{"paper_id":"014cf34c-a2a0-4053-91ab-387a957311f3","body_text":"Abstract\nPurpose of Review\nThe purpose of this review is to update readers on our current understanding of endometrial receptivity and to review the literature regarding endometrial assessment and pathologic states which may influence receptivity.\nRecent Findings\nTopics discussed include molecular mechanisms implicated in endometrial receptivity on the basis of which three commercially available yet controversial tests have been developed (Endometrial Function Test, Endometrial Receptivity Assay, and ReceptivaDx), as well as current evidence surrounding how common gynecologic conditions such as polyps, fibroids, adenomyosis, and chronic endometritis may influence endometrial receptivity and the success of assisted reproductive technologies (ART).\nSummary\nWhile the sequential action of estrogen and progesterone is central to the development of endometrial receptivity, the exact molecular mechanisms governing the transition from non-receptive to receptive endometrium remain poorly understood. Commercially available tests attempt to harness molecular markers to assess and potentially improve endometrial receptivity; however, current evidence is insufficient to support their routine clinical application. Polyps, fibroids, adenomyosis, and chronic endometritis may negatively impact implantation either directly by impeding embryo transport and attachment or indirectly by influencing endometrial receptivity. Given the likely heterogenous genetic construct and molecular expression of any pathologic condition, further research is needed to develop molecular testing to guide approach to clinical treatment.\nSimilar content being viewed by others\nReferences\nPapers of particular interest, published recently, have been highlighted as: • Of importance •• of major importance\nLessey B, Young S. Structure, function, and evaluation of the female reproductive tract. In: Strauss JI, Barbieri R, editors. Yen & Jaffe’s reproductive endocrinology. 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Published 2017 Mar 4. https://doi.org/10.1186/s12958-017-0233-x\nCicinelli E, Matteo M, Tinelli R, et al. Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment. Reprod Sci. 2014;21(5):640–7. https://doi.org/10.1177/1933719113508817.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nEthics declarations\nConflict of Interest\nThe authors declare they have no conflict of interest.\nHuman and Animal Rights and Informed Consent\nThis article does not contain and studies with human or animal subjects performed by any of the authors.\nAdditional information\nPublisher's Note\nSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.\nRights and permissions\nAbout this article\nCite this article\nBakkensen, J.B., Agarwal, R. & Shapiro, M. Recent Advances and Current Perspectives on Endometrial Receptivity. Curr Obstet Gynecol Rep 10, 45–52 (2021). https://doi.org/10.1007/s13669-021-00313-4\nAccepted:\nPublished:\nVersion of record:\nIssue date:\nDOI: https://doi.org/10.1007/s13669-021-00313-4","source_license":"CC0","license_restricted":false}