{"paper_id":"04e2ba3d-dac9-4561-8ff2-49917b3fb28f","body_text":"Pattern of Consumption of Dietary and Herbal Supplements by Individuals with Non-communicable Diseases During Covid-19 Pandemic in Nigeria | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Pattern of Consumption of Dietary and Herbal Supplements by Individuals with Non-communicable Diseases During Covid-19 Pandemic in Nigeria Bamgboye M. Afolabi, Susan A Holdbrooke, Oluwatosin O. Odubela This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2488233/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Cognizance of the implication of Covid-19 pandemic on health and well-being resulted in an upsurge is use of several dietary and herbal supplements (DHS) for the prevention and/or prophylaxis against the new disease. Objectives: To evaluate the pattern of DHS consumption among Nigerians with Non-communicable Diseases (NCD) for the prevention and treatment of COVID-19. Design: Cross-sectional questionnaire survey. Setting: Adolescents, and adults residing in Nigeria. Participants: Participants with NCD (n = 165) from a larger study (n=645) were recruited from different geo-political zones and various ethnic groups. Primary and Secondary Outcomes: Prevalence and determinants for the use of different DHS for the prevention and treatment of COVID-19 in Nigeria, and sources of information for DHS use. Results: Hypertension was the most prevalent NCD (63.6%) in the study and both breast cancer and anxiety disorder were the least (0.6%). A minimum (75.2%) of the respondents had less than 8 hours of sleep daily and almost all did not smoke cigarette at all. The proportion of male and female hypertensives who believed that dietary supplements are necessary during infectious disease outbreak such as Covid-19 was moderately high (55.2%), higher among asthmatics (65.0%), diabetes (58/105, 68.4%), those with kidney disease (100.0%), ulcer (83.3%) and liver disease. Almost all the respondents with hypertension (101/105, 96.2%), asthma (19/20, 95.0%), diabetes (19/19, 100.0%) and kidney disease (6/6, 100.0%), consumed supplements more during Covid-19 pandemic in Nigeria. The proportion of those who consumed supplements more during the pandemic in Nigeria was higher among male hypertensives (57/101, 56.4%) than among the female (44/101, 43.6%), though the difference was not significant (χ²=2.93, P-value=0.09). Vitamin C was the commonest vitamin taken by respondents with ulcer (83.3%), kidney disease (83.3%), diabetes (57.9%), asthma (50.0%), hypertension (48.6%) and the two respondents with breast cancer (1, 100.0%) and anxiety disorder (1, 100.0%) respectively. Calcium and zinc were the commonest minerals taken by respondents with ulcer (50.0%, 16.7%), diabetes (10.5%, 5.3%), asthma (30.0%, 10.0%) and hypertension (13.3%, 11.4%) respectively. High proportions (83.3%, 80.0%) of those with kidney disease and with asthma consumed DHS to maintain good health. Health workers were the dominant source of information for most on the use of supplements during Covid-19 pandemic in Nigeria. Conclusions: The findings showed widespread use of DHS for the prevention and treatment of COVID-19 among persons with NCD. The use of DHS in this study was mainly guided by health workers with a marginal role of social media and Mass media. These findings call for a more robust consolidative tactic towards DHS to ensure its proper and safe use. Black Africans Consumption Covid-19 Dietary Herbal Micro-nutrients Non-communicable diseases Supplements Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction The period 2019 to the end of 2021 witnessed crisis in global health that remains unprecedented in human history, cause by the Coronavirus Disease 2019, eventually designated as COVID-19 by the World Health Organization (WHO). The disease is defined as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) which was formally known as 2019-nCoV, initially detected amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province in People’s Republic of China [ 1 ] in early December 2019 and reported to WHO later in the month. A series of events happened to identify, categorize contain the spread and to inform the public, including the declaration of the disease as a Public Health Emergency of International Concern (PHEIC) by the WHO on January 30, 2020 [ 2 – 4 ], and as a global pandemic on March 11, 2020 [ 5 ]. By the end of 2021, over 200 countries have been affected causing a heavy health burden to individuals, families, communities, societies, countries, and health care systems throughout the world to deter and contain the pandemic [ 6 ]. Seven of the vast family of viruses known as Coronavirus are believed to be zoonotic, causing disease in humans [ 7 ]. On 23 December 2021, WHO decided that the main route by which humans get infected by SARS-CoV-12 is through exposure to respiratory droplets, generally within 6 feet radius [ 8 ]. Studies later found out other ways people are infected such as contact spread by shaking hands and airborne transmission [ 9 ] of “droplets that linger in the air over long distance (usually greater than 6 feet)” [ 10 – 12 ]. Covid-19 pandemic brought shock, panic, fear, uncertainty, distrust, conspiracy theories, disease, and death to spread throughout the world. This was brought about mainly by the rapidity with which the disease spread throughout the world causing over 175,850,000 infections and 3.8 million deaths by June 2020 [ 6 ]. Probably because of the rapidity with which many vaccines were developed, tested, and approved in order to mitigate the morbidity and mortality associated with Covid-19, many people distrusted the efficacy of such vaccines. There were a flurry of misinformation and conspiracy theories that were circulated through the social and mass media on side effects of vaccines and most people doubted the safety and effectiveness of these vaccines. World Health Organization reported a wide range of symptoms including fever, chills muscle or body aches, anorexia, and headache which make Covid-19 resemble malaria infection; cough, sore throat, nasal congestion, or rhinorrhea render it flu-like; prolonged cough, fever, and dyspnea probably confirm pneumonia; and added to these are diarrhea, and loss of taste and/or smell [ 13 ]. The possibility of severe disease rises with people age while, regardless of the age, those with underlying medical ailments such as cardiac, metabolic, pulmonary or neoplastic diseases may be at higher risk of severe COVID-19 infection relative to others without these conditions [ 13 ]. The virus itself, discovered using metagenomic RNA sequencing and virus sequestration from bronchoalveolar lavage fluid samples from patients with severe pneumonia, is a beta-coronavirus previously unknown [ 14 – 16 ]. Nigeria, a developing and the most populated country in Africa, experienced some measures of severe outbreak of the COVID-19 pandemic during the study period. The trepidation caused by Covid-19 pandemic, the high morbidity and mortality rates globally coupled with the already-known weak health systems in most parts of Africa probably drove many people, especially those with non-communicable diseases, who are more prone to Covid-19 infection, to seek other ways of maintaining good health during the pandemic. This also is probably the reason why some increased the consumption of dietary and herbal supplements. Dietary supplements defined as usable amounts of micronutrients have become a growing interest during the COVID-19 as they are widely used to potentially improve immune health [ 17 ]. A study reports that supplementation of a combination of magnesium, vitamin D and vitamin B12 resulted in significant reductions in clinical deterioration, need for oxygen support and intensive care support of elderly Covid-19 patients [ 18 ]. Also, the hypothetical impacts of supplementing vitamin C, zinc, vitamin D, and probiotics on COVID-19 consequences have also been studied with diverse findings, and several studies are also still underway [ 19 ]. Nigerian governments at all levels, the Nigerian CDC, primary, secondary, and tertiary health facilities across the country and the Nigerian Institute of Medical Research mobilized all resources to gather data, curtain the spread of the disease and give vaccines to as many people as possible. However, there is paucity of data on dietary and herbal supplements consumed by those with non-communicable diseases during the pandemic. The primary objective of this paper therefore is to evaluate the pattern of consumption of dietary and herbal supplements during the Covid-19 pandemic among persons with NCDs. The secondary objectives are to assess the knowledge, attitude, practice, and perception of dietary and herbal supplements at this period and document the source of information on use of DHS by this cohort. The authors of this paper are not aware of any authorization from or by the National Food and Drugs Administration and Control (NAFDAC) in Nigeria for anyone to consume any dietary and herbal supplement for the prevention, treatment, or management of Covid-19. Materials And Method Study design: This questionnaire-based cross-sectional study was designed and served to persons Nigerians aged 18 years and above to explore and describe their consumption pattern of dietary and herbal supplements (DHS) during the COVID-19 pandemic. Almost all the study subjects, males, and females, from various ethnic groups and resident in the country when the survey was conducted, with varying levels of educational background, and employment status were able to read and understand English. Information collected from respondents included socio-demographic characteristics (age, sex, educational status, employment status, and marital status), health status, knowledge, attitude, and behavioral pattern on the use of DHS. Nigerian Institute of Medical Research, where this study was developed, conducted, and analyzed is the sole medical research institute of the Federal Government. The Institute consists of the departments of Biochemistry and Nutrition (where the study was designed), Human Virology, Clinical Trials, Public Health, and Microbiology. Because of restriction of movements due to lock-down policy by the government, hard copy questionnaire survey was conducted in Lagos State. However, Google form questionnaire was sent to other parts of the country using the internet. Though a minimum of 500 responses were expected, filled questionnaires were received from only 216 people. Reasons for non-response have been stated in our earlier paper which included (i) time limit of one week that was given (ii) the survey took place during the pandemic during which people were stressed because of lock-down, social distance and other restrictions (iii) many questionnaires were circulating online during the pandemic and (iv) response fatigue on the part of the study subjects. This poor response rate from Google form prompted the administration of hard copies of the questionnaire in various communities in metropolitan Lagos, southwest Nigeria, a multi-ethnic city of about 20 million people. Five questionnaire administrators, trained in inter-personal communication, retrieved responses from the study subjects. These administrators conducted had received their Covid-19 vaccine, and observed all precautions such as wearing face mask, using hand sanitizers, and maintaining social distance when conducting face-to-face interviews. In addition, all questionnaires and materials for writing were equally disinfected appropriately before and after use. Each respondent who was not wearing a face mask or whose face mask was defective was provided with one to wear and had his or her hands were sanitized as well. The very few respondents who could not read nor write had the questionnaire read to them. Participants’ unique identifier, as well as the intention of the survey, the process and the duration of time needed to finish each questionnaire were specified in the early part of each questionnaire. Inclusion/Exclusion criteria The only inclusion criteria to participate in the study were age of 18 years and above and residence within Nigeria as there were hardly any visitor from outside the country during the Covid-19 pandemic. Ethical clearance The study protocol, the questionnaire and the consent form were reviewed and approved by the Research and Ethics Committee at the Nigerian Institute of Medical Research (IRB/20/039). Both in the hard copy and Google form of the questionnaire, study participants were assured of concealment of personal identity, confidentiality, and choice to decline at any point in the filling of the questionnaire before the survey started. On-line study responders had to accept to participate after agreeing to terms and conditions of the study before the questionnaire could be accessed electronically. Definition For the purpose of this study, dietary and/or herbal supplements were defined as any ingredient (except tobacco products) that are consumed as nutrients or micronutrients to prevent and treat Covid-19 infection. Statistical analysis of data Data was first extracted from Google Form as a Microsoft Excel Spreadsheet (Microsoft Corporation) and concatenated with data from hard copy questionnaire. The completed data in the Excel spreadsheet was then cleaned, coded, and exported into NCSS v2022 (Kaysville, Utah, USA) statistical software for Windows before it was analyzed, using appropriate commands. Descriptive statistical analyses concerning frequency and percentage distribution were performed for all demographic variable and the results of these were specified as numbers (n) and percentages (%). Continuous variables were reported as mean (± standard deviation [SD]) for normally distributed variables. Pearson correlation (χ²) with Odd Ratio (OR) at 95% Confidence Interval (CI) were carried out to determine the relationship between categorical variables of interest. P-values < 0.05 were considered statistically significant. Results were rendered as Tables, Graphs and Figures Results Data of NCDs that occurred in very low frequencies – kidney disease (6, 3.6%), ulcer (6, 3.6%), sickle cell disease (5, 3.0%), liver disorder (2, 1.2%), breast cancer (1, 0.6%) and anxiety disorder (1, 0.6%) – are not included in any of the Tables or Figures (except Figures 3 and 4) but are written as narratives under appropriate sub-headings. Flowchart of recruitment of study participants. Figure 1. This paper is part of a bigger study from which data of participants with NCDs have been extracted