysregulation of these molecules—particularly the opposing effects on Notch ligands DLL4 and Jagged-1—suggests potential dysregulated angiogenic mechanisms in PE-exposed fetuses. Further studies should validate these associations and explore their long-term developmental consequences.\\u003c/p\\u003e\"},{\"header\":\"Declarations\",\"content\":\"\\u003cp\\u003e\\u003cstrong\\u003eEthics approval and consent to participate\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eData were collected after obtaining written informed consent from all participating mothers. This study was approved by the Ethics Committee of Taizhou Hospital, Zhejiang Province (Approval No. K20230639). All procedures were conducted in strict adherence to the guidelines of our institutional ethics committee and were in full compliance with the ethical principles set forth by the Declaration of Helsinki, as outlined by the World Medical Association.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eConsent for publication\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eNot applicable.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003cstrong\\u003eAvailability of data and materials\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThe data that support the findings of this study are available on request from the corresponding author, upon reasonable request.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eCompeting interests\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThe authors declare that they have no competing interests.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eFunding\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThis study is supported by Zhejiang Province Clinical Research Center for Pediatric Diseases (ZJEK2306Y). \\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eAuthors\\u0026apos; contributions\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eOXJ and YXW were accountable for the collection of patient data and the composition of the manuscript. LWT and JYY conducted the Western blotting experiment. LZW and MXZ undertook the responsibility of guiding and overseeing the research process. All authors reviewed and endorsed the final manuscript. \\u003cstrong\\u003e\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cstrong\\u003eAcknowledgements\\u003c/strong\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eNot applicable.\\u003cstrong\\u003e\\u0026nbsp;\\u003c/strong\\u003e\\u003c/p\\u003e\"},{\"header\":\"References\",\"content\":\"\\u003col\\u003e\\u003cli\\u003e\\u003cspan\\u003eWu P, Green M, Myers JE. Hypertensive disorders of pregnancy [J]. BMJ (Clinical Res ed). 2023;381:e071653.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eYang Z, Weiyaun Z. Diagnosis and treatment of hypertension and pre-eclampsia in pregnancy:a clinical practice guideline in China(2020) [J]. Chin J Obstet Gynecol, 2020, 55(4).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003ePoon LC, Shennan A, Hyett JA et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention [J]. Int J Gynaecol Obstet, 2019, 145 Suppl 1(Suppl 1).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eMagee LA, Brown MA, Hall DR, et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis \\u0026amp; management recommendations for international practice [J]. Pregnancy Hypertens. 2022;27:148\\u0026ndash;69.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003ePittara T, Vyrides A, Lamnisos D, et al. Pre-eclampsia and long-term health outcomes for mother and infant: an umbrella review [J]. BJOG: Int J Obstet Gynecol. 2021;128(9):1421\\u0026ndash;30.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eAbdelmageed WA, Lapointe A, Brown R, et al. Association between maternal hypertension and infant neurodevelopment in extremely preterm infants [J]. J Perinatology: Official J Calif Perinat Association. 2024;44(4):539\\u0026ndash;47.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eMcCoy DC, Seiden J, Cuartas J, et al. Estimates of a multidimensional index of nurturing care in the next 1000 days of life for children in low-income and middle-income countries: a modelling study [J]. Lancet Child Adolesc Health. 2022;6(5):324\\u0026ndash;34.