{"paper_id":"018fbd70-8f18-4f52-a485-a3209ce41900","body_text":"Issue\nCopyright (c) 2026 Authors\nThis work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.\nAuthors retain the copyright without restrictions for their published content in this journal. HSSR is a SHERPA ROMEO Green Journal.\nPublishing License\nThis is an open-access article distributed under the terms of\nEndometriosis as a risk factor for venous and arterial thromboembolism: A systematic review (2020-2025)\nCorresponding Author(s) : Maciej Jakubik\nHumanities & Social Sciences Reviews, Vol. 14 No. 2 (2026)\nAbstract\nResearch objective: Summarize evidence (2020–2025) on the association between endometriosis and venous/arterial thromboembolism, emphasizing deep vein thrombosis (DVT), pulmonary embolism (PE), ischemic stroke, and myocardial infarction, and evaluating how hormonal and surgical treatment affect thrombotic risk.\nMethodology: Narrative review of 2020–2025 literature on endometriosis as a systemic inflammatory disease and its links to thromboembolic outcomes. Focus includes proposed pathophysiology and the impact of therapeutic strategies on thrombosis risk.\nMain conclusions: Endometriosis is now seen as a systemic, chronically inflammatory condition linked to higher venous and arterial thromboembolic risk. Proposed mechanisms include oxidative stress, endothelial dysfunction, coagulation activation, and fibrinogen changes. Vascular compression and perioperative/postoperative hypercoagulability may add risk. Hormonal therapies may increase venous thromboembolism, especially with cardiovascular risk factors, while surgery may reduce long-term inflammation.\nApplication/Originality: Supports clinician recognition of endometriosis as systemic when planning hormonal vs surgical management, especially in patients with added cardiovascular risk. 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