for analysis. The flow chart which illustrates participants’ recruitment into the study is shown in Figure 1. Of the 782 questionnaires served, 726 (92.8%) were filled out of which 81 (11.2%) were excluded due to incomplete data, leaving 645 questionnaires that were finally analyzed. Of the remaining 645 completely filled questionnaires, 9 domains of NCD were identified in which 105 respondents were hypertensives, 20 were asthmatics, 19 were diabetics, 6 had renal disease, another 6 had ulcer, 5 had Sickle Cell Disease, 2 were with hepatic disease and one each with breast cancer and anxiety disorder. Socio-demographic characteristics of respondents relative to disease entity. Table 1. Among the 645 respondents in this questionnaire-based survey, 165 (25.6%) have been diagnosed with various non-communicable diseases (NCD) categorized as high, low, and very low prevalence. The NCD with high prevalence was hypertension (105, 63.6%), those with low prevalence were asthma (20, 12.1%), and diabetes (19, 11.5%) and those with very low prevalence were kidney disease (6, 3.6%), ulcer (6, 3.6%), sickle cell disease (5, 3.0%), liver disorder (2, 1.2%), breast cancer (1, 0.6%) and anxiety disorder (1, 0.6%). The socio-demographic characteristics of subjects with hypertension, asthma and diabetes are as illustrated in Table 1 which shows hypertension as the most prevalent NCD followed by asthma and diabetes mellitus. There was no significant difference (F-statistic=1.23, P-value=0.29) in the overall mean ±sd ages (years) of respondents with hypertension (52.0±12.2), asthma (46.5±15.3) or diabetes (54.4±10.2). Pooled analysis shows no significant difference (χ²=0.73, P-value=0.69) in the proportion of hypertensive (48, 45.7%; 57 54.3%), asthmatic (10, 50.0%; 10, 50.0%;) and diabetic (7, 36.8%, 12, 63.2%) respondents in the age groups of <50 years or ≥50 years. However, there was a significant difference (χ²=12.01, P-value=0.003) in the distribution, by sex, of hypertension (male: 57, 54.3%, female: 48, 45.7%), asthma (male: 4, 20.0%, female: 16, 80.0%) and diabetes (male: 14, 73.7%, female: 5, 26.3%). Pooled analysis shows a significant difference (F-statistics=3.97, P-value=0.04) in the mean ages of respondents with renal disease (n=6, 64.3±17.9), ulcer (n=6, 50.0±6.0), and SCD (n=5, 46.2±3.4) but not in the mean ages (F-statistics=2.21, P-value=0.43) of those with hepatic disorder (n=2, 27.0±9.9), breast cancer (n=1, 50.0±0.0) and anxiety disorder (n=1, 45.0±0.0). Frequency distribution of dietary pattern, social habits, and daily sleep duration. Figure 2. Majority of the study participants, irrespective of their disease entity, did not smoke at all, while those with kidney disease and anxiety disorder never took alcoholic drink. The only total vegetarian was the respondent with breast cancer who also did not engage in any formal exercise. The highest proportion (50.0%) of those who engaged in formal exercise on daily basis was among those with kidney disease. Interestingly, respondents with most of the NCDs reported having less than 8 hours of sleep per day while 10.5% of the diabetics and the respondent with breast cancer reported having more than 8 hours of sleep per day. Almost all respondents with other NCDs never smoked cigarette, a minimum of 50% never took alcohol and in a minimum of 66.7% was the hours of sleep less than 8 hours per day. Knowledge of dietary supplements by persons with non-communicable diseases relative to sex and age group. Table 2. The proportion of hypertensives (males and females) who believed that dietary supplements are necessary during infectious disease outbreak such as Covid-19 was moderately high (58/105, 55.2%; 57.9% males, 52.1% females) while the proportion was higher among those with low prevalent NCD such as asthma (13/20, 65.0%) and diabetes (58/105, 68.4%) and still higher among respondents with kidney disease (2/2, 100.0%), ulcer (5/6, 83.3%) and liver disease. While only 15.8% of the hypertensives believed that supplements can be used exclusively to treat Covid-19 infection, none of the asthmatics and 7.6% of those with diabetes believed such notion. However, 55.2% of the hypertensives, 75.0% of the asthmatics and 47.4% of the diabetics asserted that supplements can be used in conjunction with other drugs to treat Covid-19. Among respondents with low frequency NCD, the highest proportion of those who asserted that supplements can be used in conjunction with other drugs to treat Covid-19 were those with ulcer (83.3%). Consumption and frequency of dietary supplements use during Covid-19 pandemic in Nigeria relative to sex and age group. Table 3. Almost all the respondents with hypertension (101/105, 96.2%), asthma (19/20, 95.0%), diabetes (19/19, 100.0%) and kidney disease (6/6, 100.0%), consumed supplements more during Covid-19 pandemic in Nigeria. The proportion of those who consumed supplements more during the pandemic in Nigeria was higher among male hypertensives (57/101, 56.4%) than among the female (44/101, 43.6%), though the difference was not significant (χ²=2.93, P-value=0.09). Interestingly, hypertensives aged ≥50 years were approximately 4 times more likely to consume supplements more during the Covid-19 pandemic than those aged <50 years (χ²=0.47, P-value=0.49, OR=3.73, 95% CI:0.38, 37.12). Those with SCD had the lowest proportion (3/5, 60.0%) of those who consumed supplements more during the Covid-19 pandemic in Nigeria. When respondents were asked about the frequency of consumption of supplements during Covid-19 pandemic in Nigeria, the only breast cancer respondent reported consuming supplement daily, while of those who took supplements, 60.0% of the asthmatics, 57.9% of the diabetics, 36.5% among the hypertensives, and only 33.3% of those with kidney disease took them daily. Remarkably, the daily consumption of supplements during the Covid-19 pandemic in the country was higher among female respondents with hypertension (19/44, 43.2%), diabetes (3/5, 60.0%), kidney disease (2/2, 100.0%) and among ≥50 years with hypertension (24/56, 42.9%), asthma (6/10, 60.0%) and diabetes (9/12, 75.0%). Almost all respondents with other NCDs increased their intake of DHS during the Covid-19 pandemic in Nigeria in varying frequency but mostly daily and on alternate days. Dietary supplements consumed by persons with non-communicable diseases during Covid-19 pandemic in Nigeria. Table 4. The dietary and herbal supplements as well as fruits taken by respondents in each disease entity is shown in Table 4. Vitamin C was the commonest vitamin taken by respondents with ulcer (83.3%), kidney disease (83.3%), diabetes (57.9%), asthma (50.0%), hypertension (48.6%) and the two respondents with breast cancer (1, 100.0%) and anxiety disorder (1, 100.0%) respectively. Calcium and zinc were the commonest minerals taken by respondents with ulcer (50.0%, 16.7%), diabetes (10.5%, 5.3%), asthma (30.0%, 10.0%) and hypertension (13.3%, 11.4%) respectively. The commonest herbal supplements consumed by respondents with hypertension were ginger (25.7%), turmeric (24.8% and garlic (22.9%). However, a higher proportion of respondents with diabetes consumed ginger (36.8%), turmeric (47.4%) and garlic (26.3%) while a lower proportion of those with asthma consumed ginger (10.0%), turmeric (20.0%) and garlic (15.0%). Surprisingly, negligible proportion of respondents took fruits, which was observed only in 1 (5.0%) respondent with asthma, though slightly higher proportion of them (10.5%) took apple cider during the Covid-19 pandemic. Except for the respondents with liver disorder, almost all other low-frequency NCDs increased their intake of Vitamin C, and to a lesser extent, Vitamin D. Hardly did any one of this group of respondents take mineral supplement those with gastric ulcer who took increased their intake of calcium (50.0%) and zinc (16.7%) and the only respondent with anxiety disorder who also took increased his intake of zinc (100.0%). Very few of them consumed either herbal supplements or fruits. Reasons for the consumption of DHS during Covid-19 pandemic in Nigeria. Figure 3. Respondents were then asked for the reasons why they took dietary and herbal supplements during the Covid-10 pandemic in Nigeria. Their responses are illustrated in Figure 2 which show that “to maintain good health” was the main reason why the two respondents with breast cancer and anxiety disorder, 83.3% of those with kidney disease, 80% of the asthmatics, 64.8% of the hypertensives and 63.2% of the diabetics took supplements during that period. The respondent with anxiety disorder as well as 33.3% of respondents with ulcer and with kidney disease and 26.3% of the diabetics also took supplements to “hasten recovery from current illness”. Source of information of practices related to food and dietary supplements used to prevent/treat COVID-19. Figure 4. Health workers were the dominant source of information on the use of supplements during Covid-19 pandemic in Nigeria as stated by all the respondents with kidney disease, liver disease, breast cancer and anxiety disorder. However, only 60.0% of asthmatics, 56.2% of the hypertensives and 47.4% of the diabetics got information related to use of supplements at that period from health workers. Social media was also the main source of information of supplement use during Covid-19 pandemic in Nigeria for the respondent with anxiety disorder, 66.7% of those with ulcer, and just 20.0%, 15.8% and 14.3% of the asthmatics, diabetics, and hypertensive respectively among respondents. The internet as source of information for use of supplements at the time of study was not prominent as only 33.3 % of respondents with ulcer, 15.0% of the asthmatics, 15.2% of the hypertensives and a mere 5.3% of the diabetics sourced information of supplement consumption used this medium of information. Mass media did not feature well as source of information. Only 50.0% of ulcer patients, 15.0% of the asthmatics, 15.2% of the hypertensives and a mere 5.3% of the diabetics used mass media to source for relevant information on supplement use a that period. Discussion In this cohort of respondents with non-communicable diseases, hypertension claimed the highest prevalence, followed by asthma and diabetes. This group of who are probably the most prevalent of NCDs are known to be related to the severe outcomes of COVID-19 infection [ 20 ]. Nikoloski et al (2021) reported that patients with NCDs such as diabetes, hypertension, chronic respiratory illnesses, chronic kidney, and liver conditions are more likely to be affected by Covid-19 and are more likely to develop a severely critical form of the illness or even dying other average patients [ 21 ]. This is probably due to (i) elevated level of ACE2 (angiotensin-converting enzyme 2) receptor expressions, which assists the viral penetration into host’s body and (ii) cytokine storm, a hyperinflammatory response [ 21 ]. A plethora of dietary supplements are currently being evaluated for their proficiency in safeguarding and enhancing human immune response to COVID-19, including omega-3 fatty acids, melatonin, and vitamin D, in patients with COVID-19 [ 22 ]. This probably because, as stated by National Institute of Health, “many people are searching for ways to protect themselves against COVID-19” and that sales of supplements increased notwithstanding dearth of dependable indication that these supplements are effective at averting SARS-CoV-2 infection or lessening COVID-19 disease severity [ 22 ]. Human immune system consisting of intrinsic reactions in the vanguard of defense, and adaptive responses, protects the body against disease-causing pathogens [ 23 – 25 ]. Though COVID-19 vaccines are reliable and highly efficient at lowering the threat against human health posed by diseases [ 26 , 27 ] and though medications for treatments are also existing and accessible, still no permanent remedy has been found for COVID-19 [ 22 ]. For this and probably more reasons, awareness, interest in, and attention to DHS that might boost immune function in the prevention or management of COVID-19 illness was high during the pandemic. Of all the three major NCDs, a higher proportion of diabetics (68.4%) agreed that dietary supplements are necessary during infectious disease outbreak such as Covid-19, more than asthmatics (65.0%) or hypertensives (55.3%). This might be due to many factors including aspiration for lessened disease severity which might be stronger among diabetics, stronger will to prevent Covid-19 infection among diabetics because of their easy susceptibility, current medication taken, affordability of the medication and accessibility to health care. This concept is supported by the result that all diabetics increased consumption of DHS during the pandemic mostly on daily basis (57.9%). Although a high proportion of hypertensives also increased consumption of DHS during the pandemic, however, the proportion that did so on daily basis was less (37.6%) than the proportion among the diabetics. Diabetes, as a chronic disease, may reduce the quality of life more than hypertension and sufferers may probably indulge more in taking supplements in an attempt not only to prevent Covid-19 infection but also to improve their quality of life. Vitamin C was the most consume supplements, mainly by diabetic respondents (57.9%), followed by the asthmatics (50.0%) and least by the hypertensive (48.6%). Studies have shown that, due to its antioxidant effects, Vitamin C has a vital function in both innate and adaptive immunity, in antimicrobial and antiviral actions, and in influencing immune system modulators [ 28 – 31 ]. Report from the study of Carr and Maggini shows that Vitamin C supports epithelial integrity, enhances the diversity and proliferation of B cells and T cells, improves phagocytosis, normalizes cytokine production, and lowers histamine levels [ 29 ] while it may also impede viral replication [ 32 ]. Interestingly, diabetic respondents were also those who consumed Vitamin B complex mostly (21.1%), that asthmatics (15.0%) and hypertensives (11.4%). Probably, diabetics may have taken their illness more seriously, especially during the pandemic, than hypertensives or asthmatics. More study, especially in resource-limited countries, need to be conducted on this. While selenium was the mineral least consumed by the diabetics (5.3%), hypertensives (2.9%) and asthmatic (0.0%), a high proportion of asthmatics (30.0%), more than hypertensives (13.3%) and diabetics (10.5%) increased their intake of calcium during the pandemic. While selenium is