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eBlack MM, Walker SP, Fernald LCH, et al. Early childhood development coming of age: science through the life course [J]. Lancet (London England). 2017;389(10064):77\\u0026ndash;90.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eFlint EJ, Cerdeira AS, Redman CW, et al. The role of angiogenic factors in the management of preeclampsia [J]. Acta Obstet Gynecol Scand. 2019;98(6):700\\u0026ndash;7.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eYu GZ, Reilly S, Lewandowski AJ, et al. Neonatal Micro-RNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies [J]. Hypertension. 2018;72(4):937\\u0026ndash;45.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eR\\u0026auml;tsep MT, Paolozza A, Hickman AF, et al. Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study [J]. AJNR Am J Neuroradiol. 2016;37(5):939\\u0026ndash;45.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eLara E, Rivera N, Gonz\\u0026aacute;lez-Bernal A, et al. Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model [J]. J Cereb Blood Flow Metab. 2022;42(12):2318\\u0026ndash;32.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eZhou B, Lin W, Long Y, et al. Notch signaling pathway: architecture, disease, and therapeutics [J]. Signal Transduct Target Ther. 2022;7(1):95.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eBenedito R, Roca C, S\\u0026ouml;rensen I, et al. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis [J]. Cell. 2009;137(6):1124\\u0026ndash;35.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eHellstr\\u0026ouml;m M, Phng L-K, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis [J]. Nature. 2007;445(7129):776\\u0026ndash;80.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eKim GS, Park H-S, Lee YC. OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor [J]. Mol Cells. 2018;41(9):842\\u0026ndash;52.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eWei Y, Ma D, Gao Y, et al. Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish [J]. Blood. 2014;124(10):1578\\u0026ndash;85.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eSpiers H, Hannon E, Schalkwyk LC, et al. Methylomic trajectories across human fetal brain development [J]. Genome Res. 2015;25(3):338\\u0026ndash;52.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003ePrasun P. NCOR2 Is a Candidate Gene for Neurodevelopmental Disorders [J]. Pediatr Neurol. 2024;156:1\\u0026ndash;3.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eFinik J, Buthmann J, Zhang W, et al. Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood [J]. J Abnorm Child Psychol. 2020;48(6):783\\u0026ndash;95.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003ePedrosa AR, Trindade A, Fernandes AC et al. Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1 [J]. (1524\\u0026ndash;4636 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eDimitriadis EA-O, Rolnik DA-O, Zhou W et al. Pre-eclampsia [J]. (2056-676X (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eIshige-Wada M, Kwon SM, Eguchi M et al. Jagged-1 Signaling in the Bone Marrow Microenvironment Promotes Endothelial Progenitor Cell Expansion and Commitment of CD133\\u0026thinsp;+\\u0026thinsp;Human Cord Blood Cells for Postnatal Vasculogenesis [J]. (1932\\u0026ndash;6203 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eLiu X, Luo Q, Zheng Y et al. The role of Delta-like 4 ligand/Notch-ephrin-B2 cascade in the pathogenesis of preeclampsia by regulating functions of endothelial progenitor cell [J]. (1532\\u0026ndash;3102 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eLevin HI, Sullivan-Pyke CS, Papaioannou VE et al. Dynamic maternal and fetal Notch activity and expression in placentation [J]. (1532\\u0026ndash;3102 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eCobellis L, Mastrogiacomo A, Fau - Federico E, Federico E, Fau - Schettino MT et al. Distribution of Notch protein members in normal and preeclampsia-complicated placentas [J]. (0302-766X (Print)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eHunkapiller NM, Gasperowicz M, Fau - Kapidzic M, Kapidzic M, Fau - Plaks V et al. A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia [J]. (1477\\u0026ndash;9129 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003ePedrosa AR, Trindade A, Fernandes AC, et al. Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1 [J]. Arterioscler Thromb Vasc Biol. 2015;35(5):1134\\u0026ndash;46.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eHuang W, Zhang J, Huo M et al. CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway [J]. (2198\\u0026ndash;3844 (Electronic)).\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eHuang Z, Huang S, Song T, et al. Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients [J]. Adv Nutr. 2021;12(6):2415\\u0026ndash;34.\\u003c/span\\u003e\\u003c/li\\u003e\\u003c/ol\\u003e\"}],\"fulltextSource\":\"\",\"fullText\":\"\",\"funders\":[],\"hasAdminPriorityOnWorkflow\":false,\"hasManuscriptDocX\":true,\"hasOptedInToPreprint\":true,\"hasPassedJournalQc\":\"\",\"hasAnyPriority\":false,\"hideJournal\":false,\"highlight\":\"\",\"institution\":\"\",\"isAcceptedByJournal\":true,\"isAuthorSuppliedPdf\":false,\"isDeskRejected\":\"\",\"isHiddenFromSearch\":false,\"isInQc\":false,\"isInWorkflow\":false,\"isPdf\":false,\"isPdfUpToDate\":true,\"isWithdrawnOrRetracted\":false,\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"bmc-pregnancy-and-childbirth\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":false,\"externalIdentity\":\"prch\",\"sideBox\":\"Learn more about [BMC Pregnancy and Childbirth](http://bmcpregnancychildbirth.biomedcentral.com/)\",\"snPcode\":\"\",\"submissionUrl\":\"https://www.editorialmanager.com/prch/default.aspx\",\"title\":\"BMC Pregnancy and Childbirth\",\"twitterHandle\":\"@BMC_series\",\"acdcEnabled\":true,\"dfaEnabled\":false,\"editorialSystem\":\"em\",\"reportingPortfolio\":\"BMC Series\",\"inReviewEnabled\":true,\"inReviewRevisionsEnabled\":true},\"keywords\":\"Preeclampsia, NCOR2, DLL-4, Jagged-1\",\"lastPublishedDoi\":\"10.21203/rs.3.rs-8591375/v1\",\"lastPublishedDoiUrl\":\"https://doi.org/10.21203/rs.3.rs-8591375/v1\",\"license\":{\"name\":\"CC BY 4.0\",\"url\":\"https://creativecommons.org/licenses/by/4.0/\"},\"manuscriptAbstract\":\"\\u003cp\\u003eObjective: This study aims to investigate the differential expression of NCOR2, DLL-4, and Jagged-1 proteins in cord blood samples from offspring of mothers with preeclampsia (PE), gestational hypertension (GH), and healthy controls, to understand the impact of these conditions on offspring health.\\u003c/p\\u003e\\n\\u003cp\\u003eMethods: This is a prospective cohort study, including 17 mother-offspring pairs with gestational hypertension, 17 mother-offspring pairs with preeclampsia, and 34 healthy mother-offspring pairs as controls. Standardized questionnaires were used to collect family and birth information, medical records were used to collect clinical data, and Western blot was employed to measure the expression levels of NCOR2, DLL-4, and Jagged-1 in cord blood. We analyzed the differences in offspring cord blood proteins among the three groups.\\u003c/p\\u003e\\n\\u003cp\\u003eResults: Protein expression levels of NCOR2, DLL-4, and Jagged-1 differed significantly among the control, GH, and PE groups:\\u003c/p\\u003e\\n\\u003cp\\u003e①NCOR2: 1.36±0.44 (control), 1.00±0.12 (GH), 0.94±0.15 (PE) (\\u003cem\\u003ep\\u003c/em\\u003e=0.001), with the GH and PE significantly lower than control group.\\u003c/p\\u003e\\n\\u003cp\\u003e②DLL-4: 0.82±0.28 (control), 0.98±0.17 (GH), 1.27±0.40 (PE) (\\u003cem\\u003ep\\u003c/em\\u003e=0.001), with the PE significantly higher than GH, and GH higher than control group.\\u003c/p\\u003e\\n\\u003cp\\u003e③Jagged-1: 1.36±0.28 (control), 1.02±0.12 (GH), 0.87±0.18 (PE) (\\u003cem\\u003ep\\u003c/em\\u003e\\u0026lt;0.001), with the PE significantly lower than GH, and GH lower than control group.\\u003c/p\\u003e\\n\\u003cp\\u003eConclusion: The offspring cord blood levels of NCOR2 and Jagged-1 proteins were significantly increased in offspring of PE and GH, while DLL-4 protein expression was significantly decreased.\\u003c/p\\u003e\",\"manuscriptTitle\":\"Altered Notch Pathway-Related Protein Expression in Cord Blood of Preeclampsia Offspring\",\"msid\":\"\",\"msnumber\":\"\",\"nonDraftVersions\":[{\"code\":1,\"date\":\"2026-02-09 17:16:18\",\"doi\":\"10.21203/rs.3.rs-8591375/v1\",\"editorialEvents\":[{\"type\":\"communityComments\",\"content\":0},{\"type\":\"decision\",\"content\":\"Revision 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