{"paper_id":"03765c7c-b52e-4834-962f-9d6fcc064dc2","body_text":"Abstract\nObjective\nTo assess the advantages of High-Intensity Focused Ultrasound (HIFU) in the treatment of uterine leiomyomas and adenomyosis.\nMethods\nPatients with uterine leiomyomas (435 cases) and adenomyosis (78 cases) treated in our hospital from March 2020 to October 2023 were selected to receive non-invasive treatment with HIFU. Clinical symptom improvement and fibroid shrinkage were observed, and the incidence of complications and adverse reactions during and after treatment were analyzed.\nResults\nThe success rate of HIFU treatment in 435 cases of uterine leiomyomas was as high as 94.71%. The success rate of HIFU treatment was 96.15% in 78 cases of adenomyosis. Compared with before treatment, the improvement of clinical symptoms and the reduction of leiomyomas at one month, three months and six months after treatment were relatively better than those at the treatment period (P < 0.05). There were no serious adverse reactions in the patients during the treatment.\nConclusion\nThe noninvasive application of HIFU on leiomyomas and adenomyosis effectively improves the clinical symptoms of patients, and the volume of fibroids decreases significantly. At the same time, HIFU is safe and worthy of clinical application.\nGraphical abstract\nSimilar content being viewed by others\nData availability\nThe experimental data used to support the findings of this study are available from the corresponding author upon request.\nReferences\nS. Naz, A. Rehman, A. Riyaz, F. Jehangir, S. Naeem, and T. Iqbal, “Leiomyoma: its variants and secondary changes a five-year study,” Journal of Ayub Medical College Abbottabad, vol. 31, no. 2, pp. 192–195, 2019.\nN. Ji, L. Wang, S. Liu, M. Liu, X. Zeng, and M. Zhou, “Disease burden on uterine fibroids in China, 1990 and 2016,” Zhonghua liu Xing Bing xue za zhi = Zhonghua Liuxingbingxue Zazhi, vol. 40, no. 2, pp. 160–164, 2019.\nE. A. Stewart, S. 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Junjie Wen: Data curation, Investigation.\nCorresponding author\nEthics declarations\nCompeting interests\nThe authors declare no competing interests.\nAdditional information\nPublisher’s note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nSpringer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.\nAbout this article\nCite this article\nSu, Z., Liu, S., Wang, J. et al. Retrospective cohort study on the efficacy and safety of high-intensity focused ultrasound in non-invasive treatment of uterine leiomyomas and adenomyosis. Abdom Radiol 50, 4995–5003 (2025). https://doi.org/10.1007/s00261-025-04908-w\nReceived:\nRevised:\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s00261-025-04908-w","source_license":"CC0","license_restricted":false}