known to augment the immune systems through enhancing T-cell maturation and role and in natural killer cell function, it is also known to lower the risk of infections [ 33 – 40 ]. Studies have also shown that selenium’s anti-oxidant property may assist in reducing systemic inflammatory response causing acute respiratory distress syndrome and organ failure [ 41 – 43 ]. Alexander et al [ 43 ] ascertained that selenium and other minerals and vitamins such as zinc and vitamin D are indispensable for fighting viral infections, for optimal immune function, lowering inflammation and protecting against the novel coronavirus SARS-CoV-2. Vitamin E, which was not consumed by diabetic or hypertensive responders and by a mere 15.0% of asthmatics is known to reduce inflammation by preventing the production of pro-inflammatory cytokines [ 44 ]. Studies found that Vitamin E deficiency weakens humoral and cell-mediated immunity and elevates vulnerability to infections [ 37 , 45 – 46 ]. More diabetic respondents increased their consumption of garlic (26.3%), ginger (36.8%), turmeric (47.4%) and moringa (26.3%) than asthmatics (15.0%, 10.0%, 20.0% and 5.0% respectively) or hypertensives (22.9%, 257%, 24.8% and 10.5% respectively). In a case control study, Wang et al reported that, among other observations, patients with Covid-19 who received garlic essential oil had lesser duration of symptoms, shorter time to negative nucleic acid testing (NAT) results and shorter time to improvement on the computed tomography (CT) [ 47 ]. The use of ginger, garlic, and turmeric among respondents with diabetes, asthma and hypertension in this study was much less than the 87.1%, 78.9%, 57.9% use of these herbal supplements among the general public in another study [ 48 ]. Of the respondents with high frequency NCDs, asthmatics were those who mostly (60.0%) depended on health workers as source of information for use of supplements during the Covid-19 pandemic, followed by the hypertensives (56.2%) and the diabetics (47.4%) and 20.0% or less depended on social media for such information. This may be due to uncertainty, circulating conspiracy theories and fake news on social media and print media. To confirm what Jayaseelan et al [ 49 ] stated that incorrect or deceptive information could be dispersed willingly or malevolently through the internet for concealed purposes, another study evaluated Twitter contents during the pandemic and reported that 25% of information on Covid-19 were deceptive [ 50 ]. Study limitations This study has some potential limitations which are (i) the study did not meet the expected number of respondents from Google Form which was sent to all the six geo-political zones of the country. This necessitated face-to-face interviews in Lagos City populated by all ethnic groups. (ii) Bias into the study may have been introduce by convenient sampling (iii) Respondents who filled the Google Form on-line may have misconstrued, misinterpreted the questions, and responded without elucidation. Vulnerable population may have been excluded. The interviewer-mediated survey may have presented latent social desirability and interviewer biases. Moreover, it is important to note that the study population consisted of a relatively high proportion of persons with hypertension and fewer proportion of other non-communicable diseases, especially cancer, anxiety disorder and Sickle Cell Disease. This, however, may be representative of the profile of NCDs among the general population in Nigeria. Therefore, the relatively small sample size of the NCDs and the cross-sectional survey design restricts causal associations between study variables. There are hardly any studies conducted in Nigeria or in Africa on the advantages and benefits of using dietary and herbal supplements for preventing and treating COVID-19 infection, especially among hypertensives, asthmatics, and diabetics, which weakened this current study to compare its findings with those of other African countries. Further studies, preferably multi-center and multidiscipline, and in different parts of continental Africa are needed to determine the exact predictive value of findings in this current study. Conclusion This study evaluated the proportion of Nigerians with Non-communicable diseases, especially hypertension, asthma, and diabetes, who took dietary and herbal supplements to boost their immunity during the COVID-19 pandemic in the country. Hypertension was the most prevalent non-communicable disease. Almost all respondents increased their consumption of one form of dietary supplements or another during the Covid-19 pandemic, more among male than female hypertensives. Vitamin C was the most common vitamin consumed and calcium and zinc were the minerals that were also moderately consumed by those with ulcer, diabetes, asthma, and hypertension. The most prevalent reason why a high proportion of respondents, especially those with kidney disease and with asthma, increased their consumption of dietary supplement was to maintain good health. Declarations Declaration of Competing Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Acknowledgments: The authors are appreciative of Nigerian Institute of Medical Research for providing the fund to carry out the study in Nigeria. In addition, the authors hereby express their sincere appreciation to study participants who painstakingly contributed their time and efforts to complete the surveys for the successful completion of this survey. Contributors BMA, SJAH and OOO conceived and designed the initial research questions and coordinated the data collection. BMA, SH and OOO had full access to the study’s data and take responsibility for the integrity and accuracy of the data analysis. BM and SH completed the statistical analysis and supervised the conduct of the research. BMA and SH drafted the final paper. BMA, SH, and OOO critically reviewed the write up of the manuscript. All authors approved the final version of the manuscript and agreed to be accountable for all aspects of the work. Funding Source Declaration This research received was funded by the Nigerian Institute of Medical Research Grant No: NMG-CIF-38-0056 References CDC. 2019 Novel Coronavirus, Wuhan, China. CDC. Available at https://www.cdc.gov/coronavirus/2019-ncov/about/index.html . January 26, 2020. Accessed: December 30, 2022. World Health Organization. 2020. Coronavirus Disease 2019 (COVID-19) Situation Report – 37. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19.pdf?sfvrsn=2146841e_2 . Accessed: December 30, 2022. 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Socio-demographic characteristics of respondents relative to disease entity Variable Category Statistics Non-communicable disease entity Hypertension Asthma Diabetes Total (%) 105 (63.6) 20 (12.1) 19 (11.5) Age (yrs) Mean (±sd) 52.0 (12.2) 46.5 (15.3) 54.4 (10.2) Median 50.0 45.0 59.0 Min./Max. 28/80 24/69 36/66 Age group (yrs) <50 Frequency (%) 48 (45.7) 10 (50.0) 7 (36.8) ≤50 57 (54.3) 10 (50.0) 12 (63.2) Gender Male 57 (54.3) 4 (20.0) 14 (73.7) Female 48 (45.7) 16 (80.0) 5 (26.3) Marital status Single 5 (4.8) 5 (25.0) 2 (10.5) Ever married 100 (95.2) 15 (75.0) 17 (89.5) Educational status Primary 2 (1.9) 1 (5.0) 2 (10.5) Secondary 27 (25.7) 5 (25.0) 5 (26.3) Tertiary 76 (72.4) 14 (70.0) 12 (63.2) Occupation Employed 63 (60.0) 14 (70.0) 4 (21.1) Unemployed 28 (26.7) 6 (30.0) 10 (52.6) Trader 5 (4.8) 0 (0.0) 3 (15.8) Retired 9 (8.6) 0 (0.0) 2 (10.5) Religion Christianity 79 (75.2) 18 (90.0) 9 (47.4) Islam 26 (24.8) 2 (10.0) 10 (52.6) Table 2. Knowledge of dietary supplements by persons with non-communicable diseases relative to sex and age group Disease Variable Category Dietary supplements are necessary during infectious disease outbreak such as COVID-19 Supplements can be used exclusively to treat COVID-19 Supplements can be used in conjunction with other drugs to treat COVID-19 Yes No Don’t know Yes No Don’t know Yes No Don’t know Hypertension (n=105) Sex All 58 (55.3) 18 (17.1) 29 (27.6) 8 (7.6) 60 (57.1) 37 (35.3) 58 (55.3) 18 (17.1) 29 (27.6) Male 33 (57.9) 10 (17.5) 14 (24.6) 1 (1.8) 32 (56.1) 24 (42.1) 32 (56.1) 7 (12.3) 18 (31.6) Female 25 (52.1) 8 (16.7) 15 (31.2) 7 (14.6) 28 (58.3) 13 (27.1) 26 (54.2) 11 (22.9) 11 (22.9) χ² (P-value) 0.59 (0.74) 7.53 (0.03) * 2.45 (0.29) Age group (yrs.) <50 22 (45.8) 11 (22.9) 7 (31.3) 4 (8.3) 32 (66.7) 12 (25.0) 29 (60.4) 8 (16.7) 11 (22.9) ≥50 36 (63.1) 7 (12.3) 14 (24.6) 4 (7.0) 28 (49.1) 25 (43.9) 29 (50.9) 10 (17.5) 18 (31.6) χ² (P-value) 3.74 (0.15) 4.16 (0.13) * 1.15 (0.56) Asthma (n=20) Sex All 13 (65.0) 2 (10.0) 5 (25.0) 0 (0.0) 18 (90.0) 2 (10.0) 15 (75.0) 4 (20.0) 1 (5.0) Male 1 (25.0) 1 (25.0) 2 (50.0) 0 (0.0) 3 (75.0) 1 (25.0) 1 (25.0) 2 (50.0) 1 (25.0) Female 12 (75.0) 1 (6.3) 3 (18.7) 0 (0.0) 15 (93.8) 1 (6.2) 14 (87.5) 2 (12.5) 0 (0.0) χ² (P-value) 3.46 (0.18) * 1.02 (0.31) * 7.12 (0.03) Age group (yrs.) <50 6 (60.0) 1 (10.0) 3 (30.0) 0 (0.0) 8 (80.0) 2 (20.0) 8 (80.0) 1 (10.0) 1 (10.0) ≥50 7 (70.0) 1 (10.0) 2 (20.0) 0 (0.0) 10 (100.0) 0 (0.0) 7 (70.0) 3 (30.0) 0 (0.0) χ² (P-value) 0.28 (0.87) * 3.00 (0.08) * 2.50 (0.29) * Diabetes mellitus (n=19) Sex All 13 (68.4) 3 (15.8) 3 (15.8) 3 (15.8) 13 (68.4) 3 (15.8) 9 (47.4) 4 (21.0) 6 (31.6) Male 10 (71.4) 3 (21.4) 1 (7.2) 1 (7.2) 12 (85.7) 1 (7.2) 6 (42.9) 3 (21.4) 5 (35.7) Female 3 (60.0) 0 (0.0) 2 (40.0) 2 (40.0) 1 (20.0) 2 (40.0) 3 (60.0) 1 (20.0) 1 (20.0) χ² (P-value) 4.04 (0.13) * 7.36 (0.03) * 0.54 (0.76) Age group (yrs.) <50 2 (28.6) 0 (0.0) 5 (71.4) 0 (0.0) 5 (71.4) 2 (28.6) 1 (14.3) 2 (28.6) 4 (57.1) ≥50 11 (91.7) 0 (0.0) 1 (8.3) 3 (25.0) 8 (66.7) 1 (8.3) 8 (66.6) 2 (16.7) 2 (16.7) χ² (P-value) 8.44 (0.004) * 3.87 (0.14) * 5.55 (0.06) * *=Fisher’s exact test applied Table 3. Consumption and frequency of dietary supplements use during Covid-19 pandemic in Nigeria relative to sex and age group. Variable Category Did you take dietary supplements more during this Covid-19 If yes, how often did you take dietary supplements Yes No Occasionally Alternate days Daily Once a week Twice a week Hypertension All 101 (96.2) 4 (3.8) 23 (22.8) 23 (22.8) 38 (37.6) 10 (9.9) 6 (5.9) Sex Male 57 (56.4) 0 (0.0) 12 (21.1) 15 (26.3) 19 (33.3) 7 (12.3) 4 (7.0) Female 44 (43.6) 4 (100) 11 (25.0) 8 (18.2) 19 (43.2) 3 (6.8) 2 (4.5) χ² (P-value) / OR (95% CI) 2.93 (0.09) / undefined 9.16 (0.10) Age group (yrs.) <50 45 (44.6) 3 (6.7) 12 (26.7) 16 (35.6) 14 (31.1) 3 (6.7) 2 (4.4) ≥50 56 (55.4) 1 (25.0) 11 (19.6) 7 (12.5) 24 (42.9) 7 (12.5) 4 (7.1) χ² (P-value) / OR (95% CI) 0.47 (0.49) / 0.27 (0.03, 2.66); 0.47 (0.49) / 3.73 (0.38, 37.12) 9.08 (0.11) Asthma All 19 (95.0) 1 (5.0) 2 (10.5) 2 (10.5) 12 (63.2) 1 (5.3) 1 (5.3) Sex Male 4 (21.1) 0 (0.0) 0 (0.0) 0 (0.0) 3 (75.0) 0 (0.0) 0 (0.0) Female 15 (78.9) 1 (100.0) 2 (13.3) 2 (13.3) 9 (60.0) 1 (6.6) 1 (6.6) χ² (P-value) / OR (95% CI) 0.00 (1.00) / undefined 9.82 (0.83) Age group (yrs.) <50 9 (47.4) 1 (100.0) 2 (22.2) 0 (0.0) 6 (66.7) 0 (0.0) 0 (0.0) ≥50 10 (52.6) 0 (0.0) 0 (0.0) 2 (20.0) 6 (60.0) 1 (10.0) 1 (10.0) χ² (P-value) 0.00 (1.00) / undefined 11.09 (0.049) Diabetes mellitus All 19 (100.0) 0 (0.0) 1 (5.3) 5 (26.3) 11 (57.9) 1 (5.3) 1 (5.3) Sex Male 14 (76.7) 0 (0.0) 1 (7.2) 5 (35.7) 8 (57.1) 0 (0.0) 0 (0.0) Female 5 (26.3) 0 (0.0) 0 (0.0) 0 (0.0) 3 (60.0) 1 (20.0) 1 (20.0) χ² (P-value) / OR (95% CI) 3.31 (0.07) / undefined 7.75 (0.45) Age group (yrs.) <50 7 (36.8) 0 (0.0) 1 (14.3) 2 (28.6) 2 (28.6) 1 (14.3) 1 (14.3) ≥50 12 (63.2) 0 (0.0) 0 (0.0) 3 (25.0) 9 (75.0) 0 (0.0) 0 (0.0) χ² (P-value) 3.31 (0.07) / undefined 7.85 (0.10) Table 4. Dietary supplements consumed by persons with non-communicable diseases during Covid-19 pandemic in Nigeria Supplement Non-communicable diseases Hypertension Asthma Diabetes Types of Supplements mentioned as taken Vitamins Vitamin B co 12 (11.4) 3 (15.0) 4 (21.1) Vitamin C 51 (48.6) 10 (50.0) 11 (57.9) Vitamin D 10 (9.5) 7 (35.0) 2 (10.5) Vitamin E 0 (0.0) 3 (15.0) 0 (0.0) Folic Acid 8 (7.6) 4 (20.0) 3 (15.8) Multivitamin 28 (26.7) 8 (40.0) 4 (21.1) Minerals Selenium 3 (2.9) 0 (0.0) 1 (5.3) Iron 1 (0.9) 0 (0.0) 1 (5.3) Calcium 14 (13.3) 6 (30.0) 2 (10.5) Zinc 12 (11.4) 2 (10.0) 1 (5.3) Types of herbal supplements mentioned as consumed Garlic 24 (22.9) 3 (15.0) 5 (26.3) Ginger 27 (25.7) 2 (10.0) 7 (36.8) Tumeric 26 (24.8) 4 (20.0) 9 (47.4) Moringa 11 (10.5) 1 (5.0) 5 (26.3) Ginseng 2 (1.9) 0 (0.0) 0 (0.0) Herbal tea 16 (15.2) 2 (10.0) 2 (10.5) Others 0 (0.0) 3 (15.0) 0 (0.0) Types of citrus fruits mentioned as consumed Lime/Lemon 1 (0.9) 0 (0.0) 0 (0.0) Apple Cider 2 (1.9) 3 (15.0) 2 (10.5) Fruits 0 (0.0) 1 (5.0) 0 (0.0) Additional Declarations No competing interests reported. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {\"props\":{\"pageProps\":{\"initialData\":{\"identity\":\"rs-2488233\",\"acceptedTermsAndConditions\":true,\"allowDirectSubmit\":true,\"archivedVersions\":[],\"articleType\":\"Research Article\",\"associatedPublications\":[],\"authors\":[{\"id\":168937627,\"identity\":\"c00a3b4b-1112-4c06-b954-12a078672cb8\",\"order_by\":0,\"name\":\"Bamgboye M. Afolabi\",\"email\":\"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA20lEQVRIiWNgGAWjYBACAyD+wFDAkMDG3gDiWhClhXEGkExg4zkA4kqQoIVBIgHEJ0KLudjhhw0fDOzy+CSfX93wo0CCgb+9OwGvFsvZaYaNMwySi9mkc8pu9gAdJnHm7Ab8DrudYP6Yx4A5sU06J+0GD1CLgUQuIS3pH5t5DOoT2yTPpN38Q5yWHEOglsOJbRLsx24TZYvl7JxCoF+OF7Px5LDdljGQ4CHoF3Pp9I0NHyqq8+Tbjz+7+eaPjRx/ey9+LUiAxwBMEqscBNgfkKJ6FIyCUTAKRhAAACY+RsWtX0JPAAAAAElFTkSuQmCC\",\"orcid\":\"\",\"institution\":\"Nigerian Institute of Medical Research\",\"correspondingAuthor\":true,\"prefix\":\"\",\"firstName\":\"Bamgboye\",\"middleName\":\"M.\",\"lastName\":\"Afolabi\",\"suffix\":\"\"},{\"id\":168937628,\"identity\":\"1dcecfd2-6afb-412c-9722-25e97ec508ad\",\"order_by\":1,\"name\":\"Susan A Holdbrooke\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Nigerian Institute of Medical Research\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Susan\",\"middleName\":\"A\",\"lastName\":\"Holdbrooke\",\"suffix\":\"\"},{\"id\":168937631,\"identity\":\"341971e1-a334-48b4-982e-9ef489bfaabc\",\"order_by\":2,\"name\":\"Oluwatosin O. Odubela\",\"email\":\"\",\"orcid\":\"\",\"institution\":\"Nigerian Institute of Medical Research\",\"correspondingAuthor\":false,\"prefix\":\"\",\"firstName\":\"Oluwatosin\",\"middleName\":\"O.\",\"lastName\":\"Odubela\",\"suffix\":\"\"}],\"badges\":[],\"createdAt\":\"2023-01-17 14:44:20\",\"currentVersionCode\":1,\"declarations\":\"\",\"doi\":\"10.21203/rs.3.rs-2488233/v1\",\"doiUrl\":\"https://doi.org/10.21203/rs.3.rs-2488233/v1\",\"draftVersion\":[],\"editorialEvents\":[],\"editorialNote\":\"\",\"failedWorkflow\":false,\"files\":[{\"id\":32229923,\"identity\":\"b8ef7702-f4dd-4d50-83f3-e251025018cf\",\"added_by\":\"auto\",\"created_at\":\"2023-01-30 20:43:23\",\"extension\":\"jpeg\",\"order_by\":1,\"title\":\"Figure 1\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":700849,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003e\\u003cem\\u003eFlowchart of recruitment of study participants.\\u003c/em\\u003e\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"floatimage1.jpeg\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-2488233/v1/8bd0dac6db45c8df0a9ef386.jpeg\"},{\"id\":32230142,\"identity\":\"ff3f1d33-4389-41df-bc98-7e7b1912f8a5\",\"added_by\":\"auto\",\"created_at\":\"2023-01-30 20:51:23\",\"extension\":\"png\",\"order_by\":2,\"title\":\"Figure 2\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":15965,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003e\\u003cem\\u003eFrequency distribution of dietary pattern, social habits, and daily sleep duration.\\u003c/em\\u003e\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"Onlinedrawingimage1.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-2488233/v1/ad05010c8f61ca352ca11a1b.png\"},{\"id\":32229920,\"identity\":\"280fd8a4-352b-40ba-aeee-b9baaec625f9\",\"added_by\":\"auto\",\"created_at\":\"2023-01-30 20:43:23\",\"extension\":\"png\",\"order_by\":3,\"title\":\"Figure 3\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":57365,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003e\\u003cem\\u003eReasons for the consumption of DHS during Covid-19 pandemic in Nigeria.\\u003c/em\\u003e\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"3.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-2488233/v1/49847354f4a94eaead61a672.png\"},{\"id\":32229922,\"identity\":\"8ff01b0a-6a03-4fbe-9248-ee0ad7ac38b4\",\"added_by\":\"auto\",\"created_at\":\"2023-01-30 20:43:23\",\"extension\":\"png\",\"order_by\":4,\"title\":\"Figure 4\",\"display\":\"\",\"copyAsset\":false,\"role\":\"figure\",\"size\":140715,\"visible\":true,\"origin\":\"\",\"legend\":\"\\u003cp\\u003e\\u003cem\\u003eSource of information of practices related to food and dietary supplements used to prevent/treat COVID-19.\\u003c/em\\u003e\\u003c/p\\u003e\",\"description\":\"\",\"filename\":\"4.png\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-2488233/v1/dd1641aef5f688ccc6517a22.png\"},{\"id\":32230143,\"identity\":\"768588b1-6ad3-452a-9946-672cb8ee7c82\",\"added_by\":\"auto\",\"created_at\":\"2023-01-30 20:51:29\",\"extension\":\"pdf\",\"order_by\":0,\"title\":\"\",\"display\":\"\",\"copyAsset\":false,\"role\":\"manuscript-pdf\",\"size\":585436,\"visible\":true,\"origin\":\"\",\"legend\":\"\",\"description\":\"\",\"filename\":\"manuscript.pdf\",\"url\":\"https://assets-eu.researchsquare.com/files/rs-2488233/v1/8558ce5d-aa3e-4ffc-8510-c23e7df7064e.pdf\"}],\"financialInterests\":\"No competing interests reported.\",\"formattedTitle\":\"Pattern of Consumption of Dietary and Herbal Supplements by Individuals with Non-communicable Diseases During Covid-19 Pandemic in Nigeria\",\"fulltext\":[{\"header\":\"Introduction\",\"content\":\"\\u003cp\\u003eThe period 2019 to the end of 2021 witnessed crisis in global health that remains unprecedented in human history, cause by the Coronavirus Disease 2019, eventually designated as COVID-19 by the World Health Organization (WHO). The disease is defined as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) which was formally known as 2019-nCoV, initially detected amid an outbreak of respiratory illness cases in Wuhan City, Hubei Province in People\\u0026rsquo;s Republic of China [\\u003cspan citationid=\\\"CR1\\\" class=\\\"CitationRef\\\"\\u003e1\\u003c/span\\u003e] in early December 2019 and reported to WHO later in the month. A series of events happened to identify, categorize contain the spread and to inform the public, including the declaration of the disease as a Public Health Emergency of International Concern (PHEIC) by the WHO on January 30, 2020 [\\u003cspan additionalcitationids=\\\"CR3\\\" citationid=\\\"CR2\\\" class=\\\"CitationRef\\\"\\u003e2\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR4\\\" class=\\\"CitationRef\\\"\\u003e4\\u003c/span\\u003e], and as a global pandemic on March 11, 2020 [\\u003cspan citationid=\\\"CR5\\\" class=\\\"CitationRef\\\"\\u003e5\\u003c/span\\u003e]. By the end of 2021, over 200 countries have been affected causing a heavy health burden to individuals, families, communities, societies, countries, and health care systems throughout the world to deter and contain the pandemic [\\u003cspan citationid=\\\"CR6\\\" class=\\\"CitationRef\\\"\\u003e6\\u003c/span\\u003e]. Seven of the vast family of viruses known as Coronavirus are believed to be zoonotic, causing disease in humans [\\u003cspan citationid=\\\"CR7\\\" class=\\\"CitationRef\\\"\\u003e7\\u003c/span\\u003e]. On 23 December 2021, WHO decided that the main route by which humans get infected by SARS-CoV-12 is through exposure to respiratory droplets, generally within 6 feet radius [\\u003cspan citationid=\\\"CR8\\\" class=\\\"CitationRef\\\"\\u003e8\\u003c/span\\u003e]. Studies later found out other ways people are infected such as contact spread by shaking hands and airborne transmission [\\u003cspan citationid=\\\"CR9\\\" class=\\\"CitationRef\\\"\\u003e9\\u003c/span\\u003e] of \\u0026ldquo;droplets that linger in the air over long distance (usually greater than 6 feet)\\u0026rdquo; [\\u003cspan additionalcitationids=\\\"CR11\\\" citationid=\\\"CR10\\\" class=\\\"CitationRef\\\"\\u003e10\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR12\\\" class=\\\"CitationRef\\\"\\u003e12\\u003c/span\\u003e]. Covid-19 pandemic brought shock, panic, fear, uncertainty, distrust, conspiracy theories, disease, and death to spread throughout the world. This was brought about mainly by the rapidity with which the disease spread throughout the world causing over 175,850,000 infections and 3.8\\u0026nbsp;million deaths by June 2020 [\\u003cspan citationid=\\\"CR6\\\" class=\\\"CitationRef\\\"\\u003e6\\u003c/span\\u003e]. Probably because of the rapidity with which many vaccines were developed, tested, and approved in order to mitigate the morbidity and mortality associated with Covid-19, many people distrusted the efficacy of such vaccines. There were a flurry of misinformation and conspiracy theories that were circulated through the social and mass media on side effects of vaccines and most people doubted the safety and effectiveness of these vaccines. World Health Organization reported a wide range of symptoms including fever, chills muscle or body aches, anorexia, and headache which make Covid-19 resemble malaria infection; cough, sore throat, nasal congestion, or rhinorrhea render it flu-like; prolonged cough, fever, and dyspnea probably confirm pneumonia; and added to these are diarrhea, and loss of taste and/or smell [\\u003cspan citationid=\\\"CR13\\\" class=\\\"CitationRef\\\"\\u003e13\\u003c/span\\u003e]. The possibility of severe disease rises with people age while, regardless of the age, those with underlying medical ailments such as cardiac, metabolic, pulmonary or neoplastic diseases may be at higher risk of severe COVID-19 infection relative to others without these conditions [\\u003cspan citationid=\\\"CR13\\\" class=\\\"CitationRef\\\"\\u003e13\\u003c/span\\u003e]. The virus itself, discovered using metagenomic RNA sequencing and virus sequestration from bronchoalveolar lavage fluid samples from patients with severe pneumonia, is a beta-coronavirus previously unknown [\\u003cspan additionalcitationids=\\\"CR15\\\" citationid=\\\"CR14\\\" class=\\\"CitationRef\\\"\\u003e14\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR16\\\" class=\\\"CitationRef\\\"\\u003e16\\u003c/span\\u003e]. Nigeria, a developing and the most populated country in Africa, experienced some measures of severe outbreak of the COVID-19 pandemic during the study period. The trepidation caused by Covid-19 pandemic, the high morbidity and mortality rates globally coupled with the already-known weak health systems in most parts of Africa probably drove many people, especially those with non-communicable diseases, who are more prone to Covid-19 infection, to seek other ways of maintaining good health during the pandemic. This also is probably the reason why some increased the consumption of dietary and herbal supplements. Dietary supplements defined as usable amounts of micronutrients have become a growing interest during the COVID-19 as they are widely used to potentially improve immune health [\\u003cspan citationid=\\\"CR17\\\" class=\\\"CitationRef\\\"\\u003e17\\u003c/span\\u003e]. A study reports that supplementation of a combination of magnesium, vitamin D and vitamin B12 resulted in significant reductions in clinical deterioration, need for oxygen support and intensive care support of elderly Covid-19 patients [\\u003cspan citationid=\\\"CR18\\\" class=\\\"CitationRef\\\"\\u003e18\\u003c/span\\u003e]. Also, the hypothetical impacts of supplementing vitamin C, zinc, vitamin D, and probiotics on COVID-19 consequences have also been studied with diverse findings, and several studies are also still underway [\\u003cspan citationid=\\\"CR19\\\" class=\\\"CitationRef\\\"\\u003e19\\u003c/span\\u003e]. Nigerian governments at all levels, the Nigerian CDC, primary, secondary, and tertiary health facilities across the country and the Nigerian Institute of Medical Research mobilized all resources to gather data, curtain the spread of the disease and give vaccines to as many people as possible. However, there is paucity of data on dietary and herbal supplements consumed by those with non-communicable diseases during the pandemic. The primary objective of this paper therefore is to evaluate the pattern of consumption of dietary and herbal supplements during the Covid-19 pandemic among persons with NCDs. The secondary objectives are to assess the knowledge, attitude, practice, and perception of dietary and herbal supplements at this period and document the source of information on use of DHS by this cohort.\\u003c/p\\u003e \\u003cp\\u003eThe authors of this paper are not aware of any authorization from or by the National Food and Drugs Administration and Control (NAFDAC) in Nigeria for anyone to consume any dietary and herbal supplement for the prevention, treatment, or management of Covid-19.\\u003c/p\\u003e\"},{\"header\":\"Materials And Method\",\"content\":\"\\u003cdiv id=\\\"Sec3\\\" class=\\\"Section2\\\"\\u003e \\u003ch2\\u003eStudy design:\\u003c/h2\\u003e \\u003cp\\u003eThis questionnaire-based cross-sectional study was designed and served to persons Nigerians aged 18 years and above to explore and describe their consumption pattern of dietary and herbal supplements (DHS) during the COVID-19 pandemic. Almost all the study subjects, males, and females, from various ethnic groups and resident in the country when the survey was conducted, with varying levels of educational background, and employment status were able to read and understand English. Information collected from respondents included socio-demographic characteristics (age, sex, educational status, employment status, and marital status), health status, knowledge, attitude, and behavioral pattern on the use of DHS. Nigerian Institute of Medical Research, where this study was developed, conducted, and analyzed is the sole medical research institute of the Federal Government. The Institute consists of the departments of Biochemistry and Nutrition (where the study was designed), Human Virology, Clinical Trials, Public Health, and Microbiology. Because of restriction of movements due to lock-down policy by the government, hard copy questionnaire survey was conducted in Lagos State. However, Google form questionnaire was sent to other parts of the country using the internet. Though a minimum of 500 responses were expected, filled questionnaires were received from only 216 people. Reasons for non-response have been stated in our earlier paper which included (i) time limit of one week that was given (ii) the survey took place during the pandemic during which people were stressed because of lock-down, social distance and other restrictions (iii) many questionnaires were circulating online during the pandemic and (iv) response fatigue on the part of the study subjects. This poor response rate from Google form prompted the administration of hard copies of the questionnaire in various communities in metropolitan Lagos, southwest Nigeria, a multi-ethnic city of about 20\\u0026nbsp;million people. Five questionnaire administrators, trained in inter-personal communication, retrieved responses from the study subjects. These administrators conducted had received their Covid-19 vaccine, and observed all precautions such as wearing face mask, using hand sanitizers, and maintaining social distance when conducting face-to-face interviews. In addition, all questionnaires and materials for writing were equally disinfected appropriately before and after use. Each respondent who was not wearing a face mask or whose face mask was defective was provided with one to wear and had his or her hands were sanitized as well. The very few respondents who could not read nor write had the questionnaire read to them. Participants\\u0026rsquo; unique identifier, as well as the intention of the survey, the process and the duration of time needed to finish each questionnaire were specified in the early part of each questionnaire.\\u003c/p\\u003e \\u003cp\\u003e \\u003cstrong\\u003eInclusion/Exclusion criteria\\u003c/strong\\u003e \\u003cp\\u003eThe only inclusion criteria to participate in the study were age of 18 years and above and residence within Nigeria as there were hardly any visitor from outside the country during the Covid-19 pandemic.\\u003c/p\\u003e \\u003c/p\\u003e \\u003cp\\u003e \\u003cstrong\\u003eEthical clearance\\u003c/strong\\u003e \\u003cp\\u003eThe study protocol, the questionnaire and the consent form were reviewed and approved by the Research and Ethics Committee at the Nigerian Institute of Medical Research (IRB/20/039). Both in the hard copy and Google form of the questionnaire, study participants were assured of concealment of personal identity, confidentiality, and choice to decline at any point in the filling of the questionnaire before the survey started. On-line study responders had to accept to participate after agreeing to terms and conditions of the study before the questionnaire could be accessed electronically.\\u003c/p\\u003e \\u003c/p\\u003e \\u003cp\\u003e \\u003cstrong\\u003eDefinition\\u003c/strong\\u003e \\u003cp\\u003eFor the purpose of this study, dietary and/or herbal supplements were defined as any ingredient (except tobacco products) that are consumed as nutrients or micronutrients to prevent and treat Covid-19 infection.\\u003c/p\\u003e \\u003c/p\\u003e \\u003cp\\u003e \\u003cstrong\\u003eStatistical analysis of data\\u003c/strong\\u003e \\u003cp\\u003eData was first extracted from Google Form as a Microsoft Excel Spreadsheet (Microsoft Corporation) and concatenated with data from hard copy questionnaire. The completed data in the Excel spreadsheet was then cleaned, coded, and exported into NCSS v2022 (Kaysville, Utah, USA) statistical software for Windows before it was analyzed, using appropriate commands. Descriptive statistical analyses concerning frequency and percentage distribution were performed for all demographic variable and the results of these were specified as numbers (n) and percentages (%). Continuous variables were reported as mean (\\u0026plusmn;\\u0026thinsp;standard deviation [SD]) for normally distributed variables. Pearson correlation (χ\\u0026sup2;) with Odd Ratio (OR) at 95% Confidence Interval (CI) were carried out to determine the relationship between categorical variables of interest. P-values\\u0026thinsp;\\u0026lt;\\u0026thinsp;0.05 were considered statistically significant. Results were rendered as Tables, Graphs and Figures\\u003c/p\\u003e \\u003c/p\\u003e \\u003c/div\\u003e\"},{\"header\":\"Results\",\"content\":\"\\u003cp\\u003eData of NCDs that occurred in very low frequencies \\u0026ndash; kidney disease (6, 3.6%), ulcer (6, 3.6%), sickle cell disease (5, 3.0%), liver disorder (2, 1.2%), breast cancer (1, 0.6%) and anxiety disorder (1, 0.6%) \\u0026ndash; are not included in any of the Tables or Figures (except Figures 3 and 4) but are written as narratives under appropriate sub-headings.\\u0026nbsp;\\u003cem\\u003e\\u0026nbsp;\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eFlowchart of recruitment of study participants. Figure 1.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThis paper is part of a bigger study from which data of participants with NCDs have been extracted for analysis. The flow chart which illustrates participants\\u0026rsquo; recruitment into the study is shown in Figure 1. Of the 782 questionnaires served, 726 (92.8%) were filled out of which 81 (11.2%) were excluded due to incomplete data, leaving 645 questionnaires that were finally analyzed. Of the remaining 645 completely filled questionnaires, 9 domains of NCD were identified in which 105 respondents were hypertensives, 20 were asthmatics, 19 were diabetics, 6 had renal disease, another 6 had ulcer, 5 had Sickle Cell Disease, 2 were with hepatic disease and one each with breast cancer and anxiety disorder. \\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eSocio-demographic characteristics of respondents relative to disease entity. Table 1.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eAmong the 645 respondents in this questionnaire-based survey, 165 (25.6%) have been diagnosed with various non-communicable diseases (NCD) categorized as high, low, and very low prevalence. The NCD with high prevalence was hypertension (105, 63.6%), those with low prevalence were asthma (20, 12.1%), and diabetes (19, 11.5%) and those with very low prevalence were kidney disease (6, 3.6%), ulcer (6, 3.6%), sickle cell disease (5, 3.0%), liver disorder (2, 1.2%), breast cancer (1, 0.6%) and anxiety disorder (1, 0.6%). The socio-demographic characteristics of subjects with hypertension, asthma and diabetes are as illustrated in Table 1 which shows hypertension as the most prevalent NCD followed by asthma and diabetes mellitus. There was no significant difference (F-statistic=1.23, P-value=0.29) in the overall mean \\u0026plusmn;sd ages (years) of respondents with hypertension (52.0\\u0026plusmn;12.2), asthma (46.5\\u0026plusmn;15.3) or diabetes (54.4\\u0026plusmn;10.2). Pooled analysis shows no significant difference (\\u0026chi;\\u0026sup2;=0.73, P-value=0.69) in the proportion of hypertensive (48, 45.7%; 57 54.3%), asthmatic (10, 50.0%; 10, 50.0%;) and diabetic (7, 36.8%, 12, 63.2%) respondents in the age groups of \\u0026lt;50 years or \\u0026ge;50 years. However, there was a significant difference (\\u0026chi;\\u0026sup2;=12.01, P-value=0.003) in the distribution, by sex, of hypertension (male: 57, 54.3%, female: 48, 45.7%), asthma (male: 4, 20.0%, female: 16, 80.0%) and diabetes (male: 14, 73.7%, female: 5, 26.3%). Pooled analysis shows a significant difference (F-statistics=3.97, P-value=0.04) in the mean ages of respondents with renal disease (n=6, 64.3\\u0026plusmn;17.9), ulcer (n=6, 50.0\\u0026plusmn;6.0), and SCD (n=5, 46.2\\u0026plusmn;3.4) but not in the mean ages (F-statistics=2.21, P-value=0.43) of those with hepatic disorder (n=2, 27.0\\u0026plusmn;9.9), breast cancer (n=1, 50.0\\u0026plusmn;0.0) and anxiety disorder (n=1, 45.0\\u0026plusmn;0.0).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eFrequency distribution of dietary pattern, social habits, and daily sleep duration. Figure 2.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eMajority of the study participants, irrespective of their disease entity, did not smoke at all, while those with kidney disease and anxiety disorder never took alcoholic drink. The only total vegetarian was the respondent with breast cancer who also did not engage in any formal exercise. The highest proportion (50.0%) of those who engaged in formal exercise on daily basis was among those with kidney disease. Interestingly, respondents with most of the NCDs reported having less than 8 hours of sleep per day while 10.5% of the diabetics and the respondent with breast cancer reported having more than 8 hours of sleep per day. Almost all respondents with other NCDs never smoked cigarette, a minimum of 50% never took alcohol and in a minimum of 66.7% was the hours of sleep less than 8 hours per day.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eKnowledge of dietary supplements by persons with non-communicable diseases relative to sex and age group. Table 2.\\u0026nbsp;\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eThe proportion of hypertensives (males and females) who believed that dietary supplements are necessary during infectious disease outbreak such as Covid-19 was moderately high (58/105, 55.2%; 57.9% males, 52.1% females) while the proportion was higher among those with low prevalent NCD such as asthma (13/20, 65.0%) and diabetes (58/105, 68.4%) and still higher among respondents with kidney disease (2/2, 100.0%), ulcer (5/6, 83.3%) and liver disease. While only 15.8% of the hypertensives believed that supplements can be used exclusively to treat Covid-19 infection, none of the asthmatics and 7.6% of those with diabetes believed such notion. However, 55.2% of the hypertensives, 75.0% of the asthmatics and 47.4% of the diabetics asserted that supplements can be used in conjunction with other drugs to treat Covid-19. Among respondents with low frequency NCD, the highest proportion of those who asserted that supplements can be used in conjunction with other drugs to treat Covid-19 were those with ulcer (83.3%).\\u003c/p\\u003e\\n\\u003cp\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eConsumption and frequency of dietary supplements use during Covid-19 pandemic in Nigeria relative to sex and age group. Table 3. \\u0026nbsp;\\u0026nbsp;\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eAlmost all the respondents with hypertension (101/105, 96.2%), asthma (19/20, 95.0%), diabetes (19/19, 100.0%) and kidney disease (6/6, 100.0%), consumed supplements more during Covid-19 pandemic in Nigeria. The proportion of those who consumed supplements more during the pandemic in Nigeria was higher among male hypertensives (57/101, 56.4%) than among the female (44/101, 43.6%), though the difference was not significant (\\u0026chi;\\u0026sup2;=2.93, P-value=0.09). Interestingly, hypertensives aged \\u0026ge;50 years were approximately 4 times more likely to consume supplements more during the Covid-19 pandemic than those aged \\u0026lt;50 years (\\u0026chi;\\u0026sup2;=0.47, P-value=0.49, OR=3.73, 95% CI:0.38, 37.12). Those with SCD had the lowest proportion (3/5, 60.0%) of those who consumed supplements more during the Covid-19 pandemic in Nigeria. When respondents were asked about the frequency of consumption of supplements during Covid-19 pandemic in Nigeria, the only breast cancer respondent reported consuming supplement daily, while of those who took supplements, 60.0% of the asthmatics, 57.9% of the diabetics, 36.5% among the hypertensives, and only 33.3% of those with kidney disease took them daily. Remarkably, the daily consumption of supplements during the Covid-19 pandemic in the country was higher among female respondents with hypertension (19/44, 43.2%), diabetes (3/5, 60.0%), kidney disease (2/2, 100.0%) and among \\u0026ge;50 years with hypertension (24/56, 42.9%), asthma (6/10, 60.0%) and diabetes (9/12, 75.0%). Almost all respondents with other NCDs increased their intake of DHS during the Covid-19 pandemic in Nigeria in varying frequency but mostly daily and on alternate days.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eDietary supplements consumed by persons with non-communicable diseases during Covid-19 pandemic in Nigeria. Table 4.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eThe dietary and herbal supplements as well as fruits taken by respondents in each disease entity is shown in Table 4. Vitamin C was the commonest vitamin taken by respondents with ulcer (83.3%), kidney disease (83.3%), diabetes (57.9%), asthma (50.0%), hypertension (48.6%) and the two respondents with breast cancer (1, 100.0%) and anxiety disorder (1, 100.0%) respectively. Calcium and zinc were the commonest minerals taken by respondents with ulcer (50.0%, 16.7%), diabetes (10.5%, 5.3%), asthma (30.0%, 10.0%) and hypertension (13.3%, 11.4%) respectively. The commonest herbal supplements consumed by respondents with hypertension were ginger (25.7%), turmeric (24.8% and garlic (22.9%). However, a higher proportion of respondents with diabetes consumed ginger (36.8%), turmeric (47.4%) and garlic (26.3%) while a lower proportion of those with asthma consumed ginger (10.0%), turmeric (20.0%) and garlic (15.0%). Surprisingly, negligible proportion of respondents took fruits, which was observed only in 1 (5.0%) respondent with asthma, though slightly higher proportion of them (10.5%) took apple cider during the Covid-19 pandemic. \\u0026nbsp;Except for the respondents with liver disorder, almost all other low-frequency NCDs increased their intake of Vitamin C, and to a lesser extent, Vitamin D. Hardly did any one of this group of respondents take mineral supplement those with gastric ulcer who took increased their intake of calcium (50.0%) and zinc (16.7%) and the only respondent with anxiety disorder who also took increased his intake of zinc (100.0%). Very few of them consumed either herbal supplements or fruits.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eReasons for the consumption of DHS during Covid-19 pandemic in Nigeria. Figure 3.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eRespondents were then asked for the reasons why they took dietary and herbal supplements during the Covid-10 pandemic in Nigeria. Their responses are illustrated in Figure 2 which show that \\u0026ldquo;to maintain good health\\u0026rdquo; was the main reason why the two respondents with breast cancer and anxiety disorder, 83.3% of those with kidney disease, 80% of the asthmatics, 64.8% of the hypertensives and 63.2% of the diabetics took supplements during that period. The respondent with anxiety disorder as well as 33.3% of respondents with ulcer and with kidney disease and 26.3% of the diabetics also took supplements to \\u0026ldquo;hasten recovery from current illness\\u0026rdquo;.\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eSource of information of practices related to food and dietary supplements used to prevent/treat COVID-19. Figure 4.\\u003c/em\\u003e\\u003c/p\\u003e\\n\\u003cp\\u003eHealth workers were the dominant source of information on the use of supplements during Covid-19 pandemic in Nigeria as stated by all the respondents with kidney disease, liver disease, breast cancer and anxiety disorder. However, only 60.0% of asthmatics, 56.2% of the hypertensives and 47.4% of the diabetics got information related to use of supplements at that period from health workers. Social media was also the main source of information of supplement use during Covid-19 pandemic in Nigeria for the respondent with anxiety disorder, 66.7% of those with ulcer, and just 20.0%, 15.8% and 14.3% of the asthmatics, diabetics, and hypertensive respectively among respondents. The internet as source of information for use of supplements at the time of study was not prominent as only 33.3 % of respondents with ulcer, 15.0% of the asthmatics, 15.2% of the hypertensives and a mere 5.3% of the diabetics sourced information of supplement consumption used this medium of information. Mass media did not feature well as source of information. Only 50.0% of ulcer patients, 15.0% of the asthmatics, 15.2% of the hypertensives and a mere 5.3% of the diabetics used mass media to source for relevant information on supplement use a that period.\\u0026nbsp;\\u003c/p\\u003e\"},{\"header\":\"Discussion\",\"content\":\"\\u003cp\\u003eIn this cohort of respondents with non-communicable diseases, hypertension claimed the highest prevalence, followed by asthma and diabetes. This group of who are probably the most prevalent of NCDs are known to be related to the severe outcomes of COVID-19 infection [\\u003cspan citationid=\\\"CR20\\\" class=\\\"CitationRef\\\"\\u003e20\\u003c/span\\u003e]. Nikoloski et al (2021) reported that patients with NCDs such as diabetes, hypertension, chronic respiratory illnesses, chronic kidney, and liver conditions are more likely to be affected by Covid-19 and are more likely to develop a severely critical form of the illness or even dying other average patients [\\u003cspan citationid=\\\"CR21\\\" class=\\\"CitationRef\\\"\\u003e21\\u003c/span\\u003e]. This is probably due to (i) elevated level of ACE2 (angiotensin-converting enzyme 2) receptor expressions, which assists the viral penetration into host\\u0026rsquo;s body and (ii) cytokine storm, a hyperinflammatory response [\\u003cspan citationid=\\\"CR21\\\" class=\\\"CitationRef\\\"\\u003e21\\u003c/span\\u003e]. A plethora of dietary supplements are currently being evaluated for their proficiency in safeguarding and enhancing human immune response to COVID-19, including omega-3 fatty acids, melatonin, and vitamin D, in patients with COVID-19 [\\u003cspan citationid=\\\"CR22\\\" class=\\\"CitationRef\\\"\\u003e22\\u003c/span\\u003e]. This probably because, as stated by National Institute of Health, \\u0026ldquo;many people are searching for ways to protect themselves against COVID-19\\u0026rdquo; and that sales of supplements increased notwithstanding dearth of dependable indication that these supplements are effective at averting SARS-CoV-2 infection or lessening COVID-19 disease severity [\\u003cspan citationid=\\\"CR22\\\" class=\\\"CitationRef\\\"\\u003e22\\u003c/span\\u003e]. Human immune system consisting of intrinsic reactions in the vanguard of defense, and adaptive responses, protects the body against disease-causing pathogens [\\u003cspan additionalcitationids=\\\"CR24\\\" citationid=\\\"CR23\\\" class=\\\"CitationRef\\\"\\u003e23\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR25\\\" class=\\\"CitationRef\\\"\\u003e25\\u003c/span\\u003e]. Though COVID-19 vaccines are reliable and highly efficient at lowering the threat against human health posed by diseases [\\u003cspan citationid=\\\"CR26\\\" class=\\\"CitationRef\\\"\\u003e26\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR27\\\" class=\\\"CitationRef\\\"\\u003e27\\u003c/span\\u003e] and though medications for treatments are also existing and accessible, still no permanent remedy has been found for COVID-19 [\\u003cspan citationid=\\\"CR22\\\" class=\\\"CitationRef\\\"\\u003e22\\u003c/span\\u003e]. For this and probably more reasons, awareness, interest in, and attention to DHS that might boost immune function in the prevention or management of COVID-19 illness was high during the pandemic. Of all the three major NCDs, a higher proportion of diabetics (68.4%) agreed that dietary supplements are necessary during infectious disease outbreak such as Covid-19, more than asthmatics (65.0%) or hypertensives (55.3%). This might be due to many factors including aspiration for lessened disease severity which might be stronger among diabetics, stronger will to prevent Covid-19 infection among diabetics because of their easy susceptibility, current medication taken, affordability of the medication and accessibility to health care. This concept is supported by the result that all diabetics increased consumption of DHS during the pandemic mostly on daily basis (57.9%). Although a high proportion of hypertensives also increased consumption of DHS during the pandemic, however, the proportion that did so on daily basis was less (37.6%) than the proportion among the diabetics. Diabetes, as a chronic disease, may reduce the quality of life more than hypertension and sufferers may probably indulge more in taking supplements in an attempt not only to prevent Covid-19 infection but also to improve their quality of life. Vitamin C was the most consume supplements, mainly by diabetic respondents (57.9%), followed by the asthmatics (50.0%) and least by the hypertensive (48.6%). Studies have shown that, due to its antioxidant effects, Vitamin C has a vital function in both innate and adaptive immunity, in antimicrobial and antiviral actions, and in influencing immune system modulators [\\u003cspan additionalcitationids=\\\"CR29 CR30\\\" citationid=\\\"CR28\\\" class=\\\"CitationRef\\\"\\u003e28\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR31\\\" class=\\\"CitationRef\\\"\\u003e31\\u003c/span\\u003e]. Report from the study of Carr and Maggini shows that Vitamin C supports epithelial integrity, enhances the diversity and proliferation of B cells and T cells, improves phagocytosis, normalizes cytokine production, and lowers histamine levels [\\u003cspan citationid=\\\"CR29\\\" class=\\\"CitationRef\\\"\\u003e29\\u003c/span\\u003e] while it may also impede viral replication [\\u003cspan citationid=\\\"CR32\\\" class=\\\"CitationRef\\\"\\u003e32\\u003c/span\\u003e]. Interestingly, diabetic respondents were also those who consumed Vitamin B complex mostly (21.1%), that asthmatics (15.0%) and hypertensives (11.4%). Probably, diabetics may have taken their illness more seriously, especially during the pandemic, than hypertensives or asthmatics. More study, especially in resource-limited countries, need to be conducted on this. While selenium was the mineral least consumed by the diabetics (5.3%), hypertensives (2.9%) and asthmatic (0.0%), a high proportion of asthmatics (30.0%), more than hypertensives (13.3%) and diabetics (10.5%) increased their intake of calcium during the pandemic. While selenium is known to augment the immune systems through enhancing T-cell maturation and role and in natural killer cell function, it is also known to lower the risk of infections [\\u003cspan additionalcitationids=\\\"CR34 CR35 CR36 CR37 CR38 CR39\\\" citationid=\\\"CR33\\\" class=\\\"CitationRef\\\"\\u003e33\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR40\\\" class=\\\"CitationRef\\\"\\u003e40\\u003c/span\\u003e]. Studies have also shown that selenium\\u0026rsquo;s anti-oxidant property may assist in reducing systemic inflammatory response causing acute respiratory distress syndrome and organ failure [\\u003cspan additionalcitationids=\\\"CR42\\\" citationid=\\\"CR41\\\" class=\\\"CitationRef\\\"\\u003e41\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR43\\\" class=\\\"CitationRef\\\"\\u003e43\\u003c/span\\u003e]. Alexander et al [\\u003cspan citationid=\\\"CR43\\\" class=\\\"CitationRef\\\"\\u003e43\\u003c/span\\u003e] ascertained that selenium and other minerals and vitamins such as zinc and vitamin D are indispensable for fighting viral infections, for optimal immune function, lowering inflammation and protecting against the novel coronavirus SARS-CoV-2. Vitamin E, which was not consumed by diabetic or hypertensive responders and by a mere 15.0% of asthmatics is known to reduce inflammation by preventing the production of pro-inflammatory cytokines [\\u003cspan citationid=\\\"CR44\\\" class=\\\"CitationRef\\\"\\u003e44\\u003c/span\\u003e]. Studies found that Vitamin E deficiency weakens humoral and cell-mediated immunity and elevates vulnerability to infections [\\u003cspan citationid=\\\"CR37\\\" class=\\\"CitationRef\\\"\\u003e37\\u003c/span\\u003e, \\u003cspan citationid=\\\"CR45\\\" class=\\\"CitationRef\\\"\\u003e45\\u003c/span\\u003e\\u0026ndash;\\u003cspan citationid=\\\"CR46\\\" class=\\\"CitationRef\\\"\\u003e46\\u003c/span\\u003e]. More diabetic respondents increased their consumption of garlic (26.3%), ginger (36.8%), turmeric (47.4%) and moringa (26.3%) than asthmatics (15.0%, 10.0%, 20.0% and 5.0% respectively) or hypertensives (22.9%, 257%, 24.8% and 10.5% respectively). In a case control study, Wang et al reported that, among other observations, patients with Covid-19 who received garlic essential oil had lesser duration of symptoms, shorter time to negative nucleic acid testing (NAT) results and shorter time to improvement on the computed tomography (CT) [\\u003cspan citationid=\\\"CR47\\\" class=\\\"CitationRef\\\"\\u003e47\\u003c/span\\u003e]. The use of ginger, garlic, and turmeric among respondents with diabetes, asthma and hypertension in this study was much less than the 87.1%, 78.9%, 57.9% use of these herbal supplements among the general public in another study [\\u003cspan citationid=\\\"CR48\\\" class=\\\"CitationRef\\\"\\u003e48\\u003c/span\\u003e].\\u003c/p\\u003e \\u003cp\\u003eOf the respondents with high frequency NCDs, asthmatics were those who mostly (60.0%) depended on health workers as source of information for use of supplements during the Covid-19 pandemic, followed by the hypertensives (56.2%) and the diabetics (47.4%) and 20.0% or less depended on social media for such information. This may be due to uncertainty, circulating conspiracy theories and fake news on social media and print media. To confirm what Jayaseelan et al [\\u003cspan citationid=\\\"CR49\\\" class=\\\"CitationRef\\\"\\u003e49\\u003c/span\\u003e] stated that incorrect or deceptive information could be dispersed willingly or malevolently through the internet for concealed purposes, another study evaluated Twitter contents during the pandemic and reported that 25% of information on Covid-19 were deceptive [\\u003cspan citationid=\\\"CR50\\\" class=\\\"CitationRef\\\"\\u003e50\\u003c/span\\u003e].\\u003c/p\\u003e \\u003cp\\u003eStudy limitations\\u003c/p\\u003e \\u003cp\\u003eThis study has some potential limitations which are (i) the study did not meet the expected number of respondents from Google Form which was sent to all the six geo-political zones of the country. This necessitated face-to-face interviews in Lagos City populated by all ethnic groups. (ii) Bias into the study may have been introduce by convenient sampling (iii) Respondents who filled the Google Form on-line may have misconstrued, misinterpreted the questions, and responded without elucidation. Vulnerable population may have been excluded. The interviewer-mediated survey may have presented latent social desirability and interviewer biases. Moreover, it is important to note that the study population consisted of a relatively high proportion of persons with hypertension and fewer proportion of other non-communicable diseases, especially cancer, anxiety disorder and Sickle Cell Disease. This, however, may be representative of the profile of NCDs among the general population in Nigeria. Therefore, the relatively small sample size of the NCDs and the cross-sectional survey design restricts causal associations between study variables. There are hardly any studies conducted in Nigeria or in Africa on the advantages and benefits of using dietary and herbal supplements for preventing and treating COVID-19 infection, especially among hypertensives, asthmatics, and diabetics, which weakened this current study to compare its findings with those of other African countries. Further studies, preferably multi-center and multidiscipline, and in different parts of continental Africa are needed to determine the exact predictive value of findings in this current study.\\u003c/p\\u003e \"},{\"header\":\"Conclusion\",\"content\":\"\\u003cp\\u003eThis study evaluated the proportion of Nigerians with Non-communicable diseases, especially hypertension, asthma, and diabetes, who took dietary and herbal supplements to boost their immunity during the COVID-19 pandemic in the country. Hypertension was the most prevalent non-communicable disease. Almost all respondents increased their consumption of one form of dietary supplements or another during the Covid-19 pandemic, more among male than female hypertensives. Vitamin C was the most common vitamin consumed and calcium and zinc were the minerals that were also moderately consumed by those with ulcer, diabetes, asthma, and hypertension. The most prevalent reason why a high proportion of respondents, especially those with kidney disease and with asthma, increased their consumption of dietary supplement was to maintain good health.\\u003c/p\\u003e \\u003c/div\\u003e\"},{\"header\":\"Declarations\",\"content\":\"\\u003cp\\u003eDeclaration of Competing Interest:\\u003c/p\\u003e\\n\\u003cp\\u003eThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eAcknowledgments:\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eThe authors are appreciative of Nigerian Institute of Medical Research for providing the fund to carry out the study in Nigeria. In addition, the authors hereby express their sincere appreciation to study participants who painstakingly contributed their time and efforts to complete the surveys for the successful completion of this survey.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eContributors\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eBMA, SJAH and OOO conceived and designed the initial research questions and coordinated the data collection. BMA, SH and OOO had full access to the study\\u0026rsquo;s data and take responsibility for the integrity and accuracy of the data analysis. BM and SH completed the statistical analysis and supervised the conduct of the research. BMA and SH drafted the final paper. BMA, SH, and OOO critically reviewed the write up of the manuscript. All authors approved the final version of the manuscript and agreed to be accountable for all aspects of the work.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003eFunding Source Declaration\\u003c/em\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003eThis research received was funded by the Nigerian Institute of Medical Research Grant No: NMG-CIF-38-0056\\u003c/p\\u003e\"},{\"header\":\"References\",\"content\":\"\\u003col\\u003e\\u003cli\\u003e\\u003cspan\\u003eCDC. 2019 Novel Coronavirus, Wuhan, China. CDC. Available at \\u003cspan class=\\\"ExternalRef\\\"\\u003e\\u003cspan class=\\\"RefSource\\\"\\u003ehttps://www.cdc.gov/coronavirus/2019-ncov/about/index.html\\u003c/span\\u003e\\u003cspan address=\\\"https://www.cdc.gov/coronavirus/2019-ncov/about/index.html\\\" targettype=\\\"URL\\\" class=\\\"RefTarget\\\"\\u003e\\u003c/span\\u003e\\u003c/span\\u003e. January 26, 2020. 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[PubMed abstract]\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eBae M, Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19. Molecules 2020;25: 5346. [PubMed abstract]\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eZhang J, Saad R, Taylor EW, Rayman MP. Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biol 2020;37:101715\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eAllingstrup M, Afshari A. Selenium supplementation for critically ill adults. Cochrane Database Syst Rev 2015;2015:Cd003703.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eAlexander J, Tinkov A, Strand TA, Alehagen U, Skalny A, Aaseth J. Early nutritional interventions with zinc, selenium, and vitamin D for raising anti-viral resistance against progressive COVID-19. Nutrients 2020;12.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eFiorino S, Gallo C, Zippi M, Sabbatani S, Manfredi R, Moretti R, et al. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy. Aging Clin Exp Res 2020;32:2115\\u0026ndash;31.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eJames PT, Ali Z, Armitage AE, Bonell A, Cerami C, Drakesmith H, et al. The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review. J Nutr 2021;151:1854\\u0026ndash;78.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eJayawardena R, Sooriyaarachchi P, Chourdakis M, Jeewandara C, Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes Metab Syndr 2020;14:367\\u0026ndash;82.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eWang Y, Wu Y, Fu P, Zhou H, Guo X, et al. Effect of garlic essential oil in 97 patients hospitalized with covid-19: A multi-center experience. Pak J Pharm Sci. 2022 Jul;35(4):1077\\u0026ndash;1082.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eRadwan H, Hasan H, Jaafar Z, Abbas N, Saif ER, Al Kitbi M, Al Hilali M, Naja F. Diets, and dietary supplements used during the COVID-19 pandemic in the United Arab Emirates: A cross-sectional survey. Saudi Pharmaceutical Journal, 2022;30:421\\u0026ndash;432.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eJayaseelan, R., Brindha, D., Kades, W., 2020. Social Media Reigned by Information or Misinformation About COVID-19: A Phenomenological Study. SSRN Electronic J. \\u003cspan class=\\\"ExternalRef\\\"\\u003e\\u003cspan class=\\\"RefSource\\\"\\u003ehttps://doi.org/10.2139/ssrn.3596058\\u003c/span\\u003e\\u003cspan address=\\\"10.2139/ssrn.3596058\\\" targettype=\\\"DOI\\\" class=\\\"RefTarget\\\"\\u003e\\u003c/span\\u003e\\u003c/span\\u003e.\\u003c/span\\u003e\\u003c/li\\u003e \\u003cli\\u003e\\u003cspan\\u003eKouzy, R., Abi Jaoude, J., Kraitem, A., el Alam, M.B., Karam, B., Adib, E., Zarka, J., Traboulsi, C., Akl, E., Baddour, K., 2020. Coronavirus Goes Viral: Quantifying the COVID-19 Misinformation Epidemic on Twitter. Cureus 12. \\u003cspan class=\\\"ExternalRef\\\"\\u003e\\u003cspan class=\\\"RefSource\\\"\\u003ehttps://doi.org/10.7759/cureus.7255\\u003c/span\\u003e\\u003cspan address=\\\"10.7759/cureus.7255\\\" targettype=\\\"DOI\\\" class=\\\"RefTarget\\\"\\u003e\\u003c/span\\u003e\\u003c/span\\u003e.\\u003c/span\\u003e\\u003c/li\\u003e\\u003c/ol\\u003e\"},{\"header\":\"Tables\",\"content\":\"\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:19px;line-height:107%;font-family:\\\"Times New Roman\\\",serif;'\\u003eTable 1. Socio-demographic characteristics of respondents relative to disease entity\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cdiv align=\\\"center\\\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\n \\u003ctable style=\\\"width: 4.8e+2pt;border-collapse:collapse;border:none;\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width:99.4pt;border:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:26.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVariable\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:72.85pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:26.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eCategory\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:67.0pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:26.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eStatistics\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:237.5pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:26.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eNon-communicable disease entity\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:89.1pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eHypertension\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eAsthma\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eDiabetes\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width:139.85pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eTotal (%)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:89.1pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e105 (63.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e20 (12.1)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e19 (11.5)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" rowspan=\\\"3\\\" style=\\\"width:172.25pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:18.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eAge (yrs)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003cp 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(4.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e3 (15.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:72.85pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eRetired\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:89.1pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e9 (8.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.3pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e2 (10.5)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:99.4pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eReligion\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:72.85pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eChristianity\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:89.1pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e79 (75.2)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e18 (90.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e9 (47.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:72.85pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eIslam\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:89.1pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e26 (24.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.4pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e2 (10.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.0pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.5pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e10 (52.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n \\u003c/table\\u003e\\n\\u003c/div\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:19px;line-height:107%;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;margin-left:.5in;text-align:justify;'\\u003e\\u003cspan style=\\\"font-size:16px;\\\"\\u003eTable 2. Knowledge of dietary supplements by persons with non-communicable diseases relative to sex and age group\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:justify;'\\u003e\\u003cspan style=\\\"font-size:16px;\\\"\\u003e\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cdiv align=\\\"center\\\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\n \\u003ctable style=\\\"width:603.15pt;border-collapse:collapse;border:none;\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:68.65pt;border:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eDisease\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:49.45pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eVariable\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:53.95pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eCategory\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:168.35pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eDietary supplements are necessary during infectious disease outbreak such as COVID-19\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:127.15pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eSupplements can be used exclusively to treat COVID-19\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:135.6pt;border:solid windowtext 1.0pt;border-left:none;padding:0in 5.4pt 0in 5.4pt;height:23.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:justify;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eSupplements can be used in conjunction with other drugs to treat COVID-19\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:67.1pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eYes\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:49.8pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eNo\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:51.45pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eDon\\u0026rsquo;t know\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eYes\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eNo\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eDon\\u0026rsquo;t know\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eYes\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eNo\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:54.2pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:16.1pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eDon\\u0026rsquo;t know\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"7\\\" style=\\\"width:68.65pt;border:solid windowtext 1.0pt;border-top:none;padding:0in 5.4pt 0in 5.4pt;height:12.25pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u003cstrong\\u003eHypertension (n=105)\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"4\\\" style=\\\"width:49.45pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:12.25pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eSex\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd 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5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e1 (20.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:54.2pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e1 (20.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:53.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026chi;\\u0026sup2; (P-value)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:168.35pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e4.04 (0.13) *\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:127.15pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e7.36 (0.03) *\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:135.6pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e0.54 (0.76)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"3\\\" style=\\\"width:49.45pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003eAge group (yrs.)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:53.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026lt;50\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 67.1pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;height: 13pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e2 (28.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 49.8pt;border-color: currentcolor windowtext windowtext currentcolor;border-style: none solid solid none;border-width: medium 1pt 1pt medium;padding: 0in 5.4pt;height: 13pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:51.45pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e5 (71.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e5 (71.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e2\\u003c/span\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026nbsp;(28.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e1 (14.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e2 (28.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:54.2pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e4 (57.1)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:53.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026ge;50\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:67.1pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e11 (91.7)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:49.8pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:51.45pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e1 (8.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e3 (25.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e8 (66.7)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.75pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e1 (8.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e8 (66.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:40.7pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e2 (16.7)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:54.2pt;border-top:none;border-left:none;border-bottom: solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e2 (16.7)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:53.95pt;border-top:none;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026chi;\\u0026sup2; (P-value)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:168.35pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e\\u0026nbsp;8.44 (0.004) *\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:127.15pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e3.87 (0.14) *\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:135.6pt;border-top:none;border-left: none;border-bottom:solid windowtext 1.0pt;border-right:solid windowtext 1.0pt;padding:0in 5.4pt 0in 5.4pt;height:13.0pt;\\\"\\u003e\\n \\u003cp style='margin:0in;font-size:13px;font-family:\\\"Times New Roman\\\",serif;text-align:center;'\\u003e\\u003cspan style=\\\"font-size:11px;\\\"\\u003e5.55 (0.06) *\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n \\u003c/table\\u003e\\n\\u003c/div\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:12px;line-height:107%;font-family:\\\"Times New Roman\\\",serif;'\\u003e*=Fisher\\u0026rsquo;s exact test applied\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:16px;line-height:107%;font-family:\\\"Times New Roman\\\",serif;'\\u003eTable 3. Consumption and frequency of dietary supplements use during Covid-19 pandemic in Nigeria relative to sex and age group. \\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cdiv align=\\\"center\\\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\n \\u003ctable style=\\\"width: 5.7e+2pt;border-collapse:collapse;border:none;\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width: 60.1pt;padding: 0in 5.4pt;height: 49.05pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:100.15pt;padding:0in 5.4pt 0in 5.4pt;height:49.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVariable\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:49.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eCategory\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:49.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eDid you take dietary supplements more during this Covid-19\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"5\\\" style=\\\"width:240.5pt;padding:0in 5.4pt 0in 5.4pt;height:49.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eIf yes, how often did you take dietary supplements\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:65.05pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eYes\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eNo\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:55.1pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eOccasionally\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.05pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eAlternate days\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eDaily\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eOnce a week\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.15pt;padding:0in 5.4pt 0in 5.4pt;height:21.0pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:9px;font-family:\\\"Times New Roman\\\",serif;'\\u003eTwice a week\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"7\\\" style=\\\"width:60.1pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:11px;font-family: \\\"Times New Roman\\\",serif;'\\u003eHypertension\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width:150.3pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eAll\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:65.05pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e101 (96.2)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e4 (3.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:55.1pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e23 (22.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.05pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e23 (22.8)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e38 (37.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e10 (9.9)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.15pt;padding:0in 5.4pt 0in 5.4pt;height:19.2pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e6 (5.9)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"2\\\" style=\\\"width:100.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eSex\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eMale\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:65.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e57 (56.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:55.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e12 (21.1)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e15 (26.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e19 (33.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e7 (12.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e4 (7.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003eFemale\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:65.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e44 (43.6)\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026nbsp;4 (100)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:55.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e11 (25.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026nbsp;8 (18.2)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 45.05pt;padding: 0in 5.4pt;height: 15.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e1 (14.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026ge;50\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:65.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e12 (63.2)\\u0026nbsp;\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:55.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:50.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e3 (25.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e9 (75.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.05pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:45.15pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e0 (0.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width:150.3pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e\\u0026chi;\\u0026sup2; (P-value)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width:1.6in;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e3.31 (0.07) / undefined\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"5\\\" style=\\\"width:240.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:11px;font-family:\\\"Times New Roman\\\",serif;'\\u003e7.85 (0.10)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003c/tbody\\u003e\\n \\u003c/table\\u003e\\n\\u003c/div\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:16px;line-height:107%;font-family:\\\"Times New Roman\\\",serif;'\\u003eTable 4. Dietary supplements consumed by persons with non-communicable diseases during Covid-19 pandemic in Nigeria\\u003c/span\\u003e\\u003c/p\\u003e\\n\\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cdiv align=\\\"center\\\" style='margin-top:0in;margin-right:0in;margin-bottom:8.0pt;margin-left:0in;line-height:107%;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\n \\u003ctable style=\\\"width: 4.7e+2pt;border-collapse:collapse;border:none;\\\"\\u003e\\n \\u003ctbody\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" rowspan=\\\"2\\\" style=\\\"width:226.5pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:16px;font-family:\\\"Times New Roman\\\",serif;'\\u003eSupplement\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd colspan=\\\"3\\\" style=\\\"width:245.75pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:12px;font-family:\\\"Times New Roman\\\",serif;'\\u003eNon-communicable diseases\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:86.75pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:12px;font-family:\\\"Times New Roman\\\",serif;'\\u003eHypertension\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:81.9pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:12px;font-family:\\\"Times New Roman\\\",serif;'\\u003eAsthma\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:77.1pt;padding:0in 5.4pt 0in 5.4pt;height:15.45pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cstrong\\u003e\\u003cspan style='font-size:12px;font-family:\\\"Times New Roman\\\",serif;'\\u003eDiabetes\\u003c/span\\u003e\\u003c/strong\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"5\\\" style=\\\"width:472.3pt;padding:0in 5.4pt 0in 5.4pt;height:16.6pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eTypes of Supplements mentioned as taken\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd rowspan=\\\"6\\\" style=\\\"width:125.3pt;padding:0in 5.4pt 0in 5.4pt;height:13.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVitamins\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width:101.2pt;padding:0in 5.4pt 0in 5.4pt;height:13.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVitamin B co\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 13.05pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e12 (11.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 81.9pt;padding: 0in 5.4pt;height: 13.05pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e3 (15.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 77.1pt;padding: 0in 5.4pt;height: 13.05pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e4 (21.1)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:101.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVitamin C\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e51 (48.6)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 81.9pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e10 (50.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 77.1pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e11 (57.9)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:101.2pt;padding:0in 5.4pt 0in 5.4pt;height:11.85pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVitamin D\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e10 (9.5)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 81.9pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e7 (35.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 77.1pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e2 (10.5)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd style=\\\"width:101.2pt;padding:0in 5.4pt 0in 5.4pt;height:13.05pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eVitamin E\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 13.05pt;vertical-align: top;\\\"\\u003e\\n \\u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eZinc\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e12 (11.4)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 81.9pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e2 (10.0)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 77.1pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003e1 (5.3)\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"5\\\" style=\\\"width:472.3pt;padding:0in 5.4pt 0in 5.4pt;height:14.25pt;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;text-align:center;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eTypes of herbal supplements mentioned as consumed\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003c/tr\\u003e\\n \\u003ctr\\u003e\\n \\u003ctd colspan=\\\"2\\\" style=\\\"width: 226.5pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;line-height:normal;font-size:15px;font-family:\\\"Calibri\\\",sans-serif;'\\u003e\\u003cspan style='font-size:13px;font-family:\\\"Times New Roman\\\",serif;'\\u003eGarlic\\u003c/span\\u003e\\u003c/p\\u003e\\n \\u003c/td\\u003e\\n \\u003ctd style=\\\"width: 86.75pt;padding: 0in 5.4pt;height: 11.85pt;vertical-align: top;\\\"\\u003e\\n \\u003cp 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Square\",\"twitterHandle\":\"researchsquare\",\"acdcEnabled\":true,\"dfaEnabled\":false,\"editorialSystem\":\"\",\"reportingPortfolio\":\"\",\"inReviewEnabled\":false,\"inReviewRevisionsEnabled\":true},\"keywords\":\"Black Africans, Consumption, Covid-19, Dietary, Herbal, Micro-nutrients, Non-communicable diseases, Supplements\",\"lastPublishedDoi\":\"10.21203/rs.3.rs-2488233/v1\",\"lastPublishedDoiUrl\":\"https://doi.org/10.21203/rs.3.rs-2488233/v1\",\"license\":{\"name\":\"CC BY 4.0\",\"url\":\"https://creativecommons.org/licenses/by/4.0/\"},\"manuscriptAbstract\":\"\\u003cp\\u003eCognizance of the implication of Covid-19 pandemic on health and well-being resulted in an upsurge is use of several dietary and herbal supplements (DHS) for the prevention and/or prophylaxis against the new disease.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003eObjectives: \\u003c/strong\\u003e\\u003c/em\\u003eTo evaluate the pattern of DHS consumption among Nigerians with Non-communicable Diseases (NCD) for the prevention and treatment of COVID-19.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003eDesign: \\u003c/strong\\u003e\\u003c/em\\u003eCross-sectional questionnaire survey. Setting: Adolescents, and adults residing in Nigeria.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003eParticipants:\\u003c/strong\\u003e\\u003c/em\\u003eParticipants with NCD (n = 165) from a larger study (n=645) were recruited from different geo-political zones and various ethnic groups.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003ePrimary and Secondary Outcomes: \\u003c/strong\\u003e\\u003c/em\\u003ePrevalence and determinants for the use of different DHS for the prevention and treatment of COVID-19 in Nigeria, and sources of information for DHS use.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003eResults:\\u003c/strong\\u003e\\u003c/em\\u003e Hypertension was the most prevalent NCD (63.6%) in the study and both breast cancer and anxiety disorder were the least (0.6%). A minimum (75.2%) of the respondents had less than 8 hours of sleep daily and almost all did not smoke cigarette at all. The proportion of male and female hypertensives who believed that dietary supplements are necessary during infectious disease outbreak such as Covid-19 was moderately high (55.2%), higher among asthmatics (65.0%), diabetes (58/105, 68.4%), those with kidney disease (100.0%), ulcer (83.3%) and liver disease. Almost all the respondents with hypertension (101/105, 96.2%), asthma (19/20, 95.0%), diabetes (19/19, 100.0%) and kidney disease (6/6, 100.0%), consumed supplements more during Covid-19 pandemic in Nigeria. The proportion of those who consumed supplements more during the pandemic in Nigeria was higher among male hypertensives (57/101, 56.4%) than among the female (44/101, 43.6%), though the difference was not significant (χ²=2.93, P-value=0.09). Vitamin C was the commonest vitamin taken by respondents with ulcer (83.3%), kidney disease (83.3%), diabetes (57.9%), asthma (50.0%), hypertension (48.6%) and the two respondents with breast cancer (1, 100.0%) and anxiety disorder (1, 100.0%) respectively. Calcium and zinc were the commonest minerals taken by respondents with ulcer (50.0%, 16.7%), diabetes (10.5%, 5.3%), asthma (30.0%, 10.0%) and hypertension (13.3%, 11.4%) respectively. High proportions (83.3%, 80.0%) of those with kidney disease and with asthma consumed DHS to maintain good health. Health workers were the dominant source of information for most on the use of supplements during Covid-19 pandemic in Nigeria.\\u0026nbsp;\\u003c/p\\u003e\\n\\u003cp\\u003e\\u003cem\\u003e\\u003cstrong\\u003eConclusions: \\u003c/strong\\u003e\\u003c/em\\u003eThe findings showed widespread use of DHS for the prevention and treatment of COVID-19 among persons with NCD. The use of DHS in this study was mainly guided by health workers with a marginal role of social media and Mass media. These findings call for a more robust consolidative tactic towards DHS to ensure its proper and safe use.\\u003c/p\\u003e\",\"manuscriptTitle\":\"Pattern of Consumption of Dietary and Herbal Supplements by Individuals with Non-communicable Diseases During Covid-19 Pandemic in Nigeria\",\"msid\":\"\",\"msnumber\":\"\",\"nonDraftVersions\":[{\"code\":1,\"date\":\"2023-01-30 20:43:18\",\"doi\":\"10.21203/rs.3.rs-2488233/v1\",\"editorialEvents\":[{\"type\":\"communityComments\",\"content\":0}],\"status\":\"published\",\"journal\":{\"display\":true,\"email\":\"info@researchsquare.com\",\"identity\":\"researchsquare\",\"isNatureJournal\":false,\"hasQc\":true,\"allowDirectSubmit\":true,\"externalIdentity\":\"\",\"sideBox\":\"\",\"snPcode\":\"\",\"submissionUrl\":\"/submission\",\"title\":\"Research Square\",\"twitterHandle\":\"researchsquare\",\"acdcEnabled\":true,\"dfaEnabled\":false,\"editorialSystem\":\"\",\"reportingPortfolio\":\"\",\"inReviewEnabled\":false,\"inReviewRevisionsEnabled\":true}}],\"origin\":\"\",\"ownerIdentity\":\"f181146e-ae7c-495d-b071-f5a1c664e7ad\",\"owner\":[],\"postedDate\":\"January 30th, 2023\",\"published\":true,\"recentEditorialEvents\":[],\"rejectedJournal\":[],\"revision\":\"\",\"amendment\":\"\",\"status\":\"posted\",\"subjectAreas\":[],\"tags\":[],\"updatedAt\":\"2023-01-30T20:43:18+00:00\",\"versionOfRecord\":[],\"versionCreatedAt\":\"2023-01-30 20:43:18\",\"video\":\"\",\"vorDoi\":\"\",\"vorDoiUrl\":\"\",\"workflowStages\":[]},\"version\":\"v1\",\"identity\":\"rs-2488233\",\"journalConfig\":\"researchsquare\"},\"__N_SSP\":true},\"page\":\"/article/[identity]/[[...version]]\",\"query\":{\"redirect\":\"/article/rs-2488233\",\"identity\":\"rs-2488233\",\"version\":[\"v1\"]},\"buildId\":\"J0_U0BvcaRcwD8yVFaRlm\",\"isFallback\":false,\"isExperimentalCompile\":false,\"dynamicIds\":[84888],\"gssp\":true,\"scriptLoader\":[]}","source_license":"CC-BY-4.0","license_restricted